2023
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
Rocos N, Coulter F, Tan T, Kaufman J. The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes. Immunogenetics 2023, 75: 455-464. PMID: 37405420, PMCID: PMC10514180, DOI: 10.1007/s00251-023-01313-9.Peer-Reviewed Original ResearchConceptsClass I genesCytotoxic T lymphocytesI geneNucleotide direct repeatChicken MHC haplotypesChicken major histocompatibility complexDirect repeatsHomologous genesTranscriptional orientationSplice sitePhenotypic effectsUntranslated regionChicken MHCBG genesB locusGenesHaplotypesB15 haplotypeMajor histocompatibility complexDeletionT lymphocytesCell ligands
2021
Innate immune genes of the chicken MHC and related regions
Kaufman J. Innate immune genes of the chicken MHC and related regions. Immunogenetics 2021, 74: 167-177. PMID: 34697647, PMCID: PMC8813856, DOI: 10.1007/s00251-021-01229-2.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexMajor histocompatibility complexNatural killer (NK) cellsImmune responseGene systemInnate immunityAdaptive immune responsesMammalian immune responseInnate immune genesChicken microchromosomesMultigene familyImmune lymphocytesComplement component C4Immune genesGenesHistocompatibility complexHomologyChickenAdaptive responseComponent C4ImmunityMicrochromosomesReceptor regionChromosome
2020
From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles
Kaufman J. From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles. Frontiers In Immunology 2020, 11: 601089. PMID: 33381122, PMCID: PMC7767893, DOI: 10.3389/fimmu.2020.601089.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMajor histocompatibility complexPeptide motifsClass I moleculesCytotoxic T lymphocytesCell surfaceChicken major histocompatibility complexClass I allelesBinding peptidesI moleculesNatural killerClassical class I moleculesResistance to infectious diseasesMultigene familyRepertoire of bound peptidesI allelesThymus-derived (T) cellsReceptor-ligand interactionsNK cell functionImmunoglobulin-like receptorsPeptide-bindingMajor histocompatibility complex class I allelePeptide repertoireAllelesMHC-I molecules
2019
Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC
Potts N, Bichet C, Merat L, Guitton E, Krupa A, Burke T, Kennedy L, Sorci G, Kaufman J. Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC. Immunogenetics 2019, 71: 647-663. PMID: 31761978, PMCID: PMC6900278, DOI: 10.1007/s00251-019-01149-2.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complex genesSingle nucleotide polymorphismsClassical class IMajor histocompatibility complexClass II B genesChicken MHC haplotypesStrand-mediated conformational analysisGenes of chickenChicken major histocompatibility complexMajor histocompatibility complex allelesSusceptibility to infectious pathogensB geneInfectious pathogensClass II BImmune responses to infectious pathogensNucleotide polymorphismsResponse to infectious pathogensTyping protocolHaplotypesClass IMHC haplotypesChickenAllelesPathogensClass I alleles
2015
Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity
Tregaskes C, Harrison M, Sowa A, van Hateren A, Hunt L, Vainio O, Kaufman J. Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: 692-697. PMID: 26699458, PMCID: PMC4725490, DOI: 10.1073/pnas.1511859113.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexChicken MHC haplotypesCell surfaceMHC haplotypesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeCell surface expression levelsClass I moleculesPeptide-loading complexB21 haplotypeChicken haplotypesResistance to Marek's diseaseExpression level of MHC class I moleculesHaplotypesGenetic associationAssembly assayHomozygote cellsClass I proteinsAllelic polymorphismI moleculesPeptide libraryTranslocation specificityPromiscuous bindingI proteinCo‐evolution with chicken class I genes
Kaufman J. Co‐evolution with chicken class I genes. Immunological Reviews 2015, 267: 56-71. PMID: 26284471, DOI: 10.1111/imr.12321.Peer-Reviewed Original ResearchConceptsClass I genesI geneMajor histocompatibility complexAdaptive immune system of jawed vertebratesImmune system of jawed vertebratesCo-evolutionPrimordial MHCResistance to infectious pathogensClass I-like genesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeClassical class ICD1 genesCo-receptor genesMammalian lineagesJawed vertebratesRfp-YClass INatural killer (NK) cell receptorsGenesAntigen-processing genesT cell receptorAdaptive immune systemFunctional consequences
2008
High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC
Rogers S, Kaufman J. High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC. Immunogenetics 2008, 60: 461. PMID: 18574582, DOI: 10.1007/s00251-008-0307-1.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceChickensDNA, ComplementaryFlow CytometryGenetic VariationHaplotypesHumansKiller Cells, NaturalLectins, C-TypeModels, ImmunologicalMolecular Sequence DataPolymorphism, GeneticReceptors, ImmunologicReceptors, MitogenSelection, GeneticSequence Homology, Amino AcidConceptsMarek's disease virusChicken major histocompatibility complexB-lecDisease virusB-NKLines of domestic chickensModerate sequence diversityHighest allelic polymorphismsMajor histocompatibility complexSequence diversityAssociated with resistanceOncogenic herpes virusDomestic chickensComplementary deoxyribonucleic acidType II membrane proteinAllelic polymorphismChickenN-linked glycosylation sitesAmino acid substitutionsAllelic variationActivation-induced receptorLigand-binding facePurifying selectionDisulfide-linked homodimerProtein sequences
2007
Structures of an MHC Class I Molecule from B21 Chickens Illustrate Promiscuous Peptide Binding
Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny H, van Hateren A, Hunt L, Jacob J, Johnston F, Marston D, Shaw I, Dunbar P, Cerundolo V, Jones E, Kaufman J. Structures of an MHC Class I Molecule from B21 Chickens Illustrate Promiscuous Peptide Binding. Immunity 2007, 27: 885-899. PMID: 18083574, DOI: 10.1016/j.immuni.2007.11.007.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexB21 haplotypeChicken major histocompatibility complexBF2*2101Peptide-binding siteMajor histocompatibility complex class I moleculesClass I moleculesBinding grooveGenetic associationStructure of major histocompatibility complexPromiscuous bindingPeptide bindingI moleculesHaplotypesCharge-transfer systemsMajor histocompatibility complex moleculesConformational flexibilityCentral cavityInfectious pathogensHistocompatibility complexAnchor residuesBindingOncogenic herpesvirusPeptideResidues
2005
Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism
Walker B, van Hateren A, Milne S, Beck S, Kaufman J. Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism. Immunogenetics 2005, 57: 232-247. PMID: 15900495, DOI: 10.1007/s00251-005-0786-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsATP-Binding Cassette TransportersBase SequenceCell LineChickensChromosome MappingConserved SequenceDNA, ComplementaryExonsGenes, MHC Class IHaplotypesInterferon-gammaMajor Histocompatibility ComplexMolecular Sequence DataPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalPromoter Regions, GeneticRecombinant ProteinsRNA, MessengerSequence Homology, Amino AcidSpecies SpecificityUp-RegulationConceptsTAP genesClass I genesSequence featuresI geneTranscription Factor Binding SitesProtein sequence featuresLevel of polymorphismFactor binding sitesChicken major histocompatibility complexEndoplasmic reticulum retentionBi-directional promoterClass I gene promoterInbred lines of chickensGene sizeGene structureBind ATPHuman orthologueProcessing genesExon 1Tapasin bindingHeterodimer formationTransporters associated with antigen processing genesLines of chickensHuman TAPInbred lines
2004
2004 Nomenclature for the chicken major histocompatibility (B and Y ) complex
Miller M, Bacon L, Hala K, Hunt H, Ewald S, Kaufman J, Zoorob R, Briles W. 2004 Nomenclature for the chicken major histocompatibility (B and Y ) complex. Immunogenetics 2004, 56: 261-279. PMID: 15257423, DOI: 10.1007/s00251-004-0682-1.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexInternational Society of Animal GeneticsMajor histocompatibility complex genesChicken major histocompatibility complexGenBank numbersAllele designationAllele sequencesB haplotypesAnimal geneticsSystem of nomenclatureReference stocksHaplotypesPolymorphic regionMajor histocompatibility complex class IAllelesGenesChickenHistocompatibility complexSequenceStandard nomenclatureMajor histocompatibilityNomenclatureChicken major histocompatibilityGenBankStandard system of nomenclature9 Genetic resistance to Marek's disease
Bumstead N, Kaufman J. 9 Genetic resistance to Marek's disease. 2004, 112-vi. DOI: 10.1016/b978-012088379-0/50013-x.Peer-Reviewed Original ResearchChicken major histocompatibility complexGenome mappingMajor histocompatibility complexMD resistance genesChicken genome sequenceMD resistanceMarek's diseaseExpressed class I moleculeInbred chicken linesMajor histocompatibility complex haplotypeGenome sequencePositional cloningGene interactionsResistance genesDNA arraysGenetic mechanismsChicken linesProteomic technologiesGenesIndividual chickensHaplotypesChickenHistocompatibility complexClass I moleculesClass II molecules
2000
