2023
Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD
Li R, Li J, Liu Y, Li D, Chu L, Zhang J, Luo X, Zhang Y. Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD. Journal Of Affective Disorders 2023, 327: 31-37. PMID: 36739005, DOI: 10.1016/j.jad.2023.01.107.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersBrain-Derived Neurotrophic FactorEscitalopramHumansPanic DisorderConceptsBaseline serum BDNF levelsSerum BDNF levelsBrain-derived neurotrophic factorState-Trait Anxiety InventoryBDNF levelsPanic disorderTrait anxietyHAMA-14PD patientsHealthy controlsBrain-derived neurotrophic factor serum levelsDiagnosis of panic disorderTreatment response to escitalopramHamilton Anxiety Rating ScaleResponse to escitalopramAnxiety Rating ScaleTreatment responseEscitalopram treatmentAnxiety symptomsNeuropsychological testsNinety PD patientsState-TraitAnxiety InventoryRating ScaleWeeks of treatment
2022
Association between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD
Liu X, Li P, Ma X, Zhang J, Sun X, Luo X, Zhang Y. Association between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD. Journal Of Affective Disorders 2022, 315: 190-197. PMID: 35908604, DOI: 10.1016/j.jad.2022.07.041.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressive Disorder, MajorGlial Cell Line-Derived Neurotrophic FactorHumansPrognosisConceptsAntidepressant treatmentPlasma levelsGDNF levelsMATRICS Consensus Cognitive BatteryMDD patientsHealthy controlsDepression severityWeeks antidepressant treatmentFirst-episode depressionPeripheral plasma levelsPeripheral venous bloodWeeks of treatmentDiagnosis of MDDDecreased plasma levelsHAMA-14Plasma BDNFAntidepressant medicationClinical symptomsHDRS-17Venous bloodCognitive dysfunctionPlasma concentrationsTreatment responseConsensus Cognitive BatteryPatients
2021
The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesBrain-Derived Neurotrophic FactorHumansPsychiatric Status Rating ScalesPsychopathologySchizophreniaConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2020
Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder
Wang W, Liu Y, Luo S, Guo X, Luo X, Zhang Y. Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder. Brain And Behavior 2020, 10: e01885. PMID: 33047489, PMCID: PMC7749616, DOI: 10.1002/brb3.1885.Peer-Reviewed Original ResearchMeSH KeywordsBrain-Derived Neurotrophic FactorCognitive DysfunctionGenotypeHumansPanic DisorderPolymorphism, GeneticPolymorphism, Single NucleotideConceptsBDNF Met/Met genotypeMet/Met genotypeLower BDNF plasma levelsPanic disorderCognitive impairmentMet genotypeMontreal Cognitive AssessmentStroop interferenceVerbal learningNeurocognitive measuresCognitive performanceBDNF plasma levelsMoCA dataCognitive AssessmentAnxiety ScaleBDNF Val66Met polymorphismVal/ValPanic symptomsLower scoresPD patientsHamilton Anxiety ScaleProcessing domainPlasma levelsHealthy controlsModerate positive correlation
2016
BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls.
Zhang XY, Chen da C, Tan YL, Tan S, Luo X, Zuo L, Soares JC. BDNF Polymorphisms Are Associated With Cognitive Performance in Schizophrenia Patients Versus Healthy Controls. The Journal Of Clinical Psychiatry 2016, 77: e1011-8. PMID: 27561148, DOI: 10.4088/jcp.15m10269.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain-Derived Neurotrophic FactorCase-Control StudiesChinaCognitionCognitive DysfunctionFemaleHumansMaleMiddle AgedPolymorphism, GeneticSchizophreniaConceptsBrain-derived neurotrophic factorHealthy controlsCognitive functionBDNF gene variantsCase-control studyBDNF genetic variantsBDNF gene polymorphismPathogenesis of schizophreniaCognitive performanceRBANS total scoreHan Chinese populationBDNF polymorphismVal66Met polymorphismNeurotrophic factorBDNF geneGene polymorphismsCognitive impairmentPatientsPotential associationChinese populationNeuropsychological StatusHan Chinese individualsRepeatable BatterySchizophreniaTotal score
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individuals
2014
Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study
Zhang XY, Chen DC, Tan YL, Luo X, Zuo L, Lv MH, Shah NN, Zunta-Soares GB, Soares JC. Smoking and BDNF Val66Met polymorphism in male schizophrenia: A case-control study. Journal Of Psychiatric Research 2014, 60: 49-55. PMID: 25455509, DOI: 10.1016/j.jpsychires.2014.09.023.Peer-Reviewed Original ResearchConceptsVal/Val genotypeBDNF Val66Met polymorphismHealthy controlsNicotine dependenceVal66Met polymorphismVal genotypeSchizophrenia patientsChronic male schizophrenia patientsMet alleleBDNF Val66Met gene polymorphismBDNF Val66Met genotypePANSS negative symptomsHigher FTND scoresCase-control studyMale schizophrenia patientsNegative Syndrome ScaleChinese Han populationCase-control designVal66Met genotypeMore hospitalizationsPatient groupSmoking indexMale schizophreniaFagerstrom TestHigh HSI scores
2012
BDNF Val66Met Variant and Smoking in a Chinese Population
Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met Variant and Smoking in a Chinese Population. PLOS ONE 2012, 7: e53295. PMID: 23285275, PMCID: PMC3532294, DOI: 10.1371/journal.pone.0053295.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF Val66Met gene polymorphismBDNF Val66Met polymorphismSerum levelsVal66Met polymorphismGene polymorphismsChinese populationBDNF serum levelsSerum BDNF levelsVal/Val genotypeNumber of cigarettesHealthy male volunteersChinese male populationNicotine dependence scoresNeurotrophic factor familyBDNF Val66Met variantBDNF levelsNeurotrophic factorFagerstrom TestBDNF geneMale volunteersLarge cohortNicotine dependenceVal66Met variantNicotine addictionCognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Human Genetics 2012, 131: 1187-1195. PMID: 22362486, PMCID: PMC3671849, DOI: 10.1007/s00439-012-1150-x.Peer-Reviewed Original ResearchConceptsBDNF Val66Met polymorphismBDNF levelsRBANS total scoreHealthy controlsSchizophrenic patientsVal66Met polymorphismHippocampal-dependent cognitive functionsCognitive deficitsBrain-derived neurotrophic factor (BDNF) geneTotal scoreBDNF serum levelsBDNF Val66Met gene polymorphismPeripheral BDNF levelsSerum BDNF levelsMet variantNeurotrophic factor geneNegative Syndrome ScaleSerum BDNFSerum levelsPatient groupNormal controlsSchizophrenic inpatientsGene polymorphismsSyndrome ScaleCognitive impairment