2012
ATP activates P2X receptors to mediate gap junctional coupling in the cochlea
Zhu Y, Zhao H. ATP activates P2X receptors to mediate gap junctional coupling in the cochlea. Biochemical And Biophysical Research Communications 2012, 426: 528-532. PMID: 22982314, PMCID: PMC3471361, DOI: 10.1016/j.bbrc.2012.08.119.Peer-Reviewed Original ResearchConceptsP2X receptorsGap junctional couplingCochlear gap junctionsP2Y receptor agonist UTPGap junctionsJunctional couplingP2X receptor antagonistMetabotropic purinergic receptorsReceptor agonist UTPStimulation of ATPPhysiological levelsReceptor antagonistP2Y receptorsPurinergic controlPurinergic receptorsBenzoylbenzoyl-ATPNoise stressReceptorsIonic homeostasisCochleaDisulfonic acidCritical roleIntercellular channelsATPCells
2010
ATP-mediated potassium recycling in the cochlear supporting cells
Zhu Y, Zhao H. ATP-mediated potassium recycling in the cochlear supporting cells. Purinergic Signalling 2010, 6: 221-229. PMID: 20806014, PMCID: PMC2912999, DOI: 10.1007/s11302-010-9184-9.Peer-Reviewed Original ResearchExtracellular concentrationPurinergic receptor antagonistsMembrane potentialCochlear supporting cellsNegative membrane potentialsP2X7 antagonistsReceptor antagonistP2X receptorsInward currentsCell depolarizationPathological conditionsPotassium recyclingSupporting cellsAntagonistConcentration of ATPIonic homeostasisCellsDisulfonic acidCritical roleATPCochlear
2008
ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance
Yu N, Zhao H. ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance. Pflügers Archiv - European Journal Of Physiology 2008, 457: 453-461. PMID: 18491132, PMCID: PMC5531446, DOI: 10.1007/s00424-008-0522-5.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsCalciumChelating AgentsEgtazic AcidElectric CapacitanceGuinea PigsHair Cells, Auditory, OuterMembrane PotentialsPatch-Clamp TechniquesPotassiumPurinergic P2 Receptor AntagonistsPyridoxal PhosphateReceptors, Purinergic P2Signal TransductionSodiumSuraminTime FactorsUridine TriphosphateConceptsP2X receptorsATP effectP2Y receptor agonistsMetabotropic purinergic receptorsActive cochlear amplifierEffect of ATPReceptor agonistHearing functionP2Y receptorsPurinergic receptorsDisulfonic acidImportant mediatorReceptorsCell functionOuter hair cell electromotilityHair cell electromotilityIonotropic purinergicCochlear amplifierOHC electromotilityTetraacetic acidATPAgonistsPurinergicVoltage dependenceSuramin
2007
SLC26A7 Can function as a chloride-loading mechanism in parietal cells
Kosiek O, Busque SM, Föller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP. SLC26A7 Can function as a chloride-loading mechanism in parietal cells. Pflügers Archiv - European Journal Of Physiology 2007, 454: 989-998. PMID: 17404755, DOI: 10.1007/s00424-007-0254-y.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAntiportersChloride-Bicarbonate AntiportersChloridesFluorescent Antibody TechniqueGastric AcidGastric MucosaImage Processing, Computer-AssistedIn Vitro TechniquesMaleOocytesParietal Cells, GastricPatch-Clamp TechniquesRatsRats, Sprague-DawleySodiumSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Sulfate TransportersXenopusConceptsParietal cellsXenopus laevis oocyte expression systemRat parietal cellsExpression of SLC26A7Rat gastric glandsAcid secretionOocyte expression systemNKCC inhibitorWestern blotHistamine stimulationPharmacological inhibitorsAcidic pHiGastric glandsDIDS concentrationExchanger AE2Subsequent readditionTransporter activityDisulfonic acidInhibitorsCellsSLC26A7InfluxImmunohistochemistrySecretagoguesUptake systemCharacteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells
Barmeyer C, Ye JH, Sidani S, Geibel J, Binder HJ, Rajendran VM. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells. Pflügers Archiv - European Journal Of Physiology 2007, 454: 441-450. PMID: 17492310, DOI: 10.1007/s00424-007-0213-7.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmino Acid SequenceAnimalsAntiportersBase SequenceBicarbonatesCell LineChloridesCloning, MolecularColonDNA PrimersFatty Acids, VolatileHumansHydrogen-Ion ConcentrationIon TransportMolecular Sequence DataRatsRecombinant ProteinsSequence Homology, Amino AcidSulfate TransportersTransfectionConceptsRat distal colonDistal colonHEK-293 cellsExtracellular Cl- concentrationCrypt cellsMRNA expressionColonRatsDigestive tractCharacteristics of ratsAdenomasHigh rateDIDSCl- influxSurface cellsIntracellular acidApical membrane vesiclesCellsDisulfonic acidApical membraneCl- uptakePrior observationsUptakeLungJejunum
