2024
AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice
Cavinato C, Spronck B, Caulk A, Murtada S, Humphrey J. AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice. Journal Of The Royal Society Interface 2024, 21: 20240110. PMID: 39192727, PMCID: PMC11350382, DOI: 10.1098/rsif.2024.0110.Peer-Reviewed Original ResearchConceptsAngiotensin II infusionAT1B receptorsII infusionAngiotensin IIChronic angiotensin II infusionDays of angiotensin II infusionWild-typeAortas of WTSmooth muscle contractilityDescending Thoracic AortaAngiotensin II SignalingInflammatory cell responseRenin-angiotensin systemRegulating blood pressureAngII infusionAortic remodelingCell biological changesImmunohistological changesIndependent of sexMuscle contractilityMale miceMouse modelAbdominal aortaArterial remodelingBlood pressureCentral Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Hopper S, Weiss D, Mikush N, Jiang B, Spronck B, Cavinato C, Humphrey J, Figueroa C. Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia. Annals Of Biomedical Engineering 2024, 52: 1051-1066. PMID: 38383871, PMCID: PMC11418744, DOI: 10.1007/s10439-024-03440-0.Peer-Reviewed Original ResearchEffects of angiotensin II infusionMouse-to-mouse variationAngiotensin II-induced hypertensionRegional vascular structuresII-induced hypertensionAngiotensin II-infused miceAngiotensin II infusionWild-type miceDescending Thoracic AortaGroups of miceSuprarenal abdominal aortaEffects of hypertensionCentral arterial stiffnessDepressed hemodynamicsII infusionIndicator of hypertensionSystemic hypertensionRenovascular diseaseCardiac functionInduced hypertensionDistal aortaThoracic aortaEffects of anesthesiaMouse modelAbdominal aorta
2023
Nutcracker syndrome in children: review of symptom, diagnosis, and treatment
Kalantar D, Park S, Shin J. Nutcracker syndrome in children: review of symptom, diagnosis, and treatment. Childhood Kidney Diseases 2023, 27: 89-96. DOI: 10.3339/ckd.23.018.Peer-Reviewed Original ResearchNutcracker syndromePediatric patientsLeft renal veinRenal vein thrombosisInvasive surgical treatmentRenal nutcracker syndromePediatric clinical studiesSuperior mesenteric arteryReview of symptomsFlank painSurgical treatmentRenal veinSevere complicationsVein thrombosisMesenteric arteryNoninvasive managementClinical studiesAbdominal aortaEarly diagnosisVariable incidenceFirstline optionDiagnosisSymptomsPatientsSyndromeRole of POCUS in Assessing an Acute Aortic Thrombus
Boivin Z, Mensel E, She T. Role of POCUS in Assessing an Acute Aortic Thrombus. POCUS Journal 2023, 8: 129-131. PMID: 38099158, PMCID: PMC10721302, DOI: 10.24908/pocus.v8i2.16480.Peer-Reviewed Original ResearchAortic thrombusComputed tomographyEnd-organ ischemiaRole of POCUSProximal abdominal aortaParoxysmal atrial fibrillationUrgent surgical consultationMajor arterial branchesAbdominal painMobile thrombusFemale patientsAtrial fibrillationSurgical consultationFilling defectRecent diagnosisAbdominal aortaPatient managementArterial branchesCare ultrasoundThrombusNovel casePatientsPOCUSPainIschemiaTrehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells.
