2025
R-Wave Amplitude Changes in Lead aVL Predict Outcomes in Cardiac Resynchronization Therapy: Exploring the Role of Papillary Muscle Dyssynchrony and Mitral Regurgitation
Eötvös C, Avram T, Zehan I, Moldovan M, Sarb A, Lazar R, Coseriu G, Schiop-Tentea P, Blendea E, Mocan-Hognogi D, Chiorescu R, Gusetu G, Pop S, McPherson C, Heist E, Singh J, Blendea D. R-Wave Amplitude Changes in Lead aVL Predict Outcomes in Cardiac Resynchronization Therapy: Exploring the Role of Papillary Muscle Dyssynchrony and Mitral Regurgitation. Heart Rhythm O2 2025 DOI: 10.1016/j.hroo.2025.06.004.Peer-Reviewed Original ResearchCardiac resynchronization therapyPapillary muscle dyssynchronyMitral regurgitationQRS durationResynchronization therapyPapillary musclesMarker of electrical dyssynchronyCardiac resynchronization therapy implantationPredictors of clinical responsePost-CRT changesAnterolateral papillary muscleReducing mitral regurgitationShorter QRS durationMultivariate Cox regressionAnterolateral left ventricular wallLong-term survivalMultivariate logistic regressionR-wave amplitudeClinical responseMR severityPost-CRTElectrical dyssynchronyElectrical resynchronizationMechanical resynchronizationMR improvement
2024
Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators
Rosman L, Lampert R, Wang K, Gehi A, Dziura J, Salmoirago-Blotcher E, Brandt C, Sears S, Burg M. Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators. Journal Of The American College Of Cardiology 2024, 85: 42-55. PMID: 39570241, DOI: 10.1016/j.jacc.2024.09.006.Peer-Reviewed Original ResearchImplantable cardioverter-defibrillatorYear of device implantationAll-Cause MortalityCardiac resynchronization therapyDeath/HF hospitalizationValidation cohortHeart failureDevice implantationTime of ICD implantationArea under the receiver-operating characteristic curveMedian Follow-UpReceiver-operating characteristic curvePredicting all-cause mortalityImplantable cardioverter-defibrillator patientsVeterans Health AdministrationPersonalized risk estimatesImplantable cardioverter defibrillatorResynchronization therapyBaseline demographicsICD implantationTraining cohortTrajectories of individual patientsProspective studyComposite outcomeContinuum of riskEffects of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction: An analysis of DAPA‐HF and DELIVER
Abdin A, Kondo T, Böhm M, Jhund P, Claggett B, Vaduganathan M, Hernandez A, Lam C, Inzucchi S, Martinez F, de Boer R, Desai A, Køber L, Sabatine M, Petersson M, Bachus E, Solomon S, McMurray J, Committees and Investigators O. Effects of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction: An analysis of DAPA‐HF and DELIVER. European Journal Of Heart Failure 2024, 26: 1952-1963. PMID: 39016033, DOI: 10.1002/ejhf.3350.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSpectrum of left ventricular ejection fractionEffects of dapagliflozinProlongation of QRS durationVentricular ejection fractionQRS durationEjection fractionDAPA-HFHeart failurePrimary outcomeHF phenotypesPrimary composite outcome of cardiovascular deathMedian follow-up timeComposite outcome of cardiovascular deathOutcome of cardiovascular deathAssociated with worse outcomesReduced ejection fractionCardiac resynchronization therapyFollow-up timePrimary composite outcomeFavorable ventricular remodelingWorsening HFResynchronization therapyPharmacological therapyVentricular remodelingBundled Payments for Care Improvement and Quality of Care and Outcomes in Heart Failure
Oddleifson D, Holmes D, Alhanti B, Xu X, Heidenreich P, Wadhera R, Allen L, Greene S, Fonarow G, Spatz E, Desai N. Bundled Payments for Care Improvement and Quality of Care and Outcomes in Heart Failure. JAMA Cardiology 2024, 9: 222-232. PMID: 38170516, PMCID: PMC10765313, DOI: 10.1001/jamacardio.2023.5009.Peer-Reviewed Original ResearchNon-BPCI hospitalsCause readmission rateReadmission ratesHeart failureSignificant differential changesCare measuresHospital participationBPCI hospitalsHospital mortalityEnzyme inhibitors/angiotensin receptor blockersMortality rateBPCI programAngiotensin receptor neprilysin inhibitorEvidence-based β-blockersGuidelines-Heart Failure registryEnd pointBPCI Model 2Heart failure educationAngiotensin receptor blockersPrimary end pointSecondary end pointsThird of patientsCardiac resynchronization therapyCause mortality ratesHeart failure programIntegration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)
