Featured Publications
Global Perspective on the Impact of the COVID‐19 Pandemic on Rheumatology and Health Equity
Hsieh E, Dey D, Grainger R, Li M, Machado P, Ugarte‐Gil M, Yazdany J. Global Perspective on the Impact of the COVID‐19 Pandemic on Rheumatology and Health Equity. Arthritis Care & Research 2023, 76: 22-31. PMID: 37277949, DOI: 10.1002/acr.25169.Peer-Reviewed Original ResearchConceptsRheumatic diseasesRheumatology practiceHealth service useHealth care utilizationCOVID-19 morbidityHealth care accessCOVID-19 pandemicMental health outcomesUptake of telemedicinePublic health emergencyPublic health communicationAcute phaseVaccine uptakeCare utilizationVaccination practicesRapid guidelinesWorse diseaseCare accessService useHealth outcomesPatient careDiseaseHealth equityHealth emergencyPandemic wanesPrevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV
Cabrera D, Cornejo M, Slotkin R, Pinedo Y, Yu W, Guan W, Garcia P, Hsieh E. Prevalence of and risk factors for vertebral fracture and low bone mineral density among Peruvian women aging with HIV. Archives Of Osteoporosis 2023, 18: 64. PMID: 37160770, PMCID: PMC10170032, DOI: 10.1007/s11657-023-01250-w.Peer-Reviewed Original ResearchConceptsBone mineral densityLow bone mineral densityThoracolumbar X-rayVertebral fracturesFemoral neckRisk factorsLumbar spineOsteoporosis treatmentTotal hipTreatment gapMineral densityTotal hip bone mineral densityPresence of VFsPeruvian womenTH bone mineral densityHip bone mineral densityFN bone mineral densityLower FN BMDSubset of patientsGenant semiquantitative methodLower femoral neckImportant treatment gapsKey risk factorsAntiretroviral therapyFRAX scoreSARS–CoV‐2 Infection and COVID‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis
Conway R, Grimshaw AA, Konig MF, Putman M, Duarte‐García A, Tseng LY, Cabrera DM, Chock YPE, Degirmenci HB, Duff E, Egeli BH, Graef ER, Gupta A, Harkins P, Hoyer BF, Jayatilleke A, Jin S, Kasia C, Khilnani A, Kilian A, Kim AHJ, Lin CMA, Low C, Proulx L, Sattui SE, Singh N, Sparks JA, Tam H, Ugarte‐Gil M, Ung N, Wang K, Wise LM, Yang Z, Young KJ, Liew JW, Grainger R, Wallace ZS, Hsieh E, Alliance T. SARS–CoV‐2 Infection and COVID‐19 Outcomes in Rheumatic Diseases: A Systematic Literature Review and Meta‐Analysis. Arthritis & Rheumatology 2022, 74: 766-775. PMID: 34807517, PMCID: PMC9011807, DOI: 10.1002/art.42030.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMechanical ventilationRisk ratioOdds ratioMortality rateCOVID-19 disease severityJoanna Briggs Institute critical appraisal toolsCOVID-19Odds of hospitalizationNewcastle-Ottawa ScaleCOVID-19 outcomesRandom-effects modelCritical appraisal toolMantel-Haenszel formulaSystematic literature reviewAdjusted riskICU admissionRMD patientsClinical outcomesRheumatic diseasesMethodologic qualityRelative riskObservational studyGeneral populationLower riskGlobal Rheumatology Research: Frontiers, Challenges, and Opportunities
Bilsborrow JB, Peláez‐Ballestas I, Pons‐Estel B, Scott C, Tian X, Alarcon GS, Bucala R, Lewandowski LB, Hsieh E. Global Rheumatology Research: Frontiers, Challenges, and Opportunities. Arthritis & Rheumatology 2021, 74: 1-4. PMID: 34535973, PMCID: PMC8712358, DOI: 10.1002/art.41980.Books
2024
The Feasibility and Acceptability of a Clinical Pharmacist-delivered Intervention to Reduce Bothersome Health Symptoms from Polypharmacy and Alcohol Use and Communicate Risk among People with HIV: Pilot Study Protocol
