Buqu Hu
Programmer Analyst Internal Medicine PulmonaryCards
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Research
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2026
Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway
Hu B, Guo P, Bar-Joseph I, Imanishi Y, Jarzynka M, Bogler O, Mikkelsen T, Hirose T, Nishikawa R, Cheng S. Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene 2026, 45: 3021-3022. PMID: 42393289, DOI: 10.1038/s41388-026-03882-x.Commentaries, Editorials and LettersStepwise Protocol for Alternative Splicing Analysis in Single-Cell SMART-Seq2 RNA-Seq Data
Walker M, Hu B, Cheng S, Song X. Stepwise Protocol for Alternative Splicing Analysis in Single-Cell SMART-Seq2 RNA-Seq Data. Bio-protocol 2026, 16: e5735. PMID: 42367213, PMCID: PMC13293989, DOI: 10.21769/bioprotoc.5735.Peer-Reviewed Original Researchpercent-spliced-inRNA alternative splicingalternative splicingexpression-based clusteringsplicing analysisscRNA-seqsplicing patternsAS analysisadvent of single-cell RNA sequencingAS dynamicsgene-level quantificationraw sequencing readsRNA-seq datascRNA-seq datasetsscRNA-seq datacell-type annotationalternative splicing analysisR packagesingle-cell RNA sequencingsingle-cell resolutionSeurat R packageSmart-seq2sequence readsproteome diversityeukaryotic cellsPPM1G‒MET axis sustains AKT signaling to drive Twist‐associated EMT and drug resistance in hepatocellular carcinoma
Wu W, Lin S, Zhou C, Hu J, Liu K, Xu Y, Ding Z, Luo M, Hu B. PPM1G‒MET axis sustains AKT signaling to drive Twist‐associated EMT and drug resistance in hepatocellular carcinoma. View 2026 DOI: 10.1002/viw.20260024.Peer-Reviewed Original Researchmesenchymal-epithelial transition factorepithelial-mesenchymal transitionhepatocellular carcinomamultikinase inhibitorPPM1Gprotumorigenic effectsreceptor tyrosine kinase mesenchymal-epithelial transition factorgenetic silencingregulation of oncogenic signalingepithelial-mesenchymal transition markerspoor patient prognosisco-immunoprecipitation assayshuman HCC tissuestherapeutic responsetherapeutic resistancepatient prognosistumor progressiondrug resistanceproteasomal degradationsignaling networksCo-Immunoprecipitationserine/threonine phosphataseHCC cell proliferationAkt signalingoncogenic signalingGlobal Advances in Hepatocellular Carcinoma Research and Therapy in 2025
Hu B, Gao Q. Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025. Cancer Innovation 2026, 5: e70059. PMID: 42005557, PMCID: PMC13084537, DOI: 10.1002/cai2.70059.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementshepatocellular carcinomacombination of immune checkpoint inhibitorsimmune checkpoint inhibitorstyrosine kinase inhibitorshigh-risk patientsglobal health burdenliquid biopsy biomarkerslocoregional interventionscheckpoint inhibitorsgut-liver axisconventional monotherapyhepatocellular carcinoma researchpostoperative recurrencecomplex malignancyprogressive diseasemultidisciplinary managementpathological responseinvasive approachsurvival advantagetherapeutic modalitiesclinical datatreatment strategieskinase inhibitorsgut-liverearly diagnosisThe epidermal growth factor receptor regulates bacterial clearance in cystic fibrosis airway neutrophils
Rasmussen L, Luthra D, Moncada-Giraldo D, Lewis C, Soto-Vazquez Y, Li Z, Hu B, Dobosh B, Stacks D, Koff J, Gaggar A, Tirouvanziam R, Margaroli C. The epidermal growth factor receptor regulates bacterial clearance in cystic fibrosis airway neutrophils. Journal Of Clinical Investigation 2026, 136: e198292. PMID: 41979898, PMCID: PMC13262706, DOI: 10.1172/jci198292.Peer-Reviewed Original ResearchAn EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs
Yu X, Song X, Schäfer R, Meng Q, Tiek D, Wu R, He Q, Walker M, Cao Q, Yang R, Hu B, Cheng S. An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs. Nature Cell Biology 2026, 28: 972-985. PMID: 41896311, PMCID: PMC13086523, DOI: 10.1038/s41556-026-01924-w.Peer-Reviewed Original ResearchTumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced QKI isoforms
Wu R, Yu X, Song X, He Q, Walker M, Sisbarro D, Horbinski C, Tiek D, Hu B, Zhang N, Cheng S. Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced QKI isoforms. Neuro-Oncology 2026, 28: 1163-1178. PMID: 41703645, PMCID: PMC13186460, DOI: 10.1093/neuonc/noag030.Peer-Reviewed Original ResearchConceptssterol regulatory element-binding protein 2tumor-associated astrocytesQKI-5alternative splicingglioma stem-like cellscontribution of alternative splicingbiological rolemolecular analysisloss-of-function approachesRNA-binding protein Quakingcholesterol-metabolizing enzymesstructure predictionglioblastoma growthin vivo orthotopic xenograft modelorthotopic xenograft modelQKI-6sphere-forming assayin vitro proliferationmetabolic reprogrammingstem-like cellsaggressive brain tumorisoform switchingeffects in vitrometabolic enzymestumor microenvironmentTumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis
Wei H, Yu C, Hu B, Zeng X, Ichise H, Li L, Wang Y, Wang R, Germain R, Chang R, Jin C. Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis. Nature 2026, 650: 1007-1016. PMID: 41639447, PMCID: PMC12935554, DOI: 10.1038/s41586-025-10028-8.Peer-Reviewed Original ResearchConceptscancer immunitytumor microenvironmentimmune-suppressive tumor microenvironmentgenetically engineered mouse modelsanti-tumor immunityanti-cancer immunityvagal sensory neuronsvagal sensory nerveslung tumor growthsympathetic efferent activityperipheral nervous systemtumor innervationsympathetic outputvagal sensory inputssolid tumorsorgan cancerssensory neuronstumor growthsensory nerveslung adenocarcinomachemogenetic approachperipheral organsmouse modelbrainstem nucleiimmune responseEpidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury
Harris Z, Korde A, Khoury J, Manning E, Stanley G, Shin Y, Mitchell K, von der Schulenburg A, Sun Y, Hu B, Shin H, Joerns J, Clark B, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang M, Koff J. Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury. BMJ Open Respiratory Research 2026, 13: e003323. PMID: 41592865, PMCID: PMC12853440, DOI: 10.1136/bmjresp-2025-003323.Peer-Reviewed Original ResearchConceptsepidermal growth factor receptoracute lung injuryhyperoxic ALIhyperoxic acute lung injurygrowth factor receptorin vivo effectslung injuryoxidant-mediated acute lung injuryfactor receptorintensive care unit mortalityexposure to high oxygenalveolar type II cellsdelivery of supplemental oxygenpulmonary cell deathlife-saving therapypluripotent stem cellstype II cellsnormoxia controlsupplemental oxygenunit mortalityalveolar epitheliumBeclin-1cell death pathwaysstem cellstherapeutic potentialStable Disease without Tumor Shrink Cannot Benefit from Surgery following Immune-Based Therapy in Potentially Resectable Hepatocellular Carcinoma
He T, Xu B, Yang Z, Zhou S, Wang Z, Wang L, Zhong C, Shi H, Li H, Hu B, Zhu X, Shen Y, Gao Q, Zhou J, Fan J, Sun H, Huang C. Stable Disease without Tumor Shrink Cannot Benefit from Surgery following Immune-Based Therapy in Potentially Resectable Hepatocellular Carcinoma. Liver Cancer 2026, 1-13. PMID: 41815110, PMCID: PMC12975274, DOI: 10.1159/000550497.Peer-Reviewed Original Researchimmune-based therapiesstable diseasepartial responsehepatocellular carcinomaModified RECISTRECIST v1.1maximum tumor shrinkageSolid Tumors versionResponse Evaluation Criteriaimmune-based treatmentsadvanced hepatocellular carcinomaevent-free survivalresectable hepatocellular carcinomadepth of responseKaplan-Meier methodsurvival of patientssuccess rateconversion therapytumor shrinkagesurgical resectiontumor shrinkingoverall survivalsystemic therapyconversion surgeryEvaluation Criteria
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