The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis
Bertzbach L, Tregaskes C, Martin R, Deumer U, Huynh L, Kheimar A, Conradie A, Trimpert J, Kaufman J, Kaufer B. The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek’s Disease Virus Pathogenesis and Tumorigenesis. Frontiers In Immunology 2022, 13: 908305. PMID: 35693787, PMCID: PMC9186122, DOI: 10.3389/fimmu.2022.908305.Peer-Reviewed Original ResearchConceptsMarek's disease virusSPF chickensDisease resistanceMarek's disease virus infectionMarek's disease virus pathogenesisDeterminants of genetic resistanceCommercial chicken linesInfection of chickensGenetic resistanceChicken linesContact birdsDisease virusChickenOncogenic herpesvirusSpecific pathogenMarekLower tumor incidenceLymphoma formationMHC haplotypesPathogensMajor histocompatibility complex haplotypeVaccine productionB21Variable levelsInvading pathogens
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