2025
Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudication
2024
Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease
Nishibe T, Dardik A, Akiyama S, Kano M, Fukuda S, Koizumi J, Nishibe M. Reduced Muscle Mass and Muscle Quality in Patients with Intermittent Claudication due to Peripheral Artery Disease. Annals Of Vascular Surgery 2024, 105: 275-281. PMID: 38570014, DOI: 10.1016/j.avsg.2023.12.094.Peer-Reviewed Original ResearchSkeletal muscle massPeripheral arterial diseaseBioelectrical impedance analysisAnkle-brachial indexAnkle-brachial pressure indexLeg skeletal muscle massLeg ischemiaMuscle massIntermittent claudicationLeg muscle massMuscle qualityArtery diseaseAssociated with reduced muscle massTokyo Medical University HospitalAssociated with skeletal muscle myopathyReduced muscle massMedical University HospitalLeg muscle qualitySkeletal muscle myopathyUniversity HospitalMuscle myopathyPatientsIschemiaClaudicationLower extremitiesThe Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions
Alameddine D, Damara F, Pinto Rodriguez P, Huttler J, Slade M, Arhuidese I, Aboian E, Ochoa Chaar C. The Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions. Annals Of Vascular Surgery 2024, 103: 47-57. PMID: 38387798, DOI: 10.1016/j.avsg.2023.12.071.Peer-Reviewed Original ResearchImpact of cilostazolPeripheral vascular interventionsPeripheral arterial diseaseTreatment of intermittent claudicationRates of long-term mortalityPeripheral vascular interventional proceduresKaplan-Meier methodCongestive heart failureLong-term mortalityLong-term outcomesEndovascular peripheral interventionsRenal complicationsPatient demographicsBaseline characteristicsHeart failureDiabetes mellitusArtery diseaseIntermittent claudicationCilostazolPatientsVascular interventionsPeripheral interventionsClaudicationOutcomesIntervention
2023
Reply Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication
Altin S, Curtis J. Reply Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovascular Interventions 2023, 16: 2336. PMID: 37758390, DOI: 10.1016/j.jcin.2023.08.027.Peer-Reviewed Original ResearchSupervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis
Kapadia S, Huang H, Parise H, Ismayl M, Ahmed Z, Tirziu D, Altin S. Supervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication by Level of Disease: A Systematic Review and Meta-Analysis. The American Journal Of Cardiology 2023, 205: 403-405. PMID: 37659260, DOI: 10.1016/j.amjcard.2023.08.044.Peer-Reviewed Original ResearchPatient knowledge and preferences for peripheral artery disease treatment
Smolderen K, Romain G, Gosch K, Arham A, Provance J, Spertus J, Poosala A, Shishehbor M, Safley D, Scott K, Stone N, Mena-Hurtado C. Patient knowledge and preferences for peripheral artery disease treatment. Vascular Medicine 2023, 28: 397-403. PMID: 37638882, PMCID: PMC10591804, DOI: 10.1177/1358863x231181613.Peer-Reviewed Original ResearchPeripheral artery diseaseTreatment goalsPatient knowledgeTreatment optionsTreatment preferencesHeart attack/strokeSymptomatic peripheral artery diseasePeripheral artery disease treatmentImportant treatment goalQuality of lifeCost of treatmentSpecific treatment goalsMulticenter registryPAD symptomsPain reliefSecondary preventionArtery diseaseTreatment choiceTreatment benefitPatient understandingPatientsMedical decision makingDisease managementClaudicationDisease treatmentSUPERVISED EXERCISE THERAPY VERSUS PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR CLAUDICATION BY LEVEL OF DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Kapadia S, Huang H, Tirziu D, Ahmed Z, Altin S. SUPERVISED EXERCISE THERAPY VERSUS PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR CLAUDICATION BY LEVEL OF DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal Of The American College Of Cardiology 2023, 81: 2050. DOI: 10.1016/s0735-1097(23)02494-4.Peer-Reviewed Original Research
2022
Effect of preservation of antegrade hypogastric flow on development of claudication following aortoiliac aneurysm repair
Bennett K, Hurley L, Kyriakides T, Yi J, Freischlag J, Matsumura J, Group O. Effect of preservation of antegrade hypogastric flow on development of claudication following aortoiliac aneurysm repair. Journal Of Vascular Surgery 2022, 77: 1070-1076. PMID: 36565778, DOI: 10.1016/j.jvs.2022.12.022.Peer-Reviewed Original ResearchConceptsAortoiliac aneurysm repairDevelopment of claudicationButtock claudicationHypogastric flowClaudication symptomsHypogastric perfusionAneurysm repairArterial flowChronic obstructive pulmonary diseaseBilateral buttock claudicationPreoperative activity levelObstructive pulmonary diseaseBody mass indexIntervention-related changesOVER trialPulmonary diseaseStudy armsMass indexArterial perfusionClaudicationTrial investigatorsAnatomic levelTrial participantsTheoretical riskPatientsEffect Of Preservation Of Antegrade Hypogastric Flow On Development Of Claudication Following Aortoiliac Aneurysm Repair
