2012
Antigen processing and presentation: Evolution from a bird's eye view
Kaufman J. Antigen processing and presentation: Evolution from a bird's eye view. Molecular Immunology 2012, 55: 159-161. PMID: 23182425, PMCID: PMC3878743, DOI: 10.1016/j.molimm.2012.10.030.Peer-Reviewed Original ResearchConceptsClass I genesI geneTransporter associated with antigen presentationChicken MHCLevels of allelic polymorphismGene co-evolutionExpressed class I moleculeClass III regionModerate sequence diversityCo-evolutionary relationshipsNon-mammalian speciesClass I lociClass I regionClass I moleculesClass II regionCo-evolutionGenome organisationSequence diversityMultigene familyProteasome componentsPrimordial MHCI lociProcessing genesStudies of chickensReceptor-ligand interactions
2011
The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes
Walker B, Hunt L, Sowa A, Skjødt K, Göbel T, Lehner P, Kaufman J. The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8396-8401. PMID: 21536896, PMCID: PMC3100931, DOI: 10.1073/pnas.1019496108.Peer-Reviewed Original ResearchConceptsExpressed class I moleculeChicken MHC haplotypesTransporter associated with antigen presentationModerate sequence diversityMHC haplotypesClass I genesClass I moleculesSequence diversityPrimordial MHCI genePeptide motifsChicken MHCChicken linesAllelic polymorphismI moleculesPeptide translocationPeptide bindingAdaptive immune systemMHC associationsCoevolutionPeptide transportHaplotypesAntigen presentation pathwayPeptide positionChicken
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