2024
Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria
Hwang E, Kim J, Lee M, Yoon H, Shin J, Lee K. Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria. Childhood Kidney Diseases 2024, 28: 74-79. DOI: 10.3339/ckd.24.009.Peer-Reviewed Original ResearchLeft renal veinUrine protein-to-creatinine ratioNutcracker syndromeMorning urine samplesHilar portionOrthostatic proteinuriaNo significant differenceUrine samplesAfternoon urine samplesDoppler ultrasonography findingsDoppler ultrasonography examinationRenal Doppler ultrasoundSignificant differenceProtein-to-creatinine ratioSuperior mesenteric arteryDoppler sonographic findingsPV ratioConsecutive childrenUltrasonography findingsPediatric patientsRenal veinPeak velocitySonographic findingsUltrasonography examinationMesenteric artery#822 Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria
Lee K, Hwang E, Kim J, Park J, Shin J. #822 Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria. Nephrology Dialysis Transplantation 2024, 39: gfae069-1321-822. DOI: 10.1093/ndt/gfae069.1321.Peer-Reviewed Original ResearchLeft renal veinOrthostatic proteinuriaRenal veinHilar portionRenal Doppler ultrasound examinationRenal Doppler ultrasoundPediatric nephrology clinicDoppler ultrasound examinationSuperior mesenteric arteryHealthy normal childrenPeak velocity ratioDoppler sonographic findingsNutcracker syndromeConsecutive childrenPeak velocitySonographic findingsMesenteric arteryProtein/creatinine ratioUltrasound examinationNephrology clinicMorning urineSeverance HospitalDoppler ultrasoundProteinuriaResults Age
2023
Nutcracker syndrome in children: review of symptom, diagnosis, and treatment
Kalantar D, Park S, Shin J. Nutcracker syndrome in children: review of symptom, diagnosis, and treatment. Childhood Kidney Diseases 2023, 27: 89-96. DOI: 10.3339/ckd.23.018.Peer-Reviewed Original ResearchNutcracker syndromePediatric patientsLeft renal veinRenal vein thrombosisInvasive surgical treatmentRenal nutcracker syndromePediatric clinical studiesSuperior mesenteric arteryReview of symptomsFlank painSurgical treatmentRenal veinSevere complicationsVein thrombosisMesenteric arteryNoninvasive managementClinical studiesAbdominal aortaEarly diagnosisVariable incidenceFirstline optionDiagnosisSymptomsPatientsSyndrome
2022
Smooth muscle cell FTO regulates contractile function
Luse M, Krüger N, Good M, Biwer L, Serbulea V, Salamon A, Deaton R, Leitinger N, Gödecke A, Isakson B. Smooth muscle cell FTO regulates contractile function. AJP Heart And Circulatory Physiology 2022, 323: h1212-h1220. PMID: 36306211, PMCID: PMC9678421, DOI: 10.1152/ajpheart.00427.2022.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsThird-order mesenteric arteriesMuscle cellsObesity genesSmooth muscle contractilityRates of obesityHuman coronary arteriesCardiac myocyte contractilityPlasma reninBlood pressureMesenteric arteryMyogenic toneCoronary arteryFat massContractile functionMyocyte contractilityMuscle contractilityHeart rateSerum response factorMuscle depolarizationMouse body massContractilitySignificant decreaseCell deletionMicePredictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study
Rittgerodt N, Pape T, Busch M, Becker L, Schneider A, Wedemeyer H, Seeliger B, Schmidt J, Hunkemöller A, Fuge J, Knitsch W, Fegbeutel C, Gillmann H, Meyer B, Hoeper M, Hinrichs J, David S, Stahl K. Predictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study. Critical Care 2022, 26: 92. PMID: 35379286, PMCID: PMC8981621, DOI: 10.1186/s13054-022-03962-w.Peer-Reviewed Original ResearchConceptsMulti-organ failureVasodilatory therapyMesenteric ischemiaPredictors of response to therapyBackgroundNon-occlusive mesenteric ischemiaBiomarkers of intestinal injuryNon-occlusive mesenteric ischemiaLocal intra-arterial infusionIntra-arterial therapyDoses of norepinephrineResponse to therapyRetrospective case seriesIntra-arterial infusionSevere shockLife-threatening conditionImprovement of ischemiaProstaglandin infusionSecondary endpointsClinical parametersElevated lactate concentrationsCase seriesTherapeutic optionsMesenteric arteryReduction of lactateIntestinal ischemia
2021
Endovascular aneurysm repair with inferior mesenteric artery chimney in a high-risk patient with abdominal aortic aneurysm and iliac occlusion
Kostiuk V, Mena C, Sumpio B, Guzman RJ, Chaar C. Endovascular aneurysm repair with inferior mesenteric artery chimney in a high-risk patient with abdominal aortic aneurysm and iliac occlusion. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 8: 28-31. PMID: 35036669, PMCID: PMC8743168, DOI: 10.1016/j.jvscit.2021.10.012.Peer-Reviewed Original ResearchInferior mesenteric arteryEndovascular aneurysm repairLeft leg claudicationHigh-risk patientsAbdominal aortic aneurysmAneurysm repairLeg claudicationAortic aneurysmPeripheral arterial disease treatmentFemorofemoral bypassIMA graftingIMA reimplantationUneventful recoverySurgical repairArtery compromiseIliac occlusionMesenteric arteryTomography angiogramCoronary arteryPerfusion preservationAneurysm sacReasonable alternativeClaudicationDisease treatmentPatients
2020
Endothelial calreticulin deletion impairs endothelial function in aged mice
Biwer L, Askew-Page H, Hong K, Milstein J, Johnstone S, Macal E, Good M, Bagher P, Sonkusare S, Isakson B. Endothelial calreticulin deletion impairs endothelial function in aged mice. AJP Heart And Circulatory Physiology 2020, 318: h1041-h1048. PMID: 32196361, PMCID: PMC7346539, DOI: 10.1152/ajpheart.00586.2019.Peer-Reviewed Original ResearchConceptsVascular functionTauroursodeoxycholic acidMesenteric arteryAged miceCalcium signalsImpaired endothelial-dependent vasodilationThird-order mesenteric arteriesEndothelial cellsEndothelial-dependent vasodilationIncubation of arteriesImpairs endothelial functionSmall resistance arteriesMultifunctional calcium binding proteinER stress inhibitor tauroursodeoxycholic acidWk of ageEndoplasmic reticulum stressPE constrictionEndothelial functionVasodilatory functionResistance arteriesCalcium binding proteinAgonist carbacholClinical trialsMuscarinic stimulationVasodilationNon-occlusive mesenteric ischemia (NOMI): evaluation of 2D-perfusion angiography (2D-PA) for early treatment response assessment
Becker L, Stahl K, Meine T, von Falck C, Meyer B, Dewald C, Rittgerodt N, Busch M, David S, Wacker F, Hinrichs J. Non-occlusive mesenteric ischemia (NOMI): evaluation of 2D-perfusion angiography (2D-PA) for early treatment response assessment. Abdominal Radiology 2020, 45: 3342-3351. PMID: 32103299, PMCID: PMC7455582, DOI: 10.1007/s00261-020-02457-y.Peer-Reviewed Original ResearchConceptsNon-occlusive mesenteric ischemiaTime-to-peakArea under the curveDigital subtraction angiographyMesenteric ischemiaTreatment responseFeasibility of 2D-perfusion angiographyNOMI patientsEarly treatment response assessmentRetrospective case-control studyProstaglandin E1 therapyTreatment response assessmentAssess treatment responseControl groupSuperior mesenteric arteryCase-control studyVasodilatory therapyResponse assessmentMesenteric arterySubtraction angiographyPortal veinPerfusion changesAngiographyPatientsStatistical significance
