2020
Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults
Armiyaw L, Sarcone C, Fosam A, Muniyappa R. Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa234. PMID: 32382759, PMCID: PMC7266075, DOI: 10.1210/clinem/dgaa234.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesTotal β-cell responsivityΒ-cell responsivityPrimary insulin hypersecretionGlucose disposal rateInsulin sensitivityInsulin hypersecretionAfrican AmericansBasal insulin secretion rateGlucose responsivityIntravenous glucose tolerance testGlucose tolerance testHyperinsulinemic euglycemic glucose clamp techniqueC-peptide secretionGlucose clamp techniqueInsulin secretion rateNondiabetic African AmericansΒ-cell functionAfrican American adultsInsulin resistanceTolerance testNHW subjectsC-peptideInsulin secretionSignificant ethnic differences
1993
Effect of caffeine on the recognition of and responses to hypoglycemia in humans.
Kerr D, Sherwin RS, Pavalkis F, Fayad PB, Sikorski L, Rife F, Tamborlane WV, During MJ. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Annals Of Internal Medicine 1993, 119: 799-804. PMID: 8379601, DOI: 10.7326/0003-4819-119-8-199310150-00005.Peer-Reviewed Original ResearchConceptsGlucose levelsHypoglycemic symptomsCaffeine consumptionCounter-regulatory hormone levelsHyperinsulinemic glucose clamp techniqueMiddle cerebral artery velocityLarge carbohydrate loadCerebral artery velocityAcute caffeine ingestionClinical Research CenterLevels of norepinephrineAwareness of hypoglycemiaCerebral blood flowDouble-blind designGlucose clamp techniqueLate postprandial periodPlasma glucose levelsLevels of epinephrineBrain glucose useCaffeine-free colaEffects of caffeineAcute ingestionSympathoadrenal activationArtery velocityPlasma glucose
1992
Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome
Caprio S, Boulware S, Press M, Sherwin R, Rubin K, Carpenter T, Plewe G, Tamborlane W. Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome. The Journal Of Pediatrics 1992, 120: 238-243. PMID: 1735819, DOI: 10.1016/s0022-3476(05)80434-2.Peer-Reviewed Original ResearchConceptsControl subjectsGrowth hormoneTurner syndromeHyperinsulinemic responseInsulin responseHyperglycemic glucose clamp techniqueSecond-phase insulin responseInsulin-stimulated glucose metabolismGlucose-stimulated insulin responseMonths of therapyMonths of treatmentTotal cholesterol levelsExcessive insulin secretionGrowth hormone treatmentGlucose clamp techniqueGlucose clamp procedureHuman growth hormoneBlood pressureGlucose incrementGlycosylated hemoglobinInsulin resistancePlasma levelsCholesterol levelsClamp procedureHealthy children
1984
Treatment of Insulin Reactions in Diabetics
Brodows R, Williams C, Amatruda J. Treatment of Insulin Reactions in Diabetics. JAMA 1984, 252: 3378-3381. PMID: 6389915, DOI: 10.1001/jama.1984.03350240024032.Peer-Reviewed Original ResearchConceptsGlycemic responsePlasma free insulin concentrationInsulin-dependent diabeticsFree insulin concentrationsMicroU/mLGlucose clamp techniquePlasma glucose levelsRebound hyperglycemiaSevere hypoglycemiaOutpatient settingSpontaneous episodesInsulin concentrationsInsulin reactionGlucose levelsClamp techniqueHypoglycemiaIngested carbohydrateD-glucoseDiabeticsOrange juiceTreatmentImportant determinantCommon sourceHyperglycemiaPatients
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