Mullens W, Dauw J, Gustafsson F, Mebazaa A, Steffel J, Witte K, Delgado V, Linde C, Vernooy K, Anker S, Chioncel O, Milicic D, Hasenfuß G, Ponikowski P, von Bardeleben R, Koehler F, Ruschitzka F, Damman K, Schwammenthal E, Testani J, Zannad F, Böhm M, Cowie M, Dickstein K, Jaarsma T, Filippatos G, Volterrani M, Thum T, Adamopoulos S, Cohen‐Solal A, Moura B, Rakisheva A, Ristic A, Bayes‐Genis A, Van Linthout S, Tocchetti C, Savarese G, Skouri H, Adamo M, Amir O, Yilmaz M, Simpson M, Tokmakova M, González A, Piepoli M, Seferovic P, Metra M, Coats A, Rosano G. Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). European Journal Of Heart Failure 2024, 26: 483-501. PMID: 38269474, DOI: 10.1002/ejhf.3150.Peer-Reviewed Original ResearchEuropean Heart Rhythm AssociationEuropean Society of CardiologyHeart Failure AssociationHeart failureSociety of CardiologyDevice therapyFailure AssociationOptimization of drug therapyCardiac resynchronization therapyManagement of patientsImplantable device therapyEuropean SocietyImplantable cardioverter-defibrillatorClinical consensus statementClinical consensus documentClinical care pathwayReverse remodelingResynchronization therapyImproved haemodynamicsAdjunctive therapyAdvanced HFHF patientsDrug therapyCardioverter-defibrillatorLong-term mechanical support
2023
Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring
Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.Peer-Reviewed Original ResearchConceptsAppropriate device therapyMalignant ventricular arrhythmiasDevice therapyVentricular arrhythmiasImplantable cardioverter-defibrillator therapyLogistic regressionSeparate multivariable logistic regressionsLead impedanceAppropriate ICD therapyCardioverter-defibrillator therapyCardiac resynchronization therapyMultivariable logistic regressionRemote monitoring dataShock lead impedanceAtrial lead impedanceICD therapyHeart failureResynchronization therapyAppropriate therapyAtrial tachyarrhythmiasVentricular tachycardiaVentricular fibrillationDefibrillator devicesHeart ratePatientsDevice-detected atrial fibrillation in a large remote-monitored cohort: implications for anticoagulation and need for new pathways of service delivery
O’Shea C, Brooks A, Middeldorp M, Harper C, Hendriks J, Russo A, Freeman J, Gopinathannair R, Varma N, Deering T, Campbell K, Sanders P. Device-detected atrial fibrillation in a large remote-monitored cohort: implications for anticoagulation and need for new pathways of service delivery. Journal Of Interventional Cardiac Electrophysiology 2023, 66: 1659-1668. PMID: 36735111, PMCID: PMC10547627, DOI: 10.1007/s10840-023-01481-4.Peer-Reviewed Original ResearchConceptsImplantable loop recorderCardiac resynchronization therapyCHA2DS2-VASc scoreAtrial fibrillationAF episodesSymptomatic atrial fibrillationCardiac resynchronization therapy pacemakerProportion of patientsAnticoagulation of patientsDevice-detected atrial fibrillationAF episode durationCardiac implantable electronic devicesStroke prevention therapyDevice-detected AFImplantable cardioverter defibrillatorIncreased stroke riskImplantable electronic devicesMethodsConsecutive patientsResynchronization therapyPermanent pacemakerPreventive therapyAF alertsLoop recorderAnticoagulationEpisode duration
2022
Electrocardiogram Belt guidance for left ventricular lead placement and biventricular pacing optimization
Rickard J, Jackson K, Gold M, Biffi M, Ziacchi M, Silverstein J, Ramza B, Metzl M, Grubman E, Abben R, Varma N, Tabbal G, Jensen C, Wouters G, Ghosh S, Vernooy K, Group E. Electrocardiogram Belt guidance for left ventricular lead placement and biventricular pacing optimization. Heart Rhythm 2022, 20: 537-544. PMID: 36442824, DOI: 10.1016/j.hrthm.2022.11.015.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyLeft ventricular end-systolic volumeVentricular end-systolic volumeEnd-systolic volumeReverse remodelingHeart failureElectrical dyssynchronyCRT careNon-left bundle branch blockLeft ventricular lead placementLeft ventricular reverse remodelingVentricular lead placementPrimary end pointReduced ejection fractionTrial of patientsVentricular reverse remodelingBundle branch blockLow response rateCRT implantationControl patientsEjection fractionIschemic cardiomyopathyResynchronization therapyBranch blockQRS durationTemporal trends and long-term outcomes among recipients of cardiac resynchronization therapy with defibrillator in the United States, 2011–2015: Insights from the National Cardiovascular Data Registry
Darden D, Peterson PN, Xin X, Munir MB, Minges KE, Goldenberg I, Poole JE, Feld GK, Birgersdotter-Green U, Curtis JP, Hsu JC. Temporal trends and long-term outcomes among recipients of cardiac resynchronization therapy with defibrillator in the United States, 2011–2015: Insights from the National Cardiovascular Data Registry. Heart Rhythm O2 2022, 3: 405-414. PMID: 36097450, PMCID: PMC9463686, DOI: 10.1016/j.hroo.2022.03.004.Peer-Reviewed Original ResearchLong-term outcomesGuideline-concordant recommendationsHeart failure hospitalizationCardiac resynchronization therapyFailure hospitalizationCause hospitalizationCardiovascular hospitalizationResynchronization therapyNational Cardiovascular Data RegistryCRT-D implantationYear of implantHospital procedural complicationsHospital complicationsHospital outcomesMultivariable adjustmentPatient characteristicsProcedural complicationsDefibrillator recipientsHospitalizationData registryLower riskMedicare beneficiariesMedicare dataOutcomesRecipients
2021
Comparative effectiveness of cardiac resynchronization therapy in older patients with heart failure: Systematic review and meta-analysis
Juggan S, Ponnamreddy PK, Reilly CA, Dodge SE, Gilstrap LG, Zeitler EP. Comparative effectiveness of cardiac resynchronization therapy in older patients with heart failure: Systematic review and meta-analysis. Journal Of Cardiac Failure 2021, 28: 443-452. PMID: 34774750, DOI: 10.1016/j.cardfail.2021.10.013.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCardiac resynchronization therapyNYHA functional classOlder patientsYounger patientsRelative riskCause mortalityEjection fractionHeart failureResynchronization therapyFunctional classNew York Heart Association functional classYork Heart Association functional classRR of mortalityVentricular end-diastolic diameterReduced ejection fractionEnd-diastolic diameterVentricular ejection fractionYoung adult patientsIncidence of hematomaComparative effectiveness studiesFull-text screeningWeb of ScienceLVEF improvementAdult patientsUse and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry
Borne RT, Masoudi FA, Curtis JP, Zipse MM, Sandhu A, Hsu JC, Peterson PN. Use and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry. JAMA Network Open 2021, 4: e2035470. PMID: 33496796, PMCID: PMC7838925, DOI: 10.1001/jamanetworkopen.2020.35470.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyHeart failure hospitalizationClass I indicationsUse of CRTFailure hospitalizationMedian odds ratioCohort studyOlder patientsVentricular pacingImplant ratesNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryNational Cardiovascular Data Registry ICD RegistryReduced left ventricular ejection fractionMultivariable Cox proportional hazards modelsFrequent right ventricular pacingImplantable Cardioverter-Defibrillator RegistryPrior heart failure hospitalizationLeft ventricular ejection fractionImplantable cardioverter defibrillator implantationThird-degree atrioventricular blockCardiac resynchronization therapy defibrillatorCox proportional hazards modelBradycardia pacing indicationFirst-time implantationFrequent RV pacing
2020
Cardiac changes after cardiac resynchronization therapy assessed using cardiac magnetic resonance imaging during biventricular pacing