1999
Hyposmotically activated chloride channels in cultured rabbit non‐pigmented ciliary epithelial cells
Shi C, Ryan J, French A, Coca‐Prados M, Kelly M. Hyposmotically activated chloride channels in cultured rabbit non‐pigmented ciliary epithelial cells. The Journal Of Physiology 1999, 521: 57-67. PMID: 10562334, PMCID: PMC2269649, DOI: 10.1111/j.1469-7793.1999.00057.x.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsCalciumCell LineChloride ChannelsCiliary BodyEnzyme InhibitorsEpithelial CellsNiflumic AcidOsmotic PressurePatch-Clamp TechniquesPhosphorylationProtein Kinase InhibitorsRabbitsSecond Messenger SystemsStilbenesConceptsNon-pigmented ciliary epithelial cellsWhole-cell currentsCiliary epithelial cellsWhole-cell patch-clamp recording techniquePatch-clamp recording techniquesEpithelial cellsTime courseSlower time courseDisulfonic acidSmall conductanceWhole-cell conductanceCl- current amplitudeExposure of cellsVoltage-sensitive blockCl- currentVoltage-independent blockNiflumic acidRecording techniquesDepolarized potentialsCurrent activationAmplitude of currentsOutward rectificationCell swellingNPCE cellsHyposmotic shock
1995
Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes
Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.Peer-Reviewed Original ResearchConceptsBSP uptakeSkate liverTaurocholate uptakeXenopus laevis oocytesOrganic anion transport systemInjection of oocytesLaevis oocytesLiverAnion transport systemRat liverSulfobromophthalein uptakeUptake systemOocytesMRNADisulfonic acidUptake activityFunctional expressionLiver mRNAUptakeExpressionSerum albuminLower vertebrates
1994
A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP
Ballatori N, Simmons T, Boyer J. A volume-activated taurine channel in skate hepatocytes: membrane polarity and role of intracellular ATP. American Journal Of Physiology 1994, 267: g285-g291. PMID: 7521136, DOI: 10.1152/ajpgi.1994.267.2.g285.Peer-Reviewed Original ResearchConceptsCell swellingSkate hepatocytesIntracellular ATPExtracellular taurine concentrationMetabolic inhibitorsSinusoidal circulationHypotonic stimuliTaurine concentrationsTaurine effluxTaurine uptakeIndependent uptakeTaurine channelSkate liverEfflux mechanismTaurineLiverHepatocytesInhibitorsEffluxBasolateral membraneOsmolyte taurineSwellingAntimycin ADisulfonic acidTransport inhibitorsApical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1993
Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL
Bruck R, Benedetti A, Strazzabosco M, Boyer J. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. American Journal Of Physiology 1993, 265: g347-g353. PMID: 8368316, DOI: 10.1152/ajpgi.1993.265.2.g347.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAlkaliesAnimalsAnionsBariumBicarbonatesBileBiological TransportColchicineExocytosisHorseradish PeroxidaseHydrogen-Ion ConcentrationIn Vitro TechniquesIntracellular MembranesLiverMalePotassium ChannelsRatsRats, Sprague-DawleyConceptsBiliary HCO3- excretionBile flowHCO3- excretionIntracellular alkalinizationHCO3- exchangerAcute alkaline loadVesicle-mediated exocytosisBiliary excretionTransient increasePH recoveryAlkaline loadMembrane depolarizationRat liverChannel blocker BaCl2Intact liverLiverAlkalinizationMM NH4ClHCO3- concentrationDisulfonic acidDIDSRat hepatocytesColchicinePretreatmentExocytosis
1992
Taurine transport in skate hepatocytes. I. Uptake and efflux
Ballatori N, Boyer J. Taurine transport in skate hepatocytes. I. Uptake and efflux. American Journal Of Physiology 1992, 262: g445-g450. PMID: 1550234, DOI: 10.1152/ajpgi.1992.262.3.g445.Peer-Reviewed Original ResearchConceptsSkate hepatocytesDependent uptake processIntracellular taurine levelsTaurine uptake systemsTaurine levelsMicroM taurineTaurine uptakeIsosmotic replacementTaurine transportEfflux pathwaySlow effluxExtracellular ClIndependent uptake systemAmino sulfonic acidI. UptakeTaurine accumulationHepatocytesUptake systemEffluxTaurineDisulfonic acidBeta-amino acidsDistinct mechanismsUptakeReplacementLuminal flow rate regulates proximal tubule H-HCO3 transporters
