2025
Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice
Hasan M, Wang H, Luo W, Du Y, Li T. Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in Mdr2 KO mice. AJP Gastrointestinal And Liver Physiology 2025, 329: g45-g57. PMID: 40418643, PMCID: PMC12178242, DOI: 10.1152/ajpgi.00044.2025.Peer-Reviewed Original ResearchConceptsKO miceBile acid compositionBile acid pool sizeBile acid poolBile acid hydrophobicityHepatic bile acidsHepatobiliary toxicityBile acid metabolismMale miceTherapeutic benefitCholestasis modelMdr2-KO miceDecreased liver injuryBile acidsSerum alkaline phosphataseBile acid absorptionAlkaline phosphataseFecal bile acid excretionAcid compositionDiminished therapeutic efficacyImpaired bile flowAcid metabolismHepatobiliary injuryUnique pharmacokineticsBiliary injury
2024
CYP2C gene polymorphisms in North African populations
Messaoudi M, Pakstis A, Boussetta S, Ben Ammar Elgaaied A, Kidd K, Cherni L. CYP2C gene polymorphisms in North African populations. Molecular Biology Reports 2024, 51: 1145. PMID: 39532754, DOI: 10.1007/s11033-024-10093-8.Peer-Reviewed Original ResearchConceptsNorth African populationsCYP2C genesHuman CYP2C genesSuperfamily of genesAfrican populationsRegulatory regionsIntronic SNPGenetic variationHaplotype frequenciesChromosome 10Pharmacogenetic markersFunctional consequencesGenesResponse to medical treatmentSNPsTunisian populationCYP2C9Drug metabolismForeign chemicalsCYP2C19North AfricansBackgroundCytochrome P450Clinically useful drugsGene polymorphismsPrincipal component analysisEffects of cannabidiol and Δ9-tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review
Smith S, Le G, Teopiz K, Kwan A, Rhee T, Ho R, Wu J, Cao B, Ceban F, McIntyre R. Effects of cannabidiol and Δ9-tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review. Drug Metabolism Reviews 2024, 56: 164-174. PMID: 38655747, DOI: 10.1080/03602532.2024.2346767.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCannabidiolCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDronabinolDrug InteractionsHumansPsychotropic DrugsConceptsCannabinoid cannabidiolDrug-drug interactionsPsychotropic medicationsPsychotropic agentsCYP450 enzymesHigh risk of drug–drug interactionsInteraction of THCEffects of cannabidiolRisk of drug-drug interactionsInduction of CYP450 enzymesActivity of CYP450 enzymesIncreased adverse effectsPsychotropic drugsPlasma levelsClinical dataTHCClinical studiesClinicians evidenceCannabidiolHigh riskInduce cytochrome P450Clinical settingCannabisCytochrome P450 enzymesSystematic reviewKey Role of Porcine Cytochrome P450 2A19 in the Bioactivation of Aflatoxin B1 in the Liver
Wang Z, Huang Q, Zhang F, Wu J, Wang L, Sun Y, Deng Y, Jiang J. Key Role of Porcine Cytochrome P450 2A19 in the Bioactivation of Aflatoxin B1 in the Liver. Journal Of Agricultural And Food Chemistry 2024, 72: 2334-2346. PMID: 38235998, DOI: 10.1021/acs.jafc.3c08663.Peer-Reviewed Original ResearchMeSH KeywordsAflatoxin B1AnimalsCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemDNA AdductsHumansLiverMicrosomes, LiverSwineConceptsDNA damagePorcine liver microsomesStable cell linesN297A mutantProducts of AFB<sub>1</sub>Aflatoxin B<sub>1</sub>Cell deathCYP2A19DNACell linesCytochrome P450 (CYP)3ACatalytic activityProtein levelsBioactivation of aflatoxin B1Metabolic activityAdduct formationCellsMetabolic transformationAdductsLiver microsomesMutantsAFBOCYP3A46Aflatoxin B1Human-based research
2023