Womack J, Leblanc M, Sager A, Zaets L, Maisto S, Garcia A, Aoun-Barakat L, Brown S, Edelman E, Fiellin D, Fisher J, Fraenkel L, Kidwai-Khan F, Marconi V, Martino S, Pulk R, Satre D, Virata M, Justice A, Hsieh E. The Feasibility and Acceptability of a Clinical Pharmacist-delivered Intervention to Reduce Bothersome Health Symptoms from Polypharmacy and Alcohol Use and Communicate Risk among People with HIV: Pilot Study Protocol. AIDS And Behavior 2024, 1-15. PMID: 39465468, DOI: 10.1007/s10461-024-04533-6.Peer-Reviewed Original ResearchUnhealthy alcohol useAlcohol usePharmacist-delivered interventionVeterans Aging Cohort StudyPilot study protocolStudy protocolElectronic health recordsSupport behavior changePre-test/post-test designAging Cohort StudySelf-administered surveyAlcohol use disorderAlcohol Research CenterBothersome symptomsPre-test/post-testCommunicating riskHealth recordsLong-term medicationHealth symptomsCounseling interventionCounseling sessionsSessions 2 weeksQualitative interviewsAlcohol consumptionUse disorderThe Association Between Rheumatic Disease Therapies and Cardiovascular Outcomes in People with HIV—A Retrospective Cohort Study
Titanji B, Nagatomi S, Gallini J, Cui X, Hanberg J, Hsieh E, Marconi V. The Association Between Rheumatic Disease Therapies and Cardiovascular Outcomes in People with HIV—A Retrospective Cohort Study. Journal Of Clinical Medicine 2024, 13: 6209. PMID: 39458159, PMCID: PMC11508247, DOI: 10.3390/jcm13206209.Peer-Reviewed Original ResearchRisk of CVD eventsElectronic health recordsCardiovascular disease eventsCVD eventsRetrospective cohort studyCardiovascular diseaseCohort studyIncidence of CVD eventsIncreased risk of CVD eventsRheumatic diseasesCardiovascular disease outcomesCardiovascular disease riskRisk of cardiovascular diseaseHealth recordsAssociated with increased CVD eventsGeneral populationPrimary outcomeDisease therapyAtlanta VAMCIncreased riskHIV infectionExacerbated inflammationCardiovascular outcomesPatient populationHIVBoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans.
Fodeh S, Wang R, Murphy T, Kidwai-Khan F, Leo-Summers L, Tessier-Sherman B, Hsieh E, Womack J. BoneScore: A natural language processing algorithm to extract bone mineral density data from DXA scans. Health Informatics Journal 2024, 30: 14604582241295930. PMID: 39526751, DOI: 10.1177/14604582241295930.Peer-Reviewed Original ResearchConceptsT-score valuesT-scoreNLP algorithmsDXA scansFemoral neck T-scoreNatural language processing algorithmsBone mineral density dataLanguage processing algorithmsBone mineral densityExtract annotationsRegular expressionsTest dataProcessing algorithmsDXA reportsMineral densityAlgorithmMultivariate linear regressionClinical face validityRisk factorsPresence of informationDXANLPClinical validationClinical expertsAccuracyCOVID-19 Breakthrough Infection after Vaccination and Substance Use Disorders: A Longitudinal Cohort of People with and without HIV Receiving Care in the United States Veterans Health Administration
Soyer E, McGinnis K, Justice A, Hsieh E, Rodriguez-Barradas M, Williams E, Park L. COVID-19 Breakthrough Infection after Vaccination and Substance Use Disorders: A Longitudinal Cohort of People with and without HIV Receiving Care in the United States Veterans Health Administration. AIDS And Behavior 2024, 28: 3605-3614. PMID: 39046612, DOI: 10.1007/s10461-024-04449-1.Peer-Reviewed Original ResearchHIV statusSubstance use disordersBreakthrough infectionRisk of breakthroughAssociated with increased riskCOVID-19 breakthrough infectionsSARS-CoV-2Association of substance useSARS-CoV-2 infectionHIV treatment adherenceCD4 countHIV progressionSubstance useUnited States Veterans Health AdministrationHazard ratioIncreased riskPWHCD4PWoHHIVUse disorderVaccinated personsCohort of peopleTreatment adherenceLongitudinal cohort
2023
Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda
Tusubira A, Ssinabulya I, Kalyesubula R, Nalwadda C, Akiteng A, Ngaruiya C, Rabin T, Katahoire A, Armstrong-Hough M, Hsieh E, Hawley N, Schwartz J. Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda. PLOS Global Public Health 2023, 3: e0001777. PMID: 38079386, PMCID: PMC10712841, DOI: 10.1371/journal.pgph.0001777.Peer-Reviewed Original Research1312. Incidence and Microbiology of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans
Weinstein E, Re V, Stephens-Shields A, Newcomb C, Silibovsky R, Nelson C, O’Donnell J, Glaser L, Hsieh E, Hanberg J, Akgün K, Tate J, King J. 1312. Incidence and Microbiology of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans. Open Forum Infectious Diseases 2023, 10: ofad500.1151. PMCID: PMC10678406, DOI: 10.1093/ofid/ofad500.1151.Peer-Reviewed Original ResearchLate prosthetic joint infectionsPrimary total knee arthroplastyProsthetic joint infectionTotal knee arthroplastyIncidence rate ratiosElective primary total knee arthroplastyJoint infectionKnee arthroplastyIncidence rateChi-squared testGram-negative organismsCumulative incidenceConfidence intervalsIncidence of PJIMicrobiology dataEarly prosthetic joint infectionKaplan-Meier failure curvesCulture-negative prosthetic joint infectionPrimary TKA surgeryRetrospective cohort studyKaplan-Meier methodPearson's chi-squared testGrant/research supportOverall study periodIncident hospitalization1313. Determinants of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans
Weinstein E, Re V, Stephens-Shields A, Newcomb C, Silibovsky R, Nelson C, O’Donnell J, Glaser L, Hsieh E, Hanberg J, Akgün K, Tate J, King J. 1313. Determinants of Prosthetic Joint Infection According to Time Following Total Knee Arthroplasty: A Retrospective Cohort Study Among US Veterans. Open Forum Infectious Diseases 2023, 10: ofad500.1152. PMCID: PMC10679182, DOI: 10.1093/ofid/ofad500.1152.Peer-Reviewed Original ResearchPrimary total knee arthroplastyProsthetic joint infectionIncidence rate ratiosTotal knee arthroplastyAutoimmune inflammatory arthritisYear of TKAEarly prosthetic joint infectionLate prosthetic joint infectionsVA Surgical Quality Improvement ProgramPeri-operative factorsVeterans Health AdministrationJoint infectionKnee arthroplastyHCV infectionInflammatory arthritisAlcohol use disorderOperative timeRate ratioUse disordersElective primary total knee arthroplastySurgical Quality Improvement ProgramSkin/soft tissueRetrospective cohort studyConfidence intervalsQuality Improvement ProgramIncidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty
Weinstein E, Stephens-Shields A, Newcomb C, Silibovsky R, Nelson C, O’Donnell J, Glaser L, Hsieh E, Hanberg J, Tate J, Akgün K, King J, Re V. Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty. JAMA Network Open 2023, 6: e2340457. PMID: 37906194, PMCID: PMC10618849, DOI: 10.1001/jamanetworkopen.2023.40457.Peer-Reviewed Original ResearchConceptsPrimary total knee arthroplastyProsthetic joint infectionTotal knee arthroplastyIncidence rate ratiosLate prosthetic joint infectionsPostoperative periodIncidence rateCohort studyOverall cohortJoint infectionKnee arthroplastyVeterans Affairs Surgical Quality Improvement Program dataElective primary total knee arthroplastyEarly prosthetic joint infectionHepatitis C virus infectionQuality Improvement Program dataVeterans Affairs Corporate Data WarehouseAutoimmune inflammatory arthritisPostoperative antibiotic useC virus infectionRisk factor modificationChronic kidney diseasePeripheral artery diseaseLate postoperative periodYears of careAssessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study.
