2022
Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis
Chaudhary O, Trotta D, Wang K, Wang X, Chu X, Bradley C, Okulicz J, Maves RC, Kronmann K, Schofield CM, Blaylock JM, Deng Y, Schalper KA, Kaech SM, Agan B, Ganesan A, Emu B. Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis. Journal For ImmunoTherapy Of Cancer 2022, 10: e004564. PMID: 35470232, PMCID: PMC9039380, DOI: 10.1136/jitc-2022-004564.Peer-Reviewed Original ResearchConceptsViral suppressionTraditional risk factorsCase-control study designMarker of riskControl study designHIV infectionStudy cohortInhibitory receptorsRisk factorsCancer casesT cellsStudy designCancer diagnosisPLWHHIVCancerRiskCD4CellsPatientsTranscription factorsClinical cancer diagnosisCohortSuppressionInfection
2021
Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiology
2019
Risk and Protective Factors for Problematic Drinking in Early Adolescence: A Systematic Approach
Isaksson J, Schwab-Stone M, Stickley A, Ruchkin V. Risk and Protective Factors for Problematic Drinking in Early Adolescence: A Systematic Approach. Child Psychiatry & Human Development 2019, 51: 231-238. PMID: 31468271, PMCID: PMC7067730, DOI: 10.1007/s10578-019-00925-1.Peer-Reviewed Original ResearchConceptsAlcohol-related problemsInterpersonal factorsEarly adolescenceSubsequent alcohol-related problemsSixth gradeAlcohol useProspective research programSixth-grade studentsConduct problemsDelinquent peersExternalizing symptomsProblematic drinkingMarker of riskIndividual risk factorsFuture health problemsDecreased perceptionSeventh gradeContextual factorsSelf-reported informationProtective factorsRisk factorsDepressive symptomsWhite ethnicityHealth problemsAdolescence
2018
Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Pettigrew MM, Gent JF, Kong Y, Halpin AL, Pineles L, Harris AD, Johnson JK. Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients. Clinical Infectious Diseases 2018, 69: 604-613. PMID: 30383203, PMCID: PMC6669284, DOI: 10.1093/cid/ciy936.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant Pseudomonas aeruginosaIntensive care unit patientsCare unit patientsPiperacillin-tazobactamUnit patientsICU patientsMarker of riskMaryland Medical CenterRisk of colonizationRibosomal RNA gene sequencingRNA gene sequencingAdmission swabCRPA infectionPseudomonas aeruginosaICU admissionPatient characteristicsMicrobiota disruptionMedical CenterGastrointestinal tractAdditional swabsAntimicrobial exposureLower riskEvaluated associationsPatientsProtective role
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