2025
HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidence
2001
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateHuman serum albuminLaser desorption timeMatrix-assisted laser desorption timeFlight mass spectrometryWorkplace air monitoringMass spectrometryDesorption timeDiisocyanateAdductsDevelopment of immunoassaysHSA antigenSerum albuminMicrotiter platesReactionAir monitoringHexamethylene diisocyanate exposurePpbAbsence of reactionSensitive bioassayNumerous samplesSpectrometryDiphenylPolyurethaneCoatings
1999
Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II
Haque T, Skillman A, Lee C, Habashita H, Gluzman I, Ewing T, Goldberg D, Kuntz I, Ellman J. Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II. Journal Of Medicinal Chemistry 1999, 42: 1428-1440. PMID: 10212129, DOI: 10.1021/jm980641t.Peer-Reviewed Original ResearchConceptsPlasmepsin IIStructure-based designNon-peptide inhibitorsCalculated log P valuesCombinatorial chemistryLog P valuesParallel synthesisHuman serum albuminFocused libraryMolecular weightBest inhibitorApparent bindingEnzyme specificityLow-MolecularSerum albuminAspartyl protease inhibitorsCompoundsSmall molecule inhibitorsHuman proteasesChemistrySelectivitySynthesisSerum proteinsMinimal bindingBinding
1968
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1255-1265. PMID: 4235040, PMCID: PMC2138586, DOI: 10.1084/jem.128.6.1255.Peer-Reviewed Original ResearchConceptsLymph node cellsNode cellsSensitized lymph node cellsArthus reactivityLewis ratsBN ratsSkin reactivityAllogeneic fibroblastsDelayed hypersensitivitySoluble antigenSpecific antigenHomologous conjugateCytotoxic effectsRatsAntigenHypersensitivityProtein carrierHuman serum albuminCellsAnimalsRat embryo fibroblastsSpecific damageSerum albuminFibroblastsConjugates
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