2020
Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder
Atagun M, Drukker M, Hall M, Altun I, Tatli S, Guloksuz S, van Os J, van Amelsvoort T. Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder. Psychiatry Research Neuroimaging 2020, 300: 111078. PMID: 32361172, DOI: 10.1016/j.pscychresns.2020.111078.Peer-Reviewed Original ResearchConceptsP50 sensory gatingFirst-degree relativesBipolar disorderSensory gatingP50 sensory gating deficitsDual-click paradigmFirst-episode psychosisSensory gating functionSensory gating deficitsS1-S2 differenceEffect of diagnosisAuditory P50 sensory gatingSensory gating ratiosGating deficitsInclusion criteriaTreatment statusLongitudinal courseIllness statePoor real-world functioningLiterature searchSchizophreniaDisordersRedundant sensory inputsTrend levelNeurophysiological measures
2019
Involvement of hemoglobins in the pathophysiology of Alzheimer's disease
Altinoz M, Guloksuz S, Schmidt-Kastner R, Kenis G, Ince B, Rutten B. Involvement of hemoglobins in the pathophysiology of Alzheimer's disease. Experimental Gerontology 2019, 126: 110680. PMID: 31382012, DOI: 10.1016/j.exger.2019.110680.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurodegenerative disordersPathogenesis of ADCourse of ADNitric oxideIncreased Hb levelsTangle-bearing neuronsInner mitochondrial membraneBlood-brain barrierAD brain samplesLevels of HbCentral nervous systemHeme-containing proteinsRole of HbFunction of intracellularMultiple beneficial effectsHb transcriptionHb levelsAD brainImmunohistochemical studyMitochondrial membranePossible candidate moleculesBiological processesCellular respirationNervous system