2023
A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease
Han L, Wu S, Zhang T, Peng W, Zhao M, Yue C, Wen W, Cai W, Li M, Wallny H, Avila D, Mwangi W, Nair V, Ternette N, Guo Y, Zhao Y, Chai Y, Qi J, Liang H, Gao G, Kaufman J, Liu W. A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease. The Journal Of Immunology 2023, 210: 668-680. PMID: 36695776, PMCID: PMC7614295, DOI: 10.4049/jimmunol.2200211.Peer-Reviewed Original ResearchConceptsPeptide-binding grooveResistance to MDMarek's diseaseResistance to Marek's diseaseGas phase sequencingClass I genesPeptide motifsI geneGeneralist allelesChicken MHCImportant pathogensChicken linesMD resistanceCell surfaceAmino acidsB19 chickensExpression levelsChickenOncogenic herpesvirusX-ray crystallographyClass I moleculesPeptideStronger bindingI moleculesMotif
2022
The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis
Bertzbach L, Tregaskes C, Martin R, Deumer U, Huynh L, Kheimar A, Conradie A, Trimpert J, Kaufman J, Kaufer B. The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis. Frontiers In Immunology 2022, 13: 908305. PMID: 35693787, PMCID: PMC9186122, DOI: 10.3389/fimmu.2022.908305.Peer-Reviewed Original ResearchConceptsMarek's disease virusSPF chickensDisease resistanceMarek's disease virus infectionMarek's disease virus pathogenesisDeterminants of genetic resistanceCommercial chicken linesInfection of chickensGenetic resistanceChicken linesContact birdsDisease virusChickenOncogenic herpesvirusSpecific pathogenMarekLower tumor incidenceLymphoma formationMHC haplotypesPathogensMajor histocompatibility complex haplotypeVaccine productionB21Variable levelsInvading pathogens
2021
The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motif
Halabi S, Ghosh M, Stevanović S, Rammensee H, Bertzbach L, Kaufer B, Moncrieffe M, Kaspers B, Härtle S, Kaufman J. The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motif. PLOS Biology 2021, 19: e3001057. PMID: 33901176, PMCID: PMC8101999, DOI: 10.1371/journal.pbio.3001057.Peer-Reviewed Original ResearchConceptsMarek's disease virusMarek's diseaseSusceptibility to Marek's diseaseSusceptibility to many viral diseasesViral diseasesAmino acidsHaplotype B2Disease virusMarekZoonotic pathogensFood speciesChickenOncogenic herpesvirusFood sourcesViral peptide epitopesComplex virusesMajor histocompatibility complexIn vitro infection systemPeptide motifsFoodClass II moleculesQuestions of mechanismExpress class II moleculesAntigenic peptides to T lymphocytesAcid
2016
Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region
Pawlica P, Moss WN, Steitz JA. Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region. RNA 2016, 22: 1181-1189. PMID: 27335146, PMCID: PMC4931111, DOI: 10.1261/rna.054817.115.Peer-Reviewed Original ResearchConceptsSmall nuclear RNAMiR-27Nuclear RNAVivo secondary structureBioinformatic structural analysisBinding site sequenceMiRNA degradationU RNARNA functionMutagenic analysisHSUR1Interacting regionsSite sequenceHost microRNAsSecondary structureHerpesvirus saimiriT cell activationOncogenic herpesvirusRNAStructural flexibilityDecreased levelsMutantsStructural analysisDegradationMicroRNAs
2007
Structures of an MHC Class I Molecule from B21 Chickens Illustrate Promiscuous Peptide Binding
Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny H, van Hateren A, Hunt L, Jacob J, Johnston F, Marston D, Shaw I, Dunbar P, Cerundolo V, Jones E, Kaufman J. Structures of an MHC Class I Molecule from B21 Chickens Illustrate Promiscuous Peptide Binding. Immunity 2007, 27: 885-899. PMID: 18083574, DOI: 10.1016/j.immuni.2007.11.007.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexB21 haplotypeChicken major histocompatibility complexBF2*2101Peptide-binding siteMajor histocompatibility complex class I moleculesClass I moleculesBinding grooveGenetic associationStructure of major histocompatibility complexPromiscuous bindingPeptide bindingI moleculesHaplotypesCharge-transfer systemsMajor histocompatibility complex moleculesConformational flexibilityCentral cavityInfectious pathogensHistocompatibility complexAnchor residuesBindingOncogenic herpesvirusPeptideResidues
1994
The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes.
Toczyski DP, Matera AG, Ward DC, Steitz JA. The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3463-3467. PMID: 8159770, PMCID: PMC43597, DOI: 10.1073/pnas.91.8.3463.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusHuman B lymphocytesB lymphocytesEBV-positive lymphocytesEBV-positive cellsEBER1 RNAUninfected human cellsCertain patientsEBER1Ribosomal protein L22LymphocytesChromosomal translocationsOncogenic herpesvirusProtein L22Situ hybridizationUninfected cell extractsNucleoplasmic stainingVivoCell transformationHigh levelsHuman cellsCellsPatientsLeukemiaCellular proteins
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