2025
Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus. JAMA Internal Medicine 2025, 185: 324-334. PMID: 39869355, PMCID: PMC11773409, DOI: 10.1001/jamainternmed.2024.7452.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusLong-term mortalitySARS-CoV-2Syncytial virusCohort studyAssociated with higher long-term mortalityRisk differenceIntensive care unit admissionSeasonal influenza vaccineRetrospective cohort studyDisease severity of COVID-19Long-term deathAssociated with more severe disease outcomesRisk of deathCompare disease severitySevere disease outcomesRisk of hospitalizationSeverity of COVID-19Same-day testingInfluenza vaccineInverse probability weightingUnit admissionCumulative incidenceMortality of COVID-19Primary outcome
2024
Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults
Surie D, Yuengling K, DeCuir J, Zhu Y, Lauring A, Gaglani M, Ghamande S, Peltan I, Brown S, Ginde A, Martinez A, Mohr N, Gibbs K, Hager D, Ali H, Prekker M, Gong M, Mohamed A, Johnson N, Srinivasan V, Steingrub J, Leis A, Khan A, Hough C, Bender W, Duggal A, Bendall E, Wilson J, Qadir N, Chang S, Mallow C, Kwon J, Exline M, Shapiro N, Columbus C, Vaughn I, Ramesh M, Mosier J, Safdar B, Casey J, Talbot H, Rice T, Halasa N, Chappell J, Grijalva C, Baughman A, Womack K, Swan S, Johnson C, Lwin C, Lewis N, Ellington S, McMorrow M, Martin E, Self W. Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults. JAMA Network Open 2024, 7: e244954. PMID: 38573635, PMCID: PMC11192181, DOI: 10.1001/jamanetworkopen.2024.4954.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationRespiratory syncytial virusSeverity of RSV diseaseInfluenza diseaseVaccinated patientsIn-Hospital DeathUnvaccinated patientsRSV diseaseSyncytial virusClinical decision-makingComposite of invasive mechanical ventilationOutcome of invasive mechanical ventilationSeverity of respiratory syncytial virusLaboratory-confirmed respiratory syncytial virusHospitalized US adultsInfluenza vaccination statusVaccination statusAcute respiratory illnessMultivariate logistic regressionCenters for Disease Control and PreventionSeverity of COVID-19Disease Control and PreventionInfluenza infectionInfluenza severityClinical outcomes
2022
COVID‐19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity
Jiang W, Johnson D, Adekunle R, Heather H, Xu W, Cong X, Wu X, Fan H, Andersson L, Robertson J, Gisslén M. COVID‐19 is associated with bystander polyclonal autoreactive B cell activation as reflected by a broad autoantibody production, but none is linked to disease severity. Journal Of Medical Virology 2022, 95: 10.1002/jmv.28134. PMID: 36086941, PMCID: PMC9538121, DOI: 10.1002/jmv.28134.Peer-Reviewed Original ResearchConceptsAssociated with mild disease outcomeAutoreactive B cell activationMild disease outcomePlasma levels of IgGB cell activationLevels of IgGPlasma levelsAutoantibody productionAnti-type I IFN autoantibodiesPatient groupAssociated with autoimmune featuresLong-term humoral immunityDisease outcomeDisease severityLife-threatening COVID-19Antibody protein arraysHuman coronavirus (HCoV)-229ESeverity of COVID-19Nonpathogenic autoantibodiesAutoantibody levelsSpike proteinAutoimmune featuresSelf-antigensAutoreactive IgGHumoral immunityMyocarditis after COVID‐19 mRNA vaccination: A systematic review of case reports and case series
Park D, An S, Kaur A, Malhotra S, Vij A. Myocarditis after COVID‐19 mRNA vaccination: A systematic review of case reports and case series. Clinical Cardiology 2022, 45: 691-700. PMID: 35652390, PMCID: PMC9286338, DOI: 10.1002/clc.23828.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccine-associated myocarditisVaccine-associated myocarditisCOVID-19 mRNA vaccinesMRNA vaccinesSystematic review of case reportsCOVID-19 vaccineReview of case reportsAverage time to onsetElevation of troponinNonsteroidal anti-inflammatory drugsCases of myocarditisDisease severity of COVID-19Time to onsetLength of hospitalizationOccurrence of myocarditisDose of COVID vaccineAnti-inflammatory drugsPain 3Severity of COVID-19Anti-COVID-19 vaccineSystematic literature searchChest painFavorable prognosisCase seriesClinical characteristicsA 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections
Buturovic L, Zheng H, Tang B, Lai K, Kuan W, Gillett M, Santram R, Shojaei M, Almansa R, Nieto J, Muñoz S, Herrero C, Antonakos N, Koufargyris P, Kontogiorgi M, Damoraki G, Liesenfeld O, Wacker J, Midic U, Luethy R, Rawling D, Remmel M, Coyle S, Liu Y, Rao A, Dermadi D, Toh J, Jones L, Donato M, Khatri P, Giamarellos-Bourboulis E, Sweeney T. A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections. Scientific Reports 2022, 12: 889. PMID: 35042868, PMCID: PMC8766462, DOI: 10.1038/s41598-021-04509-9.Peer-Reviewed Original ResearchConceptsSeverity of viral infectionsViral infectionArea under curveViral illnessPredicting 30-day mortalitySevere respiratory failureAcute viral infectionTrained logistic regression classifierViral infected patientsViral infection settingsImprove patient managementReduce healthcare burdenUnmet medical needSeverity of COVID-19Respiratory failureRetrospective cohortInfected patientsClinical studiesPatient managementCross-validation areaHealthcare burdenGene expression assaysPatientsInfection settingsRisk assessment of COVID-19
2021
Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis
Wang Z, Joshi A, Leopold K, Jackson S, Christensen S, Nayfeh T, Mohammed K, Creo A, Tebben P, Kumar S. Association of vitamin D deficiency with COVID‐19 infection severity: Systematic review and meta‐analysis. Clinical Endocrinology 2021, 96: 281-287. PMID: 34160843, PMCID: PMC8444883, DOI: 10.1111/cen.14540.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyD deficiencyCOVID-19 infectionAssociation of vitamin D deficiencyAssociated with significantly higher mortalityIntensive care unit admissionVitamin D supplementationHospital admissionSeverity of COVID-19 infectionSeverity of coronavirus disease 2019Length of hospitalizationSignificantly higher mortalityAssociated with greater severityCOVID-19 infection severitySeverity of COVID-19D supplementationStudy geographic locationUnit admissionRate of hospital admissionsLonger hospitalSubgroup analysisObservational studyCoronavirus disease 2019Higher mortalityMeta-analysis
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