Bennett K, Hurley L, Matsumura J, Kyriakides T, Freischlag J. Effect Of Preservation Of Antegrade Hypogastric Flow On Development Of Claudication Following Aortoiliac Aneurysm Repair. Journal Of Vascular Surgery 2022, 76: e63. DOI: 10.1016/j.jvs.2022.07.136.Peer-Reviewed Original ResearchImplementation of supervised exercise therapy in a veteran population with symptomatic claudication
Altin S, Schneider MD, Parise H, Banerjee S, Wu WC, Meadows JL, Pfau S, Keefe H, Armstrong EJ. Implementation of supervised exercise therapy in a veteran population with symptomatic claudication. Vascular Medicine 2022, 27: 136-141. PMID: 35225695, DOI: 10.1177/1358863x211073622.Peer-Reviewed Original ResearchConceptsExercise treadmill testingExercise therapyMetabolic equivalentsIntermittent claudicationExercise capacityTreadmill testingAnkle-brachial indexIntermittent claudication symptomsMale veteran patientsSupervised exercise therapySymptomatic intermittent claudicationVascular specialty clinicsLow patient adherenceClaudication symptomsSymptomatic claudicationExercise groupVeteran patientsPatient adherenceRisk stratificationTherapy referralSpecialty clinicProvider awarenessVeteran populationClaudicationTherapy
2021
Endovascular aneurysm repair with inferior mesenteric artery chimney in a high-risk patient with abdominal aortic aneurysm and iliac occlusion
Kostiuk V, Mena C, Sumpio B, Guzman RJ, Chaar C. Endovascular aneurysm repair with inferior mesenteric artery chimney in a high-risk patient with abdominal aortic aneurysm and iliac occlusion. Journal Of Vascular Surgery Cases And Innovative Techniques 2021, 8: 28-31. PMID: 35036669, PMCID: PMC8743168, DOI: 10.1016/j.jvscit.2021.10.012.Peer-Reviewed Original ResearchInferior mesenteric arteryEndovascular aneurysm repairLeft leg claudicationHigh-risk patientsAbdominal aortic aneurysmAneurysm repairLeg claudicationAortic aneurysmPeripheral arterial disease treatmentFemorofemoral bypassIMA graftingIMA reimplantationUneventful recoverySurgical repairArtery compromiseIliac occlusionMesenteric arteryTomography angiogramCoronary arteryPerfusion preservationAneurysm sacReasonable alternativeClaudicationDisease treatmentPatientsReal world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data
Aggarwal N, Chow R. Real world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data. Anesthesia And Pain Medicine 2021, 16: 177-183. PMID: 33866770, PMCID: PMC8107255, DOI: 10.17085/apm.20093.Peer-Reviewed Original ResearchAdverse eventsInterspinous spacerReal-world adverse eventsProgressive neurogenic claudicationLumbar decompression surgeryLumbar spinal stenosisUser Facility Device Experience (MAUDE) databaseInterspinous process spacerInterspinous spacer devicesInterspinous process deviceConservative therapyNeurogenic claudicationDecompression surgerySpinal stenosisPain/Spacer deviceUS FoodDrug AdministrationDisproportionality analysisFurther studiesExperience databaseClaudicationStenosisSurgeryTherapyTreatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid
Smolderen KG, Pacheco C, Provance J, Stone N, Fuss C, Decker C, Bunte M, Jelani QU, Safley DM, Secemsky E, Sepucha KR, Spatz ES, Mena-Hurtado C, Spertus JA. Treatment decisions for patients with peripheral artery disease and symptoms of claudication: Development process and alpha testing of the SHOW-ME PAD decision aid. Vascular Medicine 2021, 26: 273-280. PMID: 33627058, PMCID: PMC8169642, DOI: 10.1177/1358863x20988780.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseTreatment optionsSymptoms of claudicationInvasive treatment optionNon-invasive treatmentQuality of lifeClaudication symptomsClaudication treatmentPatient knowledgeSpecialty careTreatment decisionsDecision aidPatientsCliniciansDecisional needsInternational Patient Decision Aid Standards criteriaStandard criteriaPrototype decision aidImplementation logisticsSymptomsDecisional qualityDiseaseTreatmentClaudication
2020
Multiple Reinterventions for Claudication are Associated with Progression to Chronic Limb-Threatening Ischemia
Kim TI, Kiwan G, Mohamedali A, Zhang Y, Dardik A, Guzman RJ, Ochoa Chaar CI. Multiple Reinterventions for Claudication are Associated with Progression to Chronic Limb-Threatening Ischemia. Annals Of Vascular Surgery 2020, 72: 166-174. PMID: 33227462, DOI: 10.1016/j.avsg.2020.10.004.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity revascularizationCongestive heart failureHeart failureOpen revascularizationMultiple reinterventionsSingle-center retrospective reviewChronic limb threatening ischemiaLimb threatening ischemiaLimb-threatening ischemiaNumber of reinterventionsLong-term outcomesMultivariable logistic regressionRate of progressionBenign natural historyIndex revascularizationMajor amputationRest painPerioperative complicationsExtremity revascularizationRetrospective reviewRisk factorsDisease progressionOpen procedureClaudicationPhysical Activity After Treatment for Symptomatic Peripheral Artery Disease
