2024
From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)
Li T, Feng W, Yan W, Wang T. From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review). Molecular Medicine Reports 2024, 30: 145. PMID: 38904193, DOI: 10.3892/mmr.2024.13269.Peer-Reviewed Original ResearchConceptsTrained immunityTrained macrophagesAbundant immune cellsCharacteristics of innate immunityChronic inflammatory diseaseAtherosclerotic plaquesProgression of ASImmune cellsInflammatory diseasesImmune responseTherapeutic approachesClinical strategiesEpigenetic reprogrammingDeposition of lipoproteinsCardiovascular diseaseInnate immunityMacrophagesAtherosclerosisImmunityDiseasePlaqueCellsComplex mechanismsA Novel Artificial Coronary Plaque to Model Coronary Heart Disease
Lindenhahn P, Richter J, Pepelanova I, Seeger B, Volk H, Hinkel R, Hiebl B, Scheper T, Hinrichs J, Becker L, Haverich A, Kaufeld T. A Novel Artificial Coronary Plaque to Model Coronary Heart Disease. Biomimetics 2024, 9: 197. PMID: 38667208, PMCID: PMC11048636, DOI: 10.3390/biomimetics9040197.Peer-Reviewed Original ResearchOscillatory rheological experimentsLong-term stability testCasting moldRheological experimentsAtherosclerotic plaque modelCoronary arteryPig heartsAtherosclerotic plaquesStability testCoronary artery diseaseIn vivo setupCoronary artery interventionPorcine coronary arteriesSurgical therapyCoronary heart diseaseCalcium carbonatePlaque modelArtery diseaseStenotic lesionsArtery interventionHuman atherosclerotic plaquesHeart diseasePartial stenosisDiagnostic imagingCoronary plaques
2023
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia
Benlarbi M, Richard J, Bourassa C, Tolbert W, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly M, Prévost J, Clark A, Mothes W, Kaufmann D, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril J, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia. The Journal Of Infectious Diseases 2023, 229: 763-774. PMID: 38035854, PMCID: PMC10938206, DOI: 10.1093/infdis/jiad503.Peer-Reviewed Original ResearchImmune dysfunctionAntiretroviral therapyUndetectable viremiaChronic inflammationAtherosclerotic plaquesSubclinical coronary artery diseaseSub-clinical cardiovascular diseaseCoronary artery diseasePro-inflammatory cytokinesCross-sectional assessmentCanadian HIVCD4 depletionCD4 countCD8 ratioDetectable viremiaArtery diseaseIL-6Soluble gp120Cardiovascular diseaseGp120 subunitImmunomodulatory propertiesAging CohortInflammationViremiaSgp120Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Tyrrell D, Wragg K, Chen J, Wang H, Song J, Blin M, Bolding C, Vardaman D, Giles K, Tidwell H, Ali M, Janappareddi A, Wood S, Goldstein D. Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice. Nature Aging 2023, 3: 1576-1590. PMID: 37996758, PMCID: PMC11924142, DOI: 10.1038/s43587-023-00515-w.Peer-Reviewed Original ResearchConceptsT cellsMemory CD8Aged miceAtherosclerotic plaquesDepletion of CD8Effector memory subsetsStrong risk factorT cell activationEnhanced atherosclerosisSplenic CD8Adoptive transferDonor miceMemory subsetsRecipient miceRisk factorsCD8Therapeutic targetCell activationAtherosclerosisSingle-cell RNA sequencingMiceTranscriptomic signaturesAtherogenesisPlaquesRNA sequencingMultislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating “true” coronary artery bifurcations
Radunović A, Vidaković R, Timčić S, Odanović N, Stefanović M, Lipovac M, Krupniković K, Mandić A, Kojić D, Tomović M, Ilić I. Multislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating “true” coronary artery bifurcations. Frontiers In Cardiovascular Medicine 2023, 10: 1292517. PMID: 38028491, PMCID: PMC10657987, DOI: 10.3389/fcvm.2023.1292517.Peer-Reviewed Original ResearchCT coronary angiographyPercutaneous coronary interventionCoronary angiographyCoronary artery bifurcationsIntravascular ultrasoundBland-Altman analysisAtherosclerotic plaque characteristicsMb segmentLow incidenceCharacterization of atherosclerotic plaquesPlaque evaluationBifurcation percutaneous coronary interventionCoronary interventionPlaque characteristicsProvisional stentingCalcified plaqueSide branchesCircumferential plaquesAngiographyDistal MBSignificant correlationPlaqueCoronary bifurcationsLumen areaAtherosclerotic plaquesAdvances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care
Bienstock S, Lin F, Blankstein R, Leipsic J, Cardoso R, Ahmadi A, Gelijns A, Patel K, Baldassarre L, Hadley M, LaRocca G, Sanz J, Narula J, Chandrashekhar Y, Shaw L, Fuster V. Advances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care. JACC Cardiovascular Imaging 2023, 16: 1099-1115. PMID: 37178070, DOI: 10.1016/j.jcmg.2023.02.002.Peer-Reviewed Original ResearchConceptsCoronary Computed Tomography AngiographyCoronary artery diseaseAtherosclerotic plaquesArtery diseaseRisk stratificationPreventive carePlaque volumeHigh-risk plaque featuresNonobstructive coronary artery diseaseCoronary CTAMeasurements of atherosclerosisEffective risk stratificationHigh-risk patientsTotal plaque volumeComputed tomography angiographyPatient-specific factorsCoronary artery dimensionsIntravascular ultrasound measurementsHealth care systemCoronary dominanceCardiovascular preventionPatient subsetsPlaque featuresArtery sizeTomography angiographyThe age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques
Kabir I, Zhang X, Dave J, Chakraborty R, Qu R, Chandran R, Ntokou A, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.Peer-Reviewed Original ResearchConceptsAtherosclerotic plaquesBone marrowSmooth muscle-derived cellsSMC progenitorsAtherosclerotic plaque cellsSmooth muscle cell progenitorsPredominant risk factorCause of deathNovel therapeutic strategiesTNF receptor 1Muscle-derived cellsAged bone marrowAged BMEffect of agePlaque burdenAged miceRisk factorsTumor necrosisTherapeutic strategiesPlaque cellsMyeloid cellsReceptor 1Integrin β3Cell progenitorsAtherosclerosis
2021
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107682118. PMID: 34782454, PMCID: PMC8617522, DOI: 10.1073/pnas.2107682118.Peer-Reviewed Original ResearchConceptsCholesterol biosynthetic intermediatesBiosynthetic intermediatesDependent inflammasome activationSingle-cell transcriptomicsMitochondrial reactive oxygen species productionFoam cell formationMacrophage foam cellsReactive oxygen species productionHuman coronary artery lesionsConversion of desmosterolTranscriptomic analysisMacrophage cholesterol metabolismPhysiological contextOxygen species productionLiver X receptor ligandsApoptosis-associated speck-like proteinRetinoid X receptor activationX receptor ligandsInflammasome activationAtherosclerotic plaquesSpeck-like proteinCholesterol homeostasisMacrophage inflammasome activationKey moleculesCell formationDeficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis
Zhang X, Sun J, Canfrán-Duque A, Aryal B, Tellides G, Chang YJ, Suárez Y, Osborne TF, Fernández-Hernando C. Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis. JCI Insight 2021, 6: e147984. PMID: 34003795, PMCID: PMC8262461, DOI: 10.1172/jci.insight.147984.Peer-Reviewed Original ResearchConceptsHematopoietic cellsHistone methylation/acetylationSingle-cell RNA-seq analysisMethylation/acetylationHistone H3 Lys9RNA-seq analysisProgression of atherosclerosisEpigenetic marksLysine methyltransferasesH3 Lys9Epigenetic modificationsDNA methylationNoncoding RNAsCell regulatorsSETDB2Vascular inflammationAtherosclerotic lesionsAtherosclerotic plaquesMyeloid cell recruitmentGenetic deletionLDLR knockout miceEnhanced expressionHepatic lipid metabolismMurine atherosclerotic lesionsGenes
2020
Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis
Li J, Huynh L, Cornwell WD, Tang MS, Simborio H, Huang J, Kosmider B, Rogers TJ, Zhao H, Steinberg MB, Thu Thi Le L, Zhang L, Pham K, Liu C, Wang H. Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2020, 41: 839-853. PMID: 33380174, PMCID: PMC8608030, DOI: 10.1161/atvbaha.120.315556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisDisease Models, AnimalDNA DamageDNA, MitochondrialE-Cigarette VaporFemaleHumansInflammationInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMiddle AgedMitochondriaRAW 264.7 CellsSignal TransductionSmokersToll-Like Receptor 9VapingConceptsECV exposureTLR9 expressionInflammatory cytokinesClassical monocytesTLR9 activationAtherosclerotic plaquesEight-week-old ApoEUpregulation of TLR9Expression of TLR9Atherosclerotic lesion developmentOil Red O stainingToll-like receptorsDays/weekE-cig exposureMonocytes/macrophagesNormal laboratory dietRed O stainingPotential pharmacological targetElectronic cigarette useHours/dayProinflammatory cytokinesCig vaporPlasma levelsTLR9 antagonistTLR9 inhibitorDesigned CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J. Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nature Communications 2020, 11: 5981. PMID: 33239628, PMCID: PMC7689490, DOI: 10.1038/s41467-020-19764-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnimalsAntigens, CDAtherosclerosisBinding SitesCarotid Artery, CommonChemokine CXCL12Crystallography, X-RayDisease Models, AnimalDrug DesignDrug Evaluation, PreclinicalEndarterectomy, CarotidFemaleHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMiceMice, Knockout, ApoEMiddle AgedPeptide FragmentsReceptors, CXCR4SialyltransferasesSignal TransductionConceptsMacrophage migration inhibitory factorCXC motif chemokine receptor 4Chemokine receptorsChemokine/receptor axisCXCR4/CXCL12 interactionHuman carotid endarterectomy specimensMigration inhibitory factorChemokine receptor 4MIF/CD74Carotid endarterectomy specimensAtherogenic inflammationCXCL12 interactionReceptor axisReceptor 4MIF inhibitorsReceptor-based strategiesAtherosclerotic plaquesAtherosclerosisAtypical chemokineLeukocyte adhesionCell activityProtective pathwaysInflammationChemokinesPlaquesIntroduction to Carotid Atherosclerosis
Meyer C, Ruff J, de Havenon A. Introduction to Carotid Atherosclerosis. 2020, 49-57. DOI: 10.1007/978-3-030-41138-1_4.Peer-Reviewed Original ResearchCarotid atherosclerosisContralateral hemisensory lossLarge artery atherosclerosisMonocular vision lossCarotid atherosclerotic plaquesHemisensory lossContralateral hemiparesisArtery atherosclerosisIschemic strokeCarotid diseaseClinical presentationVision lossCarotid arteryAtherosclerotic plaquesHemodynamic characteristicsAtherosclerosisModalitiesHemiparesisHypoperfusionIschemiaArterySymptomsStrokeEpidemiologyPlaquesEndothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis
Chen PY, Schwartz MA, Simons M. Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis. Frontiers In Cardiovascular Medicine 2020, 7: 53. PMID: 32478094, PMCID: PMC7232582, DOI: 10.3389/fcvm.2020.00053.Peer-Reviewed Original ResearchVascular inflammationMesenchymal transitionBiology of atherosclerosisPotential new therapeutic targetChronic progressive diseaseNew therapeutic targetsSelective inflammatory mediatorsProgressive diseaseInflammatory mediatorsAtherosclerotic plaquesBlood flowTherapeutic targetPlaque growthInflammationAtherosclerosisMultiple attemptsDiseaseMolecular mechanismsEndMTPlaquesNon-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI
Liu Y, Hanley T, Chen H, Long S, Gambhir S, Cheng Z, Wu J, Fakhri G, Anvari B, Zaman R. Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI. Scientific Reports 2020, 10: 5983. PMID: 32249814, PMCID: PMC7136251, DOI: 10.1038/s41598-020-62868-1.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial-infarctionTail vein 1 hourIndocyanine greenWeeks old male C57BL/6 miceLeft anterior descending (LADAnterior descending (LADMale C57BL/6 miceAtherosclerotic lesionsCoronary artery ligationTen-week-old male C57BL/6 miceAtherosclerotic plaquesC57BL/6 miceNon-invasiveArtery ligationInflammatory cellsPortal tractsArtery diseaseFluorescence in vivo imagingParenchymal necrosisCoronary arteryClinical detectionPathological changesContrast agentsLesions
2019
Compromised endothelial function in transgender men taking testosterone
Gulanski BI, Flannery CA, Peter PR, Leone CA, Stachenfeld NS. Compromised endothelial function in transgender men taking testosterone. Clinical Endocrinology 2019, 92: 138-144. PMID: 31765022, PMCID: PMC6957681, DOI: 10.1111/cen.14132.Peer-Reviewed Original ResearchConceptsEndothelial functionTransgender menEndothelial dysfunctionCisgender femalesClinical cardiovascular riskCardiovascular risk factorsImpaired endothelial functionEarly follicular phaseAndrogen excessCardiovascular riskVasodilatory responseCoronary arteryHormonal milieuFollicular phaseTestosterone treatmentMenstrual cycleRisk factorsFemale genderAtherosclerotic plaquesEarly signsTestosteroneTotal TSImportant markerDysfunctionMenEndothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retentionDiagnostic Accuracy of 320-Row Computed Tomography for Characterizing Coronary Atherosclerotic Plaques: Comparison with Intravascular Optical Coherence Tomography
Ybarra L, Szarf G, Ishikawa W, Chamié D, Caixeta A, Puri R, Perin M. Diagnostic Accuracy of 320-Row Computed Tomography for Characterizing Coronary Atherosclerotic Plaques: Comparison with Intravascular Optical Coherence Tomography. Cardiovascular Revascularization Medicine 2019, 21: 640-646. PMID: 31501019, DOI: 10.1016/j.carrev.2019.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedCholesterolComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsCrystallizationFemaleFibrosisHumansMacrophagesMaleMiddle AgedMultidetector Computed TomographyNeovascularization, PathologicPlaque, AtheroscleroticPredictive Value of TestsPrognosisRegistriesReproducibility of ResultsRetrospective StudiesTomography, Optical CoherenceVascular CalcificationConceptsOptical coherence tomographyVulnerable plaque characteristicsLow-attenuation plaqueNapkin-ring signPresence of macrophagesCoherence tomographyPlaque characteristicsNon-invasive evaluationCoronary atherosclerotic plaquesComputed tomographyDiagnostic accuracySpotty calcificationCoronary atheromaPositive remodelingCholesterol crystalsMinimal lumen areaAtherosclerotic plaquesNoncalcified plaqueAttenuation plaqueCoronary segmentsTomographyNeovascularizationPlaque typeFibroatheromaPlaqueCulprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review
Wang Y, Liu X, Wu X, Degnan AJ, Malhotra A, Zhu C. Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review. Atherosclerosis 2019, 287: 112-121. PMID: 31254918, PMCID: PMC6707846, DOI: 10.1016/j.atherosclerosis.2019.06.907.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsVessel wall MRISubstantial stenosisIschemic strokeStroke patientsMagnetic resonance angiographyIntracranial plaquesPlaque featuresAtherosclerotic plaquesSystematic reviewHigh-resolution vessel wall MRIHigh-risk plaque featuresAcute ischemic stroke patientsProgressive motor deficitsAcute ischemic strokeIntracranial atherosclerotic plaquesOverall functional outcomeHigh-risk plaquesRelevant clinical dataArterial atherosclerotic plaquesArticle reference listsAcute strokeCulprit plaquesIntracranial atherosclerosisMotor deficitsCompromised endothelial function in transgender men taking testosterone
Stachenfeld N, Leone C, Gulanski B. Compromised endothelial function in transgender men taking testosterone. The FASEB Journal 2019, 33: 696.4-696.4. DOI: 10.1096/fasebj.2019.33.1_supplement.696.4.Peer-Reviewed Original ResearchEndothelial functionEndothelial dysfunctionBlood pressureTransgender menRisk factorsCisgender femalesCardiovascular risk factorsEarly follicular phaseSystolic blood pressureFull-text articlesTestosterone therapyAndrogen excessCardiovascular riskVasodilatory responseBlood lipidsHDL cholesterolSystolic BPLDL cholesterolCoronary arteryHormonal milieuFollicular phaseAndrogen treatmentMenstrual cycleCardiovascular diseaseAtherosclerotic plaques
2018
Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
Misra A, Feng Z, Chandran RR, Kabir I, Rotllan N, Aryal B, Sheikh AQ, Ding L, Qin L, Fernández-Hernando C, Tellides G, Greif DM. Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications 2018, 9: 2073. PMID: 29802249, PMCID: PMC5970166, DOI: 10.1038/s41467-018-04447-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisBone Marrow TransplantationCell MovementCell ProliferationCell TransdifferentiationCells, CulturedCholesterolDisease Models, AnimalFemaleHumansIntegrin beta3MacrophagesMaleMiceMice, Inbred C57BLMice, Knockout, ApoEMuscle, Smooth, VascularMyocytes, Smooth MusclePlaque, AtheroscleroticConceptsSmooth muscle cellsPre-existing smooth muscle cellsAtherosclerotic plaquesPlaque cellsToll-like receptor 4 expressionSmooth muscle-derived cellsBone marrow-derived cellsSingle smooth muscle cellsAtherosclerotic plaque cellsReceptor 4 expressionMarrow-derived cellsBone marrow resultsMuscle-derived cellsIntegrin β3 levelsMacrophage-like phenotypeCD36 levelsMarrow resultsSMC proliferationPlaque coresSMC progenitorsMuscle cellsIntegrin β3AtherogenesisPlaquesIntegrin beta3
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