Cabrera D, Cornejo M, Pinedo Y, Garcia P, Hsieh E. Assessment of regional body composition, physical function and sarcopenia among peruvian women aging with HIV: A cross-sectional study. PLOS Global Public Health 2023, 3: e0000814. PMID: 37594923, PMCID: PMC10437949, DOI: 10.1371/journal.pgph.0000814.Peer-Reviewed Original ResearchShort Physical Performance BatteryActive antiretroviral therapyLimb lean massTrunk fat massCross-sectional studyFat massBody compositionSPPB scorePhysical functionPeruvian womenDual X-ray absorptiometryPhysical performancePhysical Performance BatteryGrip strength testChronic disease managementMultivariable regression analysisPopulation of womenX-ray absorptiometryCare of peopleLower SPPB scoresPhysical performance scoreRegional body compositionGlobal health concernEWGSOP criteriaAntiretroviral therapyNeurocognitive Impairment for Persons Living with HIV in Peru: A National Physician Survey (P4-8.003)
Slotkin R, Huff H, Calderon C, Cabera D, Diaz M, Villafane C, Hsieh E, Garcia P. Neurocognitive Impairment for Persons Living with HIV in Peru: A National Physician Survey (P4-8.003). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203802.Peer-Reviewed Original ResearchPerformance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV
Womack J, Murphy T, Leo-Summers L, Kidwai-Khan F, Skanderson M, Gill T, Gulanski B, Rodriguez-Barradas M, Tien P, Yin M, Hsieh E. Performance of a modified fracture risk assessment tool for fragility fracture prediction among older veterans living with HIV. AIDS 2023, 37: 1399-1407. PMID: 37070536, PMCID: PMC10329997, DOI: 10.1097/qad.0000000000003566.Peer-Reviewed Original ResearchConceptsFracture Risk Assessment ToolMajor osteoporotic fractureRisk assessment toolCohort studyHip fractureOsteoporotic fracturesVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionType of fractureRace/ethnicityAssessment toolGlucocorticoid useHIV cohortFragility fracturesPrevious fractureRheumatoid arthritisSmoking statusFracture riskModest discriminationOlder veteransLogistic regressionOccurrence of fracturesHIVAlcohol useAssessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV
Womack J, Murphy T, Leo‐Summers L, Bates J, Jarad S, Gill T, Hsieh E, Rodriguez‐Barradas M, Tien P, Yin M, Brandt C, Justice A. Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV. Journal Of The American Geriatrics Society 2023, 71: 1891-1901. PMID: 36912153, PMCID: PMC10258163, DOI: 10.1111/jgs.18304.Peer-Reviewed Original ResearchConceptsModifiable risk factorsFragility fracturesRisk factorsAlcohol use disorderSerious fallsPhysiologic frailtyAntiretroviral therapyOlder PWHUse disordersVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic modelAverage attributable fractionSuccessful prevention programsKey risk factorsOpioid prescriptionsCohort studyMass indexModifiable factorsSixth decadeAttributable fractionElevated riskICD9 codes
2022
Predictive Risk Model for Serious Falls Among Older Persons Living With HIV