Jiang B, Li X, Wang M, Li G, Ren P, Wang Y, Xin S, Qin L. Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells. Journal Of Geriatric Cardiology 2023, 20: 214-222. PMID: 37091261, PMCID: PMC10114191, DOI: 10.26599/1671-5411.2023.03.002.Peer-Reviewed Original ResearchElastase-induced abdominal aortic aneurysmContractile phenotypeAbdominal aortic aneurysm (AAAGieson stainingVehicle-treated miceMeasuring aortic diameterAbdominal aortic aneurysm formationAortic aneurysm formationAbdominal aortic aneurysmTrehalose-treated groupSmooth muscle cellsExpression of autophagy markersVerhoeff-Van Gieson stainSmooth muscle cell contractile phenotypeAutophagy inducerAorta dilatationAortic diameterLeukocyte infiltrationAortic aneurysmVascular histologyDecreased inflammationAAA progressionMouse modelAbdominal aortaMuscle cells
2022
Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activitymTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice
He C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G. mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI Insight 2022, 7: e155815. PMID: 35132962, PMCID: PMC8855820, DOI: 10.1172/jci.insight.155815.Peer-Reviewed Original ResearchConceptsApoE-deficient miceAngiotensin IIVascular wall cellsAortic tearAortic ruptureMTOR inhibitionSmooth muscle cell hypertrophyMatricellular proteinWall cellsSuprarenal abdominal aortaMuscle cell hypertrophyExtracellular matrix accumulationInhibition of mTORRole of mTORSubadventitial hematomaFree ruptureAortic dissectionAortic diseaseAortic aneurysmSignificant dissectionAbdominal aortaHemorrhagic lesionsExtensive dissectionMetalloproteinase expressionCell hypertrophy
2019
Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension
Latorre M, Bersi MR, Humphrey JD. Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension. International Journal Of Engineering Science 2019, 141: 35-46. PMID: 32831391, PMCID: PMC7437922, DOI: 10.1016/j.ijengsci.2019.05.014.Peer-Reviewed Original ResearchAortic remodelingBlood pressure elevationCentral artery stiffnessMajor risk factorCommon mouse modelsBasic science studiesUncontrolled hypertensionIndicators of diseaseAortic stiffeningPressure elevationAdventitial fibrosisArtery stiffnessAortic growthRisk factorsAbdominal aortaCardiovascular diseaseMouse modelTherapeutic strategiesHypertensionAortic wallCompensatory increaseInflammationFibrosisDiseaseMarked increaseMultimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall
Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C. Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall. Bioconjugate Chemistry 2019, 31: 360-368. PMID: 31095372, PMCID: PMC7460274, DOI: 10.1021/acs.bioconjchem.9b00256.Peer-Reviewed Original ResearchConceptsAtherosclerotic vessel wallPositron emission tomographyVascular permeabilityVessel wallEmission tomographyRabbit atherosclerosis modelExperimental treatment optionsPET/magnetic resonance imagingDynamic contrast-enhanced MRIMultimodal positron emission tomographyContrast-enhanced MRIMagnetic resonance imagingDevelopment of nanotherapyNoninvasive imaging approachPET/MRIAtherosclerotic diseaseAtherosclerosis modelTreatment optionsAbdominal aortaIntravenous injectionAtherosclerotic lesionsResonance imagingPET/Treatment evaluationBiodistribution pattern
2018
Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences
Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD. Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomechanics And Modeling In Mechanobiology 2018, 17: 1281-1295. PMID: 29754316, PMCID: PMC8344131, DOI: 10.1007/s10237-018-1026-7.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAorta, AbdominalAorta, ThoracicBiomechanical PhenomenaCardiovascular DiseasesCardiovascular SystemCarotid ArteriesCarotid Artery, CommonDiastoleDisease Models, AnimalElastinExtracellular Matrix ProteinsHemodynamicsHomeostasisHumansMaleMiceModels, CardiovascularPressureRecombinant ProteinsStress, MechanicalTime FactorsVascular StiffnessConceptsCentral arteriesMale wild-type miceArterial wallAberrant matrix remodelingCentral pulse pressureInfrarenal abdominal aortaCommon carotid arteryWild-type miceDiastolic functionCardiovascular consequencesCardiac massHemodynamic sequelaePulse pressureAbdominal aortaThoracic aortaArterial agingVascular agingCommon findingTreatment strategiesCarotid arteryArteryLeft ventricleCarotid vesselsCentral vesselsVivo axial stretchWhole Exome Sequencing Reveals a Monogenic Cause of Disease in ≈43% of 35 Families With Midaortic Syndrome