Czimbalmos C, Papp R, Szabo L, Toth A, Csecs I, Suhai F, Molnar L, Kosztin A, Geller L, Merkely B, Vago H. Cardiac changes after cardiac resynchronization therapy assessed using cardiac magnetic resonance imaging during biventricular pacing. European Heart Journal 2020, 41: ehaa946.0808. DOI: 10.1093/ehjci/ehaa946.0808.Peer-Reviewed Original ResearchCardiac magnetic resonanceCardiac resynchronization therapyCardiac magnetic resonance imagingBiventricular pacingRegional dyssynchronyResynchronization therapyAOO pacingCMR parametersEffectiveness of resynchronization therapyCardiac magnetic resonance examinationEffects of cardiac resynchronization therapyRight ventricular ejection fractionEnd-systolic volume indexQuantification of LV functionRemodeling indexConventional CMR parametersImprove responder rateLV remodeling indexII-III patientsOptimal medical therapyRight ventricular volumesVentricular ejection fractionEnd-diastolic indexEffects of cardiac resynchronizationRelative wall thicknessTransvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report
Egbuche O, Nwagbara K, Mezue K, Abe T, Nwokike S. Transvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report. Cardiovascular Revascularization Medicine 2020, 28: 144-146. PMID: 33077395, DOI: 10.1016/j.carrev.2020.09.037.Peer-Reviewed Original ResearchConceptsPulmonary artery catheter insertionPulmonary artery catheterInsertion of pulmonary artery cathetersCardiac resynchronization therapyCatheter knottingBlind insertionSevere left ventricular systolic dysfunctionDilated right heart chambersPulmonary artery catheter knottingLeft ventricular systolic dysfunctionManagement of acute heart failureVentricular systolic dysfunctionArtery catheter insertionAcute heart failureRight heart chambersCardiac resynchronization devicesSystolic dysfunctionResynchronization therapyFluoroscopy-guided insertionDilated CardiomyopathyCatheter insertionArtery catheterHeart failureHemodynamic managementResynchronization devicesComparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes
Hyman MC, Bao H, Curtis JP, Minges K, Schaller RD, Birgersdotter-Green U, Marchlinski FE, Hsu JC. Comparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes. Heart Rhythm 2020, 17: 1878-1886. PMID: 32497762, DOI: 10.1016/j.hrthm.2020.05.032.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyCRT-eligible patientsCRT upgradeResynchronization therapyClinical outcomesNational Cardiovascular Data Registry ICD RegistryGenerator replacementPeriprocedural complication rateLeft ventricular leadSubpopulation of patientsLong-term outcomesICD generator replacementHierarchical logistic regression modelsLogistic regression modelsSecondary endpointsCause mortalityPrimary endpointComplication rateICD RegistryProcedural complicationsMedical managementICD populationNational registryVentricular leadClaims dataPermanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study
Moore JP, Gallotti R, Shannon KM, Pilcher T, Vinocur JM, Cano Ó, Kean A, Mondesert B, Nürnberg JH, Schaller RD, Sharma PS, Nishimura T, Tung R. Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study. Heart Rhythm 2020, 17: 991-997. PMID: 32243875, DOI: 10.1016/j.hrthm.2020.01.033.Peer-Reviewed Original ResearchConventional cardiac resynchronization therapyConduction system pacingConduction systemGreat arteriesVentricular pacingNew York Heart Association functional classConventional CRTYork Heart Association functional classChronic ventricular pacingJunctional escape rhythmSpontaneous atrioventricular blockCardiac resynchronization therapyCongenital Electrophysiology SocietyPacing-induced cardiomyopathyProximal left bundle branchLeft bundle branchBundle branch pacingUnique anatomic characteristicsCcTGA patientsEscape rhythmHV intervalPrevious surgeryResynchronization therapyAtrioventricular blockPulmonary valve32 Cardiac Imaging in Heart Failure
St. John Sutton M, Morrison A, Sinusas A, Ferrari V. 32 Cardiac Imaging in Heart Failure. 2020, 418-448.e5. DOI: 10.1016/b978-0-323-60987-6.00032-6.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceHeart failureCardiac imagingCardiac resynchronization therapyManagement of patientsValvular heart diseaseAssessment of patientsNuclear medicine techniquesDetection of cardiomyopathyAssessment of metabolismAutonomic dysfunctionResynchronization therapyHeart diseaseCMR imagingThree-dimensional echoMedicine techniquesPatientsMolecular imagingImagingMagnetic resonanceStandard techniquesEchocardiographyCardiomyopathyFailureDysfunction