Preisig P. Luminal flow rate regulates proximal tubule H-HCO3 transporters. American Journal Of Physiology 1992, 262: f47-f54. PMID: 1310229, DOI: 10.1152/ajprenal.1992.262.1.f47.Peer-Reviewed Original ResearchConceptsLuminal flow rateLuminal perfusateNa-H antiporter activityProximal tubule acidificationProgressive increaseRate-dependent changesNa-H antiporterTubule acidificationVivo microperfusionH secretionLuminal amilorideAcid loadSecretory activityAlkali loadPerfusateSensitive indexSymporter activityDisulfonic acidAntiporter activityMinBase transportActivityMicroperfusionInitial rateSecretion
1990
Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH
Gleeson D, Corasanti J, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. American Journal Of Physiology 1990, 258: g299-g307. PMID: 2305896, DOI: 10.1152/ajpgi.1990.258.2.g299.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsBicarbonatesBuffersCells, CulturedCholineHydrogen-Ion ConcentrationHypertonic SolutionsHypotonic SolutionsIntracellular FluidKineticsLiverMaleOsmolar ConcentrationRatsRats, Inbred StrainsSodiumConceptsRegulatory volume decreaseAbsence of HCO3Presence of HCO3Acid-base transport systemsModulation of intracellularRat hepatocytesVolume regulationAcute withdrawalMM amilorideGreater intracellularHCO3- exchangeAcid effluxIsotonic mediumIsolated rat hepatocytesSame maneuverCell volume regulationHepatocytesNet acid effluxAmilorideSubconfluent monolayersDisulfonic acidIntracellularVolume decreaseHypotonic mediumHypertonic medium
1989
Basolateral sodium-coupled acid-base transport mechanisms of the rabbit proximal tubule
Geibel J, Giebisch G, Boron W. Basolateral sodium-coupled acid-base transport mechanisms of the rabbit proximal tubule. American Journal Of Physiology 1989, 257: f790-f797. PMID: 2556038, DOI: 10.1152/ajprenal.1989.257.5.f790.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAcid-Base EquilibriumAnimalsBiological TransportBiomechanical PhenomenaCarrier ProteinsChloridesDrug ResistanceHydrogen-Ion ConcentrationKidney Tubules, ProximalRabbitsSodiumSodium-Hydrogen Exchangers
1987
Identification of a single sinusoidal bile salt uptake system in skate liver
Fricker G, Hugentobler G, Meier P, Kurz G, Boyer J. Identification of a single sinusoidal bile salt uptake system in skate liver. American Journal Of Physiology 1987, 253: g816-g822. PMID: 3425718, DOI: 10.1152/ajpgi.1987.253.6.g816.Peer-Reviewed Original ResearchConceptsBile salt uptakeSkate liverAlpha-dihydroxy-5 betaBile salt derivativesAzo-3 alphaBile acid uptakeConcentration-dependent mannerPredominant bile saltHepatic uptakePhotolabile bile salt derivativeIndependent transport mechanismsAcid uptakeLiverApparent molecular weightBile saltsRat liverTaurocholate uptakeSkate hepatocytesAnion transport inhibitorUptake systemHepatocytesPhotoaffinity labelingTaurocholateDisulfonic acidIrreversible inhibition
1986
Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles
Moseley RH, Meier PJ, Aronson PS, Boyer JL. Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles. American Journal Of Physiology 1986, 250: g35-g43. PMID: 3002192, DOI: 10.1152/ajpgi.1986.250.1.g35.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAcridine OrangeAmilorideAmmoniaAnimalsBasement MembraneBiological Transport, ActiveCarrier ProteinsCell MembraneFiltrationHydrogen-Ion ConcentrationLithiumLiverMaleMembrane PotentialsOsmolar ConcentrationPotassiumRatsRats, Inbred StrainsSodiumSodium-Hydrogen ExchangersValinomycin
1985
Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesicles
Schron CM, Knickelbein RG, Aronson PS, Della Puca J, Dobbins JW. Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesicles. American Journal Of Physiology 1985, 249: g614-g621. PMID: 4061649, DOI: 10.1152/ajpgi.1985.249.5.g614.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsBiological TransportCations, MonovalentDose-Response Relationship, DrugHydrogen-Ion ConcentrationIleumIon ExchangeMaleMicrovilliPotassiumRabbitsSodiumStimulation, ChemicalSulfates
1984
Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles
Seifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles. American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply