2022
Chapter 7 The avian major histocompatibility complex
Kaufman J. Chapter 7 The avian major histocompatibility complex. 2022, 135-161. DOI: 10.1016/b978-0-12-818708-1.00033-6.Peer-Reviewed Original Research
2020
Origins of the RAG Transposome and the MHC
Tsakou-Ngouafo L, Paganini J, Kaufman J, Pontarotti P. Origins of the RAG Transposome and the MHC. Trends In Immunology 2020, 41: 561-571. PMID: 32467030, DOI: 10.1016/j.it.2020.05.002.Peer-Reviewed Original ResearchAdvances in the Evolutionary Understanding of MHC Polymorphism
Radwan J, Babik W, Kaufman J, Lenz T, Winternitz J. Advances in the Evolutionary Understanding of MHC Polymorphism. Trends In Genetics 2020, 36: 298-311. PMID: 32044115, DOI: 10.1016/j.tig.2020.01.008.Peer-Reviewed Original ResearchConceptsExcess of nonsynonymous changesMHC gene familyPathogen-driven selectionVertebrate adaptive immune responsePeptide-binding domainGene genealogiesAdaptive introgressionDeleterious mutationsGene familyNonsynonymous changesGeographic subdivisionMHC polymorphismMHC genesMHC allelesComplexity of selectionCell surfaceEvolutionary understandingImmune responseAdaptive immune responsesGenesPolymorphismPeptide antigensIntrogressionHitchhikingVertebrates
2019
A potential nomenclature for the Immuno Polymorphism Database (IPD) of chicken MHC genes: progress and problems
Afrache H, Tregaskes C, Kaufman J. A potential nomenclature for the Immuno Polymorphism Database (IPD) of chicken MHC genes: progress and problems. Immunogenetics 2019, 72: 9-24. PMID: 31741010, PMCID: PMC6971145, DOI: 10.1007/s00251-019-01145-6.Peer-Reviewed Original ResearchConceptsChicken MHC genesImmuno Polymorphism DatabaseMajor histocompatibility complexIdentical sequencesNomenclature systemClass II B sequencesMHC genesHighest allelic polymorphismsIPD-MHC DatabaseMHC sequencesGeneral sequence databasesClass II lociClassical class IGene conversionPolymorphism databaseSequence diversitySequence databasesCurated sequencesB sequencesII lociHaplotypesAllelic polymorphismGenesAllelesSequence
2016
Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems
Rogers S, Kaufman J. Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems. Immunogenetics 2016, 68: 499-513. PMID: 27457887, PMCID: PMC5002281, DOI: 10.1007/s00251-016-0938-6.Peer-Reviewed Original ResearchConceptsCD1 genesGenomic locationsEvolutionary historyAdaptive immune system of jawed vertebratesImmune system of jawed vertebratesGenome-wide duplicationMHC paralogous regionClass II sequencesParalogous regionsPhylogenetic analysisJawed vertebratesII sequencesLipid antigensCD1 moleculesCell surface moleculesAntigen presenting moleculesMHC genesGenesPresenting moleculesReptilesVertebratesFunctional attributesBirdsSurface moleculesCD1
2008
Characterization of a Nonclassical Class I MHC Gene in a Reptile, the Galápagos Marine Iguana (Amblyrhynchus cristatus)
Glaberman S, Du Pasquier L, Caccone A. Characterization of a Nonclassical Class I MHC Gene in a Reptile, the Galápagos Marine Iguana (Amblyrhynchus cristatus). PLOS ONE 2008, 3: e2859. PMID: 18682845, PMCID: PMC2483932, DOI: 10.1371/journal.pone.0002859.Peer-Reviewed Original ResearchConceptsGalápagos marine iguanasClass I MHC genesMHC genesMarine iguanasLarge taxonomic gapsClassical class I genesGenomic sequence dataClassical MHC genesMajor histocompatibility complex (MHC) genesPeptide-binding residuesClass I genesMHC evolutionNonclassical genesVertebrate taxaDiverse orderClass I sequencesMHC organizationCytoplasmic domainPhylogenetic analysisGenomic sequencesTaxonomic gapsConserved characterI geneSequence dataI sequencesSpecies-specific evolution of class I MHC genes in iguanas (Order: Squamata; Subfamily: Iguaninae)
Glaberman S, Caccone A. Species-specific evolution of class I MHC genes in iguanas (Order: Squamata; Subfamily: Iguaninae). Immunogenetics 2008, 60: 371-382. PMID: 18488213, DOI: 10.1007/s00251-008-0298-y.Peer-Reviewed Original ResearchConceptsMarine iguanasSpecies-specific evolutionGalápagos land iguanasGalápagos marine iguanasDifferent phylogenetic historiesNon-avian reptilesSpecies-specific mannerClass I MHC genesMajor histocompatibility complexConservation geneticsPhylogenetic historySquamate speciesVertebrate taxaDiversified orderGenetic diversityNatural selectionMHC researchDNA dataGenetic basisLand iguanasMultiple lociMHC genesMHC studiesHost resistanceIguanasF.33. Genetic Variants that Control the Expression of MHC Genes Do Not Affect Susceptibility to Multiple Sclerosis
