2025
A Review of Relapse in Opioid Use Disorder
Draghmeh K, Gold M, Fuehrlein B. A Review of Relapse in Opioid Use Disorder. Current Addiction Reports 2025, 12: 58. DOI: 10.1007/s40429-025-00672-5.Peer-Reviewed Original ResearchUse disorderEnhance treatment retentionMindfulness-based therapyStress system dysregulationRelapse vulnerabilityOpioid use disorderNeurobiological mechanismsDopamine deficitMedication-Assisted TreatmentContingency managementTreatment retentionPsychosocial interventionsMechanisms of relapseReduce relapseBehavioral componentsReviewOpioid use disorderSignificant public health challengeSystem dysregulationPublic health challengeRelapse rateAt-risk populationsSocietal burdenEmergency therapyAt-riskRelapseEpidemiology of Opioid Use, Misuse, and Overdoses
Draghmeh K, Gold M, Fuehrlein B. Epidemiology of Opioid Use, Misuse, and Overdoses. Current Addiction Reports 2025, 12: 36. DOI: 10.1007/s40429-025-00649-4.Peer-Reviewed Original ResearchOpioid use disorderEpidemiology of opioid useComplex public health challengesMental health disordersRisk factorsPublic health challengeOpioid useHarm reduction programsSocioeconomic disadvantagePsychosocial interventionsAccess barriersHealth disordersHealth challengesReduction programsOverdose deathsImprove outcomesGenetic predispositionCollaborative effortsPolysubstance useTreatment retentionEpidemiologyInnovative therapiesIncreasing overdose deathsReviewThis reviewLimited accessibilityThe Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series.
Neptune A, Kaliamurthy S. The Use of Extended-Release Buprenorphine in the Treatment of Adolescent Opioid Use Disorder: A Case Series. Journal Of Addiction Medicine 2025 PMID: 39898524, DOI: 10.1097/adm.0000000000001447.Peer-Reviewed Original ResearchExtended-release buprenorphineOpioid use disorderCase seriesUse disorderOpioid abstinenceMedical recordsTreatment of opioid use disorderChart review periodNo significant complicationsDuration of treatmentOnset of treatmentMedical records of adolescentsRecords of adolescentsExtended-releaseSublingual buprenorphinePatient ageSignificant complicationsSubcutaneous injectionOpioidBuprenorphinePatientsOutpatient settingTreatment approachesElectronic medical recordsTreatment retention
2024
Strategic Treatment and Assessment for Youth (STAY): A Theoretically-Driven, Culturally-Tailored MBC Approach
Arora P, Awad M, Parr K, Connors E. Strategic Treatment and Assessment for Youth (STAY): A Theoretically-Driven, Culturally-Tailored MBC Approach. Administration And Policy In Mental Health And Mental Health Services Research 2024, 52: 261-276. PMID: 39541064, PMCID: PMC11703679, DOI: 10.1007/s10488-024-01419-6.Peer-Reviewed Original ResearchMeasurement-based careREM youthTreatment retentionDepressive symptomsTheoretically-drivenImprove treatment retentionAlliance measuresBarriers to treatmentPremature dropoutSuicide riskSuicidal thoughtsTreatment engagementREM populationsFeedback processesClient outcomesTreatment expectationsREMWhite peersSuicideYouthCultural competency trainingCompetency trainingSymptomsTreatment assessmentDepressionMeasurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes
Schick M, Kiluk B, Nich C, LaPaglia D, Haeny A. Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes. Journal Of Substance Use And Addiction Treatment 2024, 166: 209493. PMID: 39151798, PMCID: PMC11392621, DOI: 10.1016/j.josat.2024.209493.Peer-Reviewed Original ResearchCocaine use disorderPerceived Stress ScaleTreatment retentionMeasurement invarianceTreatment outcomesSubstance Use Treatment OutcomesStress ScalePredicting treatment retentionSelf-EfficacyCoping self-efficacyTwo-factor modelInfluence treatment outcomeCocaine abuse/dependenceDSM-IVUse disorderCocaine useBetween-group differencesMetric invarianceScalar invarianceTwo-factorCocainePharmacological treatmentFactor analysisDifferential impactAbuse/dependenceThe cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections
Ivasiy R, Madden L, DiDomizio E, Johnson K, Machavariani E, Ahmad B, Oliveros D, Ram A, Kil N, Altice F. The cascade of care for commercially-insured persons with opioid use disorder and comorbid HIV and HCV infections. Drug And Alcohol Dependence 2024, 263: 112410. PMID: 39159600, PMCID: PMC12045330, DOI: 10.1016/j.drugalcdep.2024.112410.Peer-Reviewed Original ResearchOpioid use disorderXR-NTXUse disorderHCV infectionPrescribed MOUDOpioid use disorder cascadePrevalence of opioid use disorderRetrospective cohort studyHigher treatment retentionCascade of careConcurrent infectious diseasesSix-month retentionHCV/HIV coinfectionComorbid HIVCohort studyHospital-based settingPrescribed methadoneHCVMOUD initiationHIVHCV epidemicOpioidMethadoneMOUD prescriptionsTreatment retentionThe impact of emergency guidance to the COVID‐19 pandemic on treatment entry, retention and mortality among patients on methadone in Ukraine
