2024
High throughput detection of veterinary drug residues in chicken and eggs
Li F, Lv H, Zhu F, Zhang Q, Xu Q, Ji W. High throughput detection of veterinary drug residues in chicken and eggs. Food Chemistry 2024, 463: 141267. PMID: 39288463, DOI: 10.1016/j.foodchem.2024.141267.Peer-Reviewed Original ResearchSolid-phase extractionVeterinary drug residuesTarget substancesCo-extractionSolid-phase extraction methodMOF-808Detection of veterinary drug residuesPolyacrylonitrile nanofiber membraneDrug residuesDetection limitUPLC-MS/MSMatrix purificationNanofiber membranesThroughput detectionPolydopamineChickenEggsNFsMPolyacrylonitrile
2023
A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease
Han L, Wu S, Zhang T, Peng W, Zhao M, Yue C, Wen W, Cai W, Li M, Wallny H, Avila D, Mwangi W, Nair V, Ternette N, Guo Y, Zhao Y, Chai Y, Qi J, Liang H, Gao G, Kaufman J, Liu W. A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease. The Journal Of Immunology 2023, 210: 668-680. PMID: 36695776, PMCID: PMC7614295, DOI: 10.4049/jimmunol.2200211.Peer-Reviewed Original ResearchConceptsPeptide-binding grooveResistance to MDMarek's diseaseResistance to Marek's diseaseGas phase sequencingClass I genesPeptide motifsI geneGeneralist allelesChicken MHCImportant pathogensChicken linesMD resistanceCell surfaceAmino acidsB19 chickensExpression levelsChickenOncogenic herpesvirusX-ray crystallographyClass I moleculesPeptideStronger bindingI moleculesMotif
2022
The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis
Bertzbach L, Tregaskes C, Martin R, Deumer U, Huynh L, Kheimar A, Conradie A, Trimpert J, Kaufman J, Kaufer B. The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis. Frontiers In Immunology 2022, 13: 908305. PMID: 35693787, PMCID: PMC9186122, DOI: 10.3389/fimmu.2022.908305.Peer-Reviewed Original ResearchConceptsMarek's disease virusSPF chickensDisease resistanceMarek's disease virus infectionMarek's disease virus pathogenesisDeterminants of genetic resistanceCommercial chicken linesInfection of chickensGenetic resistanceChicken linesContact birdsDisease virusChickenOncogenic herpesvirusSpecific pathogenMarekLower tumor incidenceLymphoma formationMHC haplotypesPathogensMajor histocompatibility complex haplotypeVaccine productionB21Variable levelsInvading pathogensChapter 7 The avian major histocompatibility complex
Kaufman J. Chapter 7 The avian major histocompatibility complex. 2022, 135-161. DOI: 10.1016/b978-0-12-818708-1.00033-6.Peer-Reviewed Original Research
2021
Innate immune genes of the chicken MHC and related regions
Kaufman J. Innate immune genes of the chicken MHC and related regions. Immunogenetics 2021, 74: 167-177. PMID: 34697647, PMCID: PMC8813856, DOI: 10.1007/s00251-021-01229-2.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexMajor histocompatibility complexNatural killer (NK) cellsImmune responseGene systemInnate immunityAdaptive immune responsesMammalian immune responseInnate immune genesChicken microchromosomesMultigene familyImmune lymphocytesComplement component C4Immune genesGenesHistocompatibility complexHomologyChickenAdaptive responseComponent C4ImmunityMicrochromosomesReceptor regionChromosomeThe dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motif
Halabi S, Ghosh M, Stevanović S, Rammensee H, Bertzbach L, Kaufer B, Moncrieffe M, Kaspers B, Härtle S, Kaufman J. The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motif. PLOS Biology 2021, 19: e3001057. PMID: 33901176, PMCID: PMC8101999, DOI: 10.1371/journal.pbio.3001057.Peer-Reviewed Original ResearchConceptsMarek's disease virusMarek's diseaseSusceptibility to Marek's diseaseSusceptibility to many viral diseasesViral diseasesAmino acidsHaplotype B2Disease virusMarekZoonotic pathogensFood speciesChickenOncogenic herpesvirusFood sourcesViral peptide epitopesComplex virusesMajor histocompatibility complexIn vitro infection systemPeptide motifsFoodClass II moleculesQuestions of mechanismExpress class II moleculesAntigenic peptides to T lymphocytesAcidChickens as a simple system for scientific discovery: The example of the MHC
