2022
Interrogating Associations between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness
Loef D, Luykx J, Lin B, van Diermen L, Nuninga J, van Exel E, Oudega M, Rhebergen D, Schouws S, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager T, Ryan K, Arts B, van Bronswijk S, Kenis G, Schurgers G, Baune B, Arns M, van Dellen E, Somers M, Sommer I, Boks M, Gülöksüz S, McLoughlin D, Rutten B, Dols A. Interrogating Associations between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry 2022, 91: s55. DOI: 10.1016/j.biopsych.2022.02.157.Peer-Reviewed Original ResearchTherapy effectivenessPolygenic liability
2021
Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness
Luykx J, Loef D, Lin B, van Diermen L, Nuninga J, van Exel E, Oudega M, Rhebergen D, Schouws S, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager T, Ryan K, Arts B, van Bronswijk S, Kenis G, Schurgers G, Baune B, Arns M, van Dellen E, Somers M, Sommer I, Boks M, Gülöksüz S, McLoughlin D, Dols A, Rutten B. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry 2021, 91: 531-539. PMID: 34955169, DOI: 10.1016/j.biopsych.2021.10.013.Peer-Reviewed Original ResearchConceptsMajor depressive episodeHamilton Depression Rating Scale scoresDepression Rating Scale scoresRating Scale scoresPolygenic risk scoresPRS-SCZECT outcomeElectroconvulsive therapyScale scoreSevere major depressive episodeUnipolar major depressive episodeMajor depressive disorderSecondary outcomesAntidepressant responseECT treatmentDepressive episodeSubgroup analysisECT effectivenessPsychotic featuresDepressive disorderTreatment responseMAIN OUTCOMEEffective treatmentRisk scoreTherapy effectivenessTH32. POLYGENIC LIABILITY FOR SCHIZOPHRENIA IS ASSOCIATED WITH ELECTROCONVULSIVE THERAPY EFFECTIVENESS
Loef D, Luykx J, Lin B, van Diermen L, Nuninga J, Boks M, Gülöksüz S, McLoughlin D, Dols A, Rutten B. TH32. POLYGENIC LIABILITY FOR SCHIZOPHRENIA IS ASSOCIATED WITH ELECTROCONVULSIVE THERAPY EFFECTIVENESS. European Neuropsychopharmacology 2021, 51: e211. DOI: 10.1016/j.euroneuro.2021.08.205.Peer-Reviewed Original ResearchTherapy effectivenessSchizophrenia