Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis
Dahan S, Dal-Bianco J, Plakht Y, Namasivayam M, Capoulade R, Zeng X, Passeri J, Yucel E, Picard M, Levine R, Hung J. Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis. Circulation Cardiovascular Imaging 2025, 18: e017598. PMID: 40116009, DOI: 10.1161/circimaging.124.017598.Peer-Reviewed Original ResearchConceptsLow-gradient severe aortic stenosisParadoxical low-flowSevere aortic stenosisAortic valve replacementPRESERVED LEFT VENTRICULAR EJECTION FRACTIONSevere mitral regurgitationSevere MRVentricular ejection fractionAortic stenosisMitral regurgitationAll-Cause MortalityValve replacementMR degreeEjection fractionComposite outcomeAortic valve replacement ratesAssociated with adverse outcomesComplexity to diagnosisIncreased left ventricular dimensionsLow transaortic gradientNon-severe MRSevere MR groupHeart failure hospitalizationPropensity-adjusted modelLeft ventricular remodeling
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