2023
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDisease
2022
The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia
Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Li N, Luo X, Zhang P, Huang J, Tian L, Li CR, Tan Y. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Frontiers In Psychiatry 2022, 13: 966657. PMID: 36051545, PMCID: PMC9424630, DOI: 10.3389/fpsyt.2022.966657.Peer-Reviewed Original ResearchStable chronic schizophreniaNF-κB/ILWhite matter integrityHealthy controlsMATRICS Consensus Cognitive BatteryFractional anisotropyChronic schizophreniaCortical thicknessCognitive impairmentInnate immunityCognitive functionToll-like receptor 4Higher TLR4 levelsLevels of TLR4Subcortical gray matter volumesWhite matter fractional anisotropyNegative Syndrome ScaleGray matter volumeTLR4 expressionTLR4 levelsWhite matter microstructureReceptor 4Cognitive deteriorationConsensus Cognitive BatteryLPS stimulationSerum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbent
2021
Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia
Zhou Y, Huang J, Zhang P, Tong J, Fan F, Gou M, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yang F, Tian B, Tian L, Savransky A, Hare S, Ryan MC, Goldwaser E, Chiappelli J, Chen S, Kochunov P, Kvarta M, Tan Y, Hong LE. Allostatic Load Effects on Cortical and Cognitive Deficits in Essentially Normotensive, Normoweight Patients with Schizophrenia. Schizophrenia Bulletin 2021, 47: 1048-1057. PMID: 33501486, PMCID: PMC8266595, DOI: 10.1093/schbul/sbaa196.Peer-Reviewed Original ResearchConceptsHigher allostatic loadCognitive deficitsCortical thicknessCortical thinningAllostatic loadCholesterol levelsSchizophrenia patientsLow high-density lipoprotein cholesterolHypersensitive C-reactive proteinHigh-density lipoprotein cholesterolLower total cholesterol levelsDiastolic blood pressureTotal cholesterol levelsC-reactive proteinWaist-hip ratioLeft superior frontal gyrusHigh cholesterol levelsMean cortical thicknessHigher heart rateSuperior frontal gyrusEarly intervention strategiesGray matter integrityNormoweight patientsLipoprotein cholesterolBlood pressure
2020
Cortical Thickness in Alcohol Dependent Patients With Apathy
Yang K, Yang Q, Niu Y, Fan F, Chen S, Luo X, Tan S, Wang Z, Tong J, Yang F, Le TM, Li CR, Tan Y. Cortical Thickness in Alcohol Dependent Patients With Apathy. Frontiers In Psychiatry 2020, 11: 364. PMID: 32431630, PMCID: PMC7214693, DOI: 10.3389/fpsyt.2020.00364.Peer-Reviewed Original ResearchInferior parietal cortexHealthy controlsCortical thicknessSuperior parietal cortexOccipito-temporal cortexParietal cortexOccipital gyrusBilateral superior parietal cortexCritical clinical featuresStructural brain changesEducation-matched healthy controlsSeverity of apathyRight superior occipital gyrusAlcohol-dependent patientsBilateral lingual gyrusLeft middle occipital gyrusSuperior occipital gyrusMiddle occipital gyrusBilateral inferior parietal cortexOccipital-temporal cortexClinical featuresDependent patientsRight intraparietal sulcusMagnetic resonance imaging dataBrain changes