Lawrence Young, MD
Professor of Medicine (Cardiology) and of Cellular And Molecular PhysiologyCards
About
Research
Overview
Our laboratory is studying the cellular and molecular mechanisms responsible for the metabolic adaptation to the hypoxic stress associated with myocardial ischemia, recently focusing on the AMP-activated protein kinase (AMPK) signaling pathway. AMPK has emerged as a key regulator of glucose transporter (GLUT4) translocation, cellular metabolism, ion channel activity, and cell survival and apoptosis in the heart.
Combining physiologic models of ischemia with cellular and molecular techniques, we are interested in the cardio-protective action of AMPK in the heart, the upstream mechanisms of AMPK activation and its downstream interaction with other signaling pathways, as well as the discovery of novel AMPK targets. The use of transgenic mouse models allows us to dissect the role of AMPK and other signaling pathways in the intact perfused heart and in vivo. The goal of this research is to develop novel strategies to protect the heart against injury during myocardial ischemia.
- Stress signaling pathways is the heart.
- Alterations in metabolism in cardiac disease.
- AMPK as a target for protecting the heart against ischemic injury.
- LKB1 regulation of metabolic signaling and cardic growth.
- Cardiac-derived autocrine-paracrine secreted proteins in the regulation of cardiac signaling pathways.
- Insulin resistance and diabetes in cardiovascular disease.
Medical Research Interests
Academic Achievements & Community Involvement
Clinical Care
Overview
Lawrence H. Young, MD, is a cardiologist who treats patients suffering from heart conditions, both complex and common. With more than 30 years of experience, Dr. Young also specializes in diagnosing and treating patients with a rare genetic disease called hereditary hemorrhagic telangiectasia (HHT). "Yale is probably the world's leader in understanding and treating patients with HHT," Dr. Young says. HHT is a rare genetic disorder that causes abnormal blood vessel growth and heart failure.
As an intern, Dr. Young spent time treating cardiac patients in the cardiac intensive care unit and "decided then and there I wanted to be a cardiologist," he says. "I enjoy taking care of acutely ill patients, but I also enjoy seeing patients over time and helping them to stay healthy."
At the Yale School of Medicine, Dr. Young is a professor of medicine. He leads an active research group, investigating the intersection of heart health and diabetes.
Clinical Specialties
Fact Sheets
Hereditary Hemorrhagic Telangiectasia (HHT)
Learn More on Yale MedicineAVNeo (Aortic valve neocuspidization, Ozaki Procedure)
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale MedicinePulmonary Edema
Learn More on Yale Medicine
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1985
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1983
Yale Medicine News
News
News
- April 05, 2024
Faculty Appointments and Promotions Voting Privileges Expanded in the Academic Clinician Track
- January 09, 2024
Recap & Reflections: Vascular Biology & Therapeutics Program & Cardiovascular Research Center 2023 Retreat
- March 28, 2023
Appointments & Promotions Committee Facilitates Faculty Success
- February 26, 2023
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