2023
Identification of Molds on Primary Culture
Azar M, Leal S. Identification of Molds on Primary Culture. 2023, 1-8. DOI: 10.1002/9781683670438.cmph0107.Peer-Reviewed Original ResearchMatrix-assisted laser desorption ionization-time of flight mass spectrometryLaser desorption ionization-time of flight mass spectrometryMatrix-assisted laser desorption ionization-timeIonization-time of flight mass spectrometryNutrient-poor mediumIdentification of moldsAsexual reproductionInduce sporulationFilamentous fungiFlight mass spectrometryPathogenic moldsMold identificationContaminating bacteriaStandard mediumNutritive mediumClinical laboratoriesPrimary culturesInitial cultureRate of growthYeastHyphaeSporulationFungusFungiCulture
2022
Accelerating Metabolite Identification Mass Spectrometry Technology Drives Metabolite Identification Studies Forward
NASSAR A. Accelerating Metabolite Identification Mass Spectrometry Technology Drives Metabolite Identification Studies Forward. 2022, 267-302. DOI: 10.1002/9781119851042.ch8.Peer-Reviewed Original ResearchDrug candidatesDrug discoveryLC-MSLiquid chromatography-mass spectrometryChromatography-mass spectrometryMetabolite identification studiesSuccessful drug candidatesFlight mass spectrometryDrug discovery effortsMass spectrometry technologyTriple quadrupoleADMET studiesStructural assignmentMass spectrometryMetabolite characterizationLead compoundsSpectrometry technologyIon trapDiscovery effortsOverall safety profileHuman-specific metabolitesSpectrometryDrug development processMetabolism issuesMetabolite profiling
2021
Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon
Abboud Z, Galuppo L, Tolone M, Vitale M, Puleio R, Osman M, Loria G, Hamze M. Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon. Microorganisms 2021, 9: 1148. PMID: 34071800, PMCID: PMC8228836, DOI: 10.3390/microorganisms9061148.Peer-Reviewed Original ResearchMolecular characterizationMatrix-assisted laser desorptionGram-positive bacteriaResistance genesGenesPolymerase chain reactionPhylogenetic group B1Virulence factorsVirulence genesAntimicrobial resistance genesBacterial pathogensToxin genesLaser desorptionMastitis-causing pathogensNegative bacteriaBeta-lactamase genesFlight mass spectrometryBacterial identificationBacteriaQuadruplex PCR methodSymptoms of mastitisDairy animalsPhylogenetic typingIsolatesPathogens
2020
Advances in rapid diagnostics for bloodstream infections
Briggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagnostic Microbiology And Infectious Disease 2020, 99: 115219. PMID: 33059201, DOI: 10.1016/j.diagmicrobio.2020.115219.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Elucidating Environmental Fingerprinting Mechanisms of Unconventional Gas Development through Hydrocarbon Analysis
Piotrowski PK, Weggler BA, Yoxtheimer DA, Kelly CN, Barth-Naftilan E, Saiers JE, Dorman FL. Elucidating Environmental Fingerprinting Mechanisms of Unconventional Gas Development through Hydrocarbon Analysis. Analytical Chemistry 2018, 90: 5466-5473. PMID: 29580048, DOI: 10.1021/acs.analchem.8b00822.Peer-Reviewed Original ResearchGC × GC separationGC separationTwo-dimensional gas chromatographyMass defect plotsEnvironmental forensic investigationsHigh-resolution timeEnvironmental contamination eventsFlight mass spectrometryHydrocarbon fingerprintingMass spectrometryGas chromatographyCyclic hydrocarbonsSubstituted hydrocarbonsPolyaromatic hydrocarbonsInstrumental combinationFlowback fluidMethod developmentHydrocarbon analysisMarcellus Shale gas wellsHydrocarbonsPoint source identificationChemical factors
2016
Bacillus cereus Bacteremia and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Shih A, Grant M, Sankey C. Bacillus cereus Bacteremia and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. Infectious Diseases In Clinical Practice 2016, 24: 14-17. DOI: 10.1097/ipc.0000000000000335.Peer-Reviewed Case Reports and Technical NotesInjection drug useEndovascular infectionDrug useAppropriate intravenous antibiotic therapyActive injection drug useBacillus cereus bacteremiaIntravenous antibiotic therapyAcute febrile illnessHuman immunodeficiency virusMajor risk factorProsthetic heart valvesCereus bacteremiaFebrile illnessAntibiotic therapyHIV statusRare causeImmunodeficiency virusInvasive infectionsRisk factorsBlood culturesConsecutive daysInfectionHeart valvesFlight mass spectrometryPrevious cases
