2024
Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-Cause MortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlation
2022
The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis
Agha AM, Pacor J, Grandhi GR, Mszar R, Khan SU, Parikh R, Agrawal T, Burt J, Blankstein R, Blaha MJ, Shaw LJ, Al-Mallah MH, Brackett A, Cainzos-Achirica M, Miller EJ, Nasir K. The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis. JACC Cardiovascular Imaging 2022, 15: 1745-1757. PMID: 36202453, DOI: 10.1016/j.jcmg.2022.03.031.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseAcute chest painCoronary artery calciumCoronary artery diseaseStable chest painNonobstructive coronary artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsChest painCardiac eventsLow prevalenceAbsence of CACHealth care delivery modelsCare delivery modelsA Meta-AnalysisNegative predictive valueCAC assessmentArtery calciumCAC scoreIntermediate riskArtery diseaseCoronary CTACTA assessmentPrognostic valueTomography angiography
2021
Coronary Calcium to Rule Out Obstructive Coronary Artery Disease in Patients With Acute Chest Pain
Grandhi G, Mszar R, Cainzos-Achirica M, Rajan T, Latif M, Bittencourt M, Shaw L, Batlle J, Blankstein R, Blaha M, Cury R, Nasir K. Coronary Calcium to Rule Out Obstructive Coronary Artery Disease in Patients With Acute Chest Pain. JACC Cardiovascular Imaging 2021, 15: 271-280. PMID: 34656462, DOI: 10.1016/j.jcmg.2021.06.027.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary Computed Tomography AngiographyCoronary artery calciumNegative predictive valueCoronary artery diseaseAcute coronary syndromePositive predictive valueAcute chest painChest painIntermediate riskEmergency departmentDiagnostic accuracyEvaluation of acute coronary syndromeArtery diseaseCAC testingPredictive valueRegistry of patientsTriage of patientsPain RegistryArtery calciumCoronary revascularizationCoronary syndromeInvasive proceduresPatientsRevascularization
2019
Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia
Safdar B, Guo X, Johnson C, D'Onofrio G, Dziura J, Sinusas AJ, Testani J, Rao V, Desir G. Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia. International Journal Of Cardiology 2019, 279: 155-161. PMID: 30630613, PMCID: PMC6482834, DOI: 10.1016/j.ijcard.2018.12.061.Peer-Reviewed Original ResearchConceptsCoronary microvascular dysfunctionFramingham risk scorePET/CTChest painInflammatory markersMicrovascular dysfunctionEmergency departmentRisk scoreRb-82 PET/CTElevated renalase levelsAcute chest painCoronary artery diseaseC-reactive proteinVascular endothelial growth factorAnti-inflammatory proteinTumor necrosis factorEndothelial growth factorAngina historyCMD diagnosisRenalase levelsHypertensive crisisED presentationsHemodynamic instabilityArtery diseaseHeart failure
2018
Chest Pain During Chemotherapy: A Case of Severe Myocardial Bridging.
Mukhopadhyay A, Faridi KF, Asnani A, Osborn EA, Yang JX, Phillips CT, York M. Chest Pain During Chemotherapy: A Case of Severe Myocardial Bridging. Journal Of Invasive Cardiology 2018, 30: e61. PMID: 29958181, PMCID: PMC6247798.Peer-Reviewed Case Reports and Technical Notes
2017
Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department
Kim Y, Soffler M, Paradise S, Jelani QU, Dziura J, Sinha R, Safdar B. Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department. American Heart Journal 2017, 191: 47-54. PMID: 28888269, DOI: 10.1016/j.ahj.2017.06.003.Peer-Reviewed Original ResearchConceptsRecurrent chest painCoronary artery diseaseAcute chest painChest painProspective cohort studyChest pain centerClinical Anxiety ScaleEmergency departmentPerceived Stress ScalePain centerCohort studyArtery diseaseNonobstructive coronary artery diseaseObstructive coronary artery diseaseChest pain recurrenceED chest painCardiac risk factorsCardiac stress testingPatient Health QuestionnaireSignificant independent predictorsStress testingMultivariable regression modelsPain recurrenceIndependent predictorsPrimary outcomeSolitary Fibrous Tumor of the Pleura With Abdominal Aortic Blood Supply
Addagatla K, Mamtani R, Babkowski R, Ebright M. Solitary Fibrous Tumor of the Pleura With Abdominal Aortic Blood Supply. The Annals Of Thoracic Surgery 2017, 103: e415-e417. PMID: 28431714, DOI: 10.1016/j.athoracsur.2016.10.044.Peer-Reviewed Original ResearchConceptsSolitary fibrous tumorIntralobar sequestrationFibrous tumorPreoperative arterial embolizationAcute chest painAberrant arterial supplyBenign SFTPArtery embolizationChest painIntraoperative findingsIntrathoracic massUnique presentationFeeding vesselsAbdominal aortaArterial supplyBlood supplySFTPTumorPleuraIntralobarEmbolizationPainAorta
2016
Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy
Chang A, Kittle J, Wu S. Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy. Current Treatment Options In Cardiovascular Medicine 2016, 18: 20. PMID: 26874708, PMCID: PMC4957545, DOI: 10.1007/s11936-016-0443-0.Peer-Reviewed Original ResearchCardiac recoveryPathophysiology of Takotsubo syndromeAcute chest painAssociated with significant hemodynamic compromiseAcute heart failureSignificant hemodynamic compromiseResponse to injurySystolic dysfunctionChest painTakotsubo syndromeHemodynamic compromiseHeart failureDisease courseInciting insultHistological studiesTakotsuboPotential mechanismsDiseaseCardiomyopathyPainPathophysiologySyndromeCytoprotective processDysfunctionSystolicMicrovascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac Risk
Safdar B, Ali A, D’Onofrio G, Katz SD. Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac Risk. Clinical Therapeutics 2016, 38: 240-255.e1. PMID: 26778090, DOI: 10.1016/j.clinthera.2015.12.010.Peer-Reviewed Original ResearchConceptsChest painControl subjectsMicrovascular dysfunctionArtery diseaseObstructive coronary artery diseaseCommon emergency department presentationConduit vessel functionCoronary artery vasomotionTransient forearm ischemiaAcute chest painCardiac risk factorsPersistent chest painAcute coronary syndromeBrachial artery diameterFramingham risk scoreProspective cohort studyChest pain centerSystolic blood pressureAsymptomatic healthy volunteersCoronary artery diseaseEmergency department presentationsBrachial artery reactivityPeripheral microvascular dysfunctionHigh-resolution ultrasoundArtery dysfunction
2015
Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial.
Levsky J, Spevack D, Travin M, Menegus M, Huang P, Clark E, Kim C, Hirschhorn E, Freeman K, Tobin J, Haramati L. Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized Trial. Annals Of Internal Medicine 2015, 163: 174-83. PMID: 26052677, PMCID: PMC4703121, DOI: 10.7326/m14-2948.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationChest PainComparative Effectiveness ResearchCoronary AngiographyCoronary Artery DiseaseFemaleFollow-Up StudiesHealth ResourcesHospital UnitsHumansLength of StayMaleMiddle AgedMyocardial Perfusion ImagingMyocardial RevascularizationPatient SatisfactionProspective StudiesRadiation DosageTelemetryTomography, X-Ray ComputedConceptsMyocardial perfusion imagingCCTA groupMPI groupCardiovascular eventsChest painCardiac catheterizationPrimary outcomeRadiation exposurePatient experienceStress myocardial perfusion imagingInner-city medical centerNonfatal cardiovascular eventsOutpatient cardiology visitsAcute chest painMajor cardiovascular eventsIntermediate-term outcomesEmergency department visitsCoronary artery diseaseComparative effectiveness trialIncidence of deathLength of stayAmerican Heart AssociationClinical management decisionsRadionuclide myocardial perfusionLess radiation exposure
2013
Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain
Levsky J, Haramati L, Taub C, Spevack D, Menegus M, Travin M, Vega S, Lerer R, Brown‐Manhertz D, Hirschhorn E, Tobin J, Garcia M. Rationale and Design of a Randomized Trial Comparing Initial Stress Echocardiography versus Coronary CT Angiography in Low‐to‐Intermediate Risk Emergency Department Patients with Chest Pain. Echocardiography 2013, 31: 744-750. PMID: 24372760, DOI: 10.1111/echo.12464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAged, 80 and overCausalityChest PainComorbidityCoronary AngiographyCoronary Artery DiseaseEchocardiographyEmergency Service, HospitalExercise TestFemaleHealth Care CostsHospitalizationHumansIncidenceMaleMiddle AgedNew YorkResearch DesignRisk AssessmentTomography, X-Ray ComputedYoung AdultConceptsTreadmill stress echocardiographyStress echocardiographyEmergency departmentComparative effectiveness researchChest painED chest pain patientsMajor adverse cardiovascular eventsRisk Emergency Department PatientsSignificant coronary artery diseaseED/hospitalAcute chest painAdverse cardiovascular eventsIncidence of hospitalizationChest pain patientsCoronary artery diseaseEmergency department patientsImaging modalitiesLength of stayCoronary CT angiographyDecrease healthcare expendituresNoninvasive diagnostic algorithmCost of careNoninvasive imaging modalityCardiovascular eventsObservational registryPreliminary development of a clinical decision rule for acute aortic syndromes
Lovy A, Bellin E, Levsky J, Esses D, Haramati L. Preliminary development of a clinical decision rule for acute aortic syndromes. The American Journal Of Emergency Medicine 2013, 31: 1546-1550. PMID: 24055476, PMCID: PMC4275798, DOI: 10.1016/j.ajem.2013.06.005.Peer-Reviewed Original ResearchConceptsAcute aortic syndromeClinical decision ruleAcute chest painAbnormal chest radiographAortic syndromeChest painEmergency departmentChest radiographsRetrospective case-control reviewLow-risk patientsCase-control reviewNegative predictive valueAtherosclerotic ulcerIntramural hematomaOngoing painED presentationsAortic dissectionRisk factorsCT usageInclusion criteriaCT angiographyLower riskDiagnostic criteriaPatientsPrior trauma
2012
ACR Appropriateness Criteria® Acute Chest Pain—Suspected Pulmonary Embolism
Bettmann M, Baginski S, White R, Woodard P, Abbara S, Atalay M, Dorbala S, Haramati L, Hendel R, Martin E, Ryan T, Steiner R. ACR Appropriateness Criteria® Acute Chest Pain—Suspected Pulmonary Embolism. Journal Of Thoracic Imaging 2012, 27: w28-w31. PMID: 22343403, DOI: 10.1097/rti.0b013e31823efeb6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPulmonary embolismAppropriateness CriteriaClinical conditionsDiagnosis of PEDiagnostic imagingAppropriateness of imagingAcute chest painACR Appropriateness CriteriaDeep vein thrombosisTomography pulmonary angiographyLower extremity ultrasoundMultidisciplinary expert panelRadiology Appropriateness CriteriaEvidence-based guidelinesD-dimer testSpecific clinical conditionsHigh pretest probabilityCurrent medical literatureImportant clinical conditionBasis of signsMajor diagnostic modalityChest painPeer-reviewed journalsVein thrombosisClinical status
2011
Non-invasive imaging in acute chest pain syndromes
Sechtem U, Achenbach S, Friedrich M, Wackers F, Zamorano J. Non-invasive imaging in acute chest pain syndromes. European Heart Journal - Cardiovascular Imaging 2011, 13: 69-78. PMID: 22094238, DOI: 10.1093/ejechocard/jer250.Peer-Reviewed Original Research
2003
Use of radionuclide imaging in acute coronary syndromes
Abbott B, Wackers F. Use of radionuclide imaging in acute coronary syndromes. Current Cardiology Reports 2003, 5: 25-31. PMID: 12493157, DOI: 10.1007/s11886-003-0034-z.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeMyocardial infarctionChest painCoronary syndromeEmergency departmentPerfusion imagingRadionuclide myocardial perfusion imagingAcute chest painTriage of patientsAcute myocardial infarctionPerfusion imaging studyMyocardial perfusion imagingNegative predictive valueReperfusion therapyED evaluationRoutine careRandomized trialsRisk stratificationInfarct sizePrognostic valueDiagnostic challengeUnnecessary hospitalizationPredictive valueTesting modalitiesImaging studies
