2020
Origins of the RAG Transposome and the MHC
Tsakou-Ngouafo L, Paganini J, Kaufman J, Pontarotti P. Origins of the RAG Transposome and the MHC. Trends In Immunology 2020, 41: 561-571. PMID: 32467030, DOI: 10.1016/j.it.2020.05.002.Peer-Reviewed Original Research
2019
A potential nomenclature for the Immuno Polymorphism Database (IPD) of chicken MHC genes: progress and problems
Afrache H, Tregaskes C, Kaufman J. A potential nomenclature for the Immuno Polymorphism Database (IPD) of chicken MHC genes: progress and problems. Immunogenetics 2019, 72: 9-24. PMID: 31741010, PMCID: PMC6971145, DOI: 10.1007/s00251-019-01145-6.Peer-Reviewed Original ResearchConceptsChicken MHC genesImmuno Polymorphism DatabaseMajor histocompatibility complexIdentical sequencesNomenclature systemClass II B sequencesMHC genesHighest allelic polymorphismsIPD-MHC DatabaseMHC sequencesGeneral sequence databasesClass II lociClassical class IGene conversionPolymorphism databaseSequence diversitySequence databasesCurated sequencesB sequencesII lociHaplotypesAllelic polymorphismGenesAllelesSequence
2016
Different modes of variation for each BG lineage suggest different functions
Chattaway J, Ramirez-Valdez R, Chappell P, Caesar J, Lea S, Kaufman J. Different modes of variation for each BG lineage suggest different functions. Open Biology 2016, 6: 160188. PMID: 27628321, PMCID: PMC5043582, DOI: 10.1098/rsob.160188.Peer-Reviewed Original ResearchConceptsComplementarity-determining region 1BG genesGenomic locationsSequence cassettesSequence diversityChromosome 2Phenotypic variationLipid bindingIntracellular regionImmunoglobulin variableAllelic polymorphismPolymorphic residuesImmune defenceGenesT cellsRegion 1ButyrophilinBG1Co-inhibitionTissue distributionDiversityImmune systemChromosomeHomologuesCDR2IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis
Yousefi A, Mahmoudi E, Bidoki A, Varzaneh F, Noveiry B, Sadr M, Motamed F, Najafi M, Farahmand F, Rezaei N. IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. Expert Review Of Gastroenterology & Hepatology 2016, 10: 659-663. PMID: 26735262, DOI: 10.1586/17474124.2016.1139449.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisC alleleAssociation of autoimmune hepatitisMechanisms of autoimmune hepatitisAutoimmune hepatitis patientsAllelic polymorphismInvestigate potential associationsPotential therapeutic interventionsHepatocellular inflammationAuto-antibodiesTT genotypeCC genotypeGene polymorphismsIranian patientsIL4 geneGene variantsIL4RA geneSusceptibility genesIL4Therapeutic interventionsHepatitisPatientsGenetic componentGenesPolymorphism
2015
Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity
Tregaskes C, Harrison M, Sowa A, van Hateren A, Hunt L, Vainio O, Kaufman J. Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: 692-697. PMID: 26699458, PMCID: PMC4725490, DOI: 10.1073/pnas.1511859113.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexChicken MHC haplotypesCell surfaceMHC haplotypesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeCell surface expression levelsClass I moleculesPeptide-loading complexB21 haplotypeChicken haplotypesResistance to Marek's diseaseExpression level of MHC class I moleculesHaplotypesGenetic associationAssembly assayHomozygote cellsClass I proteinsAllelic polymorphismI moleculesPeptide libraryTranslocation specificityPromiscuous bindingI protein
2011
The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes
Walker B, Hunt L, Sowa A, Skjødt K, Göbel T, Lehner P, Kaufman J. The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8396-8401. PMID: 21536896, PMCID: PMC3100931, DOI: 10.1073/pnas.1019496108.Peer-Reviewed Original ResearchConceptsExpressed class I moleculeChicken MHC haplotypesTransporter associated with antigen presentationModerate sequence diversityMHC haplotypesClass I genesClass I moleculesSequence diversityPrimordial MHCI genePeptide motifsChicken MHCChicken linesAllelic polymorphismI moleculesPeptide translocationPeptide bindingAdaptive immune systemMHC associationsCoevolutionPeptide transportHaplotypesAntigen presentation pathwayPeptide positionChicken
2008
High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC
Rogers S, Kaufman J. High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC. Immunogenetics 2008, 60: 461. PMID: 18574582, DOI: 10.1007/s00251-008-0307-1.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAmino Acid SequenceAnimalsBase SequenceChickensDNA, ComplementaryFlow CytometryGenetic VariationHaplotypesHumansKiller Cells, NaturalLectins, C-TypeModels, ImmunologicalMolecular Sequence DataPolymorphism, GeneticReceptors, ImmunologicReceptors, MitogenSelection, GeneticSequence Homology, Amino AcidConceptsMarek's disease virusChicken major histocompatibility complexB-lecDisease virusB-NKLines of domestic chickensModerate sequence diversityHighest allelic polymorphismsMajor histocompatibility complexSequence diversityAssociated with resistanceOncogenic herpes virusDomestic chickensComplementary deoxyribonucleic acidType II membrane proteinAllelic polymorphismChickenN-linked glycosylation sitesAmino acid substitutionsAllelic variationActivation-induced receptorLigand-binding facePurifying selectionDisulfide-linked homodimerProtein sequences
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