2015
Prototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients
Bandaranayake TD, Mondolfi A, Peaper DR, Malinis MF. Prototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients. Transplant Infectious Disease 2015, 17: 599-604. PMID: 26040253, DOI: 10.1111/tid.12407.Peer-Reviewed Case Reports and Technical NotesConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsRenal transplant recipientsDisseminated diseaseCutaneous lesionsFatal casesEarly diagnosisRecipientsPrevious casesImpact outcomesPrototheca wickerhamiiDiseaseHuman diseasesP. wickerhamiiLesionsVoriconazoleInfectionDiagnosisFlight mass spectrometryMatrix-assisted laser desorption ionization time
2013
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database
Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G. Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Nature Protocols 2013, 8: 451-460. PMID: 23391889, PMCID: PMC3666335, DOI: 10.1038/nprot.2013.004.Peer-Reviewed Original ResearchConceptsLiquid chromatography-quadrupole timeProfiling experimentsMETLIN metabolite databaseMore populationsSeven-step protocolFlight mass spectrometry characterizationMost biological samplesFlight mass spectrometryMass spectrometry characterizationTandem MSMetabolomic featuresQuadrupole timeComprehensive platformUntargeted metabolomicsMass spectrometryMS dataMETLIN databaseLC-Q-TOFMetabolitesMetabolite databasesBiological samplesThousands of peaks
2005
Proteomic Patterns and Prediction of Glomerulosclerosis and Its Mechanisms
Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB. Proteomic Patterns and Prediction of Glomerulosclerosis and Its Mechanisms. Journal Of The American Society Of Nephrology 2005, 16: 2967-2975. PMID: 16079267, DOI: 10.1681/asn.2005030262.Peer-Reviewed Original ResearchConceptsThymosin beta4Proteomic patternsProtein expression profilesSuch early eventsPlasminogen activator inhibitor-1 expressionMatrix-assisted laser desorption/ionization timeLaser desorption/ionization timeDesorption/ionization timeLaser capture microdissectionEndothelial cellsExpression profilesProtein profilesCapture microdissectionBeta4Cultured glomerular endothelial cellsPlasminogen activator inhibitor-1Early eventsFlight mass spectrometryIonization timeActivator inhibitor-1Inhibitor-1ProteinEarly activationMass spectrometryCells
2002
A Regulatory Locus of Phosphorylation in the N Terminus of the Na-K-Cl Cotransporter, NKCC1*
Darman RB, Forbush B. A Regulatory Locus of Phosphorylation in the N Terminus of the Na-K-Cl Cotransporter, NKCC1*. Journal Of Biological Chemistry 2002, 277: 37542-37550. PMID: 12145304, DOI: 10.1074/jbc.m206293200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesCell LineDogfishHumansIon TransportKineticsModels, MolecularPeptide FragmentsPhosphopeptidesPhosphorylationProtein ConformationRecombinant ProteinsSalt GlandSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Spectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTransfectionTrypsinConceptsProtein phosphatase 1 bindsN-terminusSer/ThrPhosphorylation-dependent mechanismN-terminal domainStrong consensus siteNa-K-Cl cotransporter NKCC1Matrix-assisted laser desorption ionization timePhosphoregulatory mechanismsPhosphoacceptor sitesRegulatory lociHEK-293 cellsNa-K-Cl cotransporterLaser desorption ionization timeCalyculin AConsensus sitesPhosphorylation stoichiometryDesorption ionization timeAmino acidsTryptic fragmentsProteinGland tubulesRectal gland tubulesFlight mass spectrometryIonization time
2001
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateHuman serum albuminLaser desorption timeMatrix-assisted laser desorption timeFlight mass spectrometryWorkplace air monitoringMass spectrometryDesorption timeDiisocyanateAdductsDevelopment of immunoassaysHSA antigenSerum albuminMicrotiter platesReactionAir monitoringHexamethylene diisocyanate exposurePpbAbsence of reactionSensitive bioassayNumerous samplesSpectrometryDiphenylPolyurethaneCoatings
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