2025
Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Ujueta F, Behan D, Vlaeyen J, Jackson E, Peters M, Whipple M, Phillips K, Chung J, Mena-Hurtado C, Research O. Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation Cardiovascular Quality And Outcomes 2025, 18: e000135. PMID: 39925269, DOI: 10.1161/hcq.0000000000000135.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseArtery diseaseMultimodal pain management strategiesPain experienceAtypical leg painChronic pain syndromesGeneration of painMultimodal pain managementChronic pain experiencePain management strategiesIschemic rest painPhantom limb painAmerican Heart AssociationNeuropathic painLeg painNeuropathic mechanismsPain syndromeOpioid useChronic painRest painPain managementHeart AssociationLimb painClinical subgroupsIntermittent claudication
2024
Co-Morbidity Differences Associated With Long-Term Amputation and Repeat Revascularization Rates After Femoropopliteal Artery Intervention for Intermittent Claudication by Sex, Race, and Ethnicity
Altin S, Parise H, Hess C, Rosenthal N, Julien H, Curtis J. Co-Morbidity Differences Associated With Long-Term Amputation and Repeat Revascularization Rates After Femoropopliteal Artery Intervention for Intermittent Claudication by Sex, Race, and Ethnicity. The American Journal Of Cardiology 2024, 226: 40-49. PMID: 38834142, DOI: 10.1016/j.amjcard.2024.05.021.Peer-Reviewed Original ResearchNon-Hispanic patientsHispanic patientsIntermittent claudicationPeripheral vascular interventionsBlack patientsWhite patientsAmputation rateIndex limb amputationHazard ratioCox proportional hazards regression modelsDisease-specific issuesProportional hazards regression modelsHazards regression modelsBaseline characteristicsLimb amputationMajor amputationUnadjusted ratesAssociated with higher ratesHealthcare databasesBlack raceSecondary outcomesPrimary outcomeAmputationRevascularization ratesComparison groupReduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease
Nishibe T, Dardik A, Akiyama S, Kano M, Fukuda S, Koizumi J, Nishibe M. Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease. Annals Of Vascular Surgery 2024, 105: 275-281. PMID: 38570014, DOI: 10.1016/j.avsg.2023.12.094.Peer-Reviewed Original ResearchSkeletal muscle massPeripheral arterial diseaseBioelectrical impedance analysisAnkle-brachial indexAnkle-brachial pressure indexLeg skeletal muscle massLeg ischemiaMuscle massIntermittent claudicationLeg muscle massMuscle qualityArtery diseaseAssociated with reduced muscle massTokyo Medical University HospitalAssociated with skeletal muscle myopathyReduced muscle massMedical University HospitalLeg muscle qualitySkeletal muscle myopathyUniversity HospitalMuscle myopathyPatientsIschemiaClaudicationLower extremitiesThe Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions
Alameddine D, Damara F, Pinto Rodriguez P, Huttler J, Slade M, Arhuidese I, Aboian E, Ochoa Chaar C. The Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions. Annals Of Vascular Surgery 2024, 103: 47-57. PMID: 38387798, DOI: 10.1016/j.avsg.2023.12.071.Peer-Reviewed Original ResearchImpact of cilostazolPeripheral vascular interventionsPeripheral arterial diseaseTreatment of intermittent claudicationRates of long-term mortalityPeripheral vascular interventional proceduresKaplan-Meier methodCongestive heart failureLong-term mortalityLong-term outcomesEndovascular peripheral interventionsRenal complicationsPatient demographicsBaseline characteristicsHeart failureDiabetes mellitusArtery diseaseIntermittent claudicationCilostazolPatientsVascular interventionsPeripheral interventionsClaudicationOutcomesIntervention
2023
Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates.
