2023
A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease
Han L, Wu S, Zhang T, Peng W, Zhao M, Yue C, Wen W, Cai W, Li M, Wallny H, Avila D, Mwangi W, Nair V, Ternette N, Guo Y, Zhao Y, Chai Y, Qi J, Liang H, Gao G, Kaufman J, Liu W. A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease. The Journal Of Immunology 2023, 210: 668-680. PMID: 36695776, PMCID: PMC7614295, DOI: 10.4049/jimmunol.2200211.Peer-Reviewed Original ResearchConceptsPeptide-binding grooveResistance to MDMarek's diseaseResistance to Marek's diseaseGas phase sequencingClass I genesPeptide motifsI geneGeneralist allelesChicken MHCImportant pathogensChicken linesMD resistanceCell surfaceAmino acidsB19 chickensExpression levelsChickenOncogenic herpesvirusX-ray crystallographyClass I moleculesPeptideStronger bindingI moleculesMotif
2015
Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity
Tregaskes C, Harrison M, Sowa A, van Hateren A, Hunt L, Vainio O, Kaufman J. Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: 692-697. PMID: 26699458, PMCID: PMC4725490, DOI: 10.1073/pnas.1511859113.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexChicken MHC haplotypesCell surfaceMHC haplotypesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeCell surface expression levelsClass I moleculesPeptide-loading complexB21 haplotypeChicken haplotypesResistance to Marek's diseaseExpression level of MHC class I moleculesHaplotypesGenetic associationAssembly assayHomozygote cellsClass I proteinsAllelic polymorphismI moleculesPeptide libraryTranslocation specificityPromiscuous bindingI protein
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