2021
Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study
Fusar-Poli L, Pries LK, van Os J, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Üçok A, Alptekin K, Saka MC, investigators G, Aguglia E, Arango C, O'Donovan M, Rutten B, Guloksuz S. Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2021, 113: 110440. PMID: 34536513, DOI: 10.1016/j.pnpbp.2021.110440.Peer-Reviewed Original ResearchConceptsDegraded Facial Affect Recognition TaskFacial emotion recognitionEmotion recognitionFacial affect recognition taskAffect recognition taskSocial cognition impairmentsFER deficitsIndividual emotionsPRS-SCZFER accuracyRecognition taskHealthy controlsSchizotypy-RevisedCognition impairmentIntermediate phenotypesPsychosis riskStructured interviewsEUGEI studySchizophreniaTotal scoreSiblingsGenetic riskDifferent patternsPsychosisEmotions
2019
Phenotypic factors associated with amisulpride‐induced weight gain in first‐episode psychosis patients (from the OPTiMiSE cohort)
Pandit R, Cianci D, Hark S, Rossum I, Ebdrup B, Broberg B, Garcia‐Portilla M, Bobes J, Vinkers C, Kahn R, Guloksuz S, Huitema A, Luykx J. Phenotypic factors associated with amisulpride‐induced weight gain in first‐episode psychosis patients (from the OPTiMiSE cohort). Acta Psychiatrica Scandinavica 2019, 140: 283-290. PMID: 31323113, PMCID: PMC6771865, DOI: 10.1111/acps.13074.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis patientsPsychosis patientsWeight gainSchizophreniform disorderAntipsychotic-induced weight gainFirst-episode patientsManagement of schizophreniaLower baseline weightMultivariable regression modelsWeight-reducing strategiesOptimization of treatmentRegression modelsMajor depression disorderPhenotypic factorsAmisulpride treatmentBaseline weightEurope (Syst-Eur) trialMost antipsychoticsDepression disorderYoung subjectsBody weightPatientsBetter efficacyYounger ageAIWG
2018
Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population
Reininghaus U, Rauschenberg C, Have M, de Graaf R, van Dorsselaer S, Simons CJP, Gunther N, Pries LK, Guloksuz S, Radhakrishnan R, Bak M, van Os J. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population. Psychological Medicine 2018, 49: 1799-1809. PMID: 30160228, DOI: 10.1017/s0033291718002209.Peer-Reviewed Original ResearchConceptsComposite International Diagnostic InterviewAffective disturbancesPsychotic experiencesNetherlands Mental Health SurveySecond Netherlands Mental Health SurveyTransdiagnostic phenotypeJTC biasMental Health SurveyDose-response relationshipGeneral population sampleHealth SurveyGeneral populationIncidence studyHelp-seeking behaviorDiagnostic InterviewTime pointsMemory performanceConclusions reasoning biasPopulation sampleRecent findingsPhenotypeDigit span taskIndividualsFindingsPsychosis
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders