2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2021
Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study
Lee KS, Xiao J, Liew Z, Gau SS, Tseng WL. Perinatal and birth correlates of childhood irritability in Taiwan's national epidemiological study. Journal Of Affective Disorders 2021, 299: 273-280. PMID: 34906640, PMCID: PMC8767526, DOI: 10.1016/j.jad.2021.12.016.Peer-Reviewed Original ResearchConceptsNational epidemiological studyBirth characteristicsEpidemiological studiesChildhood irritabilityEarly life exposureAdverse mental healthBirth correlatesPerinatal perspectiveVaginal bleedingMaternal smokingAffective Reactivity IndexPerinatal risksBirth factorsLife exposureProspective assessmentIrritabilityTemper outburstsRecall biasLife outcomesPerinatalMental healthEarly etiologyChild irritabilityRetrospective assessmentEnvironmental exposuresPhysician Incentive Compensation Plans in Academic Medical Centers: The Imperative to Prioritize Value
Coleman D, Joiner K. Physician Incentive Compensation Plans in Academic Medical Centers: The Imperative to Prioritize Value. The American Journal Of Medicine 2021, 134: 1344-1349. PMID: 34343514, DOI: 10.1016/j.amjmed.2021.06.040.Peer-Reviewed Original ResearchConceptsAcademic medical centerClinical volumeMedical CenterValue of careProspective assessmentClinical valueClinical practiceHealth outcomesPhysician compensation planClinical workforceClinical encountersPractice circumstancesHealth carePublic healthCareValid measureOutcomesKey outcomesCliniciansPhysicians
2020
Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine SK, Wemm S, Fogelman N, Lacadie C, Seo D, Scheinost D, Sinha R. Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal Of Psychiatry 2020, 177: 1048-1059. PMID: 32854534, PMCID: PMC7606814, DOI: 10.1176/appi.ajp.2020.19070703.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment initiationAlcohol abstinenceHeavy drinkingFunctional MRIEarly treatment outcomesEarly treatment phaseHealthy control subjectsEarly outpatient treatmentNumber of daysStress imagesDrinking outcomesChronic alcohol abuseHeavy drinking daysSignificant hyperreactivityControl subjectsOutpatient treatmentStriatal dysfunctionEarly treatmentTreatment outcomesBrain stressFunctional pathologyProspective assessmentTreatment phaseAlcohol abuse
2017
Prospective assessment for pathogenic germline alterations (PGA) in pancreas cancer (PAC).
Jordan E, Lowery M, Wong W, Kemel Y, Mukherjee S, Ravichandran V, Basturk O, Yu K, Iacobuzio-Donahue C, Lincoln A, Varghese A, Abou-Alfa G, Leach S, Klimstra D, Allen P, Robson M, Stadler Z, Vijai J, Offit K, O'Reilly E. Prospective assessment for pathogenic germline alterations (PGA) in pancreas cancer (PAC). Journal Of Clinical Oncology 2017, 35: 4102-4102. DOI: 10.1200/jco.2017.35.15_suppl.4102.Peer-Reviewed Original ResearchPathogenic germline alterationsPancreas cancerGermline testingPlatinum therapyOverall survivalMedian ageMSK-IMPACTPancreas cancer patientsCancer predisposition syndromeMedian OSBRCA mutationsGA carriersStage III/IVClinicopathological featuresGermline alterationsPredisposition syndromeTumor samplesPathogenic variantsCancer predispositionLonger TTPSomatic profilesBlood relativesTherapyProspective assessmentCancer
2016
Limitations of lifetime alcohol use disorder assessments: A criterion-validation study
Haeny AM, Littlefield AK, Sher KJ. Limitations of lifetime alcohol use disorder assessments: A criterion-validation study. Addictive Behaviors 2016, 59: 95-99. PMID: 27082748, PMCID: PMC4850026, DOI: 10.1016/j.addbeh.2016.03.021.Peer-Reviewed Original ResearchConceptsDiagnostic Interview ScheduleLifetime AUDSingle assessmentLifetime psychiatric disordersCriterion validation studyPast-year alcoholWave 6Lifetime substance useProspective cohortCumulative assessmentProspective dataProspective assessmentPsychiatric disordersLifetime historyRelevant correlatesDSM-IIIDSM-IVSubstance useRetrospective assessmentDisorder assessmentGeneral functioningWave 7Interview scheduleWave 1DisordersTu1649 Predicting Mortality After Discharge From Hospital in Cirrhosis: A Prospective Assessment of the Karnofsky Score
Tandon P, Reddy K, O'Leary J, Garcia-Tsao G, Wong F, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. Tu1649 Predicting Mortality After Discharge From Hospital in Cirrhosis: A Prospective Assessment of the Karnofsky Score. Gastroenterology 2016, 150: s1156. DOI: 10.1016/s0016-5085(16)33906-3.Peer-Reviewed Original ResearchTHU-373 Predicting Mortality after Discharge from Hospital in Cirrhosis: A Prospective Assessment of the Karnofsky Score
Tandon P, Reddy R, O’Leary J, Garcia-Tsao G, Wong F, Biggins S, Maliakkal B, Fallon M, Subramanian R, Thuluvath P, Kamath P, Thacker L, Bajaj J. THU-373 Predicting Mortality after Discharge from Hospital in Cirrhosis: A Prospective Assessment of the Karnofsky Score. Journal Of Hepatology 2016, 64: s282. DOI: 10.1016/s0168-8278(16)00340-8.Peer-Reviewed Original Research
2013
Repeated Diagnoses of Lifetime Alcohol Use Disorders in a Prospective Study: Insights into the Extent and Nature of the Reliability and Validity Problem
Haeny AM, Littlefield AK, Sher KJ. Repeated Diagnoses of Lifetime Alcohol Use Disorders in a Prospective Study: Insights into the Extent and Nature of the Reliability and Validity Problem. Alcohol Clinical And Experimental Research 2013, 38: 489-500. PMID: 24033811, PMCID: PMC4066878, DOI: 10.1111/acer.12237.Peer-Reviewed Original ResearchConceptsLifetime alcohol use disorderAlcohol use disorderLifetime diagnosisUse disordersRetrospective assessmentPast-year diagnosesDSM-III disordersLifetime prevalence ratesProspective studyProspective dataHigh-risk sampleProspective assessmentPrevalence ratesLower riskAge 34Alcohol dependenceSymptom levelsYoung adultsDiagnosisDisordersPattern of findingsSingle measurement occasionLow sensitivityAssessmentCohort
2012
Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II)
Bauerschmidt A, Koshkelashvili N, Ezeani CC, Yoo JY, Zhang Y, Manganas LN, Kapadia K, Palenzuela D, Schmidt C, Lief R, Kiely BT, Choezom T, McClurkin M, Shorten A, Detyniecki K, Hirsch LJ, Giacino JT, Blumenfeld H. Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II). Epilepsy & Behavior 2012, 26: 25-28. PMID: 23201609, PMCID: PMC3741052, DOI: 10.1016/j.yebeh.2012.10.022.Peer-Reviewed Original ResearchTherapeutic Cancer Vaccines in Prostate Cancer: The Quest for Intermediate Markers of Response
Kim JW, Bilusic M, Heery CJ, Madan RA. Therapeutic Cancer Vaccines in Prostate Cancer: The Quest for Intermediate Markers of Response. Cancers 2012, 4: 1229-1246. PMID: 24213505, PMCID: PMC3712729, DOI: 10.3390/cancers4041229.Peer-Reviewed Original ResearchClinical benefitIntermediate markersImmunotherapy clinical trialsTherapeutic cancer vaccinesPotential clinical roleTumor growth kineticsOverall survivalImmune infiltratesClinical outcomesCytokine responsesCancer vaccinesCellular immunityIntermediate biomarkersPeripheral bloodCancer immunotherapyClinical trialsParadoxical patternProstate cancerClinical roleProspective assessmentSystemic responseTherapy mechanismsBiomarkersImmunotherapySurvival
2009
Sheehan Suicidality Tracking Scale (Sheehan-STS): Preliminary Results from a Multicenter Clinical Trial in Generalized Anxiety Disorder.
Coric V, Stock EG, Pultz J, Marcus R, Sheehan DV. Sheehan Suicidality Tracking Scale (Sheehan-STS): Preliminary Results from a Multicenter Clinical Trial in Generalized Anxiety Disorder. Innov Clin Neurosci 2009, 6: 26-31. PMID: 19724740, PMCID: PMC2719443.Peer-Reviewed Original ResearchClinical trialsHAM-D itemsGeneralized anxiety disorderSheehan Suicidality Tracking ScaleSuicidal thoughtsWeek 8Suicidal ideationCorticotropin-releasing factor antagonistAnxiety disordersTreatment-emergent suicidal ideationActive comparator studiesExploratory outcome measuresClinician-Administered Rating ScaleMulticenter clinical trialStudy time pointsScale total scoreLarger study sampleComparator studiesStudy protocolMean changeOutcome measuresWeek 4Prospective assessmentFactor antagonistsClinical care
2006
Comparison of the Glottic Closure Reflex in Traditional “Open” versus Endoscopic Laser Supraglottic Laryngectomy
Sasaki CT, Leder SB, Acton LM, Maune S. Comparison of the Glottic Closure Reflex in Traditional “Open” versus Endoscopic Laser Supraglottic Laryngectomy. Annals Of Otology Rhinology & Laryngology 2006, 115: 93-96. PMID: 16514789, DOI: 10.1177/000348940611500202.Peer-Reviewed Original ResearchConceptsGlottic closure reflexGlottic closure responseLaser supraglottic laryngectomySupraglottic laryngectomySuperior laryngeal nerve sectionCompensatory mechanismsHistorical control patientsFiberoptic endoscopic evaluationEndoscopic laser resectionControl patientsClinical factorsConsecutive patientsEndoscopic evaluationField deficitsNerve sectionPatient groupPharyngeal dysphagiaSupraglottic larynxLaser resectionNormal swallowingProspective assessmentSensory testingPatientsSurgeryReflexClinical profile, diagnosis and management of patients presenting with symptomatic pulmonary embolism.
Agarwal R, Gulati M, Mittal B, Jindal S. Clinical profile, diagnosis and management of patients presenting with symptomatic pulmonary embolism. The Indian Journal Of Chest Diseases & Allied Sciences 2006, 48: 111-4. PMID: 16696525.Peer-Reviewed Original ResearchConceptsSymptomatic pulmonary embolismPulmonary embolismClinical profileLow molecular weight heparinOutcomes of patientsPulmonary artery hypertensionManagement of patientsMolecular weight heparinArtery hypertensionVentricular dyskinesiaAggressive managementClinical featuresPredominant complaintWeight heparinPerfusion scanMean ageEarly diagnosisProspective assessmentPatientsEmbolismSuccessful outcomeStudy periodDiagnostic methodsDiagnosisOutcomes
2005
Accuracy and Predictors of Basal Cell Carcinoma Diagnosis
SCHWARTZBERG J, ELGART G, ROMANELLI P, MA F, FEDERMAN D, KIRSNER R. Accuracy and Predictors of Basal Cell Carcinoma Diagnosis. Dermatologic Surgery 2005, 31: 534-537. DOI: 10.1097/00042728-200505000-00007.Peer-Reviewed Original ResearchBackground Basal cell carcinomaPositive predictive valueBasal cell carcinoma diagnosisClinical diagnosisBasal cell carcinomaPearly borderCell carcinomaCommon cancerDiagnostic biopsyPatient referralHistologic diagnosisProspective assessmentSunscreen useCarcinoma diagnosisPredictive valuePresence of pigmentationDiagnosisDermatologists' perceptionsUniversity of MiamiBiopsyPatientsLesionsFirst studyCarcinomaReferral
2001
Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia
Lotrič-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia. Clinical Infectious Diseases 2001, 33: 503-510. PMID: 11462187, DOI: 10.1086/322586.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsBites and StingsBorrelia burgdorferi GroupCohort StudiesEhrlichiaEhrlichia chaffeensisEhrlichiosisEncephalitis Viruses, Tick-BorneEncephalitis, Tick-BorneFemaleFeverHumansLyme DiseaseMaleMiddle AgedProspective StudiesSloveniaTick-Borne DiseasesTicksConceptsFebrile illnessTick biteEhrlichia phagocytophila infectionAcute febrile illnessTickborne diseasesEvidence of infectionBorrelia burgdorferi sensu latoMeningeal involvementProspective studyClinical criteriaBurgdorferi sensu latoTickborne encephalitisProspective assessmentPatientsLaboratory evidenceImportant causeBacterial infectionsIllnessLyme borreliosisInfectionDiseaseResidents of SloveniaEtiologyBiteEncephalitis
1993
Protein-losing enteropathy and hypoalbuminemia in AIDS
Laine L, Garcia F, McGilligan K, Malinko A, Sinatra F, Thomas D. Protein-losing enteropathy and hypoalbuminemia in AIDS. AIDS 1993, 7: 837-840. PMID: 8363760, DOI: 10.1097/00002030-199306000-00012.Peer-Reviewed Original ResearchConceptsNormal bowel habitsProtein-losing enteropathyFecal alphaBowel habitsNormal serum albuminNormal albuminFecal alpha 1Normal albumin groupUrban county hospitalGroup of patientsDevelopment of hypoalbuminemiaUpper endoscopyFlexible sigmoidoscopyAlbumin groupMucosal diseaseCounty HospitalHypoalbuminemiaMAIN OUTCOMEProspective assessmentSerum albuminPatientsLinear regression analysisDiarrheaSignificant negative correlationGross abnormalities
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