Marta Piecychna
Research Assistant Internal Medicine RheumatologyCards
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Research Assistant Internal Medicine Rheumatology
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Marta Piecychna's published research.
Richard Bucala, MD, PhD
Insoo Kang, MD
Jennefer Par-Young
Thuy Tran, MD, PhD
Buqu Hu
Edward Manning, MD, PhD
Publications
2025
Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling
Kim S, Nouws J, Ruwisch J, Woodard G, Cooley J, Khoury J, Sun H, Doherty E, Piecychna M, Manning E, Kang M, Bruscia E, Wei H, Zhang Y, Yarovinsky T, Hwa J, Zacharias W, Ingram J, Lee C, Elias J, Kaminski N, Redente E, Herzog E, Prasse A, Bucala R, Sauler M. Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling. Science Translational Medicine 2025, 17: eadr2277. PMID: 41337540, DOI: 10.1126/scitranslmed.adr2277.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlveolar Epithelial CellsAnimalsAntigens, Differentiation, B-LymphocyteBleomycinDisease Models, AnimalHistocompatibility Antigens Class IIHumansIdiopathic Pulmonary FibrosisIntramolecular OxidoreductasesLungMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicProteasome Endopeptidase ComplexProteostasisSignal TransductionUbiquitinConceptsIdiopathic pulmonary fibrosisMacrophage migration inhibitory factorBronchoalveolar lavage fluidPharmacological inhibition of MIFBleomycin-induced lung injury modelMouse modelPharmacological inhibitionC-X3-C motif chemokine receptor 1Human precision-cut lung slicesTransforming growth factor-b1Inhibition of macrophage migration inhibitory factorSignals to macrophagesPrecision-cut lung slicesFibrotic lung diseaseType 2 epithelial cellsAlveolar type 2 epithelial cellsChemokine receptor 1Lung injury modelMigration inhibitory factorMIF-2Study participantsUbiquitin-proteasome systemSpontaneous fibrosisPulmonary fibrosisLavage fluidEnhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547
Doherty E, Par-Young J, Osmani L, Filler R, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Unutmaz D, Wilen C, Geall A, Kang I, Bucala R. Enhanced antibody class switching and T cell responses to a self-amplifying RNA vs mRNA vaccine against SARS-CoV-2 spike protein 4547. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2218.Peer-Reviewed Original ResearchIncreased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225
Par-Young J, Osmani L, Doherty E, Piecychna M, Abraham S, Jain N, Thambatti S, Nazaripour S, Thomas A, Leng L, Geall A, Kang I, Bucala R. Increased antibody diversification in mice vaccinated with a self-amplifying RNA versus mRNA directed against SARS-CoV-2 spike protein 9225. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2654.Peer-Reviewed Original ResearchImproving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1
Tran T, Sánchez-Zuno G, Osmani L, Caulfield J, Valdez C, Piecychna M, Leng L, Armstrong M, Donnelly S, Bifulco C, Clister T, Kulkarni R, Zhang L, Sznol M, Jilaveanu L, Kluger H, Kang I, Bucala R. Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1. JCI Insight 2025, 10: e191539. PMID: 41122966, PMCID: PMC12581657, DOI: 10.1172/jci.insight.191539.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-PD-1Macrophage migration inhibitory factorAnti-MIFMigration inhibitory factorTumor growthTherapeutic efficacyAnti-programmed cell death 1Intratumoral immune cell populationsAssociated with advanced diseaseHigh-expression MIF allelesCell death 1Inhibitory factorTh1 cytokine levelsInhibition of macrophage migration inhibitory factorDual inhibitionMurine tumor modelsColorectal cancer modelImmune cell populationsTumor-bearing animalsClinical trial developmentMultiple cancer typesAntitumor responseDeath-1PD-1Tumor burden
2024
CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells
Pellegrino B, David K, Rabani S, Lampert B, Tran T, Doherty E, Piecychna M, Meza-Romero R, Leng L, Hershkovitz D, Vandenbark A, Bucala R, Becker-Herman S, Shachar I. CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells. PLOS Biology 2024, 22: e3002905. PMID: 39576827, PMCID: PMC11623796, DOI: 10.1371/journal.pbio.3002905.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTriple-negative breast cancerMacrophage migration inhibitory factorImmunosuppressive tumor microenvironmentTolerogenic dendritic cellsRegulatory B cellsChronic lymphocytic leukemiaTumor microenvironmentDendritic cellsImmune cellsB cellsBreast cancerInfiltration of immune cellsAggressive breast cancer subtypeMassive infiltration of immune cellsLevels of CD74Cytokine macrophage migration inhibitory factorBreast cancer subtypesMigration inhibitory factorBinding to CD74Naive BTol-DCsLymphocytic leukemiaTumor environmentMassive infiltrationCancer subtypesMIF-CD74 Pathway and Its Effect on Effector T Cell Exhaustion in Alloimmunity
Younis N, Al Rahy N, Solhjou Z, Kurdi A, Zhang H, Al Chaar S, Djebli H, Badaoui A, Choi J, Piecychna M, Doherty E, Bucala R, Azzi J. MIF-CD74 Pathway and Its Effect on Effector T Cell Exhaustion in Alloimmunity. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202461m1r2m1. DOI: 10.1681/asn.202461m1r2m1.Peer-Reviewed Original ResearchA small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus
Li J, Leng L, Pantouris G, Manjula R, Piecychna M, Abriola L, Hu B, Lolis E, Armstrong M, Donnelly S, Bucala R. A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus. Journal Of Biological Chemistry 2024, 300: 107443. PMID: 38838773, PMCID: PMC11259703, DOI: 10.1016/j.jbc.2024.107443.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPromoter microsatellitesGene expressionMicrosatellite repeat numberMacrophage migration inhibitory factorLength-dependent mannerRNA expression analysisSusceptibility lociFunctional variantsSmall molecule inhibitorsExpression analysisPharmacogenomic developmentRepeat numberMicrosatelliteFunctional interactionsTranscription inhibitorInflammatory gene expressionMIF mRNA expressionCytokine macrophage migration inhibitory factorTranscriptionGenesProtein expressionMigration inhibitory factorExpressionInhibitory factorExpressing macrophages
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