Uma Reddy, MD, MPH
Professor Adjunct of Obstetrics, Gynecology & Reproductive SciencesAbout
Titles
Professor Adjunct of Obstetrics, Gynecology & Reproductive Sciences
Biography
Dr. Reddy graduated from Brown University Magna cum laude and received her M.D. degree from the Warren Alpert Medical School of Brown University. Dr. Reddy also earned a Masters in Public Health (M.P.H.) from the Johns Hopkins Bloomberg School of Public Health. She completed her residency in Obstetrics and Gynecology at the Johns Hopkins Hospital and remained there as a Robert Wood Johnson Clinical Scholar. She completed her Maternal-Fetal Medicine fellowship at Thomas Jefferson University. She was a faculty member at the University of Maryland School of Medicine prior to joining the National Institutes of Health (NIH) as a Medical Officer in the Pregnancy and Perinatology Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). During her tenure at NIH, she provided MFM clinical services at Walter Reed Medical Center (Bethesda, MD) and then Medstar Washington Hospital Center (Washington, DC) as a Professor of Obstetrics and Gynecology at the Georgetown University School of Medicine prior to joining Yale in 2018.
While at NIH, she oversaw many of the largest and most influential studies in obstetrics, including directing the Maternal-Fetal Medicine Units (MFMU) Network which funds multiple clinical trials across the country. Her research on stillbirth as part of the Stillbirth Collaborative Research Network (SCRN), preterm birth and labor management has had a profound impact on obstetrical practice both in the United States and internationally. She received numerous NIH awards for her role in advancing women’s health research agenda nationally.
Dr. Reddy is widely recognized as a scholar, educator, and mentor. Dr. Reddy has been selected to serve as a Member of the American College of Obstetrics and Gynecology (ACOG) Committee on Practice Bulletins – Obstetrics; Fellow of the American Gynecological & Obstetrical Society and was selected as Fellow in Executive Leadership in Academic Medicine (ELAM) Program for Women, 2020-2021 Class. She has published 250 peer reviewed articles, many in the most impactful journals including NEJM and JAMA.
Dr. Reddy is board certified in Obstetrics and Gynecology and Maternal-Fetal Medicine. Her expertise is in the management of high-risk pregnancies complicated by prior preterm birth or pregnancy loss as well as maternal conditions such as diabetes, hypertension, and connective tissue disorders such as lupus.
Departments & Organizations
- Improving Clinical Care for Recurrent Pregnancy Loss
- Yale Center for Genomic Health
Education & Training
- Fellow
- Thomas Jefferson University (2000)
- MPH
- Johns Hopkins Bloomberg School of Public Health, Biostatistics (1999)
- Robert Wood Johnson Clinical Scholar
- Johns Hopkins University (1997)
- Resident
- Johns Hopkins Hospital (1995)
- Intern
- Johns Hopkins Hospital (1992)
- MD
- The Warren Alpert Medical School of Brown University (1991)
- ScB
- Brown University, Biology (1988)
Research
Overview
Medical Research Interests
ORCID
0000-0001-5519-1527
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Heping Zhang, PhD
Audrey Merriam, MD, MS
Katherine Harper Campbell, MD, MPH
Lena Sweeney, BS, MD
Xiao Xu, PhD, MA
Jennifer Culhane
Pregnant Women
Publications
2025
Intersectionality of individual and neighborhood‐level adverse social determinants of health in early pregnancy
Hamilton J, Grobman W, Wu J, Yee L, Haas D, Mcneil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Wu J, Lynch C, Venkatesh K. Intersectionality of individual and neighborhood‐level adverse social determinants of health in early pregnancy. 2025, 1 DOI: 10.1002/pmf2.70002.Peer-Reviewed Original ResearchConceptsIndividual-level social determinants of healthNeighborhood-level social determinants of healthSocial determinants of healthHigher socioeconomic disadvantageInadequate food accessSDoH measuresLow walkabilitySocioeconomic disadvantageFood accessNulliparous individualsMultiple social determinants of healthNeighborhood-level social determinantsUSDA Food Access Research AtlasFood Access Research AtlasNeighborhood-level measuresAdverse social determinantsArea Deprivation IndexParticipant's home addressDeterminants of healthSecondary analysis of dataNulliparous Pregnancy Outcomes StudyMonitoring Mothers-to-BeLower household incomeCensus tract levelLower educational attainmentAssociation between induction start time and labor duration in nulliparous women undergoing elective induction of labor
Facco F, MacPherson C, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Heyborne K, Srinivas S, Swamy G, Grobman W. Association between induction start time and labor duration in nulliparous women undergoing elective induction of labor. American Journal Of Perinatology 2025 PMID: 40015324, DOI: 10.1055/a-2547-4196.Peer-Reviewed Original ResearchConceptsInduction of laborCesarean delivery rateLabor durationShorter labor durationElective inductionBishop scoreNulliparous womenLow-risk nulliparous womenElective induction of laborModified Bishop scoreMean labour durationMulti-center randomized controlled trialDelivery rateBaseline maternal characteristicsBody mass indexFrequency of deliveryARRIVE trialInsurance statusCervical statusMaternal characteristicsSecondary analysisRupture of membranesSpontaneous laborWeeks 0 daysWomen MethodsPrediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection
Sandoval G, Saade G, Hughes B, Clifton R, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Macones G, Prasad M. Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection. Obstetrics And Gynecology 2025, 145: 449-452. PMID: 40014859, PMCID: PMC11925659, DOI: 10.1097/aog.0000000000005872.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHepatitis C virus infectionPerinatal transmissionHepatitis C virusHepatitis C virus perinatal transmissionPregnant individualsEunice Kennedy Shriver National Institute of Child HealthTransmission of HCV infectionPerinatal transmission rateHCV RNA titersNeonatal follow-upC virus infectionPositive HCV antibodyMulticenter observational studyArea under the curveNational Institute of Child HealthInstitute of Child HealthAntibody-positive participantsAntepartum bleedingHCV infectionHCV antibodiesFollow-upRNA titersC virusObservational studyClinical counselingPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersGroup B Streptococcus colonization and risk of chorioamnionitis among nulliparous individuals
Berry M, Grobman W, Wu J, McNeil B, Yee L, Haas D, Pippen J, Simhan H, Reddy U, Silver R, Saade G, Chung J, Levine L, Venkatesh K. Group B Streptococcus colonization and risk of chorioamnionitis among nulliparous individuals. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101632. PMID: 39921091, DOI: 10.1016/j.ajogmf.2025.101632.Peer-Reviewed Original ResearchDeterminants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy
Cameron N, Huang X, Petito L, Ning H, Shah N, Yee L, Perak A, Haas D, Mercer B, Parry S, Saade G, Silver R, Simhan H, Reddy U, Varagic J, Licon E, Greenland P, Lloyd-Jones D, Kershaw K, Grobman W, Khan S. Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011217. PMID: 39807595, PMCID: PMC11919558, DOI: 10.1161/circoutcomes.124.011217.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsMeSH KeywordsAdultBlack or African AmericanCardiovascular DiseasesFemaleHealth Status DisparitiesHispanic or LatinoHumansMaternal HealthPregnancyPregnancy Trimester, FirstRace FactorsResidence CharacteristicsRisk AssessmentRisk FactorsSocial Determinants of HealthSocioeconomic FactorsUnited StatesWhiteWhite PeopleYoung AdultConceptsNon-Hispanic blacksNon-Hispanic whitesNeighborhood-level factorsNon-Hispanic black groupsCardiovascular health scoreMaternal cardiovascular healthNon-Hispanic White groupCardiovascular healthEthnic differencesLife's Essential 8 scoreSuboptimal cardiovascular healthContributions of individual-Public health effortsYears of educationNulliparous individualsReduce disparitiesHealth effortsProportion of differencesCohort studyOffspring outcomesEducational attainmentIndividual-Higher scoresAssess factorsSingleton pregnanciesRadon Exposure and Gestational Diabetes
Zhang Y, Angley M, Lu L, Smith B, Grobman W, Wylie B, Zork N, D’Alton M, McNeil B, Mercer B, Silver R, Simhan H, Haas D, Saade G, Parry S, Reddy U, Kahe K. Radon Exposure and Gestational Diabetes. JAMA Network Open 2025, 8: e2454319. PMID: 39792382, PMCID: PMC11724344, DOI: 10.1001/jamanetworkopen.2024.54319.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsRadon exposureGestational diabetesCohort studyPopulation-based cohort studyPregnant individualsMedical record abstractionNulliparous Pregnancy Outcomes StudyMultiple logistic regression modelsMonitoring Mothers-to-BeAssociated with greater oddsUS clinical centersMothers-to-beRadon exposure assessmentLogistic regression modelsEnvironmental risk factorsPregnancy Outcomes StudyStatistically significant interactionRecord abstractionImprove pregnancy outcomesMain OutcomesPM2.5 levelsHigher oddsPotential confoundersSmoking statusPregnant participants
2024
Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy
Venkatesh K, Grobman W, Huang X, Yee L, Catov J, Simhan H, Haas D, Mercer B, Reddy U, Silver R, Levine L, Chung J, Saade G, Greenland P, Merz C, McNeil B, Khan S. Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy. American Journal Of Preventive Cardiology 2024, 21: 100925. PMID: 39838971, PMCID: PMC11750432, DOI: 10.1016/j.ajpc.2024.100925.Peer-Reviewed Original ResearchConceptsNeighborhood-level socioeconomic disadvantageArea Deprivation IndexLife's Essential 8Socioeconomic disadvantageMaternal cardiovascular healthCardiovascular healthLife's Essential 8 scoreGreater socioeconomic disadvantageEssential 8Cross-sectional analysisBody mass indexPhysical activityDeprivation indexNulliparous individualsDiet qualityHealth StudyEarly pregnancyTobacco useLess-disadvantagedContinuous scoresMaternal ageMass indexPregnant individualsSleep quantityBlood pressureAssociation of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study
Rajamoorthi A, Zheng H, Skowronski A, Zork N, Reddy U, Tung P, Kupsco A, Gallagher D, Salem R, Leibel R, LeDuc C, Thaker V. Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes Research And Clinical Practice 2024, 220: 111967. PMID: 39716665, PMCID: PMC11840794, DOI: 10.1016/j.diabres.2024.111967.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsOral glucose tolerance testC-peptide concentrationsC-peptideInsulin sensitivityCord bloodFollow-up studyInsulinogenic indexHOMA-IRCirculating C-peptide concentrationsCord blood C-peptideMaternal glucose concentrationsBlood C-peptideBMI z-scoreGlucose tolerance testPancreatic beta-cell developmentBeta-cell developmentGestational ageOGTT glucoseMaternal fastingAssociations of gestationalPubertal stageTolerance testInsulin resistanceZ-scoreMaternal covariatesInsomnia in pregnancy and obstetric outcomes
Friedlander R, Huang X, Zee P, Khan S, Greenland P, Facco F, Chung J, Grobman W, Haas D, McNeil R, Mercer B, Reddy U, Saade G, Silver R, Wiener L, Yee L. Insomnia in pregnancy and obstetric outcomes. Sleep 2024, 48: zsae288. PMID: 39663401, DOI: 10.1093/sleep/zsae288.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor NICHD Individual Merit Award for leading the Opioid Research Effort
National AwardThe Eunice Kennedy Shriver National Institute for Child Health and Human DevelopmentDetails01/01/2017United Stateshonor NICHD Merit Award for NICHD Clinical Trials Stewardship Working Group
National AwardThe Eunice Kennedy Shriver National Institute for Child Health and Human DevelopmentDetails12/01/2015United Stateshonor National Institutes Office of the Director Honor Award for Team to Re-Engineer Scientific Oversight of Women and Minority Inclusion
National AwardNational Institutes OfficeDetails01/01/2015United Stateshonor National Institutes of Health Director’s Group Award for Pregnancy and Perinatology Branch Stillbirth Research Team
National AwardNational InstitutesDetails01/01/2014United Stateshonor National Institutes of Health Merit Award for Leadership of stillbirth research that has contributed to the successful accomplishment of the NICHD mission
National AwardThe Eunice Kennedy Shriver National Institute for Child Health and Human DevelopmentDetails01/01/2012United States
News
News
- July 02, 2021
Repeat Pregnancy Loss Will Be Focus of Genetic Study
- September 17, 2020
A Pregnancy Ended by COVID-19 Informs New Understanding and Protocols
- September 01, 2020Source: Journal of Clinical Investigation
Yale OB COVID Study Makes the Cover of JCI
- May 29, 2020Source: Nature Medicine
Nature Medicine's COVID-19 Research in Brief: 9 May to 15 May, 2020