Snyder D, Zilinyi R, Pruthi S, George S, Tirziu D, Lansky A, Mintz A, Sethi S, Parikh S. Percutaneous Transluminal Angioplasty for Infrapopliteal Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-analysis of Primary Patency and Binary Restenosis Rates. Journal Of Endovascular Therapy 2023, 15266028231212133. PMID: 38008929, DOI: 10.1177/15266028231212133.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaPercutaneous transluminal angioplastyBinary restenosis ratePrimary patencyPrimary patency rateBinary restenosisTransluminal angioplastyRestenosis rateFuture RCTsPatency ratesTrial dataChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaRandom-effects modelMeta-analysis demonstrateIntermittent claudicationEndovascular therapyCochrane CENTRALPower calculationMeta-analysis estimatesControl armPatencyRCTsSystematic reviewAnatomic patterns in claudicants who fail supervised exercise therapy
Breen T, McGinigle K, Strosberg D, Dardik A, Altin S. Anatomic patterns in claudicants who fail supervised exercise therapy. Journal Of Vascular Surgery 2023, 79: 679-684.e1. PMID: 37984757, DOI: 10.1016/j.jvs.2023.11.020.Peer-Reviewed Original ResearchCritical limb-threatening ischemiaSupervised exercise therapyPeripheral arterial diseaseIntermittent claudicationCFA diseaseExercise therapyArterial diseaseAnatomic patternsCommon femoral artery diseaseFemoral artery diseaseAnkle-brachial indexLimb-threatening ischemiaSubset of patientsVeterans Health AdministrationPersistent symptomsProgressive diseaseProgressive symptomsArtery diseaseDisease locationPatientsWest HavenHealth AdministrationMultivariate analysisRevascularizationDiseaseReply Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication
Altin S, Curtis J. Reply Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovascular Interventions 2023, 16: 2336. PMID: 37758390, DOI: 10.1016/j.jcin.2023.08.027.Peer-Reviewed Original ResearchConceptsLong-term patient outcomesPeripheral vascular interventionsIntermittent claudicationPatient outcomesVascular interventionsClaudicationPatientsLong-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication
Altin S, Parise H, Hess C, Rosenthal N, Creager M, Aronow H, Curtis J. Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovascular Interventions 2023, 16: 1668-1678. PMID: 37438035, DOI: 10.1016/j.jcin.2023.05.001.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsIndex limb amputationAmputation rateIntermittent claudicationMajor amputationRevascularization ratesVascular interventionsCox proportional hazards regressionLong-term patient outcomesMajor amputation rateProportional hazards regressionKaplan-Meier estimatesFurther risk factorsLimb amputation rateClinical trial dataIndex limbIC patientsSecondary outcomesPrimary outcomeHazards regressionRisk factorsPatient outcomesLimb amputationHealthcare databasesPatientsInfluence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease
Nishibe T, Kano M, Akiyama S, Chiba F, Nishibe M, Koizumi J, Dardik A. Influence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease. Annals Of Vascular Surgery 2023, 94: 136-142. PMID: 37019357, DOI: 10.1016/j.avsg.2023.03.031.Peer-Reviewed Original ResearchConceptsAnkle-brachial pressure indexSkeletal muscle mass indexPeripheral artery diseaseSkeletal muscle massBioelectrical impedance analysisMuscle massLimb ischemiaArtery diseaseLow ankle-brachial pressure indexSkeletal muscle mass depletionSymptomatic peripheral artery diseaseTokyo Medical University HospitalMuscle mass depletionBrachial pressure indexLower limb ischemiaMuscle mass indexMedical University HospitalNonischemic legsExercise therapyIntermittent claudicationIschemic legDuplex scanEndovascular treatmentMass indexPhysical function
2022
Implementation of supervised exercise therapy in a veteran population with symptomatic claudication
Altin S, Schneider MD, Parise H, Banerjee S, Wu WC, Meadows JL, Pfau S, Keefe H, Armstrong EJ. Implementation of supervised exercise therapy in a veteran population with symptomatic claudication. Vascular Medicine 2022, 27: 136-141. PMID: 35225695, DOI: 10.1177/1358863x211073622.Peer-Reviewed Original ResearchConceptsExercise treadmill testingExercise therapyMetabolic equivalentsIntermittent claudicationExercise capacityTreadmill testingAnkle-brachial indexIntermittent claudication symptomsMale veteran patientsSupervised exercise therapySymptomatic intermittent claudicationVascular specialty clinicsLow patient adherenceClaudication symptomsSymptomatic claudicationExercise groupVeteran patientsPatient adherenceRisk stratificationTherapy referralSpecialty clinicProvider awarenessVeteran populationClaudicationTherapy