2019
Robotic Extended Right Hemicolectomy with Complete Mesocolic Excision and D3 Lymph Node Dissection
Hameed I, Aggarwal P, Weiser MR. Robotic Extended Right Hemicolectomy with Complete Mesocolic Excision and D3 Lymph Node Dissection. Annals Of Surgical Oncology 2019, 26: 3990-3991. PMID: 31407176, PMCID: PMC6788952, DOI: 10.1245/s10434-019-07692-2.Peer-Reviewed Original ResearchConceptsD3 lymph node dissectionComplete mesocolic excisionLymph node dissectionMesocolic excisionNode dissectionRight hemicolectomyIleocolic pedicleVisceral peritoneumIndocyanine green fluorescence imagingProximal transverse colonLeft lower quadrantSuperior mesenteric arterySuperior mesenteric veinMiddle colic vesselsExtended lymphadenectomyMetastatic diseaseLymph nodesBloc resectionHepatic flexureMesenteric arteryTransverse colonLower quadrantNegative marginsBackgroundRecent studiesMesenteric vein
2017
Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function
Biwer L, Good M, Hong K, Patel R, Agrawal N, Looft-Wilson R, Sonkusare S, Isakson B. Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function. Arteriosclerosis Thrombosis And Vascular Biology 2017, 38: 120-130. PMID: 29122814, PMCID: PMC5746467, DOI: 10.1161/atvbaha.117.309886.Peer-Reviewed Original ResearchConceptsThird-order mesenteric arteriesBlood pressureMesenteric arteryVascular functionCalcium signalingIEL holesApplication of CChMyoendothelial junctionsCalcium eventsER calciumSmooth muscle cellsInternal elastic laminaVascular reactivityResistance arteriesSmall arteriesSame arteryKnockout miceArteryΔ miceElastic laminaMuscle cellsEndoplasmic reticulum calciumMiceCALRCalcium signalsLoss of endothelial Fto is protective against metabolic disease
Krüger N, Biwer L, Good M, Rüther U, Isakson B. Loss of endothelial Fto is protective against metabolic disease. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.1015.15.Peer-Reviewed Original ResearchHigh-fat dietObesity-induced metabolic changesHFD-fed miceMyogenic toneBlood pressureNormal chowMesenteric arteryResistance arteriesEndothelial cellsMetabolic changesNC-fed miceObesity-induced hypertensionSerum lipid levelsOrder mesenteric arteriesSerum lipid analysisFto-deficient miceVascular healthVascular levelVascular toneInsulin resistanceInsulin toleranceFat dietPathophysiological changesDeficient miceFat mass
2016
Explantation of infected aortic aneurysm and endograft with ascending aorta to mesenteric bypass for mesenteric ischemia
Gates L, Chin JA, Bonde PN, Chaar C, Sumpio BE, Sarac TP. Explantation of infected aortic aneurysm and endograft with ascending aorta to mesenteric bypass for mesenteric ischemia. Journal Of Vascular Surgery 2016, 65: 219-223. PMID: 27183855, DOI: 10.1016/j.jvs.2016.03.411.Peer-Reviewed Original ResearchMeSH KeywordsAgedAneurysm, InfectedAnti-Bacterial AgentsAortic Aneurysm, AbdominalAortographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCeliac ArteryCoated Materials, BiocompatibleCollateral CirculationComputed Tomography AngiographyDevice RemovalEndovascular ProceduresHepatic ArteryHumansMaleMesenteric Artery, SuperiorMesenteric IschemiaMesenteric Vascular OcclusionProsthesis-Related InfectionsReoperationRifampinSplanchnic CirculationTreatment OutcomeConceptsAortic aneurysmBilateral renal arteriesSurgical revascularization techniquesSuperior mesenteric arteryAbdominal aortic aneurysmAxillobifemoral bypassGelsoft graftAbdominal painMesenteric ischemiaRevascularization techniquesThoracoabdominal aortaInferior mesentericMesenteric arteryRenal arterySurgical issuesMesenteric bypassAneurysmsAortaPrevious treatmentEndograftArteryBypassMesentericResectionIschemia
2015
Fetal and postnatal ovine mesenteric vascular reactivity
Nair J, Gugino SF, Nielsen LC, Caty MG, Lakshminrusimha S. Fetal and postnatal ovine mesenteric vascular reactivity. Pediatric Research 2015, 79: 575-582. PMID: 26672733, PMCID: PMC4837013, DOI: 10.1038/pr.2015.260.Peer-Reviewed Original ResearchConceptsLate preterm gestationMesenteric arterial reactivityMesenteric vascular reactivityFull-term birthBasal eNOS activityMesenteric vasoconstrictionArterial reactivityEnteral nutritionVasodilator pathwaysPreterm birthVascular reactivityIntestinal circulationMesenteric arteryVasodilatory influencePostnatal lambsRisk factorsENOS activityPDE5 proteinPostnatal periodET-1Ontogenic mechanismsGestationBirthMRNAMA ringsDietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt
Liu H, Zhang J, Sun Y, Li X, Jiang S, Liu M, Shi J, Song B, Zhao D, Ma H, Zhang Z. Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt. British Journal Of Pharmacology 2015, 172: 5634-5646. PMID: 25953733, PMCID: PMC4667865, DOI: 10.1111/bph.13185.Peer-Reviewed Original ResearchConceptsEndothelium-dependent relaxationWeeks of HS dietEpithelial sodium channelMesenteric arteryENaC activityEndothelial ENaCEndothelial cellsHS dietSprague-DawleyEnhancement of endothelium-dependent relaxationSodium channelsSecond-order mesenteric arteriesBlocker of ENaCWire myograph assayPatch-clamp techniquePlasma aldosterone levelsSalt-sensitive hypertensionResponse to AChNegative modulatorRat endothelial cellsModulation of vasodilationVascular endothelial cellsFunctional ENaCENaC expressionRelease of NO
2012
Acute superior mesenteric artery embolism: reperfusion with AngioJet hydrodynamic suction thrombectomy and pharmacologic thrombolysis with the EKOS catheter
Ballehaninna U, Hingorani A, Ascher E, Shiferson A, Marks N, Aboian E, Jimenez R, Jacob T, McIntyre T. Acute superior mesenteric artery embolism: reperfusion with AngioJet hydrodynamic suction thrombectomy and pharmacologic thrombolysis with the EKOS catheter. Vascular 2012, 20: 166-169. PMID: 22442382, DOI: 10.1258/vasc.2011.cr0311.Peer-Reviewed Original ResearchConceptsSuperior mesenteric arterySuction thrombectomyEKOS catheterPharmacological thrombolysisContinuous thrombolysisNew-onset atrial fibrillationAcute SMA embolismOnset atrial fibrillationPharmaco-mechanical thrombolysisAcute mesenteric ischemiaOpen thrombectomySMA embolismSurgical thrombectomyAbdominal painMesenteric ischemiaMechanical thrombectomyRepeat angiogramPharmacologic thrombolysisSurgical explorationMesenteric arterySerum lactateAtrial fibrillationMesenteric embolismAcute embolusFilling defectChronic mesenteric ischaemia: 28-year experience of endovascular treatment
Turba U, Saad W, Arslan B, Sabri S, Trotter S, Angle J, Hagspiel K, Kern J, Cherry K, Matsumoto A. Chronic mesenteric ischaemia: 28-year experience of endovascular treatment. European Radiology 2012, 22: 1372-1384. PMID: 22302502, DOI: 10.1007/s00330-011-2376-z.Peer-Reviewed Original ResearchConceptsSuperior mesenteric arteryChronic mesenteric ischemiaTechnical success ratePercutaneous transluminal angioplastyMesenteric arteryEndovascular therapySuccess rateMethodsA retrospective review of patientsTransluminal angioplastyRetrospective review of patientsClinical success rateExperience of endovascular treatmentMethodsA retrospective reviewReview of patientsPrimary patency rateImmediate clinical improvementFemoral artery accessArtery outcomesPrimary patencyMesenteric ischemiaClinical improvementEndovascular treatmentIschaemic symptomsStent diameterPatency rates
2011
The chimney procedure is an emergently available endovascular solution for visceral aortic aneurysm rupture
Schlösser FJ, Aruny JE, Freiburg CB, Mojibian HR, Sumpio BE, Muhs BE. The chimney procedure is an emergently available endovascular solution for visceral aortic aneurysm rupture. Journal Of Vascular Surgery 2011, 53: 1386-1390. PMID: 21276684, DOI: 10.1016/j.jvs.2010.11.097.Peer-Reviewed Original ResearchConceptsComputed tomography angiographyChimney procedureAortic side branchesOpen surgical repairThoracoabdominal aortic aneurysmsAortic aneurysm rupturePlacement of stentsOpen repairMesenteric arterySurgical repairEndovascular solutionGraft migrationAortic aneurysmTomography angiographyAneurysm ruptureEmergency patientsPatientsStentsType ISide branchesRepairMost institutionsEndoleakEndograftAngiography
2009
Doppler Sonographic Criteria for the Diagnosis of Inferior Mesenteric Artery Stenosis
Pellerito JS, Revzin MV, Tsang JC, Greben CR, Naidich JB. Doppler Sonographic Criteria for the Diagnosis of Inferior Mesenteric Artery Stenosis. Journal Of Ultrasound In Medicine 2009, 28: 641-650. PMID: 19389903, DOI: 10.7863/jum.2009.28.5.641.Peer-Reviewed Original ResearchConceptsPeak systolic velocityEnd-diastolic velocityChronic mesenteric ischemiaInferior mesenteric artery stenosisNegative predictive valuePositive predictive valueMesenteric artery stenosisIMA stenosisArtery stenosisPredictive valueDoppler sonographic criteriaDoppler sonographic examinationDoppler sonographic studiesLogistic regression analysisCorrelative angiographyMesenteric ischemiaMesenteric arteryRetrospective reviewVisualization rateSonographic studySystolic velocitySonographic examinationDoppler sonographySonographic criteriaDoppler criteria
2006
Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children with hematuria
Shin J, Park J, Lee J, Kim M. Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children with hematuria. European Journal Of Pediatrics 2006, 166: 399-404. PMID: 17051355, PMCID: PMC1829442, DOI: 10.1007/s00431-006-0252-7.Peer-Reviewed Original ResearchConceptsLeft renal veinRenal Doppler ultrasoundNutcracker syndromeDoppler ultrasoundIsolated hematuriaHilar portionRenal Doppler ultrasound examinationNormal childrenDoppler ultrasound examinationSuperior mesenteric arteryPeak velocityHealthy normal childrenAortomesenteric portionConsecutive childrenRenal veinMesenteric arteryUltrasound examinationPV ratioHematuriaScreening examinationSyndromeUltrasoundDetection rateChildrenExamination
2003
Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats
Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology 2003, 125: 1452-1461. PMID: 14598261, DOI: 10.1016/j.gastro.2003.07.014.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationSuperior mesenteric arterySMA vascular resistancePortal hypertensive ratsRAL ratsMesenteric vasoconstrictionPortal pressureVascular resistanceArterial pressureHypertensive ratsMesenteric arteryNitric oxide synthase activityNitric oxide synthase enzyme activitySMA blood flowMean arterial pressurePerfusion pressure changesPortal vein ligationENOS protein expressionSham-operated ratsOxide synthase activityMonomethyl-L-arginineNitric oxide overproductionEffects of vasoconstrictionRenal artery ligationENOS catalytic activity
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