Tregaskes C, Kaufman J. Chickens as a simple system for scientific discovery: The example of the MHC. Molecular Immunology 2021, 135: 12-20. PMID: 33845329, PMCID: PMC7611830, DOI: 10.1016/j.molimm.2021.03.019.Peer-Reviewed Original ResearchCas9-expressing chickens and pigs as resources for genome editing in livestock
Rieblinger B, Sid H, Duda D, Bozoglu T, Klinger R, Schlickenrieder A, Lengyel K, Flisikowski K, Flisikowska T, Simm N, Grodziecki A, Perleberg C, Bähr A, Carrier L, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Kettler L, Luksch H, Hagag I, Wise D, Kaufman J, Kaufer B, Kupatt C, Schnieke A, Schusser B. Cas9-expressing chickens and pigs as resources for genome editing in livestock. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2022562118. PMID: 33658378, PMCID: PMC7958376, DOI: 10.1073/pnas.2022562118.Peer-Reviewed Original ResearchConceptsCross-species comparisonsGenome editingMolecular basis of healthFunction of Cas9Phylogenetically distant speciesTargeted gene disruptionGeneration of transgenic chickensIn vivo genome editingDistant speciesReverse geneticsDNA fragmentationGene disruptionGenetic methodsTarget genesMolecular basisCRISPR-Cas9Transgenic chickensCas9Cell typesSpeciesTranslational biomedical researchGeneticsChickenBases of healthPigs
2019
Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC
Potts N, Bichet C, Merat L, Guitton E, Krupa A, Burke T, Kennedy L, Sorci G, Kaufman J. Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC. Immunogenetics 2019, 71: 647-663. PMID: 31761978, PMCID: PMC6900278, DOI: 10.1007/s00251-019-01149-2.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complex genesSingle nucleotide polymorphismsClassical class IMajor histocompatibility complexClass II B genesChicken MHC haplotypesStrand-mediated conformational analysisGenes of chickenChicken major histocompatibility complexMajor histocompatibility complex allelesSusceptibility to infectious pathogensB geneInfectious pathogensClass II BImmune responses to infectious pathogensNucleotide polymorphismsResponse to infectious pathogensTyping protocolHaplotypesClass IMHC haplotypesChickenAllelesPathogensClass I alleles
2015
What chickens would tell you about the evolution of antigen processing and presentation
Kaufman J. What chickens would tell you about the evolution of antigen processing and presentation. Current Opinion In Immunology 2015, 34: 35-42. PMID: 25626087, DOI: 10.1016/j.coi.2015.01.001.Peer-Reviewed Original ResearchConceptsAdaptive immune system of jawed vertebratesChicken MHCImmune system of jawed vertebratesGenes co-evolvePeptide-binding repertoireNon-mammalian vertebratesAncestral arrangementJawed vertebratesResistance to diseasePolymorphic genesAntigen processingAdaptive immune systemMHC haplotypesVertebratesGenesCo-evolutionChickenClass I allelesMammalsI allelesOriginal pathwayHaplotypesAllelesMHC
2014
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns
Salomonsen J, Chattaway J, Chan A, Parker A, Huguet S, Marston D, Rogers S, Wu Z, Smith A, Staines K, Butter C, Riegert P, Vainio O, Nielsen L, Kaspers B, Griffin D, Yang F, Zoorob R, Guillemot F, Auffray C, Beck S, Skjødt K, Kaufman J. Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns. PLOS Genetics 2014, 10: e1004417. PMID: 24901252, PMCID: PMC4046983, DOI: 10.1371/journal.pgen.1004417.Peer-Reviewed Original ResearchConceptsMultigene familyBG genesButyrophilin geneMajor histocompatibility complexWhole-genome shotgun sequencingGenome shotgun sequencingGenes encoding homologuesActin-myosin interactionResistance to viral diseasesFluorescence in situ hybridisationGene lineagesShotgun sequencingDomain organisationEvolutionary forcesTandem repeatsIntestinal brush borderHybrid geneCo-regulationGenesExpression patternsHaplotypesButyrophilinHomologuesChickenTissue expressionStructure of the Chicken CD3ϵδ/γ Heterodimer and Its Assembly with the αβT Cell Receptor*