2001
9.2 Stress SPECT myocardial perfusion imaging optimizes the triage of emergency department patients with acute chest pain
ABBOTT B, ABDELAZIZ I, NAGULA S, WACKERS F. 9.2 Stress SPECT myocardial perfusion imaging optimizes the triage of emergency department patients with acute chest pain. Journal Of Nuclear Cardiology 2001, 8: s58-s58. DOI: 10.1016/s1071-3581(01)80643-7.Peer-Reviewed Original Research
2000
An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial
Stowers S, Eisenstein E, Wackers F, Berman D, Blackshear J, Jones A, Szymanski T, Lam L, Simons T, Natale D, Paige K, Wagner G. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial. Annals Of Emergency Medicine 2000, 35: 17-25. PMID: 28140201, DOI: 10.1016/s0196-0644(00)70100-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainClinical ProtocolsCoronary AngiographyCost ControlElectrocardiographyEmergency TreatmentExercise TestFemaleHospital CostsHumansLength of StayMaleMedicareMiddle AgedMyocardial InfarctionReproducibility of ResultsRisk FactorsSingle-Blind MethodTomography, Emission-Computed, Single-PhotonUnited StatesConceptsEarly exercise stress testingExercise stress testingLength of stayChest painHospital costsSingle photon emissionCoronary angiographyStress testingDiagnostic strategiesTomography myocardial perfusion imagingCost/charge ratiosAggressive diagnostic strategyNegative scan resultsPositive scan resultsAcute chest painIntermediate-risk patientsAcute coronary syndromeExercise treadmill testingAdverse clinical outcomesShorter median lengthEmergency department patientsAcute myocardial infarctionScan resultsMyocardial perfusion imagingPhoton emission
1998
Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms
Heller G, Stowers S, Hendel R, Herman S, Daher E, Ahlberg A, Baron J, de Leon C, Rizzo J, Wackers F. Clinical Value of Acute Rest Technetium-99m Tetrofosmin Tomographic Myocardial Perfusion Imaging in Patients With Acute Chest Pain and Nondiagnostic Electrocardiograms. Journal Of The American College Of Cardiology 1998, 31: 1011-1017. PMID: 9562001, DOI: 10.1016/s0735-1097(98)00057-6.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTomographic myocardial perfusionMyocardial infarctionChest painNondiagnostic electrocardiogramEmergency departmentHospital periodHospital admissionRest technetiumTetrofosmin SPECTMyocardial perfusionLow cardiac event rateTetrofosmin single photon emissionMultiple logistic regression analysisAcute chest painCardiac event rateNormal SPECT imagesMean cost savingsUnnecessary hospital admissionsLogistic regression analysisSingle photon emissionSPECT imagesAbnormal SPECTCardiac eventsRest Tc
1997
National Survey of Clerkship Directors in Internal Medicine on the Competencies That Should Be Addressed in the Medicine Core Clerkship
MD M, Fortin A, Morrison G, Wills M, Mumford L, Goroll A. National Survey of Clerkship Directors in Internal Medicine on the Competencies That Should Be Addressed in the Medicine Core Clerkship. The American Journal Of Medicine 1997, 102: 564-571. PMID: 9217672, DOI: 10.1016/s0002-9343(97)00054-5.Peer-Reviewed Original ResearchConceptsMean priority scoreInternal medicineIntensive careAmbulatory careChronic obstructive pulmonary diseaseAcute chest painObstructive pulmonary diseaseClerkship timeClinical competencyNational surveyMedicine core clerkshipChest painAdult patientsCoronary diseaseDiabetes mellitusElectrolyte disordersHeart failurePulmonary diseasePriority scoreOutpatient careCase presentation skillsEmergency settingGeneral internistsCore clerkshipsAssess factorsPrognostic value of normal rest tetrofosmin spect in patients with acute chest pain and nondiagnostic ECG in emergency department
Wackers F, Heller G, Stowers S, Hendel R, Herman S, Baron J, Daher E. Prognostic value of normal rest tetrofosmin spect in patients with acute chest pain and nondiagnostic ECG in emergency department. Journal Of Nuclear Cardiology 1997, 4: s26. DOI: 10.1016/s1071-3581(97)91217-4.Peer-Reviewed Original Research
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