Genetic variants in the vitamin D pathway and their association with vitamin D metabolite levels: Detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood
Fu L, Wong B, Li Z, Horst R, Williams R, Lee B, Miller J, Carpenter T, Cole D. Genetic variants in the vitamin D pathway and their association with vitamin D metabolite levels: Detailed studies of an inner-city pediatric population suggest a modest but significant effect in early childhood. The Journal Of Steroid Biochemistry And Molecular Biology 2023, 233: 106369. PMID: 37490983, DOI: 10.1016/j.jsbmb.2023.106369.Peer-Reviewed Original ResearchConceptsVitamin D pathwayD binding proteinPediatric populationInner-city pediatric populationVitamin D metabolite levelsVitamin D insufficiencyRisk pediatric populationsVitamin D metabolismVitamin D binding proteinVitamin D metabolitesD pathwayMonths of ageSanger sequencing confirmationD insufficiencyHealthy infantsD metabolismD levelsD metabolitesMultivariate regression modelLarge cohortMetabolite levelsRelevant associationsPotential roleEarly childhoodInter-individual differences
2022
Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report
Acquarulo B, Tandon P, Macica C. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. Journal Of Medical Case Reports 2022, 16: 253. PMID: 35765109, PMCID: PMC9241182, DOI: 10.1186/s13256-022-03479-4.Peer-Reviewed Original ResearchMeSH KeywordsBacopaCholinergic AgentsCytochrome P-450 Enzyme SystemFemaleHumansMiddle AgedQuinuclidinesSjogren's SyndromeThiophenesConceptsSjögren's syndromePossible drug-herb interactionsPrimary care officesDrug-herb interactionsST-T changesCevimeline hydrochlorideClinical improvementUndesirable side effectsUrinary retentionCase presentationACare officesCase reportCholinergic toxicityCaucasian femaleHerbal supplementsSide effectsClinical relevanceDrug responsivenessCommon genetic variantsSyndromeDrugsPrevious nightCytochrome P450Genetic variantsSupplementation interactionHemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukotrienes And Essential Fatty Acids 2022, 181: 102453. PMID: 35633593, DOI: 10.1016/j.plefa.2022.102453.Peer-Reviewed Original ResearchConceptsRed blood cellsHD treatmentHemodialysis treatmentEnd-stage renal disease patientsHydroxyeicosatetraenoic acidHydroxyeicosapentaenoic acidSingle hemodialysis treatmentChronic kidney diseaseRenal disease patientsRenal replacement therapyFatty acid statusVenous blood samplesHydroxydocosahexaenoic acidEpoxy fatty acidsCause of mortalityLOX pathwayRenal failureFatty acidsKidney diseaseDisease patientsVenous bloodCardiovascular functionAcid statusArteriovenous differenceCardiovascular diseaseThe metabolism and biotransformation of AFB1: Key enzymes and pathways
Wang L, Huang Q, Wu J, Wu W, Jiang J, Yan H, Huang J, Sun Y, Deng Y. The metabolism and biotransformation of AFB1: Key enzymes and pathways. Biochemical Pharmacology 2022, 199: 115005. PMID: 35318037, DOI: 10.1016/j.bcp.2022.115005.Peer-Reviewed Original ResearchConceptsAflatoxin aldehyde reductaseAspergillus parasiticusAspergillus flavusAflatoxin B<sub>1</sub>Glutathione-S-transferaseCytochrome P450sAspergillusDetoxification strategiesFood safetyMetabolismEnzymeBiotransformation of AFB1Metabolic fateDetoxificationHealth of humansEnvironmental-friendly approachDevelopment of protective strategiesNon-toxic productsParasiticusFlavusMicrobesBiotransformationAnimalsReductaseCytochrome
2021
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye
Partnership T, Li Z, Wang Z, Lee M, Zenkel M, Peh E, Ozaki M, Topouzis F, Nakano S, Chan A, Chen S, Williams S, Orr A, Nakano M, Kobakhidze N, Zarnowski T, Popa-Cherecheanu A, Mizoguchi T, Manabe S, Hayashi K, Kazama S, Inoue K, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Ideta R, Ishiko S, Yoshida A, Tokumo K, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Mori K, Ikeda Y, Ueno M, Gaston D, Rafuse P, Shuba L, Saunders J, Nicolela M, Chichua G, Tabagari S, Founti P, Sim K, Meah W, Soo H, Chen X, Chatzikyriakidou A, Keskini C, Pappas T, Anastasopoulos E, Lambropoulos A, Panagiotou E, Mikropoulos D, Kosior-Jarecka E, Cheong A, Li Y, Lukasik U, Nongpiur M, Husain R, Perera S, Álvarez L, García M, González-Iglesias H, Cueto A, Cueto L, Martinón-Torres F, Salas A, Oguz Ç, Tamcelik N, Atalay E, Batu B, Irkec M, Aktas D, Kasım B, Astakhov Y, Astakhov S, Akopov E, Giessl A, Mardin C, Hellerbrand C, Bailey J, Igo R, Haines J, Edward D, Heegaard S, Davila S, Tan P, Kang J, Pasquale L, Kruse F, Reis A, Carmichael T, Hauser M, Ramsay M, Mossböck G, Yildirim N, Tashiro K, Konstas A, Coca-Prados M, Foo J, Kinoshita S, Sotozono C, Kubota T, Dubina M, Ritch R, Wiggs J, Pasutto F, Schlötzer-Schrehardt U, Ho Y, Aung T, Tam W, Khor C. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021, 325: 753-764. PMID: 33620406, PMCID: PMC7903258, DOI: 10.1001/jama.2021.0507.Peer-Reviewed Original ResearchConceptsExfoliation syndromeValidation cohortDiscovery cohortAnterior chamberImpair protein functionFirst validation cohortSecond validation cohortSlit-lamp examinationCase-control studyAnterior segment structuresCauses of glaucomaCiliary body tissueSecondary outcomesPrimary outcomeLamp examinationSystemic disordersIrreversible blindnessMAIN OUTCOMEIndependent cohortExfoliation materialProtein-changing variantsSyndromeClinical implicationsCohortStudy participants
2019
Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Mallick P, Moreau M, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M. Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans. Toxicological Sciences 2019, 173: 86-99. PMID: 31593217, PMCID: PMC6944222, DOI: 10.1093/toxsci/kfz211.Peer-Reviewed Original ResearchMeSH KeywordsCarboxylesteraseCytochrome P-450 Enzyme SystemDose-Response Relationship, DrugHumansKineticsLiverMicrosomes, LiverModels, BiologicalNitrilesPermethrinPharmacokineticsPyrethrinsConceptsTarget tissue exposureTissue exposurePharmacokinetic modelLiver blood flowLow internal exposureAge-related sensitivityAge-dependent changesEfficient metabolic clearanceIndividual cytochrome P450Human hepatic metabolismAge-related differencesCis-permethrinHepatic metabolismBlood flowMetabolic clearanceCES enzymesHepatic CLintInternal doseIntrinsic clearanceTarget tissuesInternal exposureClearanceCarboxylesterase enzymesCytochrome P450Vivo extrapolationA Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes
Matlock M, Tambe A, Elliott-Higgins J, Hines R, Miller G, Swamidass S. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes. Chemical Research In Toxicology 2019, 32: 1707-1721. PMID: 31304741, PMCID: PMC6933754, DOI: 10.1021/acs.chemrestox.9b00223.Peer-Reviewed Original ResearchConceptsAge-dependent changesHepatic Drug Metabolizing EnzymesAdverse drug reactionsValproic acid toxicityDrug metabolizing enzymesDrug metabolism enzymesElimination of drugsPediatric patientsPediatric populationMetabolite exposureDrug reactionsClinical dataElevated riskOverall clearanceDrug toxicityFunction of ageDrug safetyFetal periodMetabolizing enzymesDrug metabolismDrug toxicity risksPotential mechanismsAcid toxicityEnzyme expressionDemographic factors
