2025
Deciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling
Tandra V, Ayala J, Gazik M, Sibley J, Singh N, Komatsu M, Li H, Su H, Li J. Deciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling. Physiology 2025, 40: 0743. DOI: 10.1152/physiol.2025.40.s1.0743.Peer-Reviewed Original ResearchCardiac remodelingUbiquitin-like protein modificationsCardiac proteinsLeft ventricleBeta-adrenergic agonist isoproterenolConjugation-deficient mutantsUb-like proteinsER stress responsePathological cardiac remodelingHypertrophic mouse heartsMonths of ageER homeostasisImpaired contractilityProtein substratesChamber dilationDilated CardiomyopathyAgonist isoproterenolCardiac contractilityCKO heartsCKO miceUfm1Heart failureUfmylationExacerbated fibrosisProtein modificationLower Extremity Flow Quantification Using Dynamic ⁸²Rb PET: A Preclinical Investigation
Guo L, Thorn S, de Rubio Cruz P, Liu Z, Gallezot J, Liu Q, Moulton E, Carson R, Sinusas A, Liu C. Lower Extremity Flow Quantification Using Dynamic ⁸²Rb PET: A Preclinical Investigation. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, 9: 918-926. DOI: 10.1109/trpms.2025.3542729.Peer-Reviewed Original ResearchBeyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series
Nazarenko N, Maliha M, Cerna L, Abittan N, Borkowski P, Csecs I, Garcia M. Beyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series. Annals Of Medicine And Surgery 2025, 87: 56-61. PMID: 40109641, PMCID: PMC11918691, DOI: 10.1097/ms9.0000000000002855.Peer-Reviewed Original ResearchLeft ventricleDextrocardia patientsICD placementSeverely reduced ejection fractionHigh risk of sudden cardiac deathRight-sided pleural effusionRisk of sudden cardiac deathAbnormal myocardial developmentYears of follow-upNon-compacted myocardiumTreated with amiodaroneSubsegmental pulmonary embolismTreated with enoxaparinLong-term outcomesSudden cardiac deathSystolic dysfunctionEvent-freeWorsening dyspneaEjection fractionPulmonary embolismAtrial dilatationPleural effusionConduction abnormalitiesMedical therapyCase series
2021
Robotic totally endoscopic triple bypass with bilateral internal mammary arteries and two different anastomotic techniques
Brownlee AR, Amabile A, Torregrossa G, Balkhy HH. Robotic totally endoscopic triple bypass with bilateral internal mammary arteries and two different anastomotic techniques. Journal Of Cardiac Surgery 2021, 37: 249-251. PMID: 34747050, DOI: 10.1111/jocs.16112.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassBilateral internal mammary artery graftsBilateral internal mammary arteryInternal mammary artery graftEndoscopic coronary artery bypassMammary artery graftsInternal mammary arteryBody mass indexDifferent anastomotic techniquesHeart TECABArtery graftHospital stayMammary arteryPostoperative qualityMass indexWound infectionPosterolateral wallAnterior wallAnastomotic techniqueTriple bypassLeft ventricleTECABBypassGraftHaemophilus Parainfluenzae mural endocarditis with large atrial septal defect and peripheral embolization
Bae JY, Murugiah K, McLeod GX, Anwer M, Howes CJ. Haemophilus Parainfluenzae mural endocarditis with large atrial septal defect and peripheral embolization. Journal Of Cardiology Cases 2021, 25: 149-152. PMID: 35261698, PMCID: PMC8888727, DOI: 10.1016/j.jccase.2021.08.002.Peer-Reviewed Case Reports and Technical NotesAtrial septal defectLarge atrial septal defectMural endocarditisInfective endocarditisSeptal defectLV massRisk factorsLeft ventriclePrior intravenous drug useBlood culture growthHemorrhagic cerebral eventsIntra-cardiac tumorPost-pericardiotomy syndromeRecent dental workIntravenous drug useUrgent surgical interventionValvular heart diseaseMitral valve repairVentricular septal defectCeftriaxone therapyPeripheral embolizationCerebral eventsDuke criteriaSymptom onsetSplenic infarctCilioretinal Artery Occlusion as the Presenting Manifestation of Left Atrial Myxoma
Mir T, Megalla M, Sinard J, Wang J. Cilioretinal Artery Occlusion as the Presenting Manifestation of Left Atrial Myxoma. Journal Of VitreoRetinal Diseases 2021, 6: 320-323. PMID: 37007931, PMCID: PMC9976024, DOI: 10.1177/24741264211034114.Peer-Reviewed Original ResearchCilioretinal artery occlusionArtery occlusionAtrial myxomaLarge left atrial massAcute vision lossLeft atrial massErythrocyte sedimentation rateC-reactive proteinLeft atrial myxomaMagnetic resonance imagingPresenting manifestationVisible emboliAtrial massFurther morbidityInitial presentationLeft eyeEmergency departmentCase reportTomography angiographyComplete workupVision lossLeft ventricleMyxomaResonance imagingOcclusion
2020
Reduction of Cerebral Emboli: In vitro Study with a Novel Cerebral Embolic Protection Device
Haiman G, Nazif T, Moses JW, Ashkenazi A, Margolis P, Lansky AJ. Reduction of Cerebral Emboli: In vitro Study with a Novel Cerebral Embolic Protection Device. Medical Devices Evidence And Research 2020, 13: 67-73. PMID: 32210643, PMCID: PMC7075333, DOI: 10.2147/mder.s234961.Peer-Reviewed Original ResearchCerebral embolic protection devicesEmbolic protection devicesMajor cerebral arteriesCerebral arteryCerebral embolizationCerebral circulationEmbolic debrisCerebral embolic protectionUnprotected controlsCerebral protectionEmbolic protectionCerebral emboliAortic archPulsatile flow patternLeft ventricleArteryPhysiologic flow conditionsCustom-made simulatorTriGuardEmbolizationEfficacyAortaAortic arch modelProtection devicesPercent of particlesGlobal longitudinal strain assessment of the left ventricle by speckle tracking echocardiography detects acute cellular rejection in orthotopic heart transplant recipients: A systematic review and meta‐analysis
Elkaryoni A, Altibi A, Khan M, Okasha O, Ellakany K, Hassan A, Singh A, Qarajeh R, Mehta S, Nanda N. Global longitudinal strain assessment of the left ventricle by speckle tracking echocardiography detects acute cellular rejection in orthotopic heart transplant recipients: A systematic review and meta‐analysis. Echocardiography 2020, 37: 302-309. PMID: 31967669, DOI: 10.1111/echo.14586.Peer-Reviewed Original ResearchConceptsAcute cellular rejectionGlobal longitudinal strainHeart transplant recipientsSpeckle tracking echocardiographyGlobal longitudinal strain assessmentOrthotopic heart transplant recipientsEndomyocardial biopsyWeighted mean differenceTracking echocardiographyTransplant recipientsCellular rejectionComparison to endomyocardial biopsyDetect acute cellular rejectionDiagnose ACRLeft ventricleNoninvasive screening modalityQuality Assessment of Diagnostic Accuracy StudiesComplication of transplantationCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsConfidence intervalsStrain assessmentDiagnostic accuracy studiesP375 To evaluate the effectiveness of primary prevention of anthracycline cardiotoxicity using modern STE technologies
Nesvetov V, Vasyuk Y, Shkolnik E, Yushuk E. P375 To evaluate the effectiveness of primary prevention of anthracycline cardiotoxicity using modern STE technologies. European Heart Journal - Cardiovascular Imaging 2020, 21 DOI: 10.1093/ehjci/jez319.223.Peer-Reviewed Original ResearchPrevention of anthracycline cardiotoxicityAnthracycline cardiotoxicityBreast cancerLeft ventricleMonths of follow-upSubclinical systolic dysfunctionLV ejection fractionEffects of ivabradineGlobal longitudinal strainCollection of anamnesisAppearance of clinical manifestationsControl groupHeart rateDevelopment of cardiomyopathySix-month treatmentHeart rate >Beats per minuteSystolic dysfunctionEjection fractionEchocardiographic indicesPrescribed chemotherapyDaily doseClinical manifestationsChemotherapeutic drugsHeart failure
2019
Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts
de Vicente L, Pinto A, Muñoz V, Rovina R, da Rocha A, Gaspar R, da Silva L, Simabuco F, Frantz F, Pauli J, de Moura L, Cintra D, Ropelle E, da Silva A. Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts. Life Sciences 2019, 240: 117107. PMID: 31785241, DOI: 10.1016/j.lfs.2019.117107.Peer-Reviewed Original ResearchConceptsAcute exercise intensityAcute physical exerciseLeft ventricleTLR4 deletionIL-17Serum levelsTNF-alphaPhysical exerciseExercise intensityER stressToll-like receptor 4Heart mRNA levelsSame exercise conditionTLR4 KO miceRole of TLR4Myocardium of miceExpression of inflammationResponse of markersEndoplasmic reticulum stressKO miceReceptor 4CK-MBImmune responseInflammationER stress genesMEF2 and the Right Ventricle: From Development to Disease
Clapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. MEF2 and the Right Ventricle: From Development to Disease. Frontiers In Cardiovascular Medicine 2019, 6: 29. PMID: 30984767, PMCID: PMC6448530, DOI: 10.3389/fcvm.2019.00029.Peer-Reviewed Original ResearchPulmonary arterial hypertensionArterial hypertensionRight ventricleRight ventricular functionLife-limiting diseaseNovel therapeutic strategiesRight ventricular developmentEndothelial dysfunctionVentricular functionTherapeutic strategiesLeft ventricleHypertensionVentricleDisease statesVentricular developmentNormal physiologyMEF2 transcription factorsDiseaseAfterloadDysfunctionTranscription factorsGradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning
Willeman M, Chawla M, Zempare M, Biwer L, Hoang L, Uprety A, Fitzhugh M, De Both M, Coleman P, Trouard T, Alexander G, Mitchell K, Barnes C, Hale T, Huentelman M. Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning. Physiological Reports 2019, 7: e14010. PMID: 30916484, PMCID: PMC6436186, DOI: 10.14814/phy2.14010.Peer-Reviewed Original ResearchConceptsTransgenic ratsBlood pressureCyp1a1-Ren2 transgenic ratsRenin-dependent hypertensionImpact of hypertensionInduction of hypertensionSystolic blood pressureTransgenic rat modelMajor health concernAge of onsetRenal hypertrophyPrevalence increasesHypertension inductionRat modelHypertensionNeurological healthCollagen depositionLeft ventricleSensory functionBrain regionsCardiovascular systemSignificant impairmentRate of inductionMorris swim taskRats
2018
Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences
Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD. Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomechanics And Modeling In Mechanobiology 2018, 17: 1281-1295. PMID: 29754316, PMCID: PMC8344131, DOI: 10.1007/s10237-018-1026-7.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAorta, AbdominalAorta, ThoracicBiomechanical PhenomenaCardiovascular DiseasesCardiovascular SystemCarotid ArteriesCarotid Artery, CommonDiastoleDisease Models, AnimalElastinExtracellular Matrix ProteinsHemodynamicsHomeostasisHumansMaleMiceModels, CardiovascularPressureRecombinant ProteinsStress, MechanicalTime FactorsVascular StiffnessConceptsCentral arteriesMale wild-type miceArterial wallAberrant matrix remodelingCentral pulse pressureInfrarenal abdominal aortaCommon carotid arteryWild-type miceDiastolic functionCardiovascular consequencesCardiac massHemodynamic sequelaePulse pressureAbdominal aortaThoracic aortaArterial agingVascular agingCommon findingTreatment strategiesCarotid arteryArteryLeft ventricleCarotid vesselsCentral vesselsVivo axial stretchQuantitative in vivo mapping of myocardial mitochondrial membrane potential
Alpert N, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour M, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup T, Normandin M, Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLOS ONE 2018, 13: e0190968. PMID: 29338024, PMCID: PMC5770041, DOI: 10.1371/journal.pone.0190968.Peer-Reviewed Original Research
2017
Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography
Egbe A, Khan A, Miranda W, Ammash N, Warnes C, Said S, Taggart N, Akintoye E, Veldtman G, Connolly H. Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography. American Heart Journal 2017, 196: 144-152. PMID: 29421006, DOI: 10.1016/j.ahj.2017.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAge FactorsCohort StudiesDouble Outlet Right VentricleEchocardiography, DopplerExercise TestExercise ToleranceFollow-Up StudiesFontan ProcedureHeart Defects, CongenitalHumansMaleMichiganOxygen ConsumptionPulmonary AtresiaRetrospective StudiesTime FactorsTreatment OutcomeTricuspid AtresiaYoung AdultConceptsCardiopulmonary exercise testTransthoracic echocardiogramLV function indicesFontan palliationExercise capacityChronotropic indexFunction IndexLeft ventricleAdult Fontan patientsFontan conversion operationSystemic left ventriclePeak oxygen consumptionSerial transthoracic echocardiogramsFontan patientsFontan conversionDoppler echocardiographyRetrospective reviewDoppler hemodynamicsMean ageHemodynamic mechanismsExercise testMayo ClinicCPET dataPatientsTemporal improvementRole of Doppler echocardiography for cardiac output assessment in Fontan patients
Egbe A, Khan A, Khan S, Anavekar N, Said S, Young P, Akintoye E, Miranda W, Al-Otaibi M, Veldtman G, Connolly H. Role of Doppler echocardiography for cardiac output assessment in Fontan patients. American Heart Journal 2017, 195: 91-98. PMID: 29224651, DOI: 10.1016/j.ahj.2017.09.014.Peer-Reviewed Original ResearchConceptsStroke volume indexSystemic left ventricleSystemic right ventricleFontan failureRight ventricleLeft ventricleFontan patientsTransthoracic echocardiographyLV patientsProtein-losing enteropathyCardiac output assessmentAge 17 yearsMean age 17 yearsHeart transplantationCardiac thrombusFontan conversionEjection fractionHeart failureDoppler echocardiographyPatientsVolume indexCMRIML/CirrhosisEchocardiographyAdverse Remodeling and Reverse Remodeling After Myocardial Infarction
Bhatt AS, Ambrosy AP, Velazquez EJ. Adverse Remodeling and Reverse Remodeling After Myocardial Infarction. Current Cardiology Reports 2017, 19: 71. PMID: 28660552, DOI: 10.1007/s11886-017-0876-4.Peer-Reviewed Original ResearchConceptsAdverse LV remodelingMyocardial infarctionLV remodelingAdverse remodelingNeurohormonal regulationLeft ventricleCurrent evidence-based therapiesPost-MI heart failurePoor clinical outcomeAdverse cardiac remodelingPost-MI settingDevice-based therapiesEvidence-based therapiesNeurohormonal blockadeEarly revascularizationPathophysiological considerationsHeart failureVentricular dyssynchronyClinical outcomesEjection fractionMultiple imaging modalitiesCardiac remodelingTreatment strategiesReviewThe purposeInfarctionPOSSIBILITIES OF IVABRADINE, A SELECTIVE INHIBITOR OF ION F-CHANNELS OF SINUS NODE, IN PREVENTION OF ANTHRACYCLINE CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER
Vasyuk Y, Nesvetov V, Shkolnik E, Shkolnik L, Varlan G, Gendlin G, Emelina E. POSSIBILITIES OF IVABRADINE, A SELECTIVE INHIBITOR OF ION F-CHANNELS OF SINUS NODE, IN PREVENTION OF ANTHRACYCLINE CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER. Rational Pharmacotherapy In Cardiology 2017, 13: 184-190. DOI: 10.20996/1819-6446-2017-13-2-184-190.Peer-Reviewed Original ResearchComplaints of palpitationsHeart rate >Breast cancerControl groupMonths of observationLV global longitudinal strainLeft ventricleMonths of follow-upRandomized uncontrolled studyTreated with polychemotherapyLeft atrium diameterLV ejection fractionGlobal longitudinal strainLeft atrium volumeEfficacy of ivabradineMonths of treatmentLongitudinal strain valuesCollection of complaintsIvabradine therapyIvabradine usePrescribed ivabradineGlobal longitudinal deformationDose titrationEjection fractionIndex mass
2016
Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Mentias A, Feng K, Alashi A, Rodriguez LL, Gillinov AM, Johnston DR, Sabik JF, Svensson LG, Grimm RA, Griffin BP, Desai MY. Long-Term Outcomes in Patients With Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. Journal Of The American College Of Cardiology 2016, 68: 2144-2153. PMID: 27855803, DOI: 10.1016/j.jacc.2016.08.045.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionAV surgeryVentricular ejection fractionAortic regurgitationLong-term survivalEjection fractionSuch patientsLeft ventricleChronic severe aortic regurgitationSex-matched U.S. populationLV end-systolic dimensionMultivariate Cox survival analysisGreater aortic regurgitationHospital postoperative mortalityMean STS scoreThoracic Surgeons scoreAortic valve surgeryChronic aortic regurgitationSevere aortic regurgitationEnd-systolic dimensionSurvival of patientsLong-term outcomesRisk of deathCox survival analysisPostoperative mortality
2014
Clinical Application of Three-Dimensional Echocardiography
Morbach C, Lin B, Sugeng L. Clinical Application of Three-Dimensional Echocardiography. Progress In Cardiovascular Diseases 2014, 57: 19-31. PMID: 25081399, DOI: 10.1016/j.pcad.2014.05.005.Peer-Reviewed Original ResearchConceptsStructural heart disease proceduresIntra-procedural guidanceRight ventricular volumesThree-dimensional echocardiographyMitral valve diseaseRight ventricleMitral valveValve diseaseSoftware developmentVentricular volumeLeft ventricleInterventional proceduresClinical applicationEchocardiographyDiagnostic toolVentricleImage qualityTransthoracicTransesophagealComplications
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply