2025
Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms
Stoiljkovic M, Song J, Hong H, Endle H, Varela L, Catarino J, Gao X, Liu Z, Sotonyi P, Diano S, Cedernaes J, Bass J, Horvath T. Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms. Journal Of Clinical Investigation 2025, 135: e185000. PMID: 40590229, PMCID: PMC12208536, DOI: 10.1172/jci185000.Peer-Reviewed Original ResearchConceptsMitochondrial dynamicsMitofusin 2Perturb mitochondrial dynamicsDaily biological rhythmsEnvironmental cuesCellular adaptationMammalian organismsCircadian oscillatorVIP neuronsConditional ablationMitochondriaLD cycleCircadian rhythmicityLight/darkAdvanced phase angleCircadian rhythmSynaptic input organizationMitofusinBiological rhythmsMfn2OrganizationInput organizationNeuronsCore body temperatureSynaptic dynamics
2024
0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions
Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.Peer-Reviewed Original ResearchOlder adult populationMental healthGeriatric conditionsSleep midpointSleep qualityAssociated with cognitive dysfunctionOlder adultsAdult populationAssociated with mental health diagnosesCommunity-dwelling older adultsAssociated with lower cognitive scoresMental health diagnosesAssociated with sleep qualityMental health conditionsSubjective sleep qualityReduced total sleep timeLower cognitive scoresCross-sectional studyGeneral adult populationPsychiatric symptomsTotal sleep timeSelf-reported sleep complaintsCognitive dysfunctionCircadian rhythmLater sleep midpoint
2023
Wake-up Call
Imes C, Tucker S, Trinkoff A, Chasens E, Weinstein S, Dunbar-Jacob J, Patrician P, Redeker N, Baldwin C. Wake-up Call. Nursing Administration Quarterly 2023, 47: e38-e53. PMID: 37643236, DOI: 10.1097/naq.0000000000000595.Peer-Reviewed Original ResearchCircadian Oscillations of Minimal Erythema Dose (MED) are Also Influenced by Diet in Patients with Psoriasis: A Chronomedical Study
Damiani G, Pacifico A, Scoditti E, di Gregorio S, Del Fabbro M, Cozzolino C, Buja A, Mercuri S, Bianchi V, Grada A, Garbarino S, Bunick C. Circadian Oscillations of Minimal Erythema Dose (MED) are Also Influenced by Diet in Patients with Psoriasis: A Chronomedical Study. Dermatology And Therapy 2023, 13: 2229-2246. PMID: 37573289, PMCID: PMC10539244, DOI: 10.1007/s13555-023-00987-z.Peer-Reviewed Original ResearchMinimal erythema dosePsoriatic patientsPsO patientsCohort studyNB-UVBErythema doseNB-UVB therapyLow minimal erythema doseDifferent dietsUVB phototherapyOngoing therapyDiet modulationMedical recordsHealthy controlsRamadan fastingPatientsHealthy individualsDietSignificant differencesPsoriasisMED valuesTherapyCircadian rhythmDosePhototherapyCARE as a wearable derived feature linking circadian amplitude to human cognitive functions
Cui S, Lin Q, Gui Y, Zhang Y, Lu H, Zhao H, Wang X, Li X, Jiang F. CARE as a wearable derived feature linking circadian amplitude to human cognitive functions. Npj Digital Medicine 2023, 6: 123. PMID: 37433859, PMCID: PMC10336141, DOI: 10.1038/s41746-023-00865-0.Peer-Reviewed Original ResearchCognitive functionMendelian randomization analysisGenome-wide association studiesCausal effectsRandomization analysisPotential intervention strategiesAssociation studiesIntervention strategiesProspective memoryCircadian amplitudeHealthy participantsShort-term memoryGlobal Executive CompositeInstrumental variablesReasoning abilityGenetic lociActivity dataPineal hormone melatoninHuman cognitive functionsGenetic basisCircadian rhythmClinical significanceExecutive CompositeMendelianBehavioral processesMelatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application
Megerian M, Kim J, Badreddine J, Hong S, Ponsky L, Shin J, Ghayda R. Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application. Aging And Disease 2023, 14: 840-857. PMID: 37191417, PMCID: PMC10187692, DOI: 10.14336/ad.2022.1010.Peer-Reviewed Original ResearchProstate cancerModel of prostate cancerTreatment of prostate cancerProstate cancer riskInhibited tumor growthEfficacy of supplementationNeuroendocrine differentiationAndrogen signalingModulate metabolic activityMelatonin therapyTumor growthCancer riskClinical trialsProstateAssociated with exogenous factorsCancerCell cycle progressionEpidemiological evidenceSecretory activityEndogenous indoleaminePineal secretory activityCell statusPoor sleepCycle progressionCircadian rhythmContributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder
Mishra H, Wei H, Rohr K, Ko I, Nievergelt C, Maihofer A, Shilling P, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nurnberger J, Oedegaard K, Zandi P, Kelsoe J, McCarthy M. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. European Neuropsychopharmacology 2023, 74: 1-14. PMID: 37126998, PMCID: PMC11801370, DOI: 10.1016/j.euroneuro.2023.04.009.Peer-Reviewed Original ResearchConceptsCell survival genesCircadian clockSurvival genesCell survivalCircadian clock genesCircadian rhythmGenetic variationClock genesKnockdown studiesCaspase activityCell deathMolecular pathwaysPrimary fibroblastsCellular modelGenesMouse fibroblastsFibroblast modelApoptosisStaurosporinePER1FibroblastsOpposite mannerLithium responsivenessDistinct patternsClock
2022
0207 Mothers’ Adverse Childhood Experiences and Protective Factors are Associated with Rest-activity Rhythms in their Children
Condon E, Jeon S, Sadler L, Redeker N. 0207 Mothers’ Adverse Childhood Experiences and Protective Factors are Associated with Rest-activity Rhythms in their Children. Sleep 2022, 45: a94-a95. DOI: 10.1093/sleep/zsac079.205.Peer-Reviewed Original ResearchRest-activity rhythmBenevolent childhood experiencesMaternal-child dyadsAdverse childhood experiencesChild healthProtective factorsCross-sectional pilot studyChildren-IVCircadian rhythmDaily electronic diaryChildhood experiencesPercent of mothersMean child agePoor health outcomesHispanic/LatinaChildhood historyChildhood physical abuseACE historyMaternal ACEsCTQ total scoresNovel preliminary findingsWrist actigraphChildhood emotional neglectHealth outcomesPreschool-age children
2021
Circadian Rhythm Modulation of Microbes During Health and Infection
Pearson JA, Voisey AC, Boest-Bjerg K, Wong FS, Wen L. Circadian Rhythm Modulation of Microbes During Health and Infection. Frontiers In Microbiology 2021, 12: 721004. PMID: 34512600, PMCID: PMC8430216, DOI: 10.3389/fmicb.2021.721004.Peer-Reviewed Original ResearchGut bacteriaProtective immune responseBeneficial therapeutic responseCircadian rhythm modulationVaccination responseTherapeutic responseTherapeutic administrationImmune responseTherapeutic successCircadian rhythm effectsHost immunityRhythm modulationAdverse effectsInfectionDay-dependent changesAdministration strategiesAltered susceptibilityRhythm effectsCircadian rhythmHealthCircadian modulationVirusOptimal timePhysiological processesResponseCircadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies
Mishra H, Ying N, Luis A, Wei H, Nguyen M, Nakhla T, Vandenburgh S, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nievergelt C, Nurnberger J, Shilling P, Oedegaard K, Zandi P, Kelsoe J, Welsh D, McCarthy M. Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Molecular Psychiatry 2021, 26: 3383-3394. PMID: 33674753, PMCID: PMC8418615, DOI: 10.1038/s41380-021-01048-7.Peer-Reviewed Original ResearchConceptsNeuronal precursor cellsBipolar disorderCircadian rhythm abnormalitiesRhythm abnormalitiesBD groupCircadian rhythmPatient-derived neuronsMania/hypomaniaExpression of Per2Induced pluripotent stem cellsPER2 protein levelsGlutamatergic neuronsRecurrent episodesBD patientsControl neuronsLithium respondersEffective drugsNeuropsychiatric illnessLithium responsivenessPatient neuronsNeuronsLithium responseProtein levelsRhythm deficitsPrecursor cells
2020
Crosstalk between circadian rhythms and the microbiota
Pearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunology 2020, 161: 278-290. PMID: 33090484, PMCID: PMC7692254, DOI: 10.1111/imm.13278.Peer-Reviewed Original ResearchConceptsHost circadian rhythmsMicrobial oscillationsGene/protein expressionAspects of biologyCircadian rhythmMicrobial associationsMolecular oscillationsCircadian oscillationsMicrobial compositionMicrobial influenceCause diseaseMolecular techniquesHost metabolismDisease susceptibilityMicrobial changesProtein expressionPeripheral rhythmsMain inducerMicrobiotaSleep-wake cycleHost immunityCrosstalkClinical successPotential connectionMicrobesFunctional Aspects of Hypothalamic Asymmetry
Kiss DS, Toth I, Jocsak G, Barany Z, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Functional Aspects of Hypothalamic Asymmetry. Brain Sciences 2020, 10: 389. PMID: 32575391, PMCID: PMC7349050, DOI: 10.3390/brainsci10060389.Peer-Reviewed Original ResearchFunctional lateralizationFunctional asymmetryHigher brain functionsHypothalamic controlSmall brain regionsCirculatory functionBrain areasReproductive functionBrain regionsBrain functionBrain halvesHypothalamic asymmetryEnergy expenditureBrain processingBody temperatureHypothalamusHomeostatic processesCircadian rhythmHemispheric specializationLateralizationData highlightPrevious studiesThe Feasibility of Measuring Sleep and Circadian Characteristics in Adults with Inflammatory Bowel Disease
Conley S, Proctor DD, Lehner V, Jeon S, Redeker NS. The Feasibility of Measuring Sleep and Circadian Characteristics in Adults with Inflammatory Bowel Disease. Western Journal Of Nursing Research 2020, 43: 53-59. PMID: 32517546, PMCID: PMC7704942, DOI: 10.1177/0193945920933926.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBowel diseaseWrist actigraphyInactive inflammatory bowel diseaseActivity diaryElectronic diarySleep/activitySalivary dim light melatonin onsetDim light melatonin onsetRest-activity rhythmWrist actigraphSaliva collectionMelatonin onsetSleepDiseaseActigraphyCircadian characteristicsAdult participantsAdultsCircadian rhythmSalivaDiaryParticipantsRhythmYearsCarbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
2019
Reconsidering Nutritional Support in Critically Ill Patients
Korwin A, Honiden S. Reconsidering Nutritional Support in Critically Ill Patients. Seminars In Respiratory And Critical Care Medicine 2019, 40: 580-593. PMID: 31826259, DOI: 10.1055/s-0039-1697967.Peer-Reviewed Original ResearchConceptsIntensive care unitIll patientsGood nutrition practicesNeeds of patientsProvision of nutritionICU nutritionSupportive careActive therapyNutritional supportCare unitFeeding interruptionsCritical careNutrition practicesGastrointestinal physiologyPatientsCircadian rhythmFeeding pumpProcess of recoveryCareMore researchNutritionProtein synthesisNon-continuous modeTherapyCliniciansCircadian Biology and Its Importance to Intensive Care Unit Care and Outcomes
Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIll patientsIntensive care unit careIntensive care unit practiceCircadian rhythmCurrent ICU practiceLow-risk interventionNumerous adverse outcomesUnit careCritical illnessImmune compromiseCardiovascular instabilityMetabolic derangementsAdverse outcomesICU practiceUnit practicesSleep disruptionCare improvementPatientsOutcomesSleepRhythmBright lightDaysCircadian biologyDelirium
2018
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D’Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology 2018, 44: 620-628. PMID: 30487653, PMCID: PMC6333516, DOI: 10.1038/s41386-018-0273-8.Peer-Reviewed Original ResearchConceptsBipolar disorderEffects of lithiumMaintenance treatmentBD patientsCircadian rhythmMinority of patientsLithium maintenance treatmentMood stabilizer treatmentSerious mood disorderCircadian rhythm abnormalitiesCircadian rhythm parametersClinical responseCircadian rhythm functionLithium monotherapyClinical trialsMood disordersRhythm abnormalitiesMood symptomsPharmacological effectsPatientsEvening chronotypeStabilizer treatmentCommon genetic variationRhythm parametersMonotherapyCircadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism
Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE. Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism. The Journal Of Immunology 2018, 201: ji1701677. PMID: 29760192, PMCID: PMC9351006, DOI: 10.4049/jimmunol.1701677.Peer-Reviewed Original ResearchConceptsImmune cellsZT 19C57BL/6 miceWorse outcomesTLR2 agonist lipoteichoic acidCircadian rhythmTLR2 knockout miceFemale C57BL/6 miceMale C57BL/6 miceSeverity of sepsisBone marrow chimerasTLR2-dependent mechanismIL-6 productionTLR2-DependentSepsis severityCecal ligationSepsis phenotypesSepsisC57BL/6 cellsSimilar outcomesMiceMouse cecumLipoteichoic acidMurine macrophagesCLPDaily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells
Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.Peer-Reviewed Original ResearchAdherent splenocytesToll-like receptor expressionMRNA levelsProtein levelsSplenic immune cellsToll-like receptorsDependent immune responsesZeitgeber time (ZT) 1Adherent cell populationDendritic cellsTLR3 ligandTLR ligandsCytokine expressionSplenocyte populationImmune cellsReceptor expressionImmune responseSplenic macrophagesB cellsRhythmic expressionCell populationsTLRSplenocytesDaily light-dark cycleCircadian rhythm
2017
0706 CONTRIBUTIONS OF INSOMNIA SYMPTOM AND CIRCADIAN RHYTHM OF ACTIVITY PATTERN ON DAYTIME SYMPTOMS AND FUNCTIONAL PERFORMANCE IN STABLE HEART FAILURE PATIENTS
Jeon S, Knies A, Redeker N. 0706 CONTRIBUTIONS OF INSOMNIA SYMPTOM AND CIRCADIAN RHYTHM OF ACTIVITY PATTERN ON DAYTIME SYMPTOMS AND FUNCTIONAL PERFORMANCE IN STABLE HEART FAILURE PATIENTS. Sleep 2017, 40: a261-a262. DOI: 10.1093/sleepj/zsx050.705.Peer-Reviewed Original ResearchStable heart failure patientsHeart failure patientsDaytime symptomsEpworth Sleepiness ScaleInsomnia symptomsCircadian quotientFailure patientsPhysical functionStable HFFunctional performanceOlder adultsStable HF patientsRespiratory disturbance indexSix-minute walkBody mass indexCircadian rhythmCross-sectional studyYears of ageActivity-rest patternNYHA classificationHF patientsMass indexFatigue ScaleEjection factionSleepiness Scale
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