Ivasiy R, Madden L, Meteliuk A, Machavariani E, Ahmad B, Zelenev A, Desai M, Bromberg D, Polonsky M, de Leon S, Farnum S, Islam Z, Altice F. The impact of emergency guidance to the COVID‐19 pandemic on treatment entry, retention and mortality among patients on methadone in Ukraine. Addiction 2024, 119: 1585-1596. PMID: 38807448, DOI: 10.1111/add.16565.Peer-Reviewed Original ResearchOpioid agonist therapyTake-home dosesCOVID-19 guidancePre-COVID cohortAgonist therapyOptimal doseTreatment retentionEmergency guidanceEffective HIV prevention strategiesAdult HIV prevalenceHIV prevention strategiesMinistry of HealthImprove treatment retentionMethadone dosePatient survivalTime-dependent predictorsProspective cohortHIV prevalencePredictors of treatment retentionGovernmental clinicsPrimary outcomeHazard ratioPatient enrollmentPatientsMethadone patients“They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose
Dickson-Gomez J, Krechel S, Ohlrich J, Montaque H, Weeks M, Li J, Havens J, Spector A. “They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose. Harm Reduction Journal 2024, 21: 52. PMID: 38413972, PMCID: PMC10900746, DOI: 10.1186/s12954-024-00964-5.Peer-Reviewed Original ResearchConceptsOpioid use disorderDrug treatmentImprove treatment retentionTreat opioid use disorderAttended group treatmentOpioid overdoseMedically managed withdrawalHeightened risk of overdoseRates of opioid overdoseCourse of treatmentTreatment retentionGroup treatmentUse disorderRisk of overdoseTreatment participationAbstinence requirementRespiratory depressionManaged withdrawalOpioidInitiate MOUDMOUD initiationMOUD stigmaMOUD treatmentHeightened riskOpioid overdose crisis
2023
An exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorder
Worden B, Tolin D, Stevens M. An exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorder. Journal Of Affective Disorders 2023, 345: 410-418. PMID: 38706461, PMCID: PMC11068362, DOI: 10.1016/j.jad.2023.10.148.Peer-Reviewed Original ResearchCognitive behavioral therapyBrain activityEffective cognitive behavioral therapyCognitive-behavioral group therapyTreatment attendanceBrain dysfunctionFunctional magnetic resonanceDiscarding taskExecutive functioningAbnormal brain activityNeural predictorsHomework completionGroup therapyTreatment engagementHD patientsTreatment complianceHD treatmentPremotor areasActivity abnormalitiesPatient's abilityBrain regionsTherapeutic benefitTreatment retentionRegion activityPrior researchAn exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorder.
Worden B, Tolin D, Stevens M. An exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorder. Journal Of Affective Disorders 2023 PMID: 39492520, DOI: 10.1016/j.jad.2023.10.148.Peer-Reviewed Original ResearchCognitive-behavioral therapyHoarding DisorderBrain activityTreatment attendanceBrain dysfunctionCognitive-behavioral group therapyEffective cognitive-behavioral therapyAssociated with treatment attendanceFunctional magnetic resonanceAbnormal brain activityExecutive functionGroup therapyHomework completionTreatment retentionTreatment engagementBrain regionsActivation abnormalitiesRegional activityPremotor areasTreatment complianceInsulaCompliance variablesBrainPatient's abilityDisordersClinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder
Kiluk B, Kleykamp B, Comer S, Griffiths R, Huhn A, Johnson M, Kampman K, Pravetoni M, Preston K, Vandrey R, Bergeria C, Bogenschutz M, Brown R, Dunn K, Dworkin R, Finan P, Hendricks P, Houtsmuller E, Kosten T, Lee D, Levin F, McRae-Clark A, Raison C, Rasmussen K, Turk D, Weiss R, Strain E. Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder. JAMA Psychiatry 2023, 80: 84-92. PMID: 36449315, PMCID: PMC10297827, DOI: 10.1001/jamapsychiatry.2022.4020.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD treatmentUse disordersClinical trial design challengesAddiction Clinical Trial TranslationsΜ-opioid receptor systemNetworks (ACTTION) public-private partnershipTrial design challengesOngoing opioid epidemicTrial design considerationsClinical trial design considerationsRole of treatmentQuality of lifeAntagonist medicationsEmerging TreatmentsAdverse eventsOpioid usePrimary outcomeStages of treatmentPatient preferencesMOR agonistsOpioid epidemicConsensus recommendationsCurrent evidenceTreatment retentionA Modified Measurement-Based Care Approach to Improve Mental Health Treatment Engagement Among Racial and Ethnic Minoritized Youth