Berry R, Headey S, Call M, McCluskey J, Tregaskes C, Kaufman J, Koh R, Scanlon M, Call M, Rossjohn J. Structure of the Chicken CD3ϵδ/γ Heterodimer and Its Assembly with the αβT Cell Receptor*. Journal Of Biological Chemistry 2014, 289: 8240-8251. PMID: 24488493, PMCID: PMC3961652, DOI: 10.1074/jbc.m113.544965.Peer-Reviewed Original ResearchConceptsTCR signaling complexSignaling ComplexIn vitro biochemical assaysPrimitive ancestral formAncestral formDimer interfaceSignaling apparatusSurface-exposedNMR structureNonconserved residuesSignaling moleculesHeterodimerSubunit arrangementBiochemical assaysBiochemical analysisCell receptorsChickenTransmembrane siteMammalsMolecular surfaceAssemblySubunitTCRReceptorsTCRA
2013
A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I (MHC I) Proteins*
van Hateren A, Carter R, Bailey A, Kontouli N, Williams A, Kaufman J, Elliott T. A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I (MHC I) Proteins*. Journal Of Biological Chemistry 2013, 288: 32797-32808. PMID: 24078633, PMCID: PMC3820913, DOI: 10.1074/jbc.m113.474031.Peer-Reviewed Original ResearchConceptsMHC-I lociI lociTapasin geneMHC allelesCo-evolutionPeptide binding propertiesMHC-I allelesPolymorphic residuesMechanistic basesCell surface to cytotoxic T cellsAllelesCo-factorMHC-IAffinity peptidesMajor histocompatibility complex class IGenesMaturation efficiencyBinding propertiesMammalsChickenTapasin functionPeptideMHC class I moleculesCo-evolveHistocompatibility complex class IThe peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV)
Butter C, Staines K, van Hateren A, Davison T, Kaufman J. The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV). Immunogenetics 2013, 65: 609-618. PMID: 23644721, PMCID: PMC3710569, DOI: 10.1007/s00251-013-0705-x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsAntigen PresentationBirnaviridae InfectionsChickensFowlpox virusGenes, MHC Class IGenes, ViralGenetic LociGenetic Predisposition to DiseaseGenetic VectorsInbreedingInfectious bursal disease virusPeptidesPoultry DiseasesRecombinant Fusion ProteinsVaccines, SyntheticViral Structural ProteinsViral VaccinesConceptsInfectious bursal disease virusExpressed class I moleculeDisease virusChicken MHCVP2 gene of infectious bursal disease virusPeptide motifsResistance to viral pathogensGenetic associationMarek's disease virusProtection to challengeFowlpox virus vectorSusceptibility to infectious pathogensRous sarcoma virusBursal damageVP2 geneParental linesBackcross familiesClass I moleculesLine CChickenPeptide-binding motifSarcoma virusI moleculesMotifB-galactosidase
2012
Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens
Zhang J, Chen Y, Qi J, Gao F, Liu Y, Liu J, Zhou X, Kaufman J, Xia C, Gao G. Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens. The Journal Of Immunology 2012, 189: 4478-4487. PMID: 23041567, PMCID: PMC5018395, DOI: 10.4049/jimmunol.1200885.Peer-Reviewed Original ResearchConceptsPolymorphic TAPAllele-specific residuesBF2*2101Susceptibility to infectious pathogensNegatively charged anchorMHC resultsPeptide-binding grooveB21 haplotypeB4 cellsGenetic associationMHC molecules to T lymphocytesDisease susceptibilityHaplotypesPeptide-binding assayNarrow groovePresentation of antigenic peptidesMHC haplotypesSpectra of peptidesPeptideInfectious pathogensChickenIn vitroAntigenic peptidesClass I moleculesImmune system
2011
The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes
Walker B, Hunt L, Sowa A, Skjødt K, Göbel T, Lehner P, Kaufman J. The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8396-8401. PMID: 21536896, PMCID: PMC3100931, DOI: 10.1073/pnas.1019496108.Peer-Reviewed Original ResearchConceptsExpressed class I moleculeChicken MHC haplotypesTransporter associated with antigen presentationModerate sequence diversityMHC haplotypesClass I genesClass I moleculesSequence diversityPrimordial MHCI genePeptide motifsChicken MHCChicken linesAllelic polymorphismI moleculesPeptide translocationPeptide bindingAdaptive immune systemMHC associationsCoevolutionPeptide transportHaplotypesAntigen presentation pathwayPeptide positionChicken
2008
Avian NK activities, cells and receptors
Rogers S, Viertlboeck B, Göbel T, Kaufman J. Avian NK activities, cells and receptors. Seminars In Immunology 2008, 20: 353-360. PMID: 18948017, DOI: 10.1016/j.smim.2008.09.005.Peer-Reviewed Original ResearchConceptsLeukocyte receptor complexNatural killer complexMajor histocompatibility complexNK receptor genesReceptor geneGenomic regionsNatural killerNK activityGammadelta T cellsIntestinal epitheliumReceptor complexNKT cellsGenesHistocompatibility complexT cellsCellsBirdsActivityAlphabetaGammadeltaChickenHigh allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC
Rogers S, Kaufman J. High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC. Immunogenetics 2008, 60: 461. PMID: 18574582, DOI: 10.1007/s00251-008-0307-1.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceChickensDNA, ComplementaryFlow CytometryGenetic VariationHaplotypesHumansKiller Cells, NaturalLectins, C-TypeModels, ImmunologicalMolecular Sequence DataPolymorphism, GeneticReceptors, ImmunologicReceptors, MitogenSelection, GeneticSequence Homology, Amino AcidConceptsMarek's disease virusChicken major histocompatibility complexB-lecDisease virusB-NKLines of domestic chickensModerate sequence diversityHighest allelic polymorphismsMajor histocompatibility complexSequence diversityAssociated with resistanceOncogenic herpes virusDomestic chickensComplementary deoxyribonucleic acidType II membrane proteinAllelic polymorphismChickenN-linked glycosylation sitesAmino acid substitutionsAllelic variationActivation-induced receptorLigand-binding facePurifying selectionDisulfide-linked homodimerProtein sequences
2007
Low frequency of the Mx allele for viral resistance predates recent intensive selection in domestic chickens
Balkissoon D, Staines K, McCauley J, Wood J, Young J, Kaufman J, Butter C. Low frequency of the Mx allele for viral resistance predates recent intensive selection in domestic chickens. Immunogenetics 2007, 59: 687-691. PMID: 17609940, DOI: 10.1007/s00251-007-0235-5.Peer-Reviewed Original ResearchConceptsInfluenza virus replicationMx allelesAncestral breedsComplementary DNASusceptibility allelesFull-length complementary DNAEgg-laying strainVirus replicationHuman pandemic virusMeat-typeBreeding techniquesChicken linesPoultry industryDomestic chickensResistant haplotypeAllelesBreedingChickenPandemic virusViral resistanceAvian influenzaReplicationSusceptibilityCodonBroilersDifferent Evolutionary Histories of the Two Classical Class I Genes BF1 and BF2 Illustrate Drift and Selection within the Stable MHC Haplotypes of Chickens
Shaw I, Powell T, Marston D, Baker K, van Hateren A, Riegert P, Wiles M, Milne S, Beck S, Kaufman J. Different Evolutionary Histories of the Two Classical Class I Genes BF1 and BF2 Illustrate Drift and Selection within the Stable MHC Haplotypes of Chickens. The Journal Of Immunology 2007, 178: 5744-5752. PMID: 17442958, DOI: 10.4049/jimmunol.178.9.5744.Peer-Reviewed Original ResearchConceptsClass I genesI geneChicken MHCChicken MHC haplotypesResistance to infectious pathogensLong-distance PCRMHC haplotypesPatterns of descentGenome organizationBF2 genesEvolutionary historyClass II BExpressed genesSite deletionHaplotypesNeutral changesB12 haplotypeGenesDendrogramWell-expressedChickenInfectious pathogensBF1Response to vaccinationClass I molecules
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