2019
FGF-23 and Cardio-Renal Interactions in Heart Failure
Stewart B, Gomez N, Barnett J, Thomas A, Wycallis E, Pattoli M, Struyk G, Fleming J, Shamlian P, Raghavendra P, Mahoney D, Ivey-Miranda J, Griffin M, Rao V, Testani J. FGF-23 and Cardio-Renal Interactions in Heart Failure. Journal Of Cardiac Failure 2019, 25: s23-s24. DOI: 10.1016/j.cardfail.2019.07.545.Peer-Reviewed Original ResearchCardio-renal dysfunctionFGF-23 levelsFGF-23NT-proBNPDiuretic responsivenessIL-6Outpatient heart failure (HF) patientsPlasma FGF-23 levelsFibroblast growth factor 23Adverse left ventricular remodelingCardio-renal interactionsHigher NT-proBNPTotal renin levelsPlasma IL-6Heart failure patientsRenal sodium retentionGrowth factor 23High plasma reninLeft ventricular remodelingInduction of inflammationStrong independent associationResults Higher levelsDiuretic doseNeurohormonal activationPhosphaturic hormoneSerum and Urine Albumin and Response to Loop Diuretics in Heart Failure
Charokopos A, Griffin M, Rao VS, Inker L, Sury K, Asher J, Turner J, Mahoney D, Cox ZL, Wilson FP, Testani JM. Serum and Urine Albumin and Response to Loop Diuretics in Heart Failure. Clinical Journal Of The American Society Of Nephrology 2019, 14: cjn.11600918. PMID: 31010938, PMCID: PMC6500945, DOI: 10.2215/cjn.11600918.Peer-Reviewed Original ResearchConceptsDiuretic efficiencyHeart failureAlbumin levelsDiuretic excretionDiuretic doseInpatient cohortUrine albuminOutpatient cohortLoop diureticsIL-6Higher urine albuminLoop diuretic doseUrinary albumin levelsLow serum albuminPlasma IL-6Heart failure cohortHuman heart failureDiuretic resistanceSuccessful decongestionDiuretic treatmentSystemic inflammationKidney functionSite of actionSerum albuminSodium output
2015
Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery
Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, McArthur E, Thiessen-Philbrook H, Shortt C, Shlipak M, Whitlock R, Parikh CR. Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal Of The American Society Of Nephrology 2015, 26: 3123-3132. PMID: 25855775, PMCID: PMC4657830, DOI: 10.1681/asn.2014080764.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCanadaCardiac Surgical ProceduresCreatinineFemaleFollow-Up StudiesHumansInterleukin-10Interleukin-6Lipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodPreoperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsUnited StatesConceptsIL-10 concentrationsIL-6 concentrationsPlasma IL-6IL-6IL-10Cardiac surgeryHigh riskLower riskPeak IL-6 concentrationNeutrophil Gelatinase-Associated LipocalinPathophysiology of AKIPostoperative IL-6Long-term mortalityGelatinase-Associated LipocalinBiomarkers of inflammationRisk of mortalityDose-dependent mannerHospital AKIAKI biomarkersCause mortalityPerioperative outcomesPreoperative concentrationsSerum creatinineDL increaseSecond tertile
2012
Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials
Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2012, 303: l634-l639. PMID: 22865551, PMCID: PMC3469636, DOI: 10.1152/ajplung.00195.2012.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAdultAgedAPACHEBiomarkersBronchoalveolar Lavage FluidCohort StudiesFemaleHumansInterleukin-6Interleukin-8MaleMiddle AgedPlasminogen Activator Inhibitor 1PneumoniaPredictive Value of TestsProtein CPulmonary EdemaRespiratory Distress SyndromeRespiratory InsufficiencyRisk FactorsSeverity of Illness IndexThrombomodulinConceptsAcute lung injuryVentilator-free daysPlasma plasminogen activator inhibitor-1IL-6Oxygenation indexClinical trialsPredictive valueClinical outcomesIL-8Treatment of ALIHigher APACHE II scoreHigher plasma IL-6Severe acute lung injuryRelevant outcomesBronchoalveolar lavage (BAL) biomarkersAPACHE II scorePlasma IL-6Cohort of patientsMarker of severitySimilar baseline characteristicsPoor clinical outcomePlasminogen activator inhibitor-1Future clinical trialsAssociation of plasmaActivator inhibitor-1
2003
Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
Vgontzas A, Zoumakis M, Bixler E, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos G. Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2087-2095. PMID: 12727959, DOI: 10.1210/jc.2002-021176.Peer-Reviewed Original ResearchConceptsRapid eye movementIL-6Total wake timeTNF-alphaDaytime sleepinessElevated plasma interleukin-6Multiple sleep latency testAssociation of IL-6Rapid eye movement sleepWake timeMeasurement of IL-6Sleep latency testPatterns of IL-6TNF-alpha secretionPlasma IL-6Daytime sleep latencyPlasma interleukin-6Young adultsCortisol plasma concentrationsCortisol levelsIL-6 secretionNocturnal wake timeAge-related alterationsAssociated with elevationLatency test
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