Connors EH, Arora PG, Resnick SG, McKay M. A Modified Measurement-Based Care Approach to Improve Mental Health Treatment Engagement Among Racial and Ethnic Minoritized Youth. Psychological Services 2023, 20: 170-184. PMID: 35130008, PMCID: PMC9357230, DOI: 10.1037/ser0000617.Peer-Reviewed Original ResearchTreatment engagementPerceptual barriersMinoritized youthTreatment engagement strategiesMental health treatment engagementMeasurement-based carePoor therapeutic allianceMental health treatmentUse of MBCFuture research directionsHealth treatmentTherapeutic allianceTreatment retentionYouthClient outcomesWhite peersClient-centred practiceRetention strategiesCase exampleClient involvementClient populationEngagement strategiesEngagementResearch directionsTreatment services
2022
The impact of benzodiazepine exposure on treatment retention in an open-access methadone program: A retrospective cohort study
Morford K, Tetrault J, Zhou B, Li F, Gleeson B, Edelman E, Stein M, Barry D, Madden L. The impact of benzodiazepine exposure on treatment retention in an open-access methadone program: A retrospective cohort study. Drug And Alcohol Dependence 2022, 241: 109707. PMID: 36423462, PMCID: PMC9777057, DOI: 10.1016/j.drugalcdep.2022.109707.Peer-Reviewed Original ResearchConceptsBenzodiazepine exposureRetrospective cohort studyKaplan-Meier analysisTreatment retentionCohort studyCox regressionTreatment durationMedian treatment durationMultivariable Cox regressionCohort of patientsOpioid treatment programsOpioid use disorderLog-rank testSame-day accessDrug Administration recommendationsTreatment discontinuationUrine toxicologyMeier analysisMethadone programsUse disordersPatientsAdministration recommendationsTreatment entryTreatment programTreatment barriersStrengthening systems of care for people with or at risk for HIV, HCV and opioid use disorder: a call for enhanced data collection
Eller AJ, DiDomizio EE, Madden LM, Oliva JD, Altice FL, Johnson KA. Strengthening systems of care for people with or at risk for HIV, HCV and opioid use disorder: a call for enhanced data collection. Annals Of Medicine 2022, 54: 1714-1724. PMID: 35775786, PMCID: PMC9377256, DOI: 10.1080/07853890.2022.2084154.Peer-Reviewed Original ResearchConceptsCascade of careHuman immunodeficiency virusOpioid use disorderHepatitis C virusPublic health planningUse disordersCo-occurring opioid use disorderHealth planningBurden of diseaseSystems of careQuality improvement activitiesOUD cascadeTreatment initiationImmunodeficiency virusC virusPatient outcomesTreatment accessPayer sourceTreatment retentionHealth systemHealthcare systemCareSyndemicDisordersVirus
2020
Measurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder
Haeny AM, Kiluk BD, Nich C, LaPaglia DM, Carroll KM. Measurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder. Addictive Behaviors 2020, 114: 106721. PMID: 33162231, PMCID: PMC7802511, DOI: 10.1016/j.addbeh.2020.106721.Peer-Reviewed Original ResearchConceptsBarratt Impulsiveness ScaleHigher motor impulsivenessCocaine use disorderMeasurement invarianceMotor impulsivenessImpulsiveness ScaleBlack subsampleUse disordersDays abstinentMulti-group confirmatory factor analysisTreatment retentionCocaine abuse/dependenceCocaine treatment outcomesFactor analysisConfirmatory factor analysisAbuse/dependenceImpulsivityCocaine-negative urinesImpulsivenessBivariate correlationsWhite subsampleAbstinentOverall sampleTotal sampleAdultsTantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior
Diaz-Stransky A, Rowley S, Zecher E, Grodberg D, Sukhodolsky DG. Tantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior. Journal Of Child And Adolescent Psychopharmacology 2020, 30: 558-566. PMID: 33035067, PMCID: PMC7699014, DOI: 10.1089/cap.2020.0089.Peer-Reviewed Original ResearchConceptsOpen pilot studyAffective Reactivity IndexOpen trialPilot studyFirst-line treatmentSecondary outcome measuresDisruptive Behavior Rating ScaleYoung childrenDisruptive behaviorSignificant reductionDisruptive behavior disordersClinical effectsParent management training interventionOutcome measuresEffective treatmentTreatment retentionBehavior disorderClinical settingParent management trainingPrimary caregiversMeaningful reductionRating ScaleIrritability scoresLimited service availabilityParent training programThe real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine
Farnum SO, Makarenko I, Madden L, Mazhnaya A, Marcus R, Prokhorova T, Bojko MJ, Rozanova J, Dvoriak S, Islam Z, Altice FL. The real‐world impact of dosing of methadone and buprenorphine in retention on opioid agonist therapies in Ukraine. Addiction 2020, 116: 83-93. PMID: 32428276, PMCID: PMC7674222, DOI: 10.1111/add.15115.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOAT discontinuationAgonist therapyTreatment retentionIndependent predictorsHIV epidemicCost-effective HIV prevention strategyMethadone maintenance treatment patientsObservational longitudinal cohort studySpecialty addictions treatmentBuprenorphine maintenance treatmentHigh dosageHIV prevention strategiesLongitudinal cohort studyOpioid-dependent peopleTreatment discontinuationCohort studyMaintenance treatmentMale sexTreatment patientsPrevention strategiesDiscontinuationYounger ageCenter settingAddiction treatmentCo-Located hepatitis C virus infection treatment within an opioid treatment program promotes opioid agonist treatment retention
Severe B, Tetrault JM, Madden L, Heimer R. Co-Located hepatitis C virus infection treatment within an opioid treatment program promotes opioid agonist treatment retention. Drug And Alcohol Dependence 2020, 213: 108116. PMID: 32599493, DOI: 10.1016/j.drugalcdep.2020.108116.Peer-Reviewed Original ResearchOpioid treatment programsOpioid use disorderOpioid agonist treatmentHCV treatmentOUD treatmentTreatment retentionHepatitis C virus infection treatmentControl groupSurvival analysisHepatitis C virus infectionTreatment programHCV care continuumC virus infectionChronic HCV infectionOutcomes of interestHCV infectionAgonist treatmentPatient retentionCare continuumVirus infectionTreatment groupsUse disordersPatientsBaseline covariatesInfection treatmentMobile, Community‐Based Buprenorphine Treatment for Veterans Experiencing Homelessness With Opioid Use Disorder: A Pilot, Feasibility Study
Iheanacho T, Payne K, Tsai J. Mobile, Community‐Based Buprenorphine Treatment for Veterans Experiencing Homelessness With Opioid Use Disorder: A Pilot, Feasibility Study. American Journal On Addictions 2020, 29: 485-491. PMID: 32367557, DOI: 10.1111/ajad.13055.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalgesics, OpioidBuprenorphineCase ManagementCommunity Health ServicesConnecticutFeasibility StudiesFemaleFollow-Up StudiesHumansIll-Housed PersonsMaleMiddle AgedMobile ApplicationsOpiate Substitution TreatmentOpioid-Related DisordersPatient CompliancePilot ProjectsRetrospective StudiesTelemedicineTreatment OutcomeVeterans HealthConceptsOpioid use disorderUtilization of buprenorphineCase management programBUP treatmentUse disordersCommunity-based case management programCommunity-based case managementFirst-line medicationRetrospective chart reviewHealth care utilizationHigh-risk populationHigher treatment retentionVeterans Experiencing HomelessnessDrug use dataChart reviewBuprenorphine treatmentCare utilizationMedication treatmentMedical recordsTreatment retentionBuprenorphineClinicCase managementSubstance useVeterans
2019
Community perspectives of South African adolescents’ experiences seeking treatment at local HIV clinics and how such clinics may influence engagement in the HIV treatment cascade: a qualitative study
Ritchwood T, Ba A, Ingram L, Atujuna M, Marcus R, Ntlapo N, Oduro A, Bekker L. Community perspectives of South African adolescents’ experiences seeking treatment at local HIV clinics and how such clinics may influence engagement in the HIV treatment cascade: a qualitative study. AIDS Care 2019, 32: 83-88. PMID: 31402674, PMCID: PMC6883151, DOI: 10.1080/09540121.2019.1653442.Peer-Reviewed Original ResearchConceptsHIV treatment cascadeClinic experienceClinic factorsTreatment cascadeSouth African adolescentsClinic environmentLargest antiretroviral treatment programmeClinic visit frequencyLocal HIV clinicsAntiretroviral treatment programAdolescents' experiencesAfrican adolescentsHIV careHIV clinicART adherenceLack of confidentialityTreatment programTreatment regimensTreatment retentionClinic staffSuch clinicsNegative aspectsClinic spaceClinic practiceStaff attitudes
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