2023
Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis
Bender U, Norris C, Dreyer R, Krumholz H, Raparelli V, Pilote L. Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis. Journal Of The American Heart Association 2023, 12: e028553. PMID: 37489737, PMCID: PMC10492965, DOI: 10.1161/jaha.122.028553.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionMyocardial infarctionGender-related factorsLonger LOSSegment elevation myocardial infarction diagnosisConclusions Older ageObservational cohort studyAdverse clinical outcomesAdjusted multivariable modelAcute myocardial infarctionLength of stayImpact of sexHealth care expendituresGENESIS-PRAXYHospital lengthNon–STCause mortalityCohort studyIndependent predictorsMyocardial infarction diagnosisClinical outcomesShorter LOSMedical historyMultivariable modelUnivariate associations
2022
Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015
Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008535-e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/circoutcomes.121.008535.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionInvasive strategyMyocardial infarctionHospital mortalityHospital outcomesMultivariable logistic regression modelCardiovascular risk factorsElevation myocardial infarctionSex-related disparitiesQuality of careProportion of womenLogistic regression modelsSex differencesClinical characteristicsClinical profileRisk factorsClinical covariatesSex-specific differencesPatientsInfarctionST segmentSex gapChinese hospitalsMortalityWomen
2021
Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015
Zhou T, Li X, Lu Y, Murugiah K, Bai X, Hu S, Gao Y, Masoudi FA, Krumholz HM, Li J, . Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015. Open Heart 2021, 8: e001666. PMID: 34599073, PMCID: PMC8488733, DOI: 10.1136/openhrt-2021-001666.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrehospital delayMyocardial infarctionSegment elevation myocardial infarctionProportion of patientsElevation myocardial infarctionAcute cardiovascular careAcute myocardial infarctionWeighted national estimateHealth service capacityRisk-adjusted ratesAcute reperfusionEligible patientsHospital deathReperfusion therapyMedical chartsPatient characteristicsHospital treatmentPatient outcomesRandom cohortCardiovascular diseaseCardiovascular carePatientsNational estimatesStandardised definitionsImpact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial Infarction
Raparelli V, Benea D, Smith M, Behlouli H, Murphy TE, D’Onofrio G, Pilote L, Dreyer RP. Impact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e021408. PMID: 34431311, PMCID: PMC8649291, DOI: 10.1161/jaha.121.021408.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac readmissionMyocardial infarctionHospital qualitySocial determinantsYoung adultsWhite individualsBlack individualsSegment elevation myocardial infarctionCardiac risk factorsMultivariable logistic regressionHigh rateWhite US adultsVIRGO StudyBlack raceAMI careRisk factorsCare scoresHigh prevalenceUS adultsReadmissionLogistic regressionInfarctionImpact of raceRacial disparitiesImpact of ST‐Segment–Elevation Myocardial Infarction Regionalization Programs on the Treatment and Outcomes of Patients Diagnosed With Non–ST‐Segment–Elevation Myocardial Infarction
Montoy JCC, Shen Y, Brindis RG, Krumholz HM, Hsia RY. Impact of ST‐Segment–Elevation Myocardial Infarction Regionalization Programs on the Treatment and Outcomes of Patients Diagnosed With Non–ST‐Segment–Elevation Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e016932. PMID: 33470136, PMCID: PMC7955417, DOI: 10.1161/jaha.120.016932.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCaliforniaCoronary AngiographyEarly DiagnosisElectrocardiographyFemaleFollow-Up StudiesHospitalizationHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionPrognosisProgram EvaluationRegistriesRetrospective StudiesRisk FactorsST Elevation Myocardial InfarctionSurvival RateTreatment OutcomeConceptsOutcomes of patientsEarly angiographyMyocardial infarctionST segmentST-segment elevation myocardial infarctionSegment elevation myocardial infarctionProportion of patientsElevation myocardial infarctionRisk of deathRisk of mortalityRegionalization programIndex admissionEmergency departmentRegionalized careNonfederal hospitalsMAIN OUTCOMETimely carePatientsAngiographyOverall populationNSTEMIInfarctionStudy periodMortalityCare