Ottoboni L, Young E, Yelensky R, Hafler D, Daly M, De Jager P. F.33. Genetic Variants that Control the Expression of MHC Genes Do Not Affect Susceptibility to Multiple Sclerosis. Clinical Immunology 2008, 127: s53-s54. DOI: 10.1016/j.clim.2008.03.145.Peer-Reviewed Original ResearchMHC genesGenetic variants
1997
The “Minimal Essential MHC” Revisited: Both Peptide‐Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens
Kaufman J, Salomonsen J. The “Minimal Essential MHC” Revisited: Both Peptide‐Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens. Hereditas 1997, 127: 67-73. PMID: 9420472, DOI: 10.1111/j.1601-5223.1997.t01-1-00067.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, ViralBinding SitesChickensEvolution, MolecularGenes, MHC Class IGenes, MHC Class IIHaplotypesHistocompatibility Antigens Class IImmunity, InnateMajor Histocompatibility ComplexMarek DiseaseModels, GeneticModels, ImmunologicalPolymorphism, GeneticPoultry DiseasesSelection, GeneticSpecies SpecificityVertebratesVirus DiseasesConceptsChicken MHC haplotypesCell surface expression levelsSusceptibility to Marek's diseaseMarek's disease virusMHC of chickensMinimal essential MHCMHC haplotypesExpression level differencesMarek's diseaseChicken linesPeptide-binding specificityDisease virusClass I moleculesPeptide motifsLevels of class I expressionChickenMHC genesHaplotypesViral diseasesOutcome of infectionPeptide-bindingMHC associationsI moleculesMouse haplotypesPathogens
1996
The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.
Riegert P, Andersen R, Bumstead N, Döhring C, Dominguez-Steglich M, Engberg J, Salomonsen J, Schmid M, Schwager J, Skjødt K, Kaufman J. The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 1243-1248. PMID: 8577748, PMCID: PMC40064, DOI: 10.1073/pnas.93.3.1243.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase CompositionBase Sequencebeta 2-MicroglobulinBlotting, SouthernChickensChromosome MappingCloning, MolecularConsensus SequenceCrosses, GeneticDNADNA, ComplementaryEnhancer Elements, GeneticErythrocytesFemaleGenes, MHC Class IHumansIn Situ HybridizationMajor Histocompatibility ComplexMaleMolecular Sequence DataPolymorphism, GeneticPolymorphism, Restriction Fragment LengthPromoter Regions, GeneticRestriction MappingSequence Homology, Nucleic AcidT-LymphocytesConceptsY-boxHigh G+C contentBeta 2-microglobulin geneDeletion of DNARestriction fragment length polymorphismInterferon regulatory elementSubunit of major histocompatibility complexFragment length polymorphismG+C contentGenome organizationGenomic clonesG+C-richAntigenic peptides to T lymphocytesPeptides to T lymphocytesRegulatory elementsCoding regionMicrochromosomesPromoter regionBackcross familiesChicken MHCLength polymorphismMHC genesGenesCongenic linesI alpha
1995
A “Minimal Essential Mhc” and an “Unrecognized Mhc”: Two Extremes in Selection for Polymorphism
Kaufman J, Völk H, Wallny H. A “Minimal Essential Mhc” and an “Unrecognized Mhc”: Two Extremes in Selection for Polymorphism. Immunological Reviews 1995, 143: 63-88. PMID: 7558083, DOI: 10.1111/j.1600-065x.1995.tb00670.x.Peer-Reviewed Original ResearchConceptsMHC polymorphismMHC genesChicken MHC haplotypesDisease resistance genesMinimal essential MHCMHC haplotypesExamples of selectionMultigene familyMammalian MHCPathogen resistancePeptide motifsDisease resistanceResistance genesVertebrate groupsHaplotypesDisease associationsGenesMammalsMHC moleculesPolymorphismPolymorphic MHCSalamandersPathogensInfectious pathogensChicken
1993
Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family
Buldyrev S, Goldberger A, Havlin S, Peng C, Stanley H, Stanley M, Simons M. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family. Biophysical Journal 1993, 65: 2673-2679. PMID: 8312501, PMCID: PMC1226007, DOI: 10.1016/s0006-3495(93)81290-6.Peer-Reviewed Original ResearchConceptsMyosin heavy chain gene familyHeavy chain gene familyIntrons-late theoryMyosin heavy chain sequencesGene evolutionMolecular evolutionGene familyNucleotide sequenceMHC genesDifferent speciesDNA walksHeavy chain sequencesFractal landscapesSequenceChain sequencesVertebratesYeastGenesEvolutionSpeciesDNALandscape analysisSimple iterative modelPolymeric sequencesFamily
1985
Lymphotoxin redux
Ruddle N. Lymphotoxin redux. Trends In Immunology 1985, 6: 156-159. PMID: 25289782, DOI: 10.1016/0167-5699(85)90144-6.Peer-Reviewed Original Research
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