2019
Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status
Johnston AL, Vemulapalli S, Gosch KL, Aronow HD, Abbott JD, Patel MR, Smolderen KG, Shishebor M, Spertus JA, Jones WS. Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status. Journal Of Vascular Surgery 2019, 69: 906-912. PMID: 30626552, DOI: 10.1016/j.jvs.2018.07.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaCost of IllnessFemaleHealth StatusHemodynamicsHumansIntermittent ClaudicationMaleMiddle AgedNetherlandsPatient Reported Outcome MeasuresPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexUnited StatesConceptsAnkle-brachial indexPeripheral artery diseasePeripheral Artery QuestionnaireIntermittent claudicationRutherford classificationABI valuesPAQ scoresArtery diseaseImpact of PADHealth statusMean ankle-brachial indexPAD-specific health statusSevere peripheral artery diseasePAQ summary scoreStudy of patientsQuality of lifeHealth status assessmentRutherford classNew onsetPatient's symptomsHemodynamic assessmentLife scoresFunctional statusPatients' perceptionsInternational cohort
2018
Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry
Noyes AM, Abbott JD, Gosch K, Smolderen K, Spertus JA, Hyder O, Soukas P, Shishehbor MH, Aronow HD. Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry. Vascular Medicine 2018, 23: 32-38. PMID: 29338591, DOI: 10.1177/1358863x17747047.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePoor health statusIntermittent claudicationHealth statusPatient characteristicsDisease-specific health status measuresNon-vascular factorsPeripheral arterial diseaseChronic lung diseaseSpecialty care visitsTime of presentationHealth status measuresMultivariable linear regressionPatients' health statusQuality of lifeCare visitsArtery diseaseInitial presentationArterial diseaseBack painExercise programTreatment disparitiesLung diseaseFemale sexFunctional status
2012
Nitinol Stent Implantation vs. Balloon Angioplasty for Lesions in the Superficial Femoral and Proximal Popliteal Arteries of Patients With Claudication: Three-Year Follow-up From the RESILIENT Randomized Trial
Laird JR, Katzen BT, Scheinert D, Lammer J, Carpenter J, Buchbinder M, Dave R, Ansel G, Lansky A, Cristea E, Collins TJ, Goldstein J, Cao AY, Jaff MR, Investigators F. Nitinol Stent Implantation vs. Balloon Angioplasty for Lesions in the Superficial Femoral and Proximal Popliteal Arteries of Patients With Claudication: Three-Year Follow-up From the RESILIENT Randomized Trial. Journal Of Endovascular Therapy 2012, 19: 1-9. PMID: 22313193, DOI: 10.1583/11-3627.1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlloysAngioplasty, BalloonArterial Occlusive DiseasesChi-Square DistributionConstriction, PathologicEuropeFemaleFemoral ArteryHumansIntermittent ClaudicationKaplan-Meier EstimateMaleMiddle AgedPopliteal ArteryPredictive Value of TestsProsthesis DesignRadiographyRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexUnited StatesVascular PatencyConceptsTarget lesion revascularizationBalloon angioplastyAngioplasty groupStent groupProximal popliteal artery lesionsGood long-term resultsNitinol stent implantationProximal popliteal arteryMajor adverse eventsLong-term resultsPopliteal artery lesionsShort-term patencyStent fracture rateThree-year followLesion revascularizationPrimary nitinolWithdrew consentIntermittent claudicationAdverse eventsArtery lesionsFemoropopliteal lesionsMulticenter trialPopliteal arteryPrimary implantationSuperficial femoral
2011
Antiplatelet Therapy in the Management of Peripheral Artery Disease
Desai N, Beckman J. Antiplatelet Therapy in the Management of Peripheral Artery Disease. 2011, 167-174. DOI: 10.1007/978-1-4614-0839-0_9.Peer-Reviewed Original ResearchPeripheral artery diseasePAD patientsArtery diseaseCommon clinical presentationAtherosclerotic occlusive diseaseCritical limb ischemiaBrachial artery pressureDistal abdominal aortaLower extremity arteriesAntiplatelet therapyArtery pressureIntermittent claudicationLimb ischemiaOcclusive diseaseClinical presentationPerfusion pressureExtremity arteriesAbdominal aortaAtypical featuresDiseasePatientsClaudicationIschemiaArteryAorta
2010
Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States