Warejko JK, Schueler M, Vivante A, Tan W, Daga A, Lawson JA, Braun DA, Shril S, Amann K, Somers MJG, Rodig NM, Baum MA, Daouk G, Traum AZ, Kim HB, Vakili K, Porras D, Lock J, Rivkin MJ, Chaudry G, Smoot LB, Singh MN, Smith ER, Mane SM, Lifton RP, Stein DR, Ferguson MA, Hildebrandt F. Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ≈43% of 35 Families With Midaortic Syndrome. Hypertension 2018, 71: 691-699. PMID: 29483232, PMCID: PMC5843550, DOI: 10.1161/hypertensionaha.117.10296.Peer-Reviewed Original ResearchConceptsMidaortic syndromeWhole-exome sequencingExome sequencingVascular diseaseMonogenic causesExtensive vascular diseaseSevere childhood hypertensionGenotype/phenotype correlationChildhood hypertensionRare causeEtiologic diagnosisInflammatory diseasesAbdominal aortaMolecular genetic diagnosisGenetic syndromesSyndromic diseaseWhole-exome sequencing dataDiseaseSyndromePhenotype correlationGenetic diagnosisExome sequencing dataDiagnosisCauseHigh percentage
2017
Solitary Fibrous Tumor of the Pleura With Abdominal Aortic Blood Supply
Addagatla K, Mamtani R, Babkowski R, Ebright M. Solitary Fibrous Tumor of the Pleura With Abdominal Aortic Blood Supply. The Annals Of Thoracic Surgery 2017, 103: e415-e417. PMID: 28431714, DOI: 10.1016/j.athoracsur.2016.10.044.Peer-Reviewed Original ResearchConceptsSolitary fibrous tumorIntralobar sequestrationFibrous tumorPreoperative arterial embolizationAcute chest painAberrant arterial supplyBenign SFTPArtery embolizationChest painIntraoperative findingsIntrathoracic massUnique presentationFeeding vesselsAbdominal aortaArterial supplyBlood supplySFTPTumorPleuraIntralobarEmbolizationPainAortaMulti-modality molecular imaging of aortic aneurysms
Malm BJ, Sadeghi MM. Multi-modality molecular imaging of aortic aneurysms. Journal Of Nuclear Cardiology 2017, 24: 1239-1245. PMID: 28447279, PMCID: PMC7720418, DOI: 10.1007/s12350-017-0883-2.BooksConceptsAortic aneurysmMulti-modality molecular imagingMolecular imagingSignificant morbidityAbdominal aortaAneurysm formationAneurysm sizeLower riskAneurysm pathogenesisAneurysmsPotential future roleImaging modalitiesComplicationsDiagnosisImagingMorbidityThrombosisPatientsAortaCurrent gapsFuture rolePathogenesisThoracicMortalityEpidemiology
2014
A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms
Di Achille P, Tellides G, Figueroa C, Humphrey J. A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms. Proceedings Of The Royal Society A 2014, 470: 20140163. DOI: 10.1098/rspa.2014.0163.Peer-Reviewed Original ResearchAbdominal aortic aneurysmIntraluminal thrombusAortic aneurysmThrombus formationUseful clinical predictorIntraluminal thrombus formationOscillatory shear indexClinical predictorsBlood-borne particlesHaemodynamic predictorsAbdominal aortaCarotid arteryHealthy subjectsThin thrombusClinical utilityHaemodynamic featuresComplex haemodynamicsThrombusTreatment planningComplex biomechanicsPatientsAneurysmsEndothelial mechanobiologyReliable predictorLesions
2013
Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner
Millon A, Dickson S, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, Ballet S, Robert P, de Castro J, Corot C, Fayad Z. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner. Atherosclerosis 2013, 228: 339-345. PMID: 23582588, PMCID: PMC4128694, DOI: 10.1016/j.atherosclerosis.2013.03.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalAortic DiseasesAtherosclerosisAtorvastatinContrast MediaDextransDisease Models, AnimalDisease ProgressionFluorodeoxyglucose F18Heptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationMagnetic Resonance ImagingMagnetite NanoparticlesPlaque, AtheroscleroticPositron-Emission TomographyPredictive Value of TestsPyrrolesRabbitsRadiographyRadiopharmaceuticalsTime FactorsConceptsFDG-PETPlaque inflammationRegression groupAbdominal aortaAtherosclerotic rabbitsAortic wallMean standard uptake valueStrong FDG uptakeStandard uptake valueContrast-enhanced MRIFDG-PET dataFunctional imaging modalitiesProgression groupBaseline imagingFDG uptakeMR scannerSUVmean valuesUSPIO uptakeAtherosclerotic plaquesMacrophage densityUptake valueEarly changesInflammationRabbit modelDietary changes
2011
Antiplatelet Therapy in the Management of Peripheral Artery Disease
Desai N, Beckman J. Antiplatelet Therapy in the Management of Peripheral Artery Disease. 2011, 167-174. DOI: 10.1007/978-1-4614-0839-0_9.Peer-Reviewed Original ResearchPeripheral artery diseasePAD patientsArtery diseaseCommon clinical presentationAtherosclerotic occlusive diseaseCritical limb ischemiaBrachial artery pressureDistal abdominal aortaLower extremity arteriesAntiplatelet therapyArtery pressureIntermittent claudicationLimb ischemiaOcclusive diseaseClinical presentationPerfusion pressureExtremity arteriesAbdominal aortaAtypical featuresDiseasePatientsClaudicationIschemiaArteryAortaImpact of Adaptive Statistical Iterative Reconstruction (ASIR) on radiation dose and image quality in aortic dissection studies: a qualitative and quantitative analysis.