2019
Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy
Inohara T, Liang L, Kosinski A, Smith E, Schwamm L, Hernandez A, Bhatt D, Fonarow G, Peterson E, Xian Y. Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy. Journal Of The American Heart Association 2019, 8: e012450. PMID: 31327296, PMCID: PMC6761665, DOI: 10.1161/jaha.119.012450.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorRecent myocardial infarctionAcute ischemic strokeHistory of MIRisk of mortalityMyocardial infarctionAIS patientsIschemic strokeIntravenous recombinant tissue-type plasminogen activatorST-segment elevation myocardial infarctionSegment elevation myocardial infarctionMultivariate logistic regression modelGuidelines-Stroke hospitalsOnly medical therapyElevation myocardial infarctionTissue-type plasminogen activatorLogistic regression modelsHospital mortalityHospital outcomesSevere strokeMedical therapyThrombolytic therapyHigh riskInfarctionPatients
2018
OUTCOMES OF CHORDAE TENDINAE AND PAPILLARY MUSCLE RUPTURE: RARE BUT POTENTIALLY FATAL COMPLICATION IN ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION
Pahuja M, Singh M, Patel A, Chauhan K, Akintoye E, Mishra T, Ando T, Debnath N, Afonso L. OUTCOMES OF CHORDAE TENDINAE AND PAPILLARY MUSCLE RUPTURE: RARE BUT POTENTIALLY FATAL COMPLICATION IN ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2018, 71: a1991. DOI: 10.1016/s0735-1097(18)32532-4.Peer-Reviewed Original ResearchAcute ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionSegment elevation myocardial infarctionElevation myocardial infarctionPapillary muscle rupture
2016
China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy
Li X, Li J, Masoudi FA, Spertus JA, Lin Z, Krumholz HM, Jiang L. China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy. BMJ Open 2016, 6: e013355. PMID: 27798032, PMCID: PMC5093680, DOI: 10.1136/bmjopen-2016-013355.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute myocardial infarctionFibrinolytic therapyLow-risk groupMyocardial infarctionHospital deathHospital mortalitySegment elevation myocardial infarctionCardiac Events (PEACE) studyHospital death riskComposite of deathElevation myocardial infarctionSystolic blood pressureTime of presentationRelative risk reductionCross-sectional studyBaseline mortality riskAcute reperfusionMajor bleedingReperfusion therapyBlood pressureDerivation cohortStudy cohortChina PatientValidation cohortEditor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis
Bucholz EM, Strait KM, Dreyer RP, Lindau ST, D’Onofrio G, Geda M, Spatz ES, Beltrame JF, Lichtman JH, Lorenze NP, Bueno H, Krumholz HM. Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2016, 6: 610-622. PMID: 27485141, PMCID: PMC5459677, DOI: 10.1177/2048872616661847.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionYoung womenTime of AMIST-segment elevation myocardial infarctionHigh clinical risk scoreSegment elevation myocardial infarctionChronic obstructive pulmonary diseaseYoung AMI patientsCardiovascular risk factorsClinical risk scorePre-hospital delayProspective cohort studyCongestive heart failureElevation myocardial infarctionObstructive pulmonary diseaseHigh-risk populationYoung menMental health statusElectrocardiogram findingsMorbid obesityCardiovascular riskCohort studyRenal failureYounger patients
2014
Design and Rationale of Gulf locals with Acute Coronary Syndrome Events (Gulf Coast) Registry