2017
Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol
Hettick JM, Law BF, Lin CC, Wisnewski AV, Siegel PD. Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol. Xenobiotica 2017, 48: 626-636. PMID: 28629263, PMCID: PMC5864557, DOI: 10.1080/00498254.2017.1344791.Peer-Reviewed Original ResearchMeSH KeywordsAerosolsAnimalsArgininosuccinate SynthaseAsthmaBronchoalveolar LavageCytochrome P-450 Enzyme SystemFemaleIsocyanatesMass SpectrometryMembrane GlycoproteinsMiceMice, Inbred BALB CConceptsLavage fluidOccupational allergic respiratory diseaseBALB/c mouse modelMurine bronchoalveolar lavage fluidDiisocyanate-induced asthmaBronchoalveolar lavage fluidAllergic respiratory diseasesBronchoalveolar lavage samplesDiphenyl diisocyanate aerosolsLabel-free quantitative proteomic strategyMDI conjugationWestern blot analysisHealth burdenLavage samplesRespiratory diseaseAerosol exposureMouse modelDisease pathogenesisRespiratory exposureCausative agentBlot analysisCytochrome P450Argininosuccinate synthaseQuantitative proteomic strategyCellular fractionsAnalysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia
Peyser R, Lanno S, Shimshak S, Coolon J. Analysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia. Insect Molecular Biology 2017, 26: 715-720. PMID: 28703934, DOI: 10.1111/imb.12329.Peer-Reviewed Original ResearchConceptsD. sechelliaDrosophila sechelliaToxin resistanceCytochrome P450 enzymatic activityEnzymatic activityCytochrome P450 gene familyP450 gene familyM. citrifolia fruitDrosophila simulansGenetic mapDrosophila melanogasterDefence compoundsGene familyBasal resistanceHost plantsGenetic basisSpecies of fruit fliesFruit flyFunctional studiesSechelliaGenesLociCytochromePrimary toxinToxinDual Organ Duel: The Hepatorenal Axis
Golestaneh L, Neugarten J. Dual Organ Duel: The Hepatorenal Axis. Advances In Kidney Disease And Health 2017, 24: 253-260. PMID: 28778366, DOI: 10.1053/j.ackd.2017.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnimalsAntihypertensive AgentsAntiviral AgentsCytochrome P-450 Enzyme SystemHepatitis CHepatorenal SyndromeHumansLiver DiseasesLypressinRenal Insufficiency, ChronicTerlipressinConceptsKidney injuryLiver failureAntiviral therapy of patientsHepatitis C antiviral therapyKidney diseaseTherapeutic strategiesMarker of systemic diseaseAcute kidney injuryTherapy of patientsKidney risk factorsTargeted therapeutic strategiesPathogenesis of kidney diseaseWorsening hepatic failurePortal hypertensionAntiviral therapyHepatitis CBiopsy dataPoor prognosisAltered pharmacodynamicsDifferential diagnosisHepatic failurePathophysiological mechanismsSystemic diseaseRisk factorsClinical potential
2014
Genotype and risk of major bleeding during warfarin treatment
Kawai V, Cunningham A, Vear S, Van Driest S, Oginni A, Xu H, Jiang M, Li C, Denny J, Shaffer C, Bowton E, Gage B, Ray W, Roden D, Stein C. Genotype and risk of major bleeding during warfarin treatment. Pharmacogenomics 2014, 15: 1973-1983. PMID: 25521356, PMCID: PMC4304738, DOI: 10.2217/pgs.14.153.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugEthnicityFemaleGene FrequencyGenetic Association StudiesGenetic VariationGenotypeHemorrhageHumansMaleMiddle AgedRisk FactorsVitamin K Epoxide ReductasesWarfarinGenetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans
Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. International Journal Of Cardiology Cardiovascular Risk And Prevention 2014, 8: 475-480. PMID: 25064769, PMCID: PMC4115247, DOI: 10.1016/j.jash.2014.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanBlood PressureCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemDNADouble-Blind MethodFemaleGenetic VariationGenotypeHumansHypertensionMaleMiddle AgedMineralocorticoid Receptor AntagonistsPilot ProjectsRadioimmunoassayUnited StatesYoung AdultConceptsBlood pressure responseBlood pressureReceptor antagonismPressure responseMineralocorticoid receptor antagonismSalt-sensitive hypertensionAfrican AmericansExploratory pilot studyGC individualsAldosterone responseResistant hypertensionAntihypertensive effectTreatment responsePrecluded analysisCC genotypeCC homozygotesSpironolactoneC alleleHypertensionPilot studyENaC activationCYP4A11AmilorideActivation of ENaC.ENaC inhibition
2013
Introduction
Brown NJ, Falck J. Introduction. Prostaglandins And Other Lipid Mediators 2013, 104: 1. PMID: 23809194, DOI: 10.1016/j.prostaglandins.2013.06.003.Peer-Reviewed Original Research
2012
Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record
Ramirez A, Shi Y, Schildcrout J, Delaney J, Xu H, Oetjens M, Zuvich R, Basford M, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley J, Ritchie M, Masys D, Roden D, Crawford D, Denny J. Predicting warfarin dosage in EuropeanAmericans and AfricanAmericans using DNA samples linked to an electronic health record. Pharmacogenomics 2012, 13: 407-418. PMID: 22329724, PMCID: PMC3361510, DOI: 10.2217/pgs.11.164.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overAnticoagulantsAryl Hydrocarbon HydroxylasesBlack or African AmericanCalcium-Binding ProteinsCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4Dose-Response Relationship, DrugDrug Administration ScheduleElectronic Health RecordsFemaleHumansMaleMiddle AgedMixed Function OxygenasesPolymorphism, Single NucleotideSubstance-Related DisordersVitamin K Epoxide ReductasesWarfarinWhite People
2011
CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow
Williams JS, Hopkins PN, Jeunemaitre X, Brown NJ. CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. Journal Of Hypertension 2011, 29: 1913-1918. PMID: 21873888, PMCID: PMC3309034, DOI: 10.1097/hjh.0b013e32834aa786.Peer-Reviewed Original ResearchConceptsMean arterial pressureHigh salt intakeRenal blood flowHypertensive individualsBlood pressureSalt intakeC alleleSalt restrictionNormotensive individualsBlood flowSalt-sensitive blood pressureSalt sensitivityLow-salt dietDiagnosis of hypertensionHigh blood pressureSalt-sensitive hypertensionRenal vasodilationPressor responseSalt dietArterial pressureAngiotensin IIAttenuated increaseSodium homeostasisCYP4A11 T8590C polymorphismHypertensionCYP4A11 variant is associated with high-density lipoprotein cholesterol in women
White CC, Feng Q, Cupples LA, Gainer JV, Dawson EP, Wilke RA, Brown NJ. CYP4A11 variant is associated with high-density lipoprotein cholesterol in women. The Pharmacogenomics Journal 2011, 13: 44-51. PMID: 21912424, PMCID: PMC3380161, DOI: 10.1038/tpj.2011.40.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesCholesterol, HDLCohort StudiesCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemFemaleGenetic VariationGenotypeHumansMaleConceptsHigh-density lipoprotein cholesterolFramingham Offspring StudyEpoxyeicosatrienoic acidsLipoprotein cholesterolLow HDLOffspring StudyHDL-C concentrationsCYP4A11 variantsMetabolic parametersPPARα activationEndogenous peroxisomeHDLBioVU cohortWomenReduced activityΩ-hydroxylaseCohortCYP4A11CholesterolPrevalenceGenotypes
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