2020
From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles
Kaufman J. From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles. Frontiers In Immunology 2020, 11: 601089. PMID: 33381122, PMCID: PMC7767893, DOI: 10.3389/fimmu.2020.601089.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMajor histocompatibility complexPeptide motifsClass I moleculesCytotoxic T lymphocytesCell surfaceChicken major histocompatibility complexClass I allelesBinding peptidesI moleculesNatural killerClassical class I moleculesResistance to infectious diseasesMultigene familyRepertoire of bound peptidesI allelesThymus-derived (T) cellsReceptor-ligand interactionsNK cell functionImmunoglobulin-like receptorsPeptide-bindingMajor histocompatibility complex class I allelePeptide repertoireAllelesMHC-I molecules
2019
Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC
Potts N, Bichet C, Merat L, Guitton E, Krupa A, Burke T, Kennedy L, Sorci G, Kaufman J. Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC. Immunogenetics 2019, 71: 647-663. PMID: 31761978, PMCID: PMC6900278, DOI: 10.1007/s00251-019-01149-2.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complex genesSingle nucleotide polymorphismsClassical class IMajor histocompatibility complexClass II B genesChicken MHC haplotypesStrand-mediated conformational analysisGenes of chickenChicken major histocompatibility complexMajor histocompatibility complex allelesSusceptibility to infectious pathogensB geneInfectious pathogensClass II BImmune responses to infectious pathogensNucleotide polymorphismsResponse to infectious pathogensTyping protocolHaplotypesClass IMHC haplotypesChickenAllelesPathogensClass I alleles
2018
An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I
Xiao J, Xiang W, Zhang Y, Peng W, Zhao M, Niu L, Chai Y, Qi J, Wang F, Qi P, Pan C, Han L, Wang M, Kaufman J, Gao G, Liu W. An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I. The Journal Of Immunology 2018, 201: 3084-3095. PMID: 30341185, DOI: 10.4049/jimmunol.1800611.Peer-Reviewed Original ResearchConceptsClassical class I moleculesC-terminusNonmammalian vertebratesChicken MHC class IC-terminal endExpressed class I moleculeClass I moleculesPeptide-binding groovePeptides to T lymphocytesJawed vertebratesClass II moleculesArg residuesChicken MHCI moleculesMHC class I allelesRepertoire of peptidesVertebratesPeptide C-terminusII moleculesMammalsClassical class II moleculesClass I allelesPeptideArgI allelesThe newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer
Caldwell A, Coleby R, Tovar C, Stammnitz M, Kwon Y, Owen R, Tringides M, Murchison E, Skjødt K, Thomas G, Kaufman J, Elliott T, Woods G, Siddle H. The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer. ELife 2018, 7: e35314. PMID: 30103855, PMCID: PMC6092122, DOI: 10.7554/elife.35314.Peer-Reviewed Original ResearchConceptsDevil facial tumour 2Devil Facial Tumour 1Contagious cancerExpressed MHC class I allelesLoss of MHCClass I allelesMHC class I allelesNon-polymorphicAllogeneic antigensTumors 2Evolutionary trajectoriesTumor 1Disease 2Tasmanian devilI allelesReduced immunogenicityCancerMHCIn vivoWidespread transmissionHostGeneralists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens
Kaufman J. Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens. Trends In Immunology 2018, 39: 367-379. PMID: 29396014, PMCID: PMC5929564, DOI: 10.1016/j.it.2018.01.001.Peer-Reviewed Original Research
2015
What chickens would tell you about the evolution of antigen processing and presentation
Kaufman J. What chickens would tell you about the evolution of antigen processing and presentation. Current Opinion In Immunology 2015, 34: 35-42. PMID: 25626087, DOI: 10.1016/j.coi.2015.01.001.Peer-Reviewed Original ResearchConceptsAdaptive immune system of jawed vertebratesChicken MHCImmune system of jawed vertebratesGenes co-evolvePeptide-binding repertoireNon-mammalian vertebratesAncestral arrangementJawed vertebratesResistance to diseasePolymorphic genesAntigen processingAdaptive immune systemMHC haplotypesVertebratesGenesCo-evolutionChickenClass I allelesMammalsI allelesOriginal pathwayHaplotypesAllelesMHC
2008
HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control
Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control. Journal Of Virology 2008, 82: 5398-5407. PMID: 18353945, PMCID: PMC2395228, DOI: 10.1128/jvi.02176-07.Peer-Reviewed Original ResearchConceptsT cell responsesHLA class IElite controllersT cellsViremic controllersVirus controlClass IInterleukin-2HIV-specific T-cell responsesT cell-mediated controlUndetectable HIV RNA levelsHuman immunodeficiency virus (HIV) infectionHLA class I allelesProtective class IHIV RNA levelsHLA class I polymorphismImmunodeficiency virus infectionLong-term virus controlCell-mediated controlHuman immunodeficiency virusClass I allelesClass I polymorphismAntiretroviral therapyHIV controllersHIV transmission
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