Zubaid M, Thani KB, Rashed W, Alsheikh-Ali A, Alrawahi N, Ridha M, Akbar M, Alenezi F, Alhamdan R, Almahmeed W, Ouda H, Al-Mulla A, Baslaib F, Shehab A, Alnuaimi A, Amin H, Krumholz HM, . Design and Rationale of Gulf locals with Acute Coronary Syndrome Events (Gulf Coast) Registry. The Open Cardiovascular Medicine Journal 2014, 8: 88-93. PMID: 25328551, PMCID: PMC4197526, DOI: 10.2174/1874192401408010088.Peer-Reviewed Original ResearchAcute coronary syndromeST-segment elevation myocardial infarctionElevation myocardial infarctionMyocardial infarctionRisk profileBundle branch block myocardial infarctionDiagnosis of ACSSegment elevation myocardial infarctionCardiovascular risk profileGulf COAST registryHistory of hypertensionOne-year outcomesPast medical historyEvent registryHigh-risk profileActive smokingHospital presentationCoronary syndromePatient demographicsUnstable anginaDischarge diagnosisMean ageTherapeutic managementPhysical findingsMedical historyInternational comparisons of the management of patients with non-ST segment elevation acute myocardial infarction in the United Kingdom, Sweden, and the United States: The MINAP/NICOR, SWEDEHEART/RIKS-HIA, and ACTION Registry-GWTG/NCDR registries
McNamara RL, Chung SC, Jernberg T, Holmes D, Roe M, Timmis A, James S, Deanfield J, Fonarow GC, Peterson ED, Jeppsson A, Hemingway H. International comparisons of the management of patients with non-ST segment elevation acute myocardial infarction in the United Kingdom, Sweden, and the United States: The MINAP/NICOR, SWEDEHEART/RIKS-HIA, and ACTION Registry-GWTG/NCDR registries. International Journal Of Cardiology 2014, 175: 240-247. PMID: 24882696, PMCID: PMC4112832, DOI: 10.1016/j.ijcard.2014.04.270.Peer-Reviewed Original ResearchConceptsNon-ST segment elevation myocardial infarctionPercutaneous coronary interventionManagement of patientsMyocardial infarctionRIKS-HIAAcute non-ST segment elevation myocardial infarctionNon-ST segment elevation acute myocardial infarctionEnzyme inhibitors/angiotensin receptor blockersSegment elevation acute myocardial infarctionElevation acute myocardial infarctionSegment elevation myocardial infarctionFuture comparative effectiveness researchAngiotensin receptor blockersPrior heart failureDual antiplatelet agentsElevation myocardial infarctionAcute myocardial infarctionComparative effectiveness researchCoronary interventionDischarge medicationsOngoing registryReceptor blockersHeart failureAntiplatelet agentsClinical registry
2012
Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction
Somma K, Bhatt D, Fonarow G, Cannon C, Cox M, Laskey W, Peacock W, Hernandez A, Peterson E, Schwamm L, Saxon L. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2012, 5: 654-661. PMID: 22949493, DOI: 10.1161/circoutcomes.111.963959.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiovascular AgentsChi-Square DistributionComorbidityCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionSTEMI patientsMedical therapyNSTEMI patientsMyocardial infarctionGuidelines-Coronary Artery Disease registryNon-ST segment elevation myocardial infarctionGuideline-based medical therapyPrior coronary artery diseaseSegment elevation myocardial infarctionLow-density lipoprotein levelsSegment elevation MISimilar medical therapyLipid-lowering medicationsCoronary artery diseaseST-segment elevationGWTG-CADMedical comorbiditiesDischarge medicationsGuideline adherenceArtery diseaseHeart failureAngiotensin receptorsElevation MIUse of a Novel Crossing and Re-Entry System in Coronary Chronic Total Occlusions That Have Failed Standard Crossing Techniques Results of the FAST-CTOs (Facilitated Antegrade Steering Technique in Chronic Total Occlusions) Trial
Whitlow PL, Burke MN, Lombardi WL, Wyman RM, Moses JW, Brilakis ES, Heuser RR, Rihal CS, Lansky AJ, Thompson CA, Investigators F. Use of a Novel Crossing and Re-Entry System in Coronary Chronic Total Occlusions That Have Failed Standard Crossing Techniques Results of the FAST-CTOs (Facilitated Antegrade Steering Technique in Chronic Total Occlusions) Trial. JACC Cardiovascular Interventions 2012, 5: 393-401. PMID: 22516395, DOI: 10.1016/j.jcin.2012.01.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCathetersChronic DiseaseCoronary AngiographyCoronary OcclusionDrug-Eluting StentsEquipment DesignFemaleHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsProspective StudiesProsthesis DesignRetreatmentTime FactorsTreatment FailureUnited StatesConceptsCoronary chronic total occlusionsElevation myocardial infarctionPercutaneous coronary interventionChronic total occlusionCrossing catheterTotal occlusionMyocardial infarctionMajor adverse cardiac event ratesST-segment elevation myocardial infarctionAdverse cardiac event ratesSuccessful percutaneous coronary interventionSegment elevation myocardial infarctionCardiac event ratePrimary efficacy endpointRe-entry catheterSingle-arm trialCTO-PCI successMean lesion lengthDistal true lumenCardiac reinterventionEfficacy endpointCoronary interventionEmergency surgeryHemodynamic instabilityPCI success
2011
Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention
Curtis JP, Rathore SS, Wang Y, Chen J, Nallamothu BK, Krumholz HM. Use and Effectiveness of Intra-Aortic Balloon Pumps Among Patients Undergoing High Risk Percutaneous Coronary Intervention. Circulation Cardiovascular Quality And Outcomes 2011, 5: 21-30. PMID: 22147887, PMCID: PMC3801197, DOI: 10.1161/circoutcomes.110.960385.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionHospital quartilesHospital mortalityIABP useCoronary interventionBalloon pumpHospital characteristicsST-segment elevation myocardial infarctionDepressed left ventricular functionHigh-risk PCI patientsSegment elevation myocardial infarctionElevation myocardial infarctionLeft ventricular functionHierarchical logistic regression modelsLogistic regression modelsIABP usageCardiogenic shockPCI patientsCathPCI RegistryHemodynamic supportVentricular functionHospital variationMultivariable analysis
2010
Delay From Symptom Onset to Hospital Presentation for Patients With Non–ST-Segment Elevation Myocardial Infarction
Ting HH, Chen AY, Roe MT, Chan PS, Spertus JA, Nallamothu BK, Sullivan MD, DeLong ER, Bradley EH, Krumholz HM, Peterson ED. Delay From Symptom Onset to Hospital Presentation for Patients With Non–ST-Segment Elevation Myocardial Infarction. JAMA Internal Medicine 2010, 170: 1834-1841. PMID: 21059977, DOI: 10.1001/archinternmed.2010.385.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital presentationSymptom onsetHospital mortalityMultivariable adjustmentMyocardial infarctionUnstable Angina Patients Suppress Adverse OutcomesCan Rapid Risk StratificationSegment elevation myocardial infarctionNational quality improvement initiativeRapid Risk StratificationQuality improvement initiativesMedian delay timeSecular trendsNon–STCurrent smokingRisk stratificationNonwhite raceAdverse outcomesFemale sexOdds ratioEarly presentationAmerican CollegePatients
2007
Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction
Garavalia LS, Decker C, Reid KJ, Lichtman JH, Parashar S, Vaccarino V, Krumholz HM, Spertus JA. Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction. Journal Of Women's Health 2007, 16: 93-101. PMID: 17324100, DOI: 10.1089/jwh.2006.m073.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHealth statusNon-ST segment elevation myocardial infarctionRisk-adjusted multivariable modelsSegment elevation myocardial infarctionChronic lung diseaseElevation myocardial infarctionWorse health statusPoor physical functioningQuality of lifeResidual anginaCoronary revascularizationHeart failureLung diseaseMI patientsPhysical functionMultivariable PoissonMultivariable modelPhysical functioningEarly recoveryGreater prevalenceInfarctionPatientsAdditional treatmentWomen
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