2025
Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial
Singh S, Nguyen J, Fudman D, Gerich M, Shah S, Hudesman D, McConnell R, Lukin D, Flynn A, Hwang C, Sprung B, Gaidos J, Mattar M, Rubin D, Hashash J, Metwally M, Ali T, Ma C, Hoentjen F, Narula N, Bessissow T, Rosenfeld G, McCurdy J, Ananthakrishnan A, Cross R, Gaytan J, Gurrola E, Patel S, Siegel C, Melmed G, Weaver S, Power S, Zou G, Jairath V, Hou J. Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial. BMJ Open Gastroenterology 2025, 12: e001615. PMID: 40164445, PMCID: PMC11962770, DOI: 10.1136/bmjgast-2024-001615.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAdvanced therapiesTreat-to-targetSymptomatic remissionBowel inflammationOpen-labelAsymptomatic patientsPatient-Centered Outcomes Research InstituteBowel diseaseControlled TrialsSafety of switchingClinical practiceActive bowel inflammationReduced bowel inflammationDeep remissionEndoscopic remissionTreatment failurePrimary endpointRandomised controlled trialsTargeted immunomodulationRemissionTherapyPatientsGood clinical practiceInformed consentPatient preference effects in a randomized comparative effectiveness study of electroconvulsive therapy and ketamine for treatment resistant depression: An ELEKT-D trial secondary analysis
Sanacora G, Barnett B, Hu B, Goes F, Mathew S, Murrough J, Reti I, Wilkinson S, Anand A. Patient preference effects in a randomized comparative effectiveness study of electroconvulsive therapy and ketamine for treatment resistant depression: An ELEKT-D trial secondary analysis. Psychiatry Research 2025, 347: 116411. PMID: 40049091, DOI: 10.1016/j.psychres.2025.116411.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionElectroconvulsive therapyResistant depressionTreatment adherenceResponse to ketamineECT-treated patientsTreatment outcome measuresInfluence treatment adherencePatient-Centered Outcomes Research InstituteAssociated with greater likelihoodKetamine treatmentIV ketamineAdverse eventsEffect of patients' preferencesPreference effectsPatient preferencesRandomized patients to treatmentKetamineRate of adverse eventsTreatment responseGreater likelihoodPatients to treatmentPhase completionTreatment preferencesDepression
2024
413-P: Comparative Effectiveness of Glucose-Lowering Agents on Kidney Outcomes in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk
NEUMILLER J, HERRIN J, SWARNA K, POLLEY E, GALINDO R, UMPIERREZ G, DENG Y, MICKELSON M, MCCOY R. 413-P: Comparative Effectiveness of Glucose-Lowering Agents on Kidney Outcomes in Adults with Type 2 Diabetes at Moderate Cardiovascular Risk. Diabetes 2024, 73 DOI: 10.2337/db24-413-p.Peer-Reviewed Original ResearchPatient-Centered Outcomes Research InstituteModerate CVD riskKidney composite outcomeAssociated with lower riskGLP-1RACVD riskType 2 diabetesKidney outcomesComposite outcomeKidney diseaseLow riskHigh riskInitiation of kidney replacement therapyEffects of glucose-lowering agentsCardiovascular diseaseHigh risk of cardiovascular diseaseAssociated with increased riskBaseline CVD riskAssociated with higher riskRisk of cardiovascular diseaseGlucose-lowering agentsCare of peopleIncident kidney diseaseModerate cardiovascular riskTarget trial framework
2023
Changes In Meaningful Non-Drug Therapy Use Among U.S. Military Veterans Within A Comparative Effectiveness Trial Augmenting Primary Care Management Of Chronic Pain
Goldsmith E, Hammett P, Nelson D, Kats A, DeRonne B, Becker W, Krebs E, Seal K. Changes In Meaningful Non-Drug Therapy Use Among U.S. Military Veterans Within A Comparative Effectiveness Trial Augmenting Primary Care Management Of Chronic Pain. Journal Of Pain 2023, 24: 58. DOI: 10.1016/j.jpain.2023.02.174.Peer-Reviewed Original ResearchPatient-Centered Outcomes Research InstituteNon-drug therapyManagement of chronic painTherapy useMeaningful useChronic painIntegrated Pain TeamPrimary care managementImprove pain managementLong-term opioid therapyU.S. military veteransAnalyses assessed changesPain teamChronic pain treatmentPragmatic trialOpioid safetyPain managementComparative effectivenessMilitary veteransPain treatmentLogistic regressionVeteransOpioid therapyPainTrial population
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