2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioning
2015
The impact of electroconvulsive therapy on the tryptophan–kynurenine metabolic pathway
Guloksuz S, Arts B, Walter S, Drukker M, Rodriguez L, Myint A, Schwarz M, Ponds R, van Os J, Kenis G, Rutten B. The impact of electroconvulsive therapy on the tryptophan–kynurenine metabolic pathway. Brain Behavior And Immunity 2015, 48: 48-52. PMID: 25765557, DOI: 10.1016/j.bbi.2015.02.029.Peer-Reviewed Original ResearchConceptsTrp-Kyn pathwayHamilton Depression Rating Scale-17 itemsElectroconvulsive therapyBeck Depression InventoryMechanism of actionKynurenic acidTrp-KynKyn/Trp ratioKYNA/KYN ratioTryptophan-kynurenine metabolic pathwayLast ECT sessionBilateral electroconvulsive therapyKyn/TrpTreatment of depressionMultilevel linear regression analysesKYN metabolitesECT sessionsAntidepressant effectsECT responseBipolar depressionECT treatmentTrp ratioNeuroprotective propertiesKynurenine pathwayNeurotoxic processes