A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease
Han L, Wu S, Zhang T, Peng W, Zhao M, Yue C, Wen W, Cai W, Li M, Wallny H, Avila D, Mwangi W, Nair V, Ternette N, Guo Y, Zhao Y, Chai Y, Qi J, Liang H, Gao G, Kaufman J, Liu W. A wider and deeper peptide-binding groove for the class I molecules from B15 compared to B19 chickens correlates with relative resistance to Marek’s disease. The Journal Of Immunology 2023, 210: 668-680. PMID: 36695776, PMCID: PMC7614295, DOI: 10.4049/jimmunol.2200211.Peer-Reviewed Original ResearchConceptsPeptide-binding grooveResistance to MDMarek's diseaseResistance to Marek's diseaseGas phase sequencingClass I genesPeptide motifsI geneGeneralist allelesChicken MHCImportant pathogensChicken linesMD resistanceCell surfaceAmino acidsB19 chickensExpression levelsChickenOncogenic herpesvirusX-ray crystallographyClass I moleculesPeptideStronger bindingI moleculesMotif
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply