2022
Ketones: the double-edged sword of SGLT2 inhibitors?
Lupsa BC, Kibbey RG, Inzucchi SE. Ketones: the double-edged sword of SGLT2 inhibitors? Diabetologia 2022, 66: 23-32. PMID: 36255460, DOI: 10.1007/s00125-022-05815-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSGLT2 inhibitorsDrug categoriesSodium-glucose cotransporter 2 inhibitorsCardio-renal benefitsNormal blood glucose concentrationsCotransporter 2 inhibitorsClasses of medicationsAnti-inflammatory effectsSerious adverse effectsType 1 diabetesBlood glucose levelsBlood glucose concentrationKidney outcomesRare complicationBlood pressureSGLT2 inhibitionGlucose levelsKetone levelsBody weightType 2Ketone bodiesAdverse effectsGlucose concentrationInhibitorsEdged swordPharmacodynamics, pharmacokinetics, safety, and tolerability of a ready‐to‐use, room temperature, liquid stable glucagon administered via an autoinjector pen to youth with type 1 diabetes
Buckingham B, Sherr J, Prestrelski S, Conoscenti V. Pharmacodynamics, pharmacokinetics, safety, and tolerability of a ready‐to‐use, room temperature, liquid stable glucagon administered via an autoinjector pen to youth with type 1 diabetes. Pediatric Diabetes 2022, 23: 754-762. PMID: 35562186, DOI: 10.1111/pedi.13360.Peer-Reviewed Original ResearchConceptsPlasma glucose concentrationType 1 diabetesAged 2 to <Common adverse eventsAge-appropriate dosesGlucose concentrationGlucagon formulationsManagement of hypoglycemiaPrimary endpointAdverse eventsMedical complicationsPK parametersPharmacodynamicsPharmacokineticsReady-to-useT1DGlucagonHypoglycemiaAge cohortsCohortAutoinjectorPlasmaBaselineAgeYearsMetformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI. Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122287119. PMID: 35238637, PMCID: PMC8916010, DOI: 10.1073/pnas.2122287119.Peer-Reviewed Original ResearchConceptsGlucose-lowering effectPlasma glucose concentrationComplex I activityHepatic gluconeogenesisType 2 diabetes mellitusGlucose concentrationGlycerol-3-phosphate dehydrogenase activityI activityDiabetes mellitusSelective inhibitionMetforminInhibitionRelevant concentrationsGluconeogenesisPhenforminVivoMost studiesDehydrogenase activityGalegineMellitus
2021
TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
Xu S, Liu Y, Hu R, Wang M, Stöhr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps K, White M, Miao J. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. ELife 2021, 10: e57462. PMID: 34622775, PMCID: PMC8555985, DOI: 10.7554/elife.57462.Peer-Reviewed Original ResearchConceptsGluconeogenic gene promotersBinding of GRGene promoterGlucocorticoid receptorGlucose homeostasisLigand-binding domainGlucose productionOverexpression of TAZHepatic glucose homeostasisWW domainsBlood glucose concentrationPhysiological fastingGluconeogenic genesGR response elementResponse elementNovel roleTAZNormal physiological stateGR transactivationPhysiological statePromoterMouse liverPericentral hepatocytesPathological statesGlucose concentrationGranular detail of β cell structures for insulin secretion
Bogan JS. Granular detail of β cell structures for insulin secretion. Journal Of Cell Biology 2021, 220: e202012082. PMID: 33427875, PMCID: PMC7802365, DOI: 10.1083/jcb.202012082.Commentaries, Editorials and Letters
2020
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks
Perry RJ, Shulman GI. Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. Journal Of Biological Chemistry 2020, 295: 14379-14390. PMID: 32796035, PMCID: PMC7573269, DOI: 10.1074/jbc.rev120.008387.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSodium-glucose cotransporter 2SGLT2 inhibitorsEuglycemic ketoacidosisGlucose reabsorptionTherapeutic promiseSGLT2 inhibitor therapyLower plasma glucose concentrationsModest weight lossGlucose-lowering agentsRenal glucose reabsorptionType 2 diabetesType 1 diabetesPlasma glucose concentrationGlucose concentrationBlood glucose concentrationHeart failureInhibitor therapyAtrial fibrillationCardiovascular diseaseCotransporter 2Preclinical studiesHealthy personsClinical utilityDiabetes managementProximal tubulesEffect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes
DuBose SN, Li Z, Sherr JL, Beck RW, Tamborlane WV, Shah VN. Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes. Journal Of Diabetes Science And Technology 2020, 15: 593-599. PMID: 32064911, PMCID: PMC8120054, DOI: 10.1177/1932296820905904.Peer-Reviewed Original ResearchConceptsEffects of exerciseSensor glucose levelsHealthy individualsResistance exerciseNadir glucoseGlucose levelsNonobese body mass indexT1D Exchange Clinic NetworkPeak postprandial glucoseBody mass indexGlucose concentrationTime of mealsNadir glucose concentrationsConsumption of alcoholMass indexPostprandial glucoseNonexercise dayAerobic exerciseExercise dayClinic networkMean changeFuture therapiesDiabetesDexcom G6Glucose monitor dataMetabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study
Galderisi A, Tricò D, Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgz207. PMID: 31972003, PMCID: PMC6977541, DOI: 10.1210/clinem/dgz207.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesChildCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenotypeGlucoseGlucose IntoleranceGlucose Tolerance TestHumansInsulin SecretionInsulin-Secreting CellsLongitudinal StudiesMalePediatric ObesityPrediabetic StateTime FactorsTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testTCF7L2 rs7903146 variantΒ-cell responsivenessObese youthT risk alleleDisposition indexGlucose peakRs7903146 variantTCF7L2 rs7903146Lower disposition indexGlucose tolerance testOral minimal modelGlucose toleranceOral challengeDiabetes riskTolerance testInsulin sensitivityHigh glucose concentrationsLate peak groupMetabolic phenotypeGlucose concentrationLongitudinal studyReproducible markerPrevalenceRs7903146
2018
Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial
Forlenza GP, Li Z, Buckingham BA, Pinsker JE, Cengiz E, Wadwa RP, Ekhlaspour L, Church MM, Weinzimer SA, Jost E, Marcal T, Andre C, Carria L, Swanson V, Lum JW, Kollman C, Woodall W, Beck RW. Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial. Diabetes Care 2018, 41: dc180771. PMID: 30089663, DOI: 10.2337/dc18-0771.Peer-Reviewed Original ResearchConceptsType 1 diabetesSAP armPredictive low glucose suspendSensor-Augmented Pump TherapyNew insulin delivery systemsRandomized Crossover StudySevere hypoglycemic eventsGlucose concentrationMin/dayMean glucose concentrationLow glucose suspendBasal-IQRebound hyperglycemiaSlim X2Glycemic controlPrimary outcomeCrossover studyMedian timeCrossover trialHypoglycemic eventsPump therapyInsulin delivery systemsPercentage of timeHypoglycemiaDiabetesInfluence of Exogenous β-Hydroxybutyrate on Walking Economy and Rating of Perceived Exertion
James S, Greer B. Influence of Exogenous β-Hydroxybutyrate on Walking Economy and Rating of Perceived Exertion. Journal Of Dietary Supplements 2018, 16: 463-469. PMID: 29953297, DOI: 10.1080/19390211.2018.1471562.Peer-Reviewed Original ResearchConceptsRespiratory exchange ratioEnergy expenditureΒ-hydroxybutyrateExogenous β-hydroxybutyratePlacebo 30 minutesBruce treadmill protocolElevated postexerciseBlood BHB concentrationsBlood glucoseErgogenic benefitsBlood ketonesTreadmill protocolHealthy individualsCrossover designBaseline levelsTrial differencesExchange ratioCON conditionTime pointsPerceived ExertionBHB concentrationsGlucose concentrationOxygen consumptionExertionSupplementation
2017
A Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care Unit
Losiouk E, Lanzola G, Galderisi A, Trevisanuto D, Steil G, Facchinetti A, Cobelli C. A Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care Unit. 2017, 1-6. DOI: 10.1109/rtsi.2017.8065890.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitCare unitPreterm newbornsLow birth weight infantsBirth weight infantsGlucose infusion rateDifferent clinical trialsHealth care staffContinuous glucose monitoringWeight infantsHeel prickNewborn careClinical benefitUniversity HospitalClinical trialsInfusion rateCare staffArterial samplingGlucose monitoringWard roomsGlucose dataGlucose concentrationPatientsNewborns
2016
A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth
De Feyter HM, Behar KL, Rao JU, Madden-Hennessey K, Ip KL, Hyder F, Drewes LR, Geschwind JF, de Graaf RA, Rothman DL. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro-Oncology 2016, 18: 1079-1087. PMID: 27142056, PMCID: PMC4933488, DOI: 10.1093/neuonc/now088.Peer-Reviewed Original ResearchConceptsKetone body oxidationKetogenic dietKetone bodiesGlioma modelBrain tumorsBrain tumor metabolismCortical brain tissuePlasma glucose concentrationRat glioma modelRodent glioma modelsContralateral brainRat gliomaTumor growthBrain tissueTumor metabolismBeta-hydroxybutyrate oxidationTumor cellsGliomasMR spectroscopyTumor's abilityMonocarboxylate transportersDietGlucose concentrationKetone body transportTherapy
2015
Admission glucose and in-hospital mortality in patients with acute myocardial infarction, with and without diabetes, from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis
Zhao S, Murugiah K, Li X, Li J, Li N, Xu Z, Cheng C, Mao H, Wang Q, Krumholz H, Jiang L, Group O. Admission glucose and in-hospital mortality in patients with acute myocardial infarction, with and without diabetes, from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis. The Lancet 2015, 386: s43. DOI: 10.1016/s0140-6736(15)00624-8.Peer-Reviewed Original ResearchAcute myocardial infarctionBlood glucose concentrationHospital mortalityMyocardial infarctionChinese patientsMortality riskGlucose concentrationAcute Myocardial Infarction StudyProportion of patientsHospital mortality riskMyocardial Infarction StudyUS National HeartEuglycaemic patientsAdmission glucoseDiabetes statusFamily Planning CommissionHospital admissionPatient characteristicsGlucose categoriesClinical statusBlood InstituteNational HeartNational HealthCardiovascular diseaseRetrospective analysis
2013
Control of serum glucose concentration in critical illness
Kandil SB, Miksa M, Faustino EV. Control of serum glucose concentration in critical illness. Current Opinion In Pediatrics 2013, 25: 297-303. PMID: 23657243, DOI: 10.1097/mop.0b013e328360c6a0.Peer-Reviewed Original ResearchConceptsTight glycemic controlIll childrenPostoperative cardiac surgery patientsCardiac surgery patientsInsulin-induced hypoglycemiaRisk of deathSerum glucose concentrationLong-term safetyCritical illnessSurgery patientsGlycemic controlPediatric patientsClinical benefitCardiac patientsAdult studiesLatest evidenceNeurocognitive developmentHypoglycemiaPatientsAdverse effectsDiscrepant resultsGlucose concentrationHyperglycemiaChildrenTrialsThe Effects of Inpatient Hybrid Closed-Loop Therapy Initiated Within 1 Week of Type 1 Diabetes DiagnosisDiabetes Research in Children Network (DirecNet) and Type 1 Diabetes TrialNet Study Groups*
Buckingham B, Beck R, Ruedy K, Cheng P, Kollman C, Weinzimer S, DiMeglio L, Bremer A, Slover R, Cantwell M. The Effects of Inpatient Hybrid Closed-Loop Therapy Initiated Within 1 Week of Type 1 Diabetes DiagnosisDiabetes Research in Children Network (DirecNet) and Type 1 Diabetes TrialNet Study Groups*. Diabetes Technology & Therapeutics 2013, 15: 401-408. PMID: 23570538, PMCID: PMC3643224, DOI: 10.1089/dia.2013.0002.Peer-Reviewed Original ResearchConceptsType 1 diabetesMean glucose concentrationHybrid closed-loop controlMedian percentageHybrid closed-loop therapyType 1Sensor-Augmented Pump TherapyPositive pancreatic autoantibodiesTrialNet Study GroupDays of diagnosisNormal glycemic controlΒ-cell functionGlucose concentrationClosed-loop therapyPancreatic autoantibodiesGlycemic controlSAP therapyPump therapyStudy groupGlucose levelsGlucose toxicityDay 2Day 3Glucose valuesTherapy
2012
NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells
Gray JP, Alavian KN, Jonas EA, Heart EA. NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells. AJP Endocrinology And Metabolism 2012, 303: e191-e199. PMID: 22550069, PMCID: PMC3431206, DOI: 10.1152/ajpendo.00465.2011.Peer-Reviewed Original ResearchConceptsGlucose-stimulated insulin secretionInsulin secretionΒ-cellsPancreatic β-cellsRedox cycling agent menadioneRat β-cell lineΒ-cell lineINS-1 832/13 cellsTwo- to threefold increaseAntioxidant defense systemRodent isletsSecretionGlucose concentrationOxidative damageOxidative defenseThreefold increaseNADPH/Cytosolic reductasesAgent menadioneAdapting To the New Consensus Guidelines for Managing Hyperglycemia During Critical Illness: the Updated Yale Insulin Infusion Protocol
Shetty S, Inzucchi SE, Goldberg PA, Cooper D, Siegel MD, Honiden S. Adapting To the New Consensus Guidelines for Managing Hyperglycemia During Critical Illness: the Updated Yale Insulin Infusion Protocol. Endocrine Practice 2012, 18: 363-370. PMID: 22138078, DOI: 10.4158/ep11260.or.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood GlucoseCohort StudiesConnecticutCritical CareDiabetes MellitusDrug MonitoringFemaleHealth Plan ImplementationHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsInfusions, IntravenousInsulin, Regular, HumanMaleMiddle AgedPractice Guidelines as TopicProspective StudiesTime FactorsConceptsYale Insulin Infusion ProtocolInsulin infusion protocolBlood glucose concentrationIntensive care unitBlood glucose valuesInsulin infusionInfusion protocolChronic Health Evaluation II scoreGlucose valuesMedical intensive care unitGlucose concentrationAdmission Acute PhysiologyUse of vasopressorsBlood glucose targetsContinuous venovenous hemodialysisIntravenous dextrose infusionBlood glucose controlBaseline blood glucose concentrationRecent national guidelinesNew consensus guidelinesInsulin infusion rateAcute PhysiologyIntravenous dextroseII scoreMedian duration
2011
Glycemic Control and Infections in Patients with Diabetes Undergoing Noncardiac Surgery
King JT, Goulet JL, Perkal MF, Rosenthal RA. Glycemic Control and Infections in Patients with Diabetes Undergoing Noncardiac Surgery. Annals Of Surgery 2011, 253: 158-165. PMID: 21135698, DOI: 10.1097/sla.0b013e3181f9bb3a.Peer-Reviewed Original ResearchConceptsSerum glucose concentrationPerioperative glucose controlPostoperative infectionGlucose controlSurgical proceduresDiabetic patientsGlucose concentrationNational Surgical Quality Improvement Program databaseInfection rateOverall postoperative infection rateQuality Improvement Program databaseMultivariate Poisson regression modelNoncardiac surgical proceduresPostoperative infectious complicationsImprovement Program databasePostoperative infection rateSurgical outcome dataNationwide samplePoisson regression modelsPreoperative HbA1cPreoperative laboratoryInfectious complicationsNoncardiac surgeryNoncardiac operationsGlycemic control
2009
Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes
Tsalikian E, Tamborlane W, Xing D, Becker D, Mauras N, Fiallo-Scharer R, Buckingham B, Weinzimer S, Steffes M, Singh R, Beck R, Ruedy K, Kollman C. Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes. Diabetes Care 2009, 32: 1954-1959. PMID: 19675205, PMCID: PMC2768200, DOI: 10.2337/dc08-2298.Peer-Reviewed Original ResearchConceptsType 1 diabetesPlasma glucose concentrationEpinephrine responsePlasma glucoseYoung childrenInsulin pump-treated patientsHypoglycemia-associated autonomic failurePump-treated patientsLower plasma glucose concentrationsIntensive insulin therapySymptoms of hypoglycemiaInsulin infusion protocolCounterregulatory hormone concentrationsGlucose concentrationAbsence of signsClosed-loop insulin delivery systemsContinuous glucose monitoringAcute complicationsAutonomic failureCounterregulatory hormonesSympathoadrenal responseInsulin therapyPatient ageNondiabetic adolescentsSymptom scoresPlasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia
Kim SH, Liu TC, Abbasi F, Lamendola C, Morton JM, Reaven GM, McLaughlin TL. Plasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia. Obesity Surgery 2009, 19: 1550. PMID: 19557485, DOI: 10.1007/s11695-009-9893-8.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryInsulin sensitivityOral glucoseInsulin concentrationsPost-RYGBBypass surgeryPlasma glucoseInsulin responseControl groupOverweight/obese controlsInsulin suppression testOral glucose challengePeak insulin concentrationsNon-surgical controlsNadir glucose concentrationsAsymptomatic patientsSymptomatic hypoglycemiaObese controlsRYGB groupGlucose challengeSuppression testPeak glucosePatientsRYGBGlucose concentration
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