Cornfeld D, Israel G, Detroy E, Bokhari J, Mojibian H. Impact of Adaptive Statistical Iterative Reconstruction (ASIR) on radiation dose and image quality in aortic dissection studies: a qualitative and quantitative analysis. American Journal Of Roentgenology 2011, 196: w336-40. PMID: 21343485, DOI: 10.2214/ajr.10.4573.Peer-Reviewed Original ResearchConceptsDose-length productAdaptive statistical iterative reconstructionAortic enhancementMuscle contrastVolume CT dose indexCT angiography examinationsStatistical iterative reconstructionCT dose indexRadiation dose reductionAngiography examinationsAbdominal aortaDose reductionDose indexAortaDissection studiesRadiation doseSubjective image qualityDiagnostic qualityIterative reconstructionAortic signalScansReviewersExaminationSimilar examinationGroupCartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2
Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu C, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W, Wang X. Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2. Circulation Research 2011, 108: 917-928. PMID: 21350216, DOI: 10.1161/circresaha.110.234328.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsCartilage oligomeric matrix proteinVascular calcificationOligomeric matrix proteinVSMC calcificationVascular smooth muscle calcificationMarker expressionHigh-phosphate dietSmooth muscle cellsCOMP deficiencyMuscle calcificationCardiovascular morbidityOsteogenic marker expressionAbdominal aortaVessel calcificationHigh inorganic phosphateEffects of COMPPeriadventitial applicationMatrix proteinsMuscle cellsCalcificationBMP-2Receptor bindingProtein levelsOsteogenic signaling
2010
Predicting the Risk of Paraplegia After Thoracic and Thoracoabdominal Aneurysm Repair
Zoli S, Roder F, Etz CD, Brenner RM, Bodian CA, Lin HM, Di Luozzo G, Griepp RB. Predicting the Risk of Paraplegia After Thoracic and Thoracoabdominal Aneurysm Repair. The Annals Of Thoracic Surgery 2010, 90: 1237-1245. PMID: 20868820, DOI: 10.1016/j.athoracsur.2010.04.091.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRisk of paraplegiaSegmental arteriesParaplegia riskEndovascular repairAneurysm repairCord injuryThoracoabdominal aortic aneurysm repairMotor-evoked potential monitoringPrevious aortic surgeryThoracoabdominal aneurysm repairIndependent risk factorThoracoabdominal aortic aneurysmsAortic aneurysm repairStandard surgical approachCerebrospinal fluid drainageCrawford classificationHospital mortalitySCI riskAortic surgeryEmergent operationSurgical approachAortic aneurysmRisk factorsAbdominal aortaThe Impact of Hypovolaemic Shock on the Aortic Diameter in a Porcine Model
Jonker F, Mojibian H, Schlösser F, Botta D, Indes J, Moll F, Muhs B. The Impact of Hypovolaemic Shock on the Aortic Diameter in a Porcine Model. European Journal Of Vascular And Endovascular Surgery 2010, 40: 564-571. PMID: 20727795, DOI: 10.1016/j.ejvs.2010.07.014.Peer-Reviewed Original ResearchConceptsTraumatic thoracic aortic injuryThoracic endovascular aortic repairAortic diameterBlood lossFluid resuscitationPorcine modelHypovolaemic shockThoracic aortaComputed tomographyIntravascular ultrasoundThoracic aortic injuryAdditional computed tomographyEndovascular aortic repairConsiderable blood lossHypovolaemic patientsAortic injuryAortic repairEndovascular managementAortic measurementsAbdominal aortaBlood volumePatientsResuscitationAortaEndograft
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