The simple chicken major histocompatibility complex: life and death in the face of pathogens and vaccines
Kaufman J. The simple chicken major histocompatibility complex: life and death in the face of pathogens and vaccines. Philosophical Transactions Of The Royal Society B Biological Sciences 2000, 355: 1077-1084. PMID: 11186309, PMCID: PMC1692814, DOI: 10.1098/rstb.2000.0645.Peer-Reviewed Original ResearchConceptsB-F/B-L regionChicken major histocompatibility complexMajor histocompatibility complexMammalian major histocompatibility complexClass II beta genesFace of pathogensExpressed class I moleculeSingle class I geneLevels of RNACell surface expression levelsRous sarcoma virusClass I genesPeptide-binding specificityHistocompatibility complexExpressed class II geneResistance to tumorsSusceptibility to tumorsKilled viral vaccinesBeta geneClass II moleculesB locusClass I moleculesSarcoma virusDisease virusThe major and a minor class II β-chain (B-LB ) gene flank the Tapasin gene in the B-F /B-L region of the chicken major histocompatibility complex
Jacob J, Milne S, Beck S, Kaufman J. The major and a minor class II β-chain (B-LB ) gene flank the Tapasin gene in the B-F /B-L region of the chicken major histocompatibility complex. Immunogenetics 2000, 51: 138-147. PMID: 10663576, DOI: 10.1007/s002510050022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Inbred StrainsAntiportersBase SequenceChickensExonsGene DosageGenes, DominantGenes, MHC Class IIGenetic LinkageHaplotypesHistocompatibility Antigens Class IIHLA-B AntigensImmunoglobulinsIntronsMembrane Transport ProteinsMolecular Sequence DataPhysical Chromosome MappingPolymorphism, GeneticSequence Homology, Nucleic AcidConceptsB-F/B-L regionChicken major histocompatibility complexAdjacent genesB chain genesWell-characterized linesDNA sequencesLines of chickensTapasin geneGenesB12 haplotypeHaplotypesMajor histocompatibility complexB-chainStructural organizationChickenHistocompatibility complexB complexResponse to vaccination
1999
The chicken B locus is a minimal essential major histocompatibility complex
Kaufman J, Milne S, Göbel T, Walker B, Jacob J, Auffray C, Zoorob R, Beck S. The chicken B locus is a minimal essential major histocompatibility complex. Nature 1999, 401: 923-925. PMID: 10553909, DOI: 10.1038/44856.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexMajor histocompatibility complexClass I region genesClass III region genesCo-evolution of genesB locusYears of divergenceMajor histocompatibility complex genesHuman major histocompatibility complexI region genesGenesRegion genesChickenMolecular levelCo-evolutionHistocompatibility complexClass I moleculesMHC5Allograft rejectionHaplotypesI moleculesBirdsHerpes virusMammalsClass II
1991
The “adjuvant effect” of the polymorphic B‐G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes
Salomonsen J, Eriksson H, Skj⊘dt K, Lundgreen T, Simonsen M, Kaufman J. The “adjuvant effect” of the polymorphic B‐G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes. European Journal Of Immunology 1991, 21: 649-658. PMID: 2009909, DOI: 10.1002/eji.1830210317.Peer-Reviewed Original ResearchChicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system.
Salomonsen J, Dunon D, Skjødt K, Thorpe D, Vainio O, Kaufman J. Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1359-1363. PMID: 1996336, PMCID: PMC51017, DOI: 10.1073/pnas.88.4.1359.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexB-G antigensB-G moleculesMajor histocompatibility complexB-F/B-L regionPolymorphic multigene familyCell typesBursal B cellsB cellsCDNA clonesSelection of B cellsB-GMultigene familyCell surface moleculesMHC class IClass II moleculesChicken bursaNorthern blottingPeripheral BErythroid lineageChickenStromal cellsFlow cytometryClass IHistocompatibility complex
1990
Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region.
Kaufman J, Salomonsen J, Skjødt K, Thorpe D. Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 8277-8281. PMID: 2236040, PMCID: PMC54938, DOI: 10.1073/pnas.87.21.8277.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexB-G moleculesIntrachain disulfide bondsSize polymorphismMajor histocompatibility complexAlpha-helical coiled-coil structureCDNA-derived protein sequenceCoiled-coil structurePolymorphic multigene familyDisulfide bondsB-G antigensN-linked carbohydratesDisulfide-linked dimersHeptad repeat regionsProtein sequencesPattern of spotsRepeat regionMultigene familyAlternative splicingB-GHeptad repeatPartial proteolysisApparent homodimerCell surface moleculesCytoplasmic region
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