Womack JA, Murphy TE, Leo-Summers L, Bates J, Jarad S, Smith AC, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt CA, Justice AC. Predictive Risk Model for Serious Falls Among Older Persons Living With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 168-174. PMID: 36094483, PMCID: PMC9470988, DOI: 10.1097/qai.0000000000003030.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransOlder PWHAntiretroviral therapySerious fallsOlder personsVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic regressionPredictive risk modelCohort studyMass indexInjury codesElevated riskGeneral populationSix monthsPWHLogistic regressionPotential predictorsSubstance useRadiology reportsHIVExternal causesVeteransProlonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey
DiIorio M, Kennedy K, Liew JW, Putman MS, Sirotich E, Sattui SE, Foster G, Harrison C, Larché MJ, Levine M, Moni TT, Thabane L, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Gore-Massy M, Howard RA, Kodhek MA, Lalonde N, Tomasella LA, Wallace J, Akpabio A, Alpízar-Rodríguez D, Beesley RP, Berenbaum F, Bulina I, Chock EY, Conway R, Duarte-García A, Duff E, Gheita TA, Graef ER, Hsieh E, Kibbi L, Liew DF, Lo C, Nudel M, Singh AD, Singh JA, Singh N, Ugarte-Gil MF, Hausmann JS, Simard JF, Sparks JA. Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2022, 8: e002587. PMID: 36104117, PMCID: PMC9475962, DOI: 10.1136/rmdopen-2022-002587.Peer-Reviewed Original ResearchConceptsSystemic autoimmune rheumatic diseasesCOVID-19 symptom durationSymptom durationAutoimmune rheumatic diseasesCOVID-19 onsetVaccines surveyRheumatic diseasesCOVID-19Test-confirmed COVID-19Complete symptom resolutionCOVID-19 severityCOVID-19 symptomsImmunomodulating medicationsComorbidity countSymptom resolutionBaseline characteristicsClinical characteristicsAcute symptomsVaccine dosesNovel viral variantsHigher oddsLower oddsDay 15Viral variantsLogistic regressionHealth-related quality of life among women aging with and without HIV in Peru
Cabrera DM, Chen M, Cornejo MP, Pinedo Y, Garcia PJ, Hsieh E. Health-related quality of life among women aging with and without HIV in Peru. PLOS ONE 2022, 17: e0269000. PMID: 35679332, PMCID: PMC9182248, DOI: 10.1371/journal.pone.0269000.Peer-Reviewed Original ResearchConceptsHealth-related qualityMental componentPhysical activityCell countLower health-related qualityShort Form Health SurveyComponent scoresHRQoL of womenLarge HIV clinicMental component scorePhysical component scoreForm Health SurveyStatistical significanceSummary component scoresCross-sectional studyRegression analysisChronic comorbiditiesHIV clinicHIV severitySF-36Mean ageRole limitationsPhysical functioningClinical dataHealth SurveyExperience with telemedicine among rheumatology clinicians during the COVID-19 pandemic: an international survey
Chock EY, Putman M, Conway R, Danila MI, Hoyer B, Hsieh E, Jayatilleke A, Kilian A, Leipe J, Liew JW, Machado PM, Robinson PC, Singh N, Ung N, Yeoh SA, Wallace ZS, Grainger R, Cappelli LC. Experience with telemedicine among rheumatology clinicians during the COVID-19 pandemic: an international survey. Rheumatology Advances In Practice 2022, 6: rkac039. PMID: 35669677, PMCID: PMC9154733, DOI: 10.1093/rap/rkac039.Peer-Reviewed Original ResearchRheumatology cliniciansHalf of cliniciansCoronavirus disease 2019 (COVID-19) pandemicYears age groupPerception of telemedicineSpecific clinical situationsQuality of careDisease 2019 pandemicCross-sectional online surveyInflammatory arthritisPhysical examinationTelemedicine encountersClinicians' perceptionsClinical scenariosClinical situationsAge groupsAdequate careFree-text responsesCliniciansCrystalline arthritisArthritisCOVID-19 pandemicTwo-thirdsTelemedicineAcademic affiliation