2024
New Treatment Approaches in Non-Muscle-Invasive Bladder Cancer
Kim S, Lerner S. New Treatment Approaches in Non-Muscle-Invasive Bladder Cancer. 2024, 439-456. DOI: 10.1007/978-3-031-68505-7_21.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerBladder cancerBCG-unresponsive NMIBCProbability of response to treatmentUS Food and Drug AdministrationNew treatment approachesResponse to treatmentFood and Drug AdministrationNuclear gradeBC casesDrug AdministrationHigh riskTreatment approachesDisease subtypesMorphological appearanceDisease statesCancerDrug developmentTreatment
2022
Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects
Peters S, Paz-Ares L, Herbst RS, Reck M. Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects. Journal For ImmunoTherapy Of Cancer 2022, 10: e004863. PMID: 35858709, PMCID: PMC9305809, DOI: 10.1136/jitc-2022-004863.Peer-Reviewed Original ResearchConceptsImmunosuppressive tumor microenvironmentCheckpoint inhibitorsTAM receptorsImmune responseTumor microenvironmentOverall survivalLung cancerStandard first-line therapyLong-term clinical responseCell death protein 1Immunostimulatory tumor microenvironmentImmune checkpoint inhibitorsInhibitor-based regimensFirst-line therapyAntitumor immune responseDeath protein 1Cell lung cancerPatients' overall survivalStrong biological rationaleNew treatment approachesLong-term survivalActivation of Tyro3Majority of casesCPI therapyAdvanced NSCLCObsessive-Compulsive Disorder Treatment Based on Neurocircuits
Shephard E, Stern E, Miguel E. Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. Psychiatric Annals 2022, 52: 152-156. DOI: 10.3928/00485713-20220317-01.Peer-Reviewed Original ResearchObsessive-compulsive disorderNew treatment approachesObsessive-compulsive disorder (OCD) treatmentClinical profileIndividual patientsGlobal burdenNeurocognitive alterationsPsychiatric disordersPsychiatric treatmentTreatment approachesDisorder treatmentPsychiatric conditionsClinical useSpecific neurocircuitsUnderlying neurobiological basisModels of OCDNeurobiological basisTreatmentNeurocircuitsDisordersPatientsEmerging Studies of Melanoma Brain Metastasis
Caulfield JI, Kluger HM. Emerging Studies of Melanoma Brain Metastasis. Current Oncology Reports 2022, 24: 585-594. PMID: 35212922, DOI: 10.1007/s11912-022-01237-9.Peer-Reviewed Original ResearchConceptsMelanoma brain metastasesBrain metastasesClinical studiesTreatment approachesRecent FindingsClinical trialsImmune checkpoint inhibitorsAdditional treatment approachesRecent preclinical studiesNew treatment approachesCentral nervous systemBrain disseminationCheckpoint inhibitorsSignificant morbidityPerilesional edemaRadiation necrosisPatient populationClinical challengePreclinical studiesNervous systemSolid tumorsEmerging studiesMetastasisTumor microenvironmentDisease controlTumor homing
2018
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC)
Brahmer JR, Govindan R, Anders RA, Antonia SJ, Sagorsky S, Davies MJ, Dubinett SM, Ferris A, Gandhi L, Garon EB, Hellmann MD, Hirsch FR, Malik S, Neal JW, Papadimitrakopoulou VA, Rimm DL, Schwartz LH, Sepesi B, Yeap BY, Rizvi NA, Herbst RS. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC). Journal For ImmunoTherapy Of Cancer 2018, 6: 75. PMID: 30012210, PMCID: PMC6048854, DOI: 10.1186/s40425-018-0382-2.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsCell lung cancerCheckpoint inhibitorsLung cancerDurable responsesConsensus statementStage III non-small cell lung cancerAdvanced non-small cell lung cancerCancer consensus statementSequencing of therapySecond-line settingAppropriate patient selectionOnly treatment optionAdverse event managementCancer-related mortalityImmunotherapy of cancerEvidence-based recommendationsNew treatment approachesStrength of evidenceAdvanced diseasePatient selectionTargetable mutationsTreatment optionsCancer immunotherapy
2013
Phenomena of Childhood Trauma and Expanding Approaches to Early Intervention
Marans S. Phenomena of Childhood Trauma and Expanding Approaches to Early Intervention. International Journal Of Applied Psychoanalytic Studies 2013, 10: 247-266. DOI: 10.1002/aps.1369.Peer-Reviewed Original ResearchChild Development-Community Policing ProgramPolice officersProfessor of childMental health professionalsNeeds of childrenSelma FraibergTraumatic eventsLives of childrenConsulting roomSupervision IPsychoanalytic principlesDorothy BurlinghamOptimal developmentPrinciples of developmentPsychoanalytic trainingClinical workChildrenEarly exposureAdult psychiatryInformed collaborationHealth professionalsPsychoanalysisTreatment approachesTrainingNew treatment approaches
2005
Role of novel targeted therapies in the clinic
Herbst RS. Role of novel targeted therapies in the clinic. British Journal Of Cancer 2005, 92: s21-s27. PMID: 15928655, PMCID: PMC2362061, DOI: 10.1038/sj.bjc.6602605.Peer-Reviewed Original Research
2003
Targeting the epidermal growth factor receptor in non-small cell lung cancer.
Herbst RS, Bunn PA. Targeting the epidermal growth factor receptor in non-small cell lung cancer. Clinical Cancer Research 2003, 9: 5813-24. PMID: 14676101.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerLung cancerEGFR-TK inhibitorsSystemic chemotherapyClinical trialsClinical developmentMetastatic non-small cell lung cancerTwo-drug combination regimenEpidermal growth factor receptor tyrosine kinase inhibitor gefitinibSingle-agent activityRate of deathNew treatment approachesKinase inhibitor gefitinibEpidermal growth factor receptorGrowth factor receptorCombination regimenDisease progressionPlatinum agentsTreatment approachesSolid tumorsTumor growthInhibitor gefitinibTherapyCancer
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