2022
Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrainChildFemaleGenome-Wide Association StudyGray MatterHumansMaleMembrane ProteinsSex CharacteristicsConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesDeficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice
Bai W, Luo X, Jin B, Zhu K, Guo W, Zhu X, Qin X, Yang Z, Zhao J, Chen S, Wang R, Hao J, Wang F, Shi Y, Kong D, Zhang W. Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice. 动物学研究 2022, 43: 851-870. PMID: 36031768, PMCID: PMC9486526, DOI: 10.24272/j.issn.2095-8137.2022.122.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttention Deficit Disorder with HyperactivityCalcium ChannelsHumansMiceMice, KnockoutProteomicsConceptsAttention deficit hyperactivity disorderTARP γKO miceAttention deficit hyperactivity disorder-like behaviorsPrefrontal cortexDysregulation of dopaminergicDevelopment of ADHDGlutamate receptor complexAMPA receptor subunitsTransmembrane AMPA receptor regulatory protein (TARP) γADHD-like behaviorsADHD-like phenotypeMajor behavioral deficitsGlutamatergic transmissionHippocampal synaptosomesRisk factorsSchool-aged childrenAlternative animal modelBehavioral deficitsNew therapiesKnockout miceAnimal modelsProtein γMemory deficitsReceptor subunits
2020
KTN1 variants and risk for attention deficit hyperactivity disorder
Luo X, Guo X, Tan Y, Zhang Y, Garcia‐Milian R, Wang Z, Shi J, Yu T, Ji J, Wang X, Xu J, Zhang H, Zuo L, Lu L, Wang K, Li C. KTN1 variants and risk for attention deficit hyperactivity disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2020, 183: 234-244. PMID: 32190980, PMCID: PMC7210069, DOI: 10.1002/ajmg.b.32782.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesAttention Deficit Disorder with HyperactivityChildComputational BiologyFamily HealthFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeGray MatterHaplotypesHumansMaleMembrane ProteinsPolymorphism, Single NucleotidePutamenRisk
2015
Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk FactorsWhite PeopleConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeuropsychiatric disordersRare variantsHyperactivity disorderDifferent neuropsychiatric disordersRNA expression changesIndependent cohortSignificant associationSignificant regulatory effectDisordersCaucasiansEuropean descentRegulatory effectsHuman brainDiseaseAssociationCis-eQTL analysisIPO11African descentExpression changesSubjectsCohortFalse discovery rateVariants