2024
Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population
Ding J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu W, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai S, Byrne C, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng M, Sun F, Chai J. Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population. Science Translational Medicine 2024, 16: eadh9940. PMID: 39504356, DOI: 10.1126/scitranslmed.adh9940.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseWhole-genome sequencingHepatocellular carcinomaMolecular subtypesLiver cirrhosisChinese cohort of patientsInfiltration of M1Risk of liver cirrhosisSerum metabolic analysisClinical diagnosisSubtype of nonalcoholic fatty liver diseaseCohort of patientsDevelopment of liver cirrhosisHepatocellular carcinoma developmentIntegrative multiomic analysisHealth care burdenFatty liver diseaseExpression of CYP1A2Urine specimensTreatment strategiesChinese cohortImpaired outcomeM2 macrophagesIntegrative multiomicsLiver disease
2019
Tubulointerstitial Infiltration of M2 Macrophages in Henoch‐Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters
Kim J, Choi S, Lee K, Jeong H, Shin J, Lim B. Tubulointerstitial Infiltration of M2 Macrophages in Henoch‐Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters. BioMed Research International 2019, 2019: 8579619. PMID: 30800680, PMCID: PMC6360621, DOI: 10.1155/2019/8579619.Peer-Reviewed Original ResearchConceptsClass III-IVChronic renal failureAssociated with chronic renal failureHenoch-Schonlein purpuraIII-IVISKDC classificationClinical parametersGlomerular crescentsInternational Study of Kidney DiseaseM2 macrophagesPresence of glomerular crescentsPresence of chronic renal failureAssociated with disease progressionInfiltration of M2 macrophagesInfiltration of M1Subtypes of macrophagesStudy of Kidney DiseaseTubulointerstitial infiltrationRenal involvementSystemic vasculitisISKDCRenal failureHistological featuresSevere manifestationsBorderline significance
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