Mahoney EM, Wang K, Keo HH, Duval S, Smolderen KG, Cohen DJ, Steg G, Bhatt DL, Hirsch AT. Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2010, 3: 642-651. PMID: 20940249, DOI: 10.1161/circoutcomes.109.930735.Peer-Reviewed Original ResearchConceptsAsymptomatic peripheral artery diseasePeripheral artery diseaseAnkle-brachial indexArtery diseaseSymptomatic peripheral artery diseaseAtherothrombotic risk factorsContinued Health (REACH) RegistryCumulative hospitalization costsHistory of claudicationLimb ischemic eventsLower limb revascularizationReduction of AtherothrombosisInternational prospective registryAbsence of symptomsRisk of atherothrombosisLower limb amputationREACH cohortIntermittent claudicationProspective registryIschemic eventsPeripheral interventionsRevascularization proceduresArterial diseaseFirst admissionUS patientsNitinol Stent Implantation Versus Balloon Angioplasty for Lesions in the Superficial Femoral Artery and Proximal Popliteal Artery
Laird JR, Katzen BT, Scheinert D, Lammer J, Carpenter J, Buchbinder M, Dave R, Ansel G, Lansky A, Cristea E, Collins TJ, Goldstein J, Jaff MR. Nitinol Stent Implantation Versus Balloon Angioplasty for Lesions in the Superficial Femoral Artery and Proximal Popliteal Artery. Circulation Cardiovascular Interventions 2010, 3: 267-276. PMID: 20484101, DOI: 10.1161/circinterventions.109.903468.Peer-Reviewed Original ResearchConceptsSuperficial femoral arteryProximal popliteal arteryTarget lesion revascularizationAngioplasty groupStent groupFemoral arteryLesion revascularizationPopliteal arteryBalloon angioplastyPrimary patencyAngiographic resultsBetter acute angiographic resultsProvisional stent implantationSuboptimal angiographic resultsEndovascular treatment strategiesFlow-limiting dissectionPercutaneous transluminal angioplastyAcute angiographic resultsTotal lesion lengthLoss of patencySuperficial femoral artery (SFA) stentingSelf-expanding nitinolBailout stentingIntermittent claudicationPrimary stenting
2009
Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia
Smolderen KG, Hoeks SE, Pedersen SS, van Domburg RT, de Liefde II, Poldermans D. Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia. Vascular Medicine 2009, 14: 297-304. PMID: 19808714, DOI: 10.1177/1358863x09104658.Peer-Reviewed Original ResearchConceptsAtypical leg symptomsPeripheral arterial diseaseExertional leg symptomsAnkle-brachial indexLeg symptomsIntermittent claudicationDepressive symptomsPAD patientsClinical factorsArterial diseaseAnkle-brachial index screeningSan Diego Claudication QuestionnaireClassic intermittent claudicationConsecutive PAD patientsLower leg symptomsDiverse clinical manifestationsErasmus Medical CenterMood statesSub-threshold symptomsCardiovascular historyMedication useTwofold riskClinical manifestationsPoor prognosisHospital AnxietyHybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up.
Nishibe T, Kondo Y, Dardik A, Muto A, Koizumi J, Nishibe M. Hybrid surgical and endovascular therapy in multifocal peripheral TASC D lesions: up to three-year follow-up. The Journal Of Cardiovascular Surgery 2009, 50: 493-9. PMID: 19734834.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, BalloonArterial Occlusive DiseasesCombined Modality TherapyConstriction, PathologicEndarterectomyFemaleFemoral ArteryHemodynamicsHumansIliac ArteryIschemiaKaplan-Meier EstimateLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Vascular DiseasesRadiographyReoperationStentsTime FactorsTreatment OutcomeVascular PatencyConceptsCommon femoral artery endarterectomyFemoral artery endarterectomyTASC D lesionsLimb salvage ratePrimary patency rateCritical limb ischemiaPeripheral artery diseaseCommon femoral arteryEndovascular therapySuperficial femoral arteryFemoral arteryPatency ratesArtery endarterectomyIntermittent claudicationArtery diseaseD lesionsLimb ischemiaSalvage rateLower limbsSurvival rateAssisted primary patencyVascular Surgery guidelinesThree-year experienceHemodynamic successPrimary patency
2004
Medical Management of Intermittent Claudication
Casey K, Tonnessen B, Sternbergh W, Money S. Medical Management of Intermittent Claudication. Vascular And Endovascular Surgery 2004, 38: 391-399. PMID: 15490035, DOI: 10.1177/153857440403800501.Peer-Reviewed Original ResearchConceptsIntermittent claudicationSymptoms of ICLifestyle-limiting claudicationLimb-threatening ischemiaMultitude of drugsClaudication symptomsAdjuvant therapyCardiovascular riskMedical managementCerebrovascular diseaseRisk factorsInvasive testingMedical attentionMinority of peopleClaudicationSubstantial riskSymptomsNumerous trialsPatientsDrugsRiskIschemiaTherapyWorkupDisease
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