Peri-Okonny PA, Patel S, Spertus JA, Jackson EA, Malik AO, Provance J, Mena-Hurtado C, Shishehbor MH, Hijjaji V, Gosch KL, Smolderen K. Physical Activity After Treatment for Symptomatic Peripheral Artery Disease. The American Journal Of Cardiology 2020, 138: 107-113. PMID: 33065083, PMCID: PMC7736254, DOI: 10.1016/j.amjcard.2020.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexConservative TreatmentEndovascular ProceduresExerciseExercise TherapyFemaleHealth StatusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntermittent ClaudicationLeisure ActivitiesLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPatient SatisfactionPeripheral Arterial DiseasePlatelet Aggregation InhibitorsQuality of LifeSedentary BehaviorSmoking CessationSocial InteractionVascular Surgical ProceduresWorkConceptsPhysical activity levelsPhysical activityInvasive treatmentSymptomatic peripheral artery diseasePeripheral artery diseaseMultivariable logistic regressionAssociation of treatmentActivity levelsMultivariable linear regressionHealth status changesHealth status gainsPAD outcomesArtery diseaseVascular clinicInvasive groupNoninvasive treatmentHealth statusLogistic regressionActivity statusLTPAClaudicationTreatmentPatientsStatus changesAssociation
2019
From the PORTRAIT Registry: Health Status and Level of Disease in Patients Presenting With Claudication
Vogel T, Kruse R, Bath J, Wang J, Smolderen K. From the PORTRAIT Registry: Health Status and Level of Disease in Patients Presenting With Claudication. Journal Of Vascular Surgery 2019, 70: e68. DOI: 10.1016/j.jvs.2019.06.151.Peer-Reviewed Original Research
2017
Popliteal Artery Entrapment Syndrome: Bilateral Lower Extremity Involvement.
Henry HT, Szolomayer LK, Sumpio BE, Sutton KM. Popliteal Artery Entrapment Syndrome: Bilateral Lower Extremity Involvement. Orthopedics 2017, 41: e295-e298. PMID: 28934539, DOI: 10.3928/01477447-20170918-10.Peer-Reviewed Original ResearchConceptsPopliteal artery entrapment syndromeArtery entrapment syndromeEntrapment syndromeBilateral popliteal artery entrapment syndromeExertional compartment syndromeLower extremity claudicationSuccessful surgical treatmentFemale collegiate athletesPopliteal neurovascular structuresCompartment syndromeExtremity involvementPersistent disabilitySurgical treatmentUnnecessary morbiditySurgical interventionPhysical examinationThorough historyAthlete's returnIdentification of individualsNeurovascular structuresSyndromeCollegiate athletesAnatomic structuresDiagnosisClaudication
2015
Superion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis
Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Davis RP, Miller LE, Block JE, Geisler FH. Superion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis. Spine 2015, 40: 275-282. PMID: 25494323, DOI: 10.1097/brs.0000000000000735.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisIntermittent neurogenic claudicationInterspinous process spacerNeurogenic claudicationClinical successSpinal stenosisModerate lumbar spinal stenosisPrimary composite endpointRate of complicationsMajority of patientsInvasive treatment alternativeConservative careLeg painSurgical decompressionControl patientsMost patientsComposite endpointNonsurgical managementHigh quality comparative dataPatient complaintsNoninferiority trialBACKGROUND DATAClaudicationInterspinous spacerPatients
2011
Antiplatelet Therapy in the Management of Peripheral Artery Disease
Desai N, Beckman J. Antiplatelet Therapy in the Management of Peripheral Artery Disease. 2011, 167-174. DOI: 10.1007/978-1-4614-0839-0_9.Peer-Reviewed Original ResearchPeripheral artery diseasePAD patientsArtery diseaseCommon clinical presentationAtherosclerotic occlusive diseaseCritical limb ischemiaBrachial artery pressureDistal abdominal aortaLower extremity arteriesAntiplatelet therapyArtery pressureIntermittent claudicationLimb ischemiaOcclusive diseaseClinical presentationPerfusion pressureExtremity arteriesAbdominal aortaAtypical featuresDiseasePatientsClaudicationIschemiaArteryAorta
2005
Association between Impaired Insulin Sensitivity and Stroke
Bravata DM, Wells CK, Kernan WN, Concato J, Brass LM, Gulanski BI. Association between Impaired Insulin Sensitivity and Stroke. Neuroepidemiology 2005, 25: 69-74. PMID: 15947493, DOI: 10.1159/000086286.Peer-Reviewed Original ResearchConceptsHomeostasis model assessmentInsulin sensitivityGlycemic controlMultivariable logistic regression analysisStroke risk factorsLower insulin sensitivityThird National HealthImpaired insulin sensitivityLogistic regression analysisStroke historyInsulin resistancePlasma insulinPlasma glucoseRisk factorsNational HealthNutrition SurveyModel assessmentStrokeRegression analysisAssociationParticipantsClaudicationInsulin
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