2019
Achievement of Target Doses of Guideline-Directed Medical Therapy Prior to Cardiac Resynchronization Therapy is Suboptimal
Balakumaran K, Goldgrab D, Krishnan A, Shah N, Kim M, Rabieihashemi S, Cipriani K, Pickett C, Tabtabai S. Achievement of Target Doses of Guideline-Directed Medical Therapy Prior to Cardiac Resynchronization Therapy is Suboptimal. Journal Of Cardiac Failure 2019, 25: s128. DOI: 10.1016/j.cardfail.2019.07.366.Peer-Reviewed Original ResearchGuideline directed medical therapyCardiac resynchronization therapyCardiac resynchronization therapy implantationHeart failureTarget doseTime of implantationCRT implantationResynchronization therapyMedical therapyDosing of guideline-directed medical therapyGuideline-directed medical therapyDirected medical therapyNYHA class IIIII heart failureDocumented atrial fibrillationProportion of patientsDevice-based treatmentBackground Heart failureBB therapyHF registryIschemic cardiomyopathyClinical characteristicsChart reviewDevice therapyAtrial fibrillationBody mass index and outcomes of cardiac resynchronization with implantable cardioverter‐defibrillator therapy in older patients with heart failure
Echouffo‐Tcheugui J, Masoudi FA, Bao H, Curtis JP, Heidenreich PA, Fonarow GC. Body mass index and outcomes of cardiac resynchronization with implantable cardioverter‐defibrillator therapy in older patients with heart failure. European Journal Of Heart Failure 2019, 21: 1093-1102. PMID: 31359595, DOI: 10.1002/ejhf.1552.Peer-Reviewed Original ResearchConceptsBody mass indexDevice-related complicationsNormal weightMass indexNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryImplantable Cardioverter-Defibrillator RegistryImplantable cardioverter-defibrillator therapyClass III obesityHeart failure outcomesCardioverter-defibrillator therapyObesity class IObesity class IICardiac resynchronization therapyObesity class IIIHF patientsUnderweight patientsDefibrillator implantationElderly patientsHazard ratioObese patientsOlder patientsBMI categoriesHeart failureResynchronization therapyCardiac resynchronizationQuadripolar versus bipolar leads in cardiac resynchronization therapy: An analysis of the National Cardiovascular Data Registry
Hakemi EU, Doukky R, Parzynski CS, Curtis JP, Madias C. Quadripolar versus bipolar leads in cardiac resynchronization therapy: An analysis of the National Cardiovascular Data Registry. Heart Rhythm 2019, 17: 81-89. PMID: 31369870, DOI: 10.1016/j.hrthm.2019.07.028.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyNational Cardiovascular Data RegistryClinical outcomesResynchronization therapyData registryLong-term clinical outcomesStimulation rateSignificant differencesCongestive heart failure admissionsMedicaid ServicesCRT device implantsHeart failure admissionsProcedural complication rateCRT implantationElderly patientsComplication ratePrimary outcomePlacement failureDevice implantsDevice malfunctionOutcomesPatientsBipolar leadsRegistryTherapyCardiac Resynchronization Defibrillator Therapy for Nonspecific Intraventricular Conduction Delay Versus Right Bundle Branch Block
Kawata H, Bao H, Curtis JP, Minges KE, Mitiku T, Birgersdotter-Green U, Feld GK, Hsu JC. Cardiac Resynchronization Defibrillator Therapy for Nonspecific Intraventricular Conduction Delay Versus Right Bundle Branch Block. Journal Of The American College Of Cardiology 2019, 73: 3082-3099. PMID: 31221257, DOI: 10.1016/j.jacc.2019.04.025.Peer-Reviewed Original ResearchConceptsNonspecific intraventricular conduction delayRight bundle branch blockCardiac resynchronization therapyCRT-D implantationCRT-eligible patientsBundle branch blockQRS durationHazard ratioBranch blockBetter outcomesCardiac resynchronization defibrillator therapyMultivariable adjusted hazard ratiosAdjusted hazard ratioIntraventricular conduction delayCareful patient selectionEligible patientsDefibrillator therapyMultivariable adjustmentResynchronization therapyClinical outcomesPatient selectionConduction abnormalitiesRegistry dataConduction delayPatients
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