2023
Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivityImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanism
2022
The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia
Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Li N, Luo X, Zhang P, Huang J, Tian L, Li CR, Tan Y. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Frontiers In Psychiatry 2022, 13: 966657. PMID: 36051545, PMCID: PMC9424630, DOI: 10.3389/fpsyt.2022.966657.Peer-Reviewed Original ResearchStable chronic schizophreniaNF-κB/ILWhite matter integrityHealthy controlsMATRICS Consensus Cognitive BatteryFractional anisotropyChronic schizophreniaCortical thicknessCognitive impairmentInnate immunityCognitive functionToll-like receptor 4Higher TLR4 levelsLevels of TLR4Subcortical gray matter volumesWhite matter fractional anisotropyNegative Syndrome ScaleGray matter volumeTLR4 expressionTLR4 levelsWhite matter microstructureReceptor 4Cognitive deteriorationConsensus Cognitive BatteryLPS stimulation