2022
The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis
Bertzbach L, Tregaskes C, Martin R, Deumer U, Huynh L, Kheimar A, Conradie A, Trimpert J, Kaufman J, Kaufer B. The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis. Frontiers In Immunology 2022, 13: 908305. PMID: 35693787, PMCID: PMC9186122, DOI: 10.3389/fimmu.2022.908305.Peer-Reviewed Original ResearchConceptsMarek's disease virusSPF chickensDisease resistanceMarek's disease virus infectionMarek's disease virus pathogenesisDeterminants of genetic resistanceCommercial chicken linesInfection of chickensGenetic resistanceChicken linesContact birdsDisease virusChickenOncogenic herpesvirusSpecific pathogenMarekLower tumor incidenceLymphoma formationMHC haplotypesPathogensMajor histocompatibility complex haplotypeVaccine productionB21Variable levelsInvading pathogens
2019
Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1): Potential Framework Genes Among a Relatively Stable Number of Genes Per Haplotype
Meziane E, Potts N, Viertlboeck B, Løvlie H, Krupa A, Burke T, Brown S, Watson K, Richardson D, Pizzari T, Göbel T, Kaufman J. Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1): Potential Framework Genes Among a Relatively Stable Number of Genes Per Haplotype. Frontiers In Immunology 2019, 10: 2222. PMID: 31620133, PMCID: PMC6760009, DOI: 10.3389/fimmu.2019.02222.Peer-Reviewed Original ResearchConceptsLeukocyte receptor complexRed junglefowlIg-like receptorsChicken Ig-like receptorsLeukocyte Ig-like receptorsCHIR-AB1Chicken linesExtracellular domainImmunoglobulin-like (Ig-likeHighly-related genesTrios of parentsExtracellular Ig-like domainsStrand-mediated conformational analysisIg-like domainsCommercial chicken linesPositively-charged residuesKiller Ig-like receptorsExperimental chicken linesCytoplasmic tailSequencing studiesIg-likeFramework genesTransmembrane regionSequence relationshipsEgg-laying chickens
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