2016
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence
Zuo L, Tan Y, Li C, Wang Z, Wang K, Zhang X, Lin X, Chen X, Zhong C, Wang X, Wang J, Lu L, Luo X. Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 1057-1071. PMID: 27473937, PMCID: PMC5587505, DOI: 10.1002/ajmg.b.32476.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAnimalsBlack or African AmericanCase-Control StudiesDatabases, Nucleic AcidFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiceNicotinePolymorphism, Single NucleotideReceptors, NicotinicTobacco Use DisorderWhite PeopleConceptsCHRN genesGenomic regionsNicotine dependenceAD risk genesAlcohol dependenceRare variantsNicotinic cholinergic receptor genesRewarding effectsDistinct subunitsMouse brainGenesMicroarray platformRisk genesNicotine's rewarding effectsCholinergic receptor genesReceptor geneSpecific brain areasDifferent neuropsychiatric disordersIndependent cohortDiscrete regionsWhole mouse brainBrain areasNeuropsychiatric disordersMRNA expressionBrain
2015
Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations
Wang KS, Zuo L, Pan Y, Xie C, Luo X. Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal Of Psychiatric Research 2015, 71: 1-7. PMID: 26522866, DOI: 10.1016/j.jpsychires.2015.09.008.Peer-Reviewed Original ResearchConceptsAlcohol dependenceSingle nucleotide polymorphismsMultiple logistic regression analysisMarshfield sampleRisk of obesityLogistic regression analysisCentral nervous systemGenetic variantsObesityNervous systemCommon genetic variantsAlcohol addictionCaucasian populationRegression analysisPLINK softwareGenetic associationV geneFirst evidenceAssociationCaucasian samplesGenetic componentPopulationA New Genomewide Association Meta‐Analysis of Alcohol Dependence
Zuo L, Tan Y, Zhang X, Wang X, Krystal J, Tabakoff B, Zhong C, Luo X. A New Genomewide Association Meta‐Analysis of Alcohol Dependence. Alcohol Clinical And Experimental Research 2015, 39: 1388-1395. PMID: 26173551, PMCID: PMC5587504, DOI: 10.1111/acer.12786.Peer-Reviewed Original ResearchConceptsAfrican American cohortAmerican cohortAlcohol dependenceSingle nucleotide polymorphismsAustralian cohortRisk genesEuropean American cohortRisk single nucleotide polymorphismsRat brainIndependent cohortMeta-AnalysisCohortMouse brainRisk variantsP-valueRNA expression analysisGenomewide association studiesBrainHuman tissuesNucleotide polymorphismsAssociation studiesGenomewide association analysis
2013
Genome-wide association studies of maximum number of drinks
Pan Y, Luo X, Liu X, Wu LY, Zhang Q, Wang L, Wang W, Zuo L, Wang KS. Genome-wide association studies of maximum number of drinks. Journal Of Psychiatric Research 2013, 47: 1717-1724. PMID: 23953852, PMCID: PMC4286179, DOI: 10.1016/j.jpsychires.2013.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol-Related DisordersAustraliaCase-Control StudiesCocaine-Related DisordersCommunity Health PlanningFamily HealthFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPhenotypePolymorphism, Single NucleotideTobacco Use DisorderWhite PeopleConceptsGenome-wide association studiesSingle nucleotide polymorphismsGenes/regionsAustralian twin-family studyAssociation studiesFirst genome-wide association studyGene discoveryAlcohol consumption phenotypeFamily sampleAddiction geneticsConsumption phenotypesAlcoholism (COGA) sampleDDC geneCaucasian samplesContinuous phenotypesMaxDrinksSage samplesPhenotypeIntermediate phenotypesGenesSignificant associationAlcohol dependenceExome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence.
Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal Of Studies On Alcohol And Drugs 2013, 74: 622-5. PMID: 23739027, PMCID: PMC3711352, DOI: 10.15288/jsad.2013.74.622.Peer-Reviewed Original ResearchConceptsApolipoprotein E receptor 2Risk genesNonsynonymous variantsRNA expression analysisExome-wide association studyE receptor 2Expression analysisAssociation studiesGenesWhole exomeProtein 2RNA expressionNsSNPReplicable associationsAlcohol dependenceNonhuman speciesEuropean American sampleReceptor 2UbiquitinVariantsMultiple testingSpeciesExomeBioinformaticsUBAP2Genetic Variants in the Fat Mass- and Obesity-Associated (FTO) Gene are Associated with Alcohol Dependence
Wang L, Liu X, Luo X, Zeng M, Zuo L, Wang KS. Genetic Variants in the Fat Mass- and Obesity-Associated (FTO) Gene are Associated with Alcohol Dependence. Journal Of Molecular Neuroscience 2013, 51: 416-424. PMID: 23771786, DOI: 10.1007/s12031-013-0044-2.Peer-Reviewed Original ResearchConceptsAlcohol dependenceSingle nucleotide polymorphismsFat massType 2 diabetesLogistic regression analysisObesity-associated (FTO) geneObesity-Associated GeneAlcohol consumptionJoint interventionsFTO geneObesityRegression analysisGenetic variantsPLINK softwareAssociationAlcoholism (COGA) sampleSage samplesHaplotype analysisCollaborative studyCaucasian samplesSingle marker analysisCOGA sampleDiabetes
2012
Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence
Zuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBeta KaryopherinsBlack or African AmericanCase-Control StudiesChromosomes, Human, Pair 5FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ATobacco Use DisorderWhite PeopleConceptsGenome-wide significance levelSingle nucleotide polymorphismsReplication cohortDiscovery cohortAlcohol dependenceExpression quantitative loci (eQTL) analysisPeripheral blood mononuclear cell samplesNeuropsychiatric disordersWide significant association signalsMononuclear cell samplesGenome-wide association studiesQuantitative loci analysisGene-disease association analysisCis-eQTL analysisTop single nucleotide polymorphismsCis-acting regulatory effectsSignificant association signalsBrain tissue samplesAmerican controlsEuropean American controlsRisk single nucleotide polymorphismsAfrican-American controlsSevere subtypeGenomic regionsAfrican American cases
2009
Population admixture modulates risk for alcohol dependence
Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.Peer-Reviewed Original Research
2007
CNR1 Variation Modulates Risk for Drug and Alcohol Dependence
Zuo L, Kranzler HR, Luo X, Covault J, Gelernter J. CNR1 Variation Modulates Risk for Drug and Alcohol Dependence. Biological Psychiatry 2007, 62: 616-626. PMID: 17509535, DOI: 10.1016/j.biopsych.2006.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanCase-Control StudiesChromosome MappingComorbidityFemaleGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMalePolymorphism, Single NucleotideReceptor, Cannabinoid, CB1Regression AnalysisRisk FactorsSubstance-Related DisordersWhite PeopleConceptsCannabinoid receptor 1Substance dependenceHealthy control subjectsHuman cannabinoid receptor 1Control subjectsSD patientsT genotypeProtective allelesAlcohol dependenceReceptor 1Disease riskModulate riskCNR1 geneCNR1 variationInitial reportCase-control sampleLarge case-control sampleRegression analysisRiskStrong genetic effectsMarkersSignificant interaction effectMultiple markersAncestry informative markersSNP8
2005
ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenetics And Genomics 2005, 15: 755-768. PMID: 16220108, DOI: 10.1097/01.fpc.0000180141.77036.dc.Peer-Reviewed Original ResearchConceptsAlcohol dependenceDrug dependenceSingle nucleotide polymorphismsDiagnosis of alcoholLogistic regression analysisUnrelated healthy controlsUnrelated casesRigorous study designsGene variationRelative risk analysisHaplotype-based haplotype relative riskHealthy controlsRelative riskHaplotype relative risk analysisDisequilibrium testCase-control association analysisInitial studyStudy designTransmission disequilibrium testStrong associationHaplotype relative riskRegression